archive-edu.com » EDU » C » COLUMBIA.EDU

Total: 1435

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • The Silvio O. Conte Center for Schizophrenia Research
    Participate EAB Publications Resources The Conte Center for Schizophrenia Research maintains several programs and groups that aim to educate and incorporate the contributions of members of the external community Follow the links below to learn more Summer Undergraduate Research Program

    Original URL path: http://www.columbia.edu/cu/conte/resources.html (2016-02-12)
    Open archived version from archive

  • The Silvio O. Conte Center for Schizophrenia Research
    6 14 pdf Gold R Butler PD Revheim N Leitman D Hansen JA Gur R et al 2012 Auditory emotion recognition impairments in schizophrenia Relationship to acoustic features and cognition American Journal of Psychiatry 169 424 432 Jacobson L Javitt DC Lavidor M 2011 Activation of inhibition Diminishing impulsive behavior by direct current stimulation over the inferior frontal gyrus Journal of Cognitive Neuroscience 23 3380 7 Martinez A Hillyard SA Bickel S Dias EC Butler PD Javitt DC 2011 Consequences of magnocellular dysfunction on processing attended information in schizophrenia Cerebral Cortex doi 10 1093 cercor bhr195 pdf Mishra J Zinni M Bavelier D Hillyard SA 2011 Neural basis of superior performance of action videogame players in an attention demanding task Journal of Neuroscience 31 992 8 pdf Ross B Hillyard SA Picton TW 2010 Temporal dynamics of selective attention during dichotic listening Cerebral Cortex 20 1360 71 pdf Yang L Chen S Chen CM Khan F Forchelli G Javitt DC 2011 Schizophrenia culture and neuropsychology Sensory deficits language impairments and social functioning in Chinese speaking schizophrenia patients Psychological Medicine 1 10 Neuro oscillations and Schizophrenia Bickel S Dias EC Javitt DC In Press Oscillations involved in executive control and motor preparation in the AX CPT task Neuroimage Hoptman MJ Zuo XN Butler PD Javitt DC D Angelo D Mauro CJ et al 2010 Amplitude of low frequency oscillations in schizophrenia A resting state fMRI study Schizophrenia Research 117 13 20 pdf Neuronal Basis of Schizophrenia Ginsberg SD 2010 Alterations in discrete glutamate receptor subunits in adult mouse dentate gyrus granule cells following perforant path transection Analytical and Bioanalytical Chemistry 397 3349 58 pdf Ginsberg SD Che S Hashim A Zavadil J Cancro R Lee SH et al 2011 Differential regulation of catechol O methyltransferase COMT expression in a mouse model of aggression Brain Structure Function 216 347 356 Hackett TA Preuss TM Smiley JF 2011 Monkey primary auditory cortex has proportionally fewer GABA neurons than association cortex Society for Neuroscience 912 04 Kantrowitz J Javitt DC 2012 Glutamatergic transmission in schizophrenia From basic research to clinical practice Current Opinions in Psychiatry 25 96 102 Moghaddam B Javitt DC 2012 From revolution to evolution The glutamate hypothesis of schizophrenia and its implication for treatment Neuropsychopharmacology 37 4 15 Pergolizzi D Dwork AJ Mancevski B Ilievski B Dias EC Bleiwas C et al 2010 Proportional densities of GABA neuron subtypes across areas of auditory cortex in schizophrenia Proceedings of the Society for Neuroscience 35 362 Pergolizzi D Dwork AJ Mancevski B Rosoklija G Bleiwas C Figarski K et al 2011 Schizophrenia and major depression have distinct profiles of altered GABA neurons density in the auditory cortex Schizophrenia Bulletin 37 185 Smiley JF Chao HM Dwork AJ Alldred MJ Elarova I Javitt DC Ginsberg SD 2010 Microarray analysis of subtypes of pyramidal and nonpyramidal neurons from auditory cerebral cortex in schizophrenia Proceedings of the Society for Neuroscience 35 225 Smiley JF Chao HM Dwork AJ Alldred MJ Elarova I Javitt DC Ginsberg SD

    Original URL path: http://www.columbia.edu/cu/conte/publications.html (2016-02-12)
    Open archived version from archive

  • The Silvio O. Conte Center for Schizophrenia Research
    analyzes mechanisms underlying sensory processing dysfunction using a multimodal imaging approach incorporating both neurophysiological and MRI based assessments Neurophysiological studies evaluate role of neuronal synchrony and oscillatory hierarchy impairments in etiology of neurocognitive dysfunction In particular it tests the hypothesis that impairments in non linear stimulus amplification and in oscillatory entrainment may prevent response optimization in patients relative to controls Four experiments have been planned The first experiment analyzes the role of oscillatory entrainment in the genesis of previously documented sensory processing deficits and object attention dysfunction For this experiment hierarchical oscillatory analyses are conducted using mathematical approaches and stimulation paradigms developed from Projects 2 and 3 respectively The second experiment analyzes the role of spatial attention in sensory processing dysfunction also using both standard ERP and oscillatory hierarchy analyses and also evaluates the role of phase reset vs exogenous activity in ERP generation in patients and controls Experiment 3 evaluates spatial attention effects further using ssVEP approaches Deficits in ERP generation are also assessed relative to symptomatic and cognitive measures The fourth experiment evaluates the role of structural and functional connectivity impairments in etiology of sensory and attentional deficits using MR measures supported by Core B DTI measures are

    Original URL path: http://www.columbia.edu/cu/conte/project1.html (2016-02-12)
    Open archived version from archive

  • The Silvio O. Conte Center for Schizophrenia Research
    in sensory processing deficits and related ERP abnormalities Sensory processing deficits are a key component of schizophrenia This project utilizes a primate model to investigate mechanisms underlying cognitive function and dysfunction We and others have recently demonstrated that neuronal oscillations are essential components or instruments of brain operation and that neural oscillatory rhythms are organized in a hierarchical fashion with theta band amplitude coupled to delta oscillation phase and gamma band amplitude coupled to theta oscillation phase While this hierarchical organization is evident when the system is at rest it is also dynamic and clearly modifiable by active cognitive operations such as attention Hierarchical cross frequency coupling permits optimization of sensory processing and mediates effects of attention both across and within sensory systems This project investigates mechanisms underlying oscillatory entrainment using intracranial recordings in monkeys trained to perform both intermodal and intramodal attention tasks One monkey is studied per year Monkeys are implanted to permit intracranial recording and training on appropriate behavioral tasks Recordings are then obtained from sensory cortex in response to attended vs unattended stimuli and mechanisms of attentional modulation of sensory processing are assessed Principal analyses are conducted in the frequency domain with special emphasis on the

    Original URL path: http://www.columbia.edu/cu/conte/project2.html (2016-02-12)
    Open archived version from archive

  • The Silvio O. Conte Center for Schizophrenia Research
    some experiments This paradigm development and testing is being carried out first in normal subjects with the aim of subsequently applying them to the study of sensory and attentional deficits in schizophrenia patients These experiments are closely coordinated with parallel studies in monkeys and in schizophrenia patients carried out by other projects in the Conte Center More specifically this project investigates the role of EEG oscillations of oscillatory hierarchies in

    Original URL path: http://www.columbia.edu/cu/conte/project3.html (2016-02-12)
    Open archived version from archive

  • The Silvio O. Conte Center for Schizophrenia Research
    cell density and morphology in monkeys chronically treated with phencyclidine PCP as a pharmacological model of schizophrenia Assess mRNA expression levels within identified pyramidal neurons calbindin CB immunoreactive and parvalbumin PV immunoreactive GABAergic interneurons within the auditory cortex in the schizophrenia and age matched control cohort Compare mRNA expression in the same identified cell types in PCP haloperidol and saline treated monkeys This project examines cell density and gene expression profiles of GABA ergic interneurons in primary visual cortex in schizophrenia using laser capture microdissection coupled with gene array expression techniques developed by the Principal Investigator Dr Ginsberg and builds as well from a prior gene array study of hippocampal stellate cells in schizophrenia showing reduced NMDA receptor related expression The Co Investigator Dr Smiley is an expert histologist who is pursuing ongoing studies of calcium binding protein GABA interneuron density in auditory cortex as part of an NIMH funded project Decreased parvalbumin expression has been extensively documented in prefrontal cortex in schizophrenia but sensory regions have been studied to only a limited degree For the NKI component of the study quantitative morphometric analyses are performed on postmortem visual cortex from schizophrenia and control subjects Immunocytochemistry is used to identify

    Original URL path: http://www.columbia.edu/cu/conte/project4.html (2016-02-12)
    Open archived version from archive

  • The Silvio O. Conte Center for Schizophrenia Research
    subjects who are medication free compared to those stabilized on medication Assess long term change in processing associated with a tw year retest This project represents an innovative integration of two theoretical approaches that have great potential for improving prediction of schizophrenia and for helping to clarify the neural mechanisms involved in the onset of psychosis Although late adolescence early adulthood is the period when onset typically occurs few prospective

    Original URL path: http://www.columbia.edu/cu/conte/project5.html (2016-02-12)
    Open archived version from archive

  • The Silvio O. Conte Center for Schizophrenia Research
    NMDA receptor on rodent neurophysiological and behavioral measures Evaluate the effects of novel NMDAR stimulation strategies on rodent neurophysiological and sensory processing analogs This project incorporates two avenues of research The first aims to determine the degree to which RG1678 a novel glycine transport inhibitor reverses the oscillatory hierarchical deficits observed in schizophrenia We are conducting frequency domain analyses on data from the ongoing industry funded trial of RG1678 in

    Original URL path: http://www.columbia.edu/cu/conte/project6.html (2016-02-12)
    Open archived version from archive