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  • Duke University Department of Molecular Genetics & Microbiology
    the next generation of scientific leaders MARCHUK AWARDED DISTINGUISHED PROFESSORSHIP Douglas Marchuk PhD was awarded a distinguished professorship and is now a James B Duke Professor WHERE DNA S COPY MACHINE PAUSES CANCER COULD BE NEXT Each time a human cell divides it must first make a copy of its 46 chromosomes to serve as an instruction manual for the new cell Training Spotlight TWELVE MGM TRAINEES RECEIVE PRESTIGIOUS FELLOWSHIPS

    Original URL path: http://mgm.duke.edu/ (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    potential identify them as rising stars the foundation said in announcing the awards Foundation president Paul L Joskow said the fellowships are targeted to researchers during the crucial stage in their careers when funding and recognition can have a large affect The 2014 recipients come from 61 colleges and universities in the United States and Canada and represent eight fields of study These researchers are pushing the boundaries of scientific knowledge in unprecedented ways Joskow said All the honorees were nominated by fellow scientists and selected by an independent panel of senior scholars Each fellow receives a 50 000 grant to support his or her research David s research program studies the ecological mechanisms stabilizing human associated microbial communities Using infectious diseases as model systems his research combines microbial ecology with high throughput gene sequencing and computational analysis An active area of research is the longitudinal study of cholera infections among residents of Dhaka Bangladesh Primary research questions include Can enteric microbial communities predict an individual s susceptibility to cholera Why do bacterial ecological successions follow cholera infection What long term effects do infection and treatment have on commensal gut microbes He is also broadly interested in developing new visualization

    Original URL path: http://mgm.duke.edu/news/david_1.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    discipline by featuring top notch scientists in the field as speakers One of the goals of the conference is to encourage participation from all sectors of the microbial pathogenesis community including post doctoral fellows students and new faculty members By engaging members of the American Society of Microbiology Triangle Microbial Interactions the Genetics Society of America and the staff and students of the organizing departments among others the conference is

    Original URL path: http://mgm.duke.edu/news/faseb_2011.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    from each of the 32 Faculties see the complete list According to the F1000Prime website F1000Prime identifies and recommends important articles in biology and medical research publications Articles are selected by a peer nominated global Faculty of the world s leading scientists and clinicians who then rate them and explain their importance From the numerical ratings awarded they have created a unique system for quantifying the importance of individual articles

    Original URL path: http://mgm.duke.edu/news/heitman_12.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    genetics and microbiology at Duke University School of Medicine Ours is the first to examine thousands of these sites across the entire genome and ask what they might have in common The term fragile sites was first coined in the 1980s to describe the chromosome breaks that appeared whenever a molecule called DNA polymerase responsible for copying DNA was blocked in mammalian cells Since that discovery research in the yeast Saccharomyces cerevisiae has shown that certain DNA sequences can make the polymerase slow down or pause as it makes copies However none of them have shown how those delays result in fragile sites In this study Petes wanted to find the link between the copier malfunction and its genetic consequences on a genome wide scale First he knocked down the levels of DNA polymerase in yeast cells to ten fold lower than normal Then he used microarray or gene chip technology to map where segments of DNA had been rearranged indicating that a fragile site had once been there After finding those fragile sites his laboratory spent more than a year combing through the literature for any recurring themes among the genomic regions they had uncovered Eventually they showed that the fragile sites were associated with sequences or structures that stalled DNA replication esoteric entities such as inverted repeats replication termination signals and transfer RNA genes We only published the tip of the iceberg there is a lot of work you don t see because the connections simply weren t significant enough Even now we didn t find any single sequence motif that would very clearly predict a fragile site said Petes I think there are just a lot of ways to slow down replication so there is not just one signal to indicate that would occur In addition Petes

    Original URL path: http://mgm.duke.edu/news/petes_5.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    in Genetics and Genomics is now the James B Duke Professor of Molecular Genetics and Microbiology Douglas Marchuk PhD who joined the Duke faculty in 1993 focuses his research on human genetics especially the genetic and molecular foundations of inherited cardiovascular diseases His research has revealed the causative genes for a number of different vascular malformations including hereditary hemorrhagic telangiectasia hypertrophic cardiomyopathy and stroke He is a pioneer in developing mouse models to map novel genes that affect the severity and progression of disease shedding important light on corresponding diseases in humans His honors include being elected as a Fellow of the American Association for the Advancement of Science the Bugher Award for the Investigation of Stroke and the Established Investigator Award both from the American Heart Association the Baxter Foundation Scholar in Human Genetics the John Mulliken Research Award from the International Society for the Study of Vascular Anomalies and twice the Simmons Research Award from the Hereditary Hemorrhagic Telangiectasia Foundation He is a member of professional organizations including the American Society of Human Genetics the American Heart Association s Basic Science Division the American Association for the Advancement of Science the International Mammalian Genome Society and the North

    Original URL path: http://mgm.duke.edu/news/marchuk_4.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    the basic science community His duties will include oversight of the biomedical graduate programs in the School of Medicine the postdoc office animal care and compliance programs School of Medicine core facilities and research lab space utilization Valdivia is an associate professor in the Department of Molecular Genetics and Microbiology He also serves as director of graduate studies for the department and as director of the Center for the Genomics of Microbial Systems Both of those leadership roles will transition to new directors this summer Valdivia received his PhD from Stanford University in 1997 and completed a Damon Runyon Cancer Research Fellowship at the University of California Berkeley before joining the faculty of Duke as an assistant professor in 2002 In his current research Valdivia focuses on understanding the molecular basis for the pathogenesis of Chlamydia trachomatis a leading sexually transmitted infection and the causative agent of blinding trachoma Valdivia is currently funded by multiple NIH grants and a private foundation grant He is an author of more than 50 publications and book chapters In 2004 Valdivia earned recognition as a Pew Scholar in the Biomedical Sciences and in 2007 was the recipient of the Merck Irving S Sigal Award

    Original URL path: http://mgm.duke.edu/news/valdivia_5.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    and approved for funding by Chancellor Victor Dzau is intended to fuel new opportunities for innovative research projects at Duke Medicine that can lead to long term externally funded research support The Discovery Program will fund five one year awards of 75 000 in 2014 to initiate support for exciting new research projects led by regular rank faculty members at the rank of assistant professor of higher with primary appointments

    Original URL path: http://mgm.duke.edu/news/chi_3.html (2014-06-13)
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