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  • Duke University Department of Molecular Genetics & Microbiology
    e1001061 Mravinac B Sullivan LL Reeves JW Yan CM Kopf KS Farr CJ Schueler MG and Sullivan BA 2009 Histone modifications within the human X centromere region PLoS ONE 4 8 e6602 Gopalakrishnan S Sullivan BA Trazzi S Della Valle G and Robertson KD 2009 DNMT3B interacts with constitutive centromere protein CENP C to modulate DNA methylation and the histone code at centromeric regions Human Mol Genet 18 3178 3193 Kim JH Ebersole T Kouprina N Noskov VN Ohzeki J Masumoto H Mravinac B Sullivan BA Pavlicek A Dovat S Pack SD Kwon YW Flanagan PT Loukinov D Lobanenkov V and Larionov V 2009 Human gamma satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing Genome Res 19 4 533 544 Gao F Ponte JF Levy M Papageorgis P Cook NM Ozturk S Lambert AW Thiagalingam A Abdolmaleky HM Sullivan BA and Thiagalingam S 2009 hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation Cancer Biol Ther 8 7 55 63 Dai J BA Sullivan and JMG Higgins 2006 Regulation of mitotic chromosome cohesion by haspin and aurora B Dev Cell 11 741 750 BAS cover illustration pdf Schueler MG and BA Sullivan 2006 Structural and functional dynamics of human centromeric chromatin Annu Rev Genomics Hum Genet 7 301 13 pdf Lam AL CD Boivin CF Bonney MK Rudd and BA Sullivan 2006 Human centromeric chromatin is a dynamic chromosomal domain that can spread over non centromeric DNA Proc Natl Acad Sci USA 103 4186 4191 pdf Scott KC and BA Sullivan 2005 Epigenetic Inheritance and RNAi at the centromere and heterochromatin In Encyclopedia of Genetics Genomics Proteomics and Bioinformatics Section editor R Nicholls Edited by Lynn Jorde John Wiley Sons Wilson KC DJ Cattel Z Wan S Rahangdale F Ren H Kornfeld BA Sullivan WW Cruikshank and DM Center 2005 Regulation of prointerleukin 16 and p27Kip1 in primary human T lymphocytes Cell Immunol 237 17 27 Lam AL DE Pazin and BA Sullivan 2005 Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions Chromosoma 114 242 251 pdf Sullivan BA 2004 Centromeres In Encyclopedia of Biological Chemistry W J Lennarz and M D Lane eds Elsevier Oxford Vol 1 pp 367 371 Sullivan BA and GH Karpen 2004 Centromeric chromatin displays a histone modification pattern that is distinct from both euchromatin and heterochromatin Nat Struc Mol Biol 11 1076 1083 cover illustration pdf Sullivan BA 2002 Centromere round up at the heterochromatin corral Trends Biotech 20 89 92 pdf Blower MD BA Sullivan GH Karpen 2002 Conserved organization of centromeric chromatin in flies and humans Dev Cell 2 319 330 joint first authors BAS cover illustration pdf Hoskins RA et al 2002 Heterochromatic sequences in a Drosophila whole genome shotgun assembly Genome Biol 3 85 1 85 16 Sullivan BA MD Blower GH Karpen 2001 Determining Centromere Identity Cyclical Stories And Forking Paths Nat Rev Genet 2 584 596 pdf Sullivan BA G Karpen 2001 Centromere

    Original URL path: http://mgm.duke.edu/faculty/sullivan/pubs.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    research biography lab members publications lab website Lab members Lomax Boyd Graduate Student Louis Jan Pilaz Postdoctoral Fellow Ashley Lennox Graduate Student Autumn Rorrer Research Technician I John McMahon Postdoctoral Fellow Debra Silver Assistant Professor Helen Mao Graduate Studen t

    Original URL path: http://mgm.duke.edu/faculty/silver/lab.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    cell migration of Drosophila ovarian epithelial cells and human ovarian cancer cells For her thesis work she was recognized with several graduate student awards including the national Weintraub award For her postdoctoral studies Dr Silver trained in mouse genetics and neural development with Dr William Pavan of the National Human Genome Research Institute where she studied genes regulating neural crest and neural stem cell development Through the cloning and characterization

    Original URL path: http://mgm.duke.edu/faculty/silver/bio.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    LJ Nelson C Silver DL Wylie J Sasaki T Cooley M Argraves SW and Apte SS ADAMTS proteases generate active versican fragments that regulate interdigital web regression Dev Cell Nov 17 17 5 687 698 2009 Matera I Watkins Chow DE Loftus SK Hou L Incao A Silver DL Rivas C Elliott EC Baxter LL and Pavan WJ A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy Hum Mol Genet July 15 17 14 2118 2131 2008 Silver DL Hou L Somerville R Young ME Apte SS and Pavan WJ The secreted metalloprotease ADAMTS20 is required for melanoblast survival PloS Genetics Feb 29 4 2 e1000003 2008 Silver DL Geisbrecht ER and Montell DJ Requirement for JAK STAT signaling throughout border cell migration in Drosophila Development Aug 132 15 3483 3492 2005 Silver DL Naora H Liu J Cheng W and Montell D J Activated signal transducer and activator of transcription STAT 3 localization in focal adhesions and function in ovarian cancer cell motility Cancer Research May 15 64 10 3550 3558 2004 Silver DL and Montell DJ Paracrine signaling through the JAK STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila Cell Dec 28

    Original URL path: http://mgm.duke.edu/faculty/silver/pubs.htm (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    Tennessee in Memphis After a few months of additional training in the laboratory of Dr Staffan Normark in Umea Sweden Dr Abraham joined the faculty of Washington University St Louis MO and also assumed the position of Director of the Clinical Serology laboratory at the Barnes Jewish Hospitals Dr Abraham moved to Duke University in 1997 where he has been actively involved in research in microbial pathogenesis examining various aspects of host pathogen interactions In addition to his research activities Dr Abraham is highly involved in the training and development of the next generation of researchers and academic mentors He works closely with undergraduates graduates and postgraduates from his and other research laboratories For the past several years Dr Abraham has served as the Director of Graduate Studies in Pathology as well as the Director of Duke s Summer Research opportunity Program for undergraduates The major contributions of the Abraham laboratory to the field of Microbial Pathogenesis includes defining the structure and contribution of bacterial fimbriae to pathogenesis in the urinary tract Dr Abraham s laboratory is also known for demonstrating the critical but largely overlooked role of mast cells in mobilizing immune responses to bacterial pathogens His laboratory has

    Original URL path: http://mgm.duke.edu/microbial/bacteriology/abraham/bio.htm (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    Genetics and Microbiology biography publications website Lab members Soman N Abraham Professor Cong Jin Graduate Student Samantha Bowen Graduate Student Christian Kunder Graduate Student Cheryl Chan Graduate Student Christopher Shelburne Senior Research Scientist Hae Woong Choi Graduate Student Guojie Li

    Original URL path: http://mgm.duke.edu/microbial/bacteriology/abraham/lab.htm (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    of CD48 J Immunol 2003 170 5590 5596 Abstract McLachlan JB Hart JP Pizzo SV Shelburne CP Staats HF Gunn MD and Abraham SN Mast cell derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection Nat Immunol 2003 4 1199 1205 Abstract Duncan MJ Li G Shin J S Carson JL and Abraham SN Bacterial penetration of bladder epithelium through lipid rafts J Biol Chem 2004 279 18944 18951 Abstract Malaviya R Ikeda T Abraham SN and Malaviya R Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E coli Immunol Lett 2004 91 103 111 Abstract Zaas DW Duncan MJ Li G Wright JR and Abraham SN Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin 2 J Biol Chem 2005 280 4864 4872 Abstract Malherbe DC Erpenbeck VJ Abraham SN Crouch EC Hohlfeld JM and Wright JR Surfactant protein D decreases pollen induced IgE dependent mast cell degranulation Am J Physiol Lung Cell Mol Physiol 2005 289 L856 866 Abstract Shelburne CP McLachlan JB and Abraham SN In vivo models for studying mast cell dependent responses to bacterial infection Am J Physiol Lung Cell Mol Physiol 2006 315 363 381 Abstract Duncan MJ Mann EL Cohen MS Ofek I Sharon N and Abraham SN The distinct binding specificities exhibited by enterobacterial type 1 fiimbriae are determined by their fimbrial shafts J Biol Chem 2005 280 37707 37716 Abstract Abraham SN Duncan MJ Li G and Zaas D Bacterial penetration of the mucosal barrier by targeting lipid rafts J Investig Med 2005 53 318 321 Abstract Zaas DW Duncan M Wright JR and Abraham SN The role of lipid rafts in the pathogenesis of bacterial infections Biochem Biophys Acta 2005 1746

    Original URL path: http://mgm.duke.edu/microbial/bacteriology/abraham/pubs.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    several important findings during his two and a half year stint in the Roy lab including the discovery of a chaperone complex in the bacterial pathogen Legionella pneumophila that is essential for the injection of virulence factors into host cells For his doctoral training Dr Coers employed transgenic mouse models to study the role of cytokine signaling in hematopoiesis at the German Cancer Research Center and at the University of Basel Switzerland in the laboratory of Radek Skoda His work led to the discovery that aberrant expression of the thrombopoietin receptor protein can cause thrombocytosis due to a shift in the balance between thrombopoietin induced proliferation of platelet precursor cells and removal of thrombopoietin by receptor mediated internalization in platelets For his postdoctoral training he returned to the topic of host pathogen interactions and applied his knowledge of mouse genetics to study infectious disease in the labs of Bill Dietrich and Michael Starnbach at Harvard Medical School He identified members of a large family of Interferon inducible GTPases as critical components in the innate immune response to the bacterial pathogen Chlamydia trachomatis the cause of a common sexually transmitted disease resulting in sterility and the leading cause of preventable blindness

    Original URL path: http://mgm.duke.edu/faculty/coers/bio.html (2014-06-13)
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