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  • BCM-HGSC
    understood to include more than 200 different diseases In all forms of cancer genomic changes cause disruptions within cellular pathways that result in uncontrolled cell growth One in three people in the Western world develops cancer One in five will die of the disease Cancer is therefore the most common genetic disease The Cancer Genome Atlas Pilot Project seeks to explore the entire spectrum of genomic change in cancer through the application of genome analysis technologies including large scale genome sequencing Charcot Marie Tooth Project The real promise of genomics will not be realized until individual patients enjoy improved medical outcomes due to the understanding that genome sequencing can bring to their treatment At the BCM HGSC we are working together with Jim Lupski and other BCM collaborators to demonstrate that this promise can be a reality with current DNA sequencing technology The BCM HGSC The BCM HGSC founded in 1996 is a world leader in genomics The fundamental interests of the BCM HGSC are in advancing biology and genetics by improved genome technologies One of three large scale sequencing centers funded by the National Institutes of Health the BCM HGSC s location at the heart of the Texas Medical

    Original URL path: https://www.hgsc.bcm.edu/ (2013-03-30)
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  • News | BCM-HGSC
    2009 Bovine genome provides clue to evolution better beef milk April 24 2009 Breast cancer genome shows evolution instability of cancer December 15 2008 Consortium unravels genetic picture of lung cancer October 23 2008 Analysis of common brain tumor finds new gene mutations September 4 2008 New technologies speed development of personal genomes April 16 2008 First beetle genome sequenced March 24 2008 Subtle changes mark common drug resistant bacteria November 19 2007 Tumor genome analysis unveils new insights into lung cancer November 4 2007 Epilepsy genes may cancel each other November 4 2007 BCM Human Microbiome Projects to sequence 150 bacteria sample human metagenome October 30 2007 Human Genome Sequencing Center at BCM increases fleet of genome sequencers October 23 2007 HapMap II demonstrates power to identify genetic variants associated with common diseases October 17 2007 Combining new gene chips with fast sequencing technology brings universal sequence a step closer October 15 2007 The Smith Foundation funds breast cancer genomic medicine research at Baylor College of Medicine September 26 2007 BCM awarded Cancer Genome Atlas grant July 2 2007 Nobel laureate James Watson receives personal genome in ceremony at Baylor College of Medicine May 31 2007 Special Event Genome of James Watson May 30 2007 DNA sequence of Rhesus macaque has evolutionary medical implications April 13 2007 114M grant aims to unlock secrets of genetics cancer genome November 21 2006 Decoded sea urchin genome shows surprising relationship to man November 9 2006 Consortium decodes honey bee genome October 25 2006 Advanced bovine genome assembly genetic resources released Cow genome project heads for home August 14 2006 Baylor College of Medicine Human Genome Sequencing Center marks end of sequencing effort with chromosome 3 April 27 2006 Chromosome 12 annotated sequence complete March 16 2006 Looking at Eyeless from two directions

    Original URL path: https://www.hgsc.bcm.edu/content/news (2013-03-30)
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  • Contact the BCM-HGSC | BCM-HGSC
    deadend at the fountain in front of Baylor College of Medicine At the stop sign take a left on E Cullen St followed by a right on Ross Sterling and enter Parking Garage 4 The Alkek building is on the corner of Ross Sterling and E Cullen After parking leave the garage and enter the Alkek building from E Cullen street From Hobby Airport I 45 South As you leave the airport turn right onto Airport Blvd Continue east until you reach I 45 North At I 45 North turn left and enter the freeway Get into the far left lane and take the left exit to 610 West Take the Fannin exit and turn right north onto Fannin Street The tall buildings are the south side of the medical center Take a right onto John Freeman Blvd This short street will deadend at the fountain in front of Baylor College of Medicine Take a left north on E Cullen St followed by a right on Ross Sterling and enter Parking Garage 4 The Alkek building is on the corner of Ross Sterling and E Cullen After parking leave the garage and enter the Alkek building from E Cullen side From I 10 Traveling East or West Exit at Highway 59 South Travel on 59 South to Highway 288 Exit at MacGregor Drive and turn right on North MacGregor Drive Continue on MacGregor Drive until you reach Fannin Street Take a left on Fannin and continue going south until you reach John Freeman Blvd Take a left onto John Freeman Blvd This short street will deadend at the fountain in front of Baylor College of Medicine Take a left north on E Cullen St followed by a right on Ross Sterling and enter Parking Garage 4 The Alkek building is

    Original URL path: https://www.hgsc.bcm.edu/content/contact-bcm-hgsc (2013-03-30)
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  • Cancer Genome Atlas Pilot Project | BCM-HGSC
    ovarian cancers The project will enable new discoveries and tools that will provide the basis for new cancer therapies diagnostics and preventive strategies The overall began in 2006 with a technical demonstration project known as the Tumor Sequencing Project TSP to determine the feasibility of a full scale program to systematically explore the universe of genomic changes involved in human lung cancer As in the Human Genome Project TCGA data are made available to the worldwide research community without restriction These data will provide researchers and clinicians with an early glimpse of an unprecedented comprehensive atlas of information describing the genomes of all cancers This atlas will enable the research community to reach the long range objective of understanding cancer at the molecular level and will help transform the bench to bedside research paradigm with prevention early diagnosis targeted treatment and cure All DNA specimens used in TCGA have been anonymized along with their phenotypic data so that an investigator cannot link an individual specimen with a patient identity The coding and naming that is visible in the public databases will not allow the traces from multiple amplicons from the same DNA sample to be associated Investigators interested in the

    Original URL path: https://www.hgsc.bcm.edu/content/cancer-genome-atlas-pilot-project (2013-03-30)
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  • Charcot-Marie-Tooth Project | BCM-HGSC
    as a model disease to describe genetic heterogeneity to posit the relation of hereditary pattern to clinical severity and to investigate the relative importance of principal and modifying genes in determining human diseases It s role as a model for genetic disease makes it the ideal starting point for these early studies in medical genomics Currently we have sequenced the whole genome of one CMT patient and are progressing to

    Original URL path: https://www.hgsc.bcm.edu/content/charcot-marie-tooth-project (2013-03-30)
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  • Home page graphic | BCM-HGSC
    Genetics Human Microbiome Research Tools Software Technology Development Genboree Publications BCM Home BCM Intranet Privacy Notices Contact BCM BCM Site Map 1998 2013 Baylor College of Medicine Human Genome Sequencing Center Mail One Baylor Plaza MS BCM226 Houston TX 77030

    Original URL path: https://www.hgsc.bcm.edu/content/home-page-graphic (2013-03-30)
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  • The BCM-HGSC | BCM-HGSC
    genome technologies One of three large scale sequencing centers funded by the National Institutes of Health the BCM HGSC s location at the heart of the Texas Medical Center provides a unique opportunity to apply the cutting edge of genome technologies in science and medicine Home Contact Us About Us Genome Data Human Genetics Human Microbiome Research Tools Software Technology Development Genboree Publications BCM Home BCM Intranet Privacy Notices Contact

    Original URL path: https://www.hgsc.bcm.edu/content/bcm-hgsc (2013-03-30)
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  • About the BCM-HGSC | BCM-HGSC
    honey bee sea urchin marmoset orangutan and cow In addition sequencing projects are currently under way for many other species including the acorn worm wallaby hyrax megabat dolphin pea aphid red flour beetle nasonia wasp gibbon baboon and over two hundred different microbial organisms When compared with the human genome sequence the genomes of these other organisms will help us predict where genes are located in human chromosomes and will lead to a better understanding of how genomes have evolved The BCM HGSC Today Today the BCM HGSC employs more than 200 staff and it occupies more than 36 000 square feet on the 14th 15th and 16th floors of the Margaret M and Albert B Alkek Building The BCM HGSC is located on the southwest edge of downtown Houston the fourth largest city in the U S in the Texas Medical Center the world s largest medical complex The major activity of the BCM HGSC is high throughput DNA sequence generation and the accompanying analysis The center currently operates multiple sequencing platforms ABI Sanger and SOLid 454 Life Sciences and Solexa Illumina The sequence data generated by these machines is analyzed in a complex bioinformatics pipeline and the data are deposited regularly in the public databases at the National Center for Biotechnology Information NCBI This ensures that the worldwide research community has timely access to the data The BCM HGSC is also involved in developing the next generation of DNA sequencing and bioinformatics technologies that will allow greater scientific advances in the future BCM HGSC and the Community The BCM HGSC has strong ties with the Houston community and the BCM HGSC has made special efforts to provide information about DNA sequencing and genomics to the public Coinciding with the announcement of the completion of the HGP in April

    Original URL path: https://www.hgsc.bcm.edu/content/about-bcm-hgsc (2013-03-30)
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