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  • Duke University Center for Microbial Pathogenesis
    Joseph Heitman s lab investigating new methods to genetically transform a microsporidian species E cuniculi as well as an interesting small RNA mediated form of drug tolerance in the human pathogenic species Mucor circinelloides Outside of lab I enjoy long distance running writing reading and spending time outside Participant in the Marine Biological Laboratory MOMY course 2009 Marcy Speer Memorial Fellowship Recipient 2009 DUMRU Meritorious Research Travel Award Winner 2009

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/shertz.htm (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    process to 1 foster a new generation of investigators who are rigorously trained in basic science while acutely aware of the unmet clinical needs in medicine and 2 to develop investigators who embrace clinicians as partners in accelerating innovation such as developing new preventatives diagnostics and therapeutics These investigators will be better poised to identify and focus on the new challenges in modern molecular medicine We envision training biomedical scientists at the Duke School of Medicine SOM who are uniquely poised and motivated to partner with clinicians to find solutions to contemporary clinical problems in the US and around the globe To address these challenges and opportunities the Duke School of Medicine is pioneering a new approach to developing the next generation of translationally minded innovator scientists We will take promising creative young basic scientists and expose them to contemporary long standing and emerging problems in a range of priority areas of medicine We will help them re think basic science in a continuum with unmet clinical needs Our new program called the Duke Scholars in Molecular Medicine is based on the highly successful Duke Scholars in Infectious Diseases Program and is designed specifically to meet these aims Though an

    Original URL path: http://mgm.duke.edu/microbial/training/dsid.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    oncogenesis during Epstein Barr virus EBV infection of human B cells Since the lab was new at the time I was involved in a broad range of projects related to B lymphocyte proliferation and development of EBV associated lymphomas Currently I am working on the host DNA damage response to Epstein Barr virus infection TLR9 induced human B lymphocytes proliferation and EBV controlled cellular adhesion and manipulation of the immune

    Original URL path: http://mgm.duke.edu/faculty/luftig/lab/nikitin.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    cmy4 duke edu I graduated from the University of California San Diego with a degree in Biochemistry and Cell Biology and came to Duke in March of 2007 and worked in Beth Sullivan s lab studying chromatin structure I joined

    Original URL path: http://mgm.duke.edu/faculty/luftig/lab/yan.html (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    pathway In my study I found that effective turnover of many incorrectly processed RNAs including hypomodified tRNAiMet required the TRAMP complex which appends a short polyA tail to the RNA designated for decay that stimulates RNA degradation by the exosome I also biochemically characterized Mtr4p as a RNA helicase and demonstrated that its helicase activity is necessary for the RNA degradation processes After receiving my Ph D degree in December 2008 I joined the Heitman lab in January 2009 and switched my focus from baker s yeast to pathogenic fungi Now I am interested in the RNAi pathway in Cryptococcus and also I am characterizing certain conserved genes at mating locus in Cryptococcus Publications Jia H Wang X Liu F Guenther UP Srinivasan S Anderson JT Jankowsky E 2011 The RNA helicase Mtr4p modulates polyadenylation in the TRAMP complex Cell 10 145 890 901 Wang X Hsueh YP Li W Floyd A Skalsky R Heitman J 2010 Sex induced RNA silencing defends the genome of Crypotococcus neoformans via RNAi Genes Dev 24 2566 2582 co first author Anderson JT Wang X 2009 Nuclear RNA surveillance no sign of substrates tailing off Crit Rev Biochem Mol Biol 44 16 24 Ozanick

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/wang.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    31 Hiro Matsunami Duke University Medical Center Host TBD Neurogenetics of olfaction Nov 7 Jeff Brodsky University of Pittsburgh Host Nicole Calakos and Dennis Thiele Protein conformational diseases and ER associated degradation ERAD Lessons from model systems Nov 14 Jonathan Howard TBD Host Harold Erickson Regulation of microtubule catastrophe by motors and MAPs Nov 21 Chris Newgard Duke University Medical Center Host Joseph Heitman Metabolomics reveals cardiometabolic disease mechanisms Dec 5 Philip Howe University of South Carolina Host Gerard Blobe Translational regulation of EMT metastasis Dec 12 Klaus Frueh Oregon Health Science University Host David Pickup Viral control of T cell activation Dec 19 Maurice Swanson University of Florida Host Mariano Garcia Blanco RNA mediated pathways to disease Jan 9 Gary Bassell Emory University Host Debra Silver mRNA traffic local translation and fragile x syndrome Jan 16 Juan Bonifacino NIH Intramural Research Program Host Michel Bagnat Mechanisms of polarized sorting in neurons Jan 23 Terence Dermody Vanderbilt University Medical Center Host Bryan Cullen Invasion of the central nervous system by reovirus Jan 30 Mark Zylka University of North Carolina School of Medicine Host Cagla Eroglu Gene length matters in autism Feb 6 James R Sellars National Heart Lung and Blood Institute Host TBD Not all myosin 2 molecules are create equal Feb 13 Rick Bushman Perlman School of Medicine at the University of Pennsylvania Host Bryan Cullen The human virome in health and disease Feb 20 Rong Li Stowers Institute for Medical Research Host Terry Lechler A numbers game Rapid cellular evolution driven by chromosome instability and dosage imbalance Feb 27 Patricia Clark University of Notre Dame Host Terry Oas Effects of synonymous codon selection on protein structure Lessons for protein design Mar 6 Eyleen Lay Keow Goh Duke NUS Graduate Medical School Host Patrick Casey Class 3 semaphorin signaling

    Original URL path: http://mgm.duke.edu/seminars/dept_sem.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Barr virus induces global changes in cellular mRNA isoform usage important for the maintenance of latency May 13 2013 Introduction Debby Silver Speakers Justyne Matheny Sullivan Lab Defining the centromere functional domain Brandt Levit Garcia Blanco Lab ERI3 is a novel RNA degrading protein required for dengue replication Debby Silver Building a bigger brain Lessons from the mouse June 10 2013 Introduction Jörn Coers Speakers Deidre Krupp Gregory Lab Title TBD Argenia Doss Aballay Lab Modulation of the innate immune response in Caenorhabiditis elegans via chemosensory neurons Jörn Coers New trick of an old enzyme IDO regulates thymic T cell differentiation October 7 2013 Introduction Hiro Matsunami Speakers Casey Purley Frothingham Lab Surface binding antibodies in active tuberculosis disease Jim Davison Rawls Lab HNF4 transcription factors specifically bind the cis regulatory element that mediates gut microbial control of zebrafish angptl4 expression Hiro Matsunami Mitochondria and initiation of respiration at birth November 11 2013 Introduction TBD Speakers Silvia Calo Varela Heitman Lab Epimutations evoke antifungal drug resistance in the human fungal pathogen Mucoor via RNAi Yuxuan Phoenix Miao Abraham Lab Epithelial expulsion of infecting bacteria in exosomes Kyla Selvig Alspaugh Lab The basics of the Cryptococcus neoformans alkaline response pathway Responding to the bitter host December 9 2013 Introduction David Tobin Speakers Sarah Jaslow Ko Lab Using genetic variation to understand signaling in IL10 producing B cells Karyn McFadden Luftig Lab EBV mediated B cell transformation is suppressed by oncogene induced senescence through the DNA damage response David Tobin Calcium dynamics in inflammation and infection January 13 2014 Introduction Raphael Valdivia Speakers Magan Aldrup MacDonald Sullivan Lab Genomic and functional variation at human centromeres Pinghuang Liu Tomaras Lab TBD Raphael Valdivia The Awesome Power of Chlamydia Genetics February 10 2014 Introduction Jack Keene Speakers Chao Chieh Jerry Lin Chi Lab Coenzyme

    Original URL path: http://mgm.duke.edu/seminars/meetings.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Colorado State University May 19 2011 Seminar How viruses escape the wrath of the cellular RNA decay machinery 2009 Yibin Kang PhD Professor Department of Molecular Biology Princeton University October 1 2009 Seminar Decoding breast cancer metastasis MGM Post Doctoral

    Original URL path: http://mgm.duke.edu/seminars/distinguished_alumnus_archives.html (2014-06-13)
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