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  • Duke University Department of Molecular Genetics & Microbiology
    heel in the battle against C neoformans which frequently causes life threatening illness in people said senior author Joseph Heitman MD PhD chair of the Duke Department of Molecular Genetics and Microbiology This protective silencing effect also operates in some animals and our studies demonstrate that the pathway operates to defend the genome during sexual reproduction Sexual reproduction in fungi produces airborne spores that are readily inhaled into the lungs and thought to be the source of human infections Thus agents that block fungal sex might stop the risk of infection at the source This work was published in the Nov 15 issue of the journal Genes Development C neoformans uses a novel sex induced RNAi RNA interference genome defense system that protects by effectively silencing the DNA so that it is not vulnerable to repeated genes and transposable elements that could cause mutations The silencing system protects the genome from changes that might be imposed by transposable elements of DNA called jumping genes that are also more active during the sexual cycle said Xuying Wang PhD a postdoctoral associate who works in the Heitman lab Through deep sequencing of the small RNAi pieces which mediate the silencing in C

    Original URL path: http://mgm.duke.edu/news/heitman_7.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    in the Bryan Research Building Room 103 from 1 00 to 4 00pm and will feature three presentations from internationally recognized experts in the field including Tom Roberts PhD Harvard Medical School PI3 kinase Tracing a cancer drug target from viral oncogene to the clinic Richard Longnecker PhD Northwestern University How to enter B cells and epitelial cells Lessons from Epstein Barr virus Ethel Cesarman MD PhD Cornell Medical College

    Original URL path: http://mgm.duke.edu/news/viral_oncology_2.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    James Sellers at the NIH National Heart Lung and Blood Institute where she applied biochemistry to study the cytoskeletal protein Myosin For her graduate training with Dr Denise Montell of The Johns Hopkins University School of Medicine she utilized Drosophila genetics to uncover genes regulating cell migration She discovered an essential role for the JAK STAT signaling complex in cell migration of Drosophila ovarian epithelial cells and human ovarian cancer cells For her thesis work she was recognized with several graduate student awards including the National Weintraub Award For her postdoctoral studies Dr Silver trained in mouse genetics and genomics with Dr William Pavan of the National Human Genome Research Institute where she studied genes regulating neural crest and neural stem cell development Through the cloning and characterization of a novel mouse mutant she uncovered a previously unappreciated requirement for an RNA binding complex in brain development neural stem cells and mitosis Her postdoctoral research was funded by an NIGMS PRAT fellowship Pharmacology Research and Training and by an NINDS NIH Pathway to Independence Award K99 R00 Dr Silver s laboratory at Duke is interested in fundamental mechanisms of developmental biology and stem cells The long term goal of her

    Original URL path: http://mgm.duke.edu/news/silver.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    University School of Medicine Joe has always demonstrated outstanding professional achievement and his commitment to advancing children s health is being recognized with this prestigious membership St Geme is a nationally recognized expert for his research on the genetic and molecular basis of virulence by Haemophilus influenzae At Duke he oversees clinical activities and research at Duke Children s Hospital Health Center one of the largest health care providers for

    Original URL path: http://mgm.duke.edu/news/stgeme.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    named the 2010 Outstanding Postdoctoral Mentor at Duke University The Outstanding Postdoctoral Mentor Award established in 2006 recognizes that an exemplary mentor serves not only as a teacher but as an advisor advocate and role model to postdoctoral fellows throughout their professional training Petes received the award at the fifth annual Postdoctoberfest on Friday October 8 The award was presented by Sally Kornbluth PhD Vice Dean for Research and Anne

    Original URL path: http://mgm.duke.edu/news/petes_3.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Hope College in Holland Michigan He then joined Francis Collins lab at the University of Michigan as a fellow where he trained in human genetics Marchuk contributed to the identification of the type I neurofibromatosis gene by positional cloning in studies published in Science and Nature Genetics In addition his studies demonstrated that the human NF1 gene product can functionally replace the yeast homolog the GTPase activating protein Ira1 2 involved in regulation of Ras function in yeast a remarkable conservation in function that was published in Cell Marchuk developed the plasmid vectors that facilitate direct cloning of PCR products T vectors for TA cloning a methods paper published in Nucleic Acids Research in 1991 that has been cited over 1000 times to date Marchuk joined the Department of Genetics at Duke in 1993 At Duke his research program has focused on inherited disorders of the vasculature with a focus on Hereditary Hemorrhagic Telangiectasia HHT He and his colleagues established linkage for the disorder to different regions of the human genome McDonald et al Nature Genetics 1994 Subsequently they identified the genes mutated in two forms of the disorder and characterized the mutations that occur in a number of affected kindreds involving components of a novel type of vasculature specific TGF beta signaling pathway endoglin and the ALK1 receptor a member of the TGF beta type I receptor family McAllister et al Nature Genetics 1994 Johnson et al Nature Genetics 1996 Marchuk s work has also focused on cerebral cavernous malformations hemangiomas and hereditary spastic periplegia with Nina Sherwood and he has pioneered the development of murine models to identify genes involved in peripheral and central ischemia and cardiomyopathy with Howard Rockman Marchuk has served in several key roles in the department including chairing the departmental faculty search committees in

    Original URL path: http://mgm.duke.edu/news/marchuk_1.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    receive the Petes Scholarship in Genetics and Cancer Biology Turner will be working in the lab of Matthias Gromeier MD a faculty member in the Departments of Surgery and Molecular Genetics and Microbiology who is working on molecular mechanisms of viral pathogenesis and the potential possibilities for new treatment strategies for cancer and infectious disease Turner received his B S in Microbiology and Molecular Biology from the University of Wisconsin

    Original URL path: http://mgm.duke.edu/news/turner.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    to a 4 000 stipend a two year ASM student membership and reimbursement for travel expenses to the 111th ASM General Meeting This year eighty one applications were received and forty one were awarded Of the forty one awardees twenty students were from doctoral research universities extensive institutions one student was from doctoral research universities intensive institutions seven students were from a master s college and university institutions and thirteen

    Original URL path: http://mgm.duke.edu/news/grossman.html (2014-06-13)
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