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  • Duke University Center for Microbial Pathogenesis
    s laboratory My thesis work focused on cell to cell fusion in Neurspora crassa I carried out a genome wide gene deletion mutant screen and identified novel genes that are required for cell to cell fusion And I further characterized three of the novel genes ham 6 ham 7 and ham 8 function upstream of MAK 1 MAP mitogen activated protein kinase pathway during cell to cell fusion Besides my

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/fu.html (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    Li J Heitman H C Kuo Y H Lee Asiegbu FO and A Olson 2013 Polyporales genomes reveal the genetic architecture underlying tetrapolar and bipolar mating systems Mycologia 105 1374 1390 Sun S F Hagen J Xu T Dawson J Heitman J Kronstad C Saunders and T Boekhout 2013 Ecogenomics of human and animal basidiomycetous yeast pathogens BYP In Ecological Genomics of the Fungi Equal Contribution Heitman J S Sun and TY James 2013 Evolution of fungal sexual reproduction Mycologia 105 1 27 Lee Soo Chan S Phadke S Sun and J Heitman 2012 Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases Eukaryotic Cell 11 1391 1398 Sun S and J Heitman 2012 Should Y stay or should Y go the evolution of non recombining sex chromosomes Bioessays 34 938 942 Wang X P Wang S Sun S Darwiche A Idnurm and J Heitman 2012 Transgene induced co suppression during vegetative growth in Cryptococcus neoformans PLoS Genetics 8 e1002885 Sun S Y P Hsueh and J Heitman 2012 Gene conversion occurs within the mating type locus of Cryptococcus neoformans during sexual reproduction PLoS Genetics 8 e1002810 Floudas D M Binder R Riley K Barry R A Blanchette B Henrissat A T Martínez R Otillar J W Spatafora J S Yadav et al 2012 The paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes Science 336 1715 1719 Wang X W Li S Sun L Kozubowski S Lee M Feretzaki and J Heitman 2012 Know your enemy how to build and vanquish a global fungal scourge Mycopathologia 173 295 301 Findley F Sun S J A Fraser Y P Hsueh A F Averette W Li F S Dietrich and J Heitman 2012 Discovery of a modified

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/sun.htm (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    C 27710 Phone 919 684 3036 Fax 919 684 5458 Email torin thielhelm duke edu I m Torin Thielhelm an undergraduate student in the Trinity College of Arts and Sciences in the class of 2016 I am pursuing a degree in Biology with a double minor in Chemistry and Global Health I began my work in the Heitman Lab in January of 2014 under the supervision of Dr Kevin Roach

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/thielhelm.html (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    I began working with Dr Young Sun Bahn who is on Sabbatical from Yonsei University and working in Dr Heitman s lab since May of 2014 Cryptococcus neoformans our primary target of interest among many Cryptococcus pathogenic species is the most prominent medically significant species It causes a severe form of meningo encephalitis in people with HIV We are conducting drug efficacy tests with our model organism galleria mellonella andCD

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/kim_t.html (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    started that new line of research and I loved it So since then I ve tried to unravel the complex mechanism of RNA silencing in Mucor The main scientific achievements of my PhD were 1 reveal that two distinct RNA dependent RNA polymerases are required for initiation and amplification of RNA silencing and 2 that RdRP1 RNA dependent RNA polymerase 1 is essential besides Dicer2 for the production of endogenous small RNAs esRNA in Mucor circinelloides Those esRNAs target the mRNA of protein coding genes from which they are produced expanding the range of esRNAs in eukaryotes and revealing a new role for esRNAs in fungi After I finished my PhD I spent some time teaching Genetics trying to show young and not so young students the amazing world hidden in the genetic code I joined Dr Heitman s lab in February 2012 and I ve had the opportunity of continuing my research in the RNA silencing pathway both in Mucor circinelloides and Cryptococcus Publications Billmyre RB Calo S Feretzaki M Wang X and Heitman J 2013 RNAi function diversity and loss in the fungal kingdom Chromosome Res 21 561 572 Calo S Billmyre RB and Heitman J 2013 Generators of phenotypic diversity in the evolution of pathogenic microorganisms PLOS Pathogens Pearls 9 e1003181 Lee SC Li A Calo S and Heitman J 2013 Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloides PLOS Pathogens 9 e1003625 Calo S Nicolás FE Vila A Torres Martínez S and Ruiz Vázquez RM 2012 Two distinct RNA dependent RNA polymerases are required for initiation and amplification of RNA silencing in the basal fungus Mucor circinelloides Molecular Microbiology 83 2 379 394 Nicolás FE Moxon S de Haro JP Calo S Grigoriev IV Torres Martínez S

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/calo.html (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    the Candida genus and investigating novel antifungal drug combinations with a calcineurin inhibitor FK506 Calcineurin is a calcium activated protein phosphatase required for drug tolerance serum survival and virulence of several fungal pathogens including C albicans Intracellular Ca2 stimulates the calcium sensor calmodulin to associate with the calcineurin AB heterodimer Cna1 Cnb1 activating its phosphatase activity My project looks as the role of calcineurin in the virulence of three emerging

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/zhang.htm (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    Durham N C 27710 Phone 919 684 2809 Fax 919 684 5458 Email june zhang duke edu I m June Zhang an undergraduate student in the Trinity College of Arts and Sciences class of 2016 I am a Biology and Global Health double major also pursuing a French minor I am currently working with Dr Eve Chow on a project examining CRZ1 a transcription factor of Cryptococcus neoformans I am

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/zhang.html (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    of projects involving Cryptococcus and Candida species One of the projects we are working on is based around C gattii an emerging fungal pathogen in the Northwestern United States In addition to work with C gattii I am also working on gene disruption to investigate if calcineurin controls virulence via thermotolerance as well as identifying the downstream targets of calcineurin in C galabrata Finally I am performing minimum inhibitory concentration

    Original URL path: http://mgm.duke.edu/microbial/mycology/heitman/lab/lehman.html (2014-06-13)
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