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  • Duke Center for RNA Biology
    the Department of Biochemistry co directs the Center The CRB brings together laboratories focused on RNA biology including the study of RNA binding proteins RNA based therapies post transcriptional regulation of gene expression non coding RNAs and RNA interference RNAi ribozyme function and RNA viruses The CRB laboratories are located at Duke University and the National Institute of Environmental Health Science and additionally the CRB coordinates regular activities with RNA

    Original URL path: http://mgm.duke.edu/biology/ (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    adhesins and cellular adhesion aggregation in the human fungal pathogen Candida albicans Fungal adhesins are surface expressed GPI anchored proteins that mediate cellular aggregation as well as colonization and invasion of C albicans to mammalian host epithelial endothelial cells Currently I am interested in characterizing the phenotypic plasticity inherent to the rapamycin and FK506 receptor FKBP12 in the zygomycete fungal pathogen Mucor circinelloides My work has uncovered a novel RNA

    Original URL path: http://mgm.duke.edu/faculty/valdivia/lab/bastidas.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    9193 Email jeffrey barker duke edu I have always been fascinated by microbial infectious diseases It amazes me that such a small unit of life has the potential to manipulate and sometimes kill humans When I am not obsessing about microbes I spend most of my spare time listening to and playing music In fact if there was a career that involved both music and microbiology I would be set

    Original URL path: http://mgm.duke.edu/faculty/valdivia/lab/barker.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Cedar Crest College for my undergraduate career where I spent 3 5 years in a lab researching the bacterial pathogen Chromobacterium violaceum During the latter part of this period I isolated different bacteriophage from the environment to determine if phage therapy could be used as a treatment for this pathogen I also had an internship at Thomas Jefferson University in Philadelphia PA where I studied HIV and the mutations that

    Original URL path: http://mgm.duke.edu/faculty/coers/lab/pilla.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    does the brain direct appropriate behavioral responses What are the mechanisms underlying development and regeneration of sensory cells and specific synapse connections We address these questions using molecular biology genome information and genetics The detection of tastants is mediated by taste receptor cells that are clustered in taste buds in the mouth Interestingly some people can taste certain chemicals such as 6 n propylthiouracil a bitter compound while others can t Likewise some strains of mice can taste certain bitter or sweet tastants while others can t Based on these variations the bitter and sweet taste loci have been mapped on human or mouse chromosomes By using the increasingly powerful genome informatics tools we as well as other groups have identified families of GPCRs that may detect bitter and sweet compounds We seek to understand how specific changes in nucleotide sequences cause these differences in taste sensitivity Another goal is to understand how the gustatory system is organized In olfaction the detection of volatile odorants is mediated by olfactory sensory neurons in the olfactory epithelium of the nose Odorants are detected by about 1000 different types of odorant receptors that are encoded by a multigene family Each olfactory sensory neuron

    Original URL path: http://mgm.duke.edu/faculty/matsunami/ (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    animal models of candida and cryptococcal infections We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome Our basic science project examines the molecular pathogenesis of cryptococcal infections We have developed a molecular foundation for C neoformans including transformation systems gene disruptions differential gene expression screens and cloning pathogenesis genes The goal of this work is to use C neoformans as a model yeast

    Original URL path: http://mgm.duke.edu/microbial/mycology/perfect/ (2014-06-13)
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  • Center for Virology - Home
    the use of attenuated viruses as gene therapy vectors or vaccines Center for Virology functions include Annual Fall Minisymposium on Viral Oncology and AIDS Malignancy Annual Spring Minisymposium on Pathogenic Human Viruses Distinguished Virologist Lecture Monthly Virology journal club Monthly Virology Works in Progress meetings NIH training grant in Virology and Viral Oncology Travel grants for virology students and post docs to present their research at virology related conferences Individuals

    Original URL path: http://mgm.duke.edu/virology/ (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    and secondary appointments in the Department with other investigators throughout the medical center and foster robust interfaces between the clinical and basic sciences The Center for Microbial Pathogenesis comprises investigators focused on fungal and bacterial microbial pathogens the Center for RNA Biology brings together investigators interested in the structure function and synthesis of RNA the Center for Virology provides a forum for investigators throughout the medical center who are focused on both basic and applied aspects of virology including vaccine development and the Center for Genomics of Microbial Systems GeMS brings together investigators focused on microbial communities and their interactions including the human microbiome and environmental niches The Department of Molecular Genetics and Microbiology is committed to a highly interactive atmosphere where students postdoctoral fellows and faculty flourish The Department sponsors a monthly Monday evening research meeting where students fellows and faculty present their latest research findings an annual scientific retreat and other social events throughout the year The Department also administers a robust graduate training program supported by institutional resources and an NIH training grant in viral oncology and actively participates in other interdepartmental graduate training programs on campus including the University Program in Genetics and Genomics UPGG directed by MGM faculty members Douglas Marchuk PhD and Beth Sullivan PhD A key feature of the Department s graduate training program is the Duke Scholars in Molecular Medicine Program including the Duke Scholars in Infectious Diseases DSID track This program accepts up to eight students and fellows each year who participate in a series of educational venues to bring basic scientists into the clinical arena Activities include rounding in the hospital attending rounds and grand rounds and participating in seminars and interacting with leading physician scientists invited to visit Duke The Department also administers a tri institutional fellows training program

    Original URL path: http://mgm.duke.edu/department.htm (2014-06-13)
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