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  • Duke University Department of Molecular Genetics & Microbiology
    Professor research biography lab members publications lab website Lab members Jörn Coers Assistant Professor Charlotte Lee Undergraduate Student Eric Feeley Graduate Student Danielle Pilla Graduate Student Ryan Finethy Graduate Student Anthony Piro Graduate Student Arun Kumar Haldar Postdoctoral Associate Germaine

    Original URL path: http://mgm.duke.edu/faculty/coers/lab.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    analysis of susceptibility to Chlamydia trachomatis in mouse Genes Immun 2006 Mar 7 2 122 129 Bernstein Hanley I Coers J Balsara Z R Taylor G A Starnbach M N Dietrich W F Authors contributed equally to this paper The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq 3 and mediate cellular resistance in mice Proc Natl Acad Sci U S A 2006 Sept 19 103 38 14092 14097 Coers J Vance R E Fontana M F Dietrich W F Authors contributed equally to this paper Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5 Ipaf signalling pathways Cell Microbiol 2007 Oct 9 10 2344 2357 Coers J Bernstein Hanley I Grotsky D Parvanova I Howard J C Taylor G A Dietrich W F Starnbach M N Chlamydia muridarum evades growth restriction by the IFNg inducible host resistance factor Irgb10 J Immunol 2008 May 1 180 9 6237 6245 Tiedt R Coers J Ziegler S Wiestner A Hao Shen H Bornmann C Schenkel J Karakhanova S de Sauvage F J Jackson C W Skoda R C Authors contributed equally to this paper Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes Blood 2009 Feb 19 113 8 1768 1777 Henry S C Daniell X G Burrough A R Indaram M Howell D N Coers J Starnbach M N Hunn J P Howard J C Feng C G Sher A Taylor G A Balance of Irgm protein activities determines IFN induced host defense J Leukoc Biol 2009 May 85 5 877 885 Coers J Starnbach M N Howard J C Modelling infectious disease in mice Co adaptation and the role of host specific IFNy responses PLoS Pathogens 2009 May 5 5 e1000333 Khaminets

    Original URL path: http://mgm.duke.edu/faculty/coers/pubs.htm (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    trachomatis and Legionella pneumophila To exert their antimicrobial activities many IFN induced host proteins must specifically localize to pathogen containing vacuoles PCV The mechanisms by which the host recognizes and discriminates between non self PCV and endogenous self membranous structures such as mitochondria or the Golgi apparatus are not well understood One of the main interests of our lab is to elucidate the molecular mechanisms that direct the localization of antimicrobial proteins to PCV Towards this goal we are taking two complementary approaches I We conduct mammalian RNAi screens to identify host genes required for PCV targeting II We use bacterial genetics cell biological and biochemical techniques to determine what PCV associated properties are recognized by the innate immune response A second interest of the lab is to understand how the obligate intracellular bacterial pathogen C trachomatis can cause chronic genital infections infertility and other complications in women Currently no small animal model exists that recapitulates the chronic disease as it manifests itself in humans We and others have found that humans and mice differ substantially in their respective IFN gamma response pathways and these differences emerge as key determinants of host tropism Therefore a goal of our lab is

    Original URL path: http://mgm.duke.edu/microbial/bacteriology/coers/ (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    his future was in research aimed at understanding the biology of disease His thesis project was carried out in the laboratory of Dr Matthew P Scott Using a combination of biochemistry cell biology genetics and animal models he pioneered a new subject in the lab examining how genetic alterations lead to the neurodegenerative lipid disorder Niemann Pick type C NPC The main findings of his studies on NPC were that 1 mutation of NPC1 slowed the dynamic trafficking of the organelles in which it is found contributing to the lipid derangements seen in this disorder 2 NPC2 binds cholesterol with sub micromolar affinity and this binding is essential for activity and 3 the requirement of NPC1 in the brain is cell autonomous and its loss can lead to neuronal cell death with properties consistent with autophagy He took a year off for personal reasons following the completion of his MD PhD degrees in June 2005 During this time he volunteered in two labs on an informal basis to remain scientifically engaged It was during this time that he decided to switch fields Two major developments helped shape this decision 1 the massive amount of genetic information from studies of human diversity and 2 improvements in studying mammalian cell biology especially RNA interference and fluorescence assays He therefore decided to engage in studies that would take advantage of these new developments in the field of host pathogen interactions As a post doctoral Life Sciences Research Foundation fellow in the lab of Samuel Miller at the University of Washington Dr Ko developed a novel screening method termed Hi HOST high throughput human in vitro susceptibility testing for identifying human genetic variation that affects cell based readouts of bacterial infection Using this approach he measured cellular variation in the human cell death response

    Original URL path: http://mgm.duke.edu/faculty/ko/bio.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Dennis Ko MD PhD Assistant Professor research biography lab members publications Lab members Dennis Ko Assistant Professor Monica Thomas Graduate Student Sarah Jaslow Graduate Student Liuyang Wang Post Doctoral Associate

    Original URL path: http://mgm.duke.edu/faculty/ko/lab.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    JP Ko DC Zou Y Bang ND Chau TT Vary JC Dunstan S Farrar JJ Thwaites G King MC Serhan CN Ramakrishnan L 2012 Therapies directed to LTA4H genotype can optimize the inflammatory response to mycobacterial infections Cell 148 3 434 46 McElwain MA Ko DC Gordon MD Fyrst H Saba JD Nusse R 2011 A Suppressor Enhancer Screen in Drosophila Reveals a Role for Wnt Mediated Lipid Metabolism in Primordial Germ Cell Migration PLoS ONE 6 11 e26993 Vinh DB Ko DC Rachubinski RA Aitchison JD Miller SI 2010 Expression of the Salmonella spp Virulence factor SifA in yeast alters RHO1 activity on peroxisomes Mol Biol Cell 21 20 3567 77 Fong C Ko DC Wasnick M Radey M Miller SI Brittnacher M 2010 GWAS Analyzer integrating genotype phenotype and public annotation data for genome wide association study analysis Bioinformatics 26 4 560 4 Ko DC Shukla KP Fong C Wasnick M Brittnacher MJ Wurfel MM Holden TD O Keefe GE Van Yserloo B Akey JM Miller SI 2009 A genome wide in vitro bacterial infection screen reveals human variation in the host response associated with inflammatory disease Am J Hum Genet 85 2 214 27 Ko ER Ko DC Chen C Lipsick JS 2008 Identification of a conserved acidic patch in the myb repeat required for activation of endogenous targets and chromatin binding Molecular Cancer 7 77 96 Ko DC Milenkovic L Beier S Manuel H Buchanan J Scott MP 2005 Cell autonomous death of cerebellar Purkinje neurons with autophagy in Niemann Pick type C disease PLoS Genetics 1 1 e7 Ohgami N Ko DC Thomas M Scott MP Chang CC Chang TY 2004 Binding between the Niemann Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol sensing domain Proc Natl Acad Sci U S

    Original URL path: http://mgm.duke.edu/faculty/ko/pubs.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Institute Investigator and Assistant Professor He currently holds a James B Duke Professorship in the Department of Molecular Genetics and Microbiology and serves as Director of the Center for Virology at Duke Bryan Cullen s interests have historically revolved around the use of viruses as genetic tools to understand aspects of the biology of the eukaryotic cell focusing particularly on RNA sequence mediated gene regulation Currently his laboratory is studying the biogenesis and function of microRNAs and in particular virus encoded microRNAs and also works on human factors that act as innate inhibitors of both retrovirus infection and retrotransposon mobility Honors Awards Recipient of the 1989 Eli Lilly Molecular Biology Contact Award Recipient of a 1993 Alexander von Humboldt Foundation Research Award Listed as one of the 10 most cited AIDS researchers by Science Heavy Hitters in AIDS Vol 260 p 1262 1993 Recipient of the University of Medicine and Dentistry of New Jersey Distinguished Alumni Award 2000 Awarded the distinguished professorship James B Duke Professor of Genetics 2000 Listed as one of the world s most Highly Cited Researchers by the Institute for Scientific Information 2001 http isihighlycited com Appointed to the honorary position of Visiting Professor by the

    Original URL path: http://mgm.duke.edu/faculty/cullen/bio.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    lab members publications lab website Lab members Hal Bogerd Research Scientist Anand Kornepati Undergraduate Research Assistant Bryan R Cullen James B Duke Professor Christy Krupa Administrative Coordinator Yuki Furuse Postdoctoral Associate Joy Marshall Lab Research Analyst Dong Harry Kang Graduate

    Original URL path: http://mgm.duke.edu/faculty/cullen/lab.htm (2014-06-13)
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