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  • Bacterial RNA polymerase can retain sigma70 through transcription | Jane Kondev Group
    how long it remains attached and its consequences for transcription regulation were unclear In this study Tim Harden and his collaborators used a novel multi wavelength single molecule fluorescence microscopy approach to directly observe and quantitatively characterize the dynamic interactions of the σ 70 protein with bacterial RNA polymerase molecules in vitro during active RNA synthesis Harden is a Brandeis Physics Ph D student who is jointly advised by Jeff Gelles and Jane Kondev The study demonstrates by direct observation that actively elongating polymerase molecules can retain σ 70 from initiation into the elongation phase of transcription shows that retained σ 70 subunits dissociate so slowly that most are still present on the elongation complex at the end of a long gene and proves that only the subpopulation of elongating polymerases with bound σ 70 recognize a class of transcriptional pause sequences which in some contexts play a well established role in regulating gene expression More generally this study provides the first quantitative framework that defines the post initiation roles of σ 70 information that is essential to the understanding of global transcription regulation in bacteria Furthermore the work demonstrates a general method for elucidating the dynamic interactions of transcription

    Original URL path: https://blogs.brandeis.edu/kondevgroup/2016/04/04/bacterial-rna-polymerase-can-retain-sigma70-through-transcription/ (2016-04-25)
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  • Multimedia Journalism Fall 2015: Welcome!
    Leave a comment on Jacob Slideshow Jacob Documentary Posted on December 17 2015 Author jacobsk Leave a comment on Jacob Documentary Bike Slideshow Posted on December 17 2015 Author jkaiser Leave a comment on Bike Slideshow Kindness Day Video Posted on December 17 2015 Author jkaiser Leave a comment on Kindness Day Video Elan s Slideshow Posted on December 17 2015 Author elankane Leave a comment on Elan s Slideshow

    Original URL path: http://blogs.brandeis.edu/multimediajournalismfall2015/ (2016-04-25)
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  • Teaching with Technology: Welcome!
    available For instance the scene editor facilitates the positioning of 3d models in your VE and or the materials that will be used to draw the surfaces Another example is the material editor allows you to change material properties e g the textures that it will use to draw the surfaces Keep in mind that the screenshot above does not show all the available editors and there are others such as the material editor While the Unity editor allows you to drag and drop assets into a 3d scene and modify their properties such as position scale orientation and or the materials used to draw the asset on the screen if you want your virtual environment to be interactive then you will have to write a script that governs that interactivity You can write scripts in three different programming languages C JavaScript and Boo You edit scripts using MonoDevelop which is installed along with Unity 3d The screenshot below shows an overview of MonoDevelop Most important are the list of scripts in your project visible on the left side of the screen and the script editor visible in the top right part of the screen Whenever you save a script and switch back to the Unity 3d editor your newly saved script will automatically get compiled and provided that your script is free of any programming or compilation errors your virtual environment is ready to be run In general you can use all the features that your scripting language of choice provides For instance if you would use C you have access to all the libraries that that language has to offer more specifically that the cross platform variant of C called Mono has to offer In that sense use of your scripting language of choice is pretty straight forward However there is one particular mechanism that needs further attention Imagine that your virtual environment has an avatar and you want that avatar to move forward when the player presses one of the arrow keys on the keyboard Or you want to quit your virtual environment when the player presses the escape key on the keyboard You do this by using the Unity 3d editor to attach what I call behavior scripts to assets in your virtual environment This process is shown in the screenshot below The screenshot above expands the example given previously of a virtual environment quitting after the player presses the escape key on the keyboard In the unity editor screen in the image above there is a scene that I called App main This scene has one gameobject called Scripts in it which has a blue selection focus bar on it in the scene editor which in this case does not draw anything to the screen If you look at the object inspector you can see that the scripts gameobject has a behavior script called Application Controller attached to it For clarity I have added a yellow highlight to the object inspector This Application Controller script contains all the programming logic required to exit the virtual environment when a press of the escape key is detected The MonoDevelop editor shown on the right in the image above shows that the Application Controller script contains a class called ApplicationController This class inherits the MonoBehaviour class highlighted in green in the image above which is provided in the UnityEngine library This inheritance is what makes the distinction between behavior scripts which can be attached to gameobjects in the virtual environment and regular scripts which can be usd by behavior scripts but not attached to gameobjects in the virtual environment While with regular scripts you are free to define your class interfaces as you see fit if you want to implement behavior scripts then there are certain guidelines that follow from your class inheriting from the MonoBehavior base class This sounds complicated but really only means that there are certain functions that you must implement Examples are for instance Start which automatically gets called when the virtual environment starts or Update which gets called every time that a frame is draw on the screen The Update function is the most commonly used function to implement any kind of behavior So for our press escape to exit example we would add an Update function to our ApplicationController class that consists of a couple of lines of code that exits the virtual environment if the escape key is pressed Several people all with little to no graphics programming experience approached me with questions about how to get started with developing virtual environments Although the level of detail of graphics programming knowledge that is required depends a bit on what you want to do in general to familiarize yourself with the essentials of the 3d rendering pipeline the following should be helpful in getting you started Familiarize yourself with basic matrix and vector algebra You do not need to understand the underlying math behind e g a translation rotation scaling TRS matrix just know that it exists and how to use it The same goes for vector math dot products cross products and so on Familiarize yourself with the basics of 3d camera transformations model view and projection matrices The model matrix contains TRS information for each individual 3d model in the world the view matrix contains TR information for the camera and the projection matrix contains information about how to project a 3d world onto a 2d screen Familiarize yourself with material rendering basics a material determines how a surface will look when it is drawn on the screen and can be as simple as a single solid color Materials can have one or more textures associated with them e g a base texture that determines the diffuse color of each point on the surface or a normal map that can be used to give the surface a rugged appearance A material uses a shader a script file that runs on the GPU of your computer s videocard that takes the

    Original URL path: http://blogs.brandeis.edu/teaching/ (2016-04-25)
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  • Peace, Conflict, and Coexistence Studies at Brandeis University
    and Coexistence Studies program PAX stands in solidarity with the students of FordHall2015 At the heart of PAX is the mission to teach students how to analyze structures and processes of injustice how to interact nonviolently with the world around them and how to work effectively to improve it We believe it is essential to seek to investigate the nature of power political participation release from domination and exploitation and the self s relation to all this We fully and enthusiastically endorse the Concerned Students efforts to make Brandeis more fully sensitive to race gender class and other issues of oppression With some expertise in conflict resolution and its many applications and nuances we offer to be as helpful as possible in any of the phases of the work ahead where we would be welcome to take part in this most urgent and promising dynamic under way Filed under Uncategorized Comment 0 Anita Sarkeesian November 2nd 2015 October 19th 2015 Please join us in welcoming Anita Sarkessian Monday November 2nd 2015 in Wasserman Cinematheque Co Sponsored by Women s Studies Research Center The Chief Information Officer Women s Gender Studies Dead of Arts Sciences Office of the Provost English Department Sociology and SJSP Filed under Uncategorized Comment 0 SJSP PAX Graduation Reception May 5th 2015 Filed under Events Comment 0 Noam Chomsky coming to Brandeis April 13th 2015 Filed under Events Comment 0 Davis Projects for Peace winners March 19th 2015 Congratulations to our Davis Projects for Peace Award winners These two students got 10 000 each to implement their projects We re very proud of the quality of their applications and their passion to activate social justice both locally and globally Filed under Announcements Comment 0 Previous Entries April 2016 M T W T F S S Mar 1

    Original URL path: http://blogs.brandeis.edu/paxblog/ (2016-04-25)
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  • Division of Social Sciences
    support from the Provost s office and the office of the Dean of Arts and Sciences invite all members of the Brandeis Community students faculty and staff to experience and celebrate the linguistic diversity of Brandeis during our annual Language Lunch event Individual language tables will host speakers of Arabic Chinese French German Hebrew Hindi Italian Latin Japanese Korean Portuguese Russian Spanish and Yiddish Stay for a few minutes or for the entire hour Do you speak several languages Visit multiple tables during lunch No matter your level of proficiency you are welcome The only rule is NO ENGLISH Please speak only the language of a specific table tables during your visit Participants are asked to sign in at their chosen language table to receive a voucher for the buffet lunch While the amount of food is limited to the first 10 12 people who sign up we encourage people who were not among the first to fill out the form to bring their own lunch fare to the table of your choice Please use this link below to sign up for the Mega Language Lunch No Comments Announcements Events Uncategorized Permalink Posted by Charity Adams French Language Docudrama Le Rêve de Champlain based on David Hackett Fischer s book by the same name wins a Gémeaux Prize September 30th 2015 Photo by Megan Bailey Known as the Emmy Awards of francophone Canada Le Rêve de Champlain won a Gémeaux prize in the category of Best digital production website and or mobile application for a program or series docudrama Professor David Hackett Fischer s bestselling book Champlain s Dream 2008 inspired and informed the French language docufiction series The prize was announced on September 20 th during the 30 th Gala des Prix Gémeaux in Montréal The innovative format of the Le Rêve de Champlain series combines dramatic scenes starring popular Canadian actor Maxime Le Flaguais as Champlain with interviews and reports hosted by renowned journalist and host Marie Louise Arsenault The Champlain series was developed by Groupe Media TFO under the direction of Martin Cadotte and produced by Slalom and the Fair Play Group The series is accompanied by a suite of digital products including a website which includes interviews with Professor Fischer as well as interactive games and educational applications that allow users of all ages to follow in the footsteps of Samuel de Champlain and to relive an era that shaped Canadian history An English Language version of this series is currently in production as well Professor Fischer is a University Professor and the Earl Warren Professor of History at Brandeis University 1 Comment Announcements Awards Permalink Posted by Charity Adams Boston Globe Professor Donahue Discusses Increased Demand in Local Food September 18th 2015 Demand for locally farmed food is on the rise in New England Not typically thought of as a farming region land devoted to farming has increased over the past decade Brandeis Professor Brian Donahue shared his thoughts in a recent Boston Globe article

    Original URL path: http://blogs.brandeis.edu/socialsciences/ (2016-04-25)
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  • Department of Sociology Blog
    and courage in asking all of us to participate in the realization of this vision We commit ourselves to actively engaging to deepen the conversation and to support concrete efforts to move towards a more equitable and just Brandeis Our discipline arose from the study of inequality and injustice and these remain central concerns We recognize the harms done by systems of structural inequality which exact deadly and unacceptable tolls on the bodies souls families and communities of people of color in the United States We also know that the values and policies that have attempted to address the persistent problems of racism and exclusion in our society and our university have often fallen short and that new discussions new ideals and new practices are necessary to move our communities forward We maintain an unshakable commitment to teaching and research focused on inequality and injustice their consequences and mechanisms for their amelioration We support continued negotiations between the students university administration interim President Lynch and the Board of Trustees to find a collaborative path for addressing the yet unfulfilled social justice promise of Brandeis We will continue to engage with our students colleagues and university leaders to address these issues on campus and beyond in a constructive and collaborative manner 0 Comments Filed under Uncategorized October 19th 2015 Anita Sarkeesian November 2nd 2015 Please join us in welcoming Anita Sarkessian Monday November 2nd 2015 in Wasserman Cinematheque Co Sponsored by Women s Studies Research Center The Chief Information Officer Women s Gender Studies Dean of Arts Sciences Office of the Provost English Department Sociology and SJSP 0 Comments Filed under events May 13th 2015 Commencement is right around the corner Congratulations Sociology graduates We are so proud of all you ve accomplished and the myriad of ways in which you

    Original URL path: http://blogs.brandeis.edu/sociology/ (2016-04-25)
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  • naya shcere
    only a few really have the motivation to work long hours at a minimum wage job Are rising costs of tuition and living pushing students across the country to find quick and easy ways to make money If I pursue this story I will hope to answer or reflect on this question more deeply and more informatively Another story that hits close to home is the difficult transition from life at home to college One of the reasons I chose to come to Brandeis was so that I could learn more about my Judaism However it has been a difficult transition and I am not the only jewish person on campus who feels the same way Brandeis has a large student population and tries its best to cater to every walk of jewish life but some people aren t fitting in regardless if they are orthodox conservative or reform Why is this such a predominant issue on a predominantly jewish campus Until next time 0 Comments January 19th 2016 hey what s up hello Posted by nschere in Uncategorized Hey everyone My name is Naya or Maya but with an N I am currently a first year and honestly I did not express any interest in journalism until this past December I have always wanted to go to law school or find a job in some type of social work and while looking for internships I realized that I don t necessarily see myself in an office looking over a tedious amount of paperwork I have always enjoyed writing and that is why I enjoy journalism I want to become an on the scene reporter or a correspondent of some sort maybe An on campus news issue that intrigued me this past semester was how some sororities at Brandeis decided

    Original URL path: http://blogs.brandeis.edu/naya/ (2016-04-25)
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  • Division of Science Events Group
    as agents of somatic diversity disease and aging Monday 5 2 16 10 am Desphande Metal dependent Function of Acireductone Dioxygenase Monday 5 2 16 11 am Lawrence Axion driven inflation and quantum gravity Monday 5 2 16 11 am Keller Characterizing the roles of alpha and theta oscillations in multisensory attention Monday 5 2 16 12 noon Plant SUMOylation mediates the early response to acute hypoxia in central neurons

    Original URL path: http://blogs.brandeis.edu/scievents/ (2016-04-25)
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