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  • Duke University Department of Molecular Genetics & Microbiology
    681 8979 Email karyn mcfadden duke edu I received my B S in biology in 1996 from the College of New Jersey After working for several years I finally decided to go back to graduate school under the mentorship of Dr Irwin Chaiken at Drexel University I received my Ph D in Biochemistry in 2011 characterizing new inhibitors of HIV 1 entry I joined Dr Micah Luftig s lab in

    Original URL path: http://mgm.duke.edu/faculty/luftig/lab/mcfadden.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    novel polysaccharide found in the Myxococcus xanthus soil bacterium and worked to determine its structure and role in osmoregulation of the cell Previously I completed my BS in Biology with a concentration in Microbiology and minor in Chemistry at Salisbury University At Salisbury University I worked in the lab of Dr Mark Frana studying the presence and source of Escherichia coli and Enterococcus faecalis in Maryland and Delaware shore sediment

    Original URL path: http://mgm.duke.edu/faculty/luftig/lab/hafez.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Andrew VanDemark During my time there I was able to solve the structure of an Xis protein that is involved in the integration and excision of the phage genome into and out of the host chromosome during lysogenic infection I came to Duke and joined MGM to continue to involve myself in the biology of microbes to be able to better understand human disease and potentially help develop cures and

    Original URL path: http://mgm.duke.edu/faculty/luftig/lab/homa.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    I was raised in North Carolina but was born in Lima Peru I am an undergraduate student in the class of 2017 working towards a major in Biology and a minor in Chemistry I have been working in the Luftig laboratory since the summer of 2010 I began by learning basic procedures until the summer of 2012 when I had the task of cloning shRNAs to knock down specific genes

    Original URL path: http://mgm.duke.edu/faculty/luftig/lab/salinas.html (2014-06-13)
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  • The Garcia-Blanco Lab
    MS impairs the ability of nerves to transmit their signals leading to a wide range of physical and cognitive issues that vary greatly from patient to patient Symptoms may be mild such as numbness in the limbs or severe such as paralysis or loss of vision Unfortunately the exact cause of MS is still unknown Animal models of human disease are often used in research to allow scientists to gather information about a disease without harming a human in the process Currently the most commonly used animal model of MS involves the induction of CNS inflammation in young adult mice with myelin antigens such as MBP PLP and MOG and pertussis toxin which will break down the blood brain barrier this animal model is known as Experimental Autoimmune Encephalomyelitis EAE However this method has downfalls including lack of spontaneous disease development B Cell involvement and lack of a genetic aspect With this imprecise model and the recent discovery of the involvement of the alternatively spliced soluble form of the Interleukin 7 receptor we have decided to create a new transgenic Tg mouse model that will produce the soluble receptor found in humans that has been linked to MS It is

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/arvai.html (2014-06-13)
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  • The Garcia-Blanco Lab
    artery wall mass and remodeling J Vasc Surg 2004 Jan 39 1 223 8 Zhao FT Li J Shi GX Liu Y and Zhu LP Inhibition of ER alpha monnosidase expression causes reduction and shortening of microvilli on rat liver epithelial cell WB F344 Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003 Feb 25 1 52 5 Zhao FT Li J Shi G Liu Y and Zhu LP Modificaiton of glycosylation reduces microvilli on rat liver epithelial cells Cell Biology International 2002 July 26 7 627 633 Li B Ma F Shi G Zhao F Li J Li Lin Wang Yi Cai Youyu and Zhu Liping Cloning of a human full lengh cDNA encoding an a manosidase Basic Medical Sciences and Clinics 1999 19 5 409 415 Book Chapters Special Expertise of Dermatologist in the Delivery of Dermatologic Care Steven R Feldman MD PhD and Jing Li MD PhD European Dermatology Forum 3rd edition Berlin ABW Verlag 2009 Abstracts Pearce JD Li J English WP Wilson DB Edwards MS and Geary RL Loss of the Receptor For Hyaluronan Mediated Motility RHAMM Enhances Collagen Reorganization and Outward Artery Wall Remodeling 2004 Lifeline Foundation Research Initiatives in Vascular Disease Conference Bethesda Li J Adams LD Schwartz SM and Geary RL Regulator of G Protein Signaling 5 RGS5 Inhibits Angiotensin II Induced Hypertrophic Responses American Heart Association Scientific Sessions 2003 November 9 12 2003 Orlando Florida oral presentation Li J Adams LD Schwartz SM and Geary RL Regulator of G protein signaling 5 RGS5 marks arterial from venous SMC and reduced expression in atherosclerotic plaque links G protein activation to lesion progression Experimental Biology 2003 April 11 15 2003 San Diego oral presentation Li J Adams LD Schwartz SM and Geary RL Expression of profiling and smooth muscle cell diversity Proceeding Research

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/li.html (2014-06-13)
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  • The Garcia-Blanco Lab
    genes previously identified by RNA interference based genome wide screening RGENs cause mutations at the target site within the genome permitting creation of gene knockout cell lines Importantly the knockout of multiple genes in the same cell line permits the identification of novel genetic interactions between genes of interest which could not be identified efficiently by traditional assay designs Barrows N Bradrick S Jamison S Kim S Le Sommer C Pearson J Garcia Blanco MA Functional genomics approach to the identification of human host factors supporting dengue viral propagation Submitted Barrows N Bradrick S Bidet K Anwar A Ward A Jamison SF Levitt B LeSommer C Garcia Blanco MA The Interface between Dengue Virus and the Human Host Submitted Le Sommer C Barrows NJ Bradrick SS Pearson JL Garcia Blanco MA G Protein Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication PLoS Negl Trop Dis 2012 Sep 6 9 e1820 PMID 23029581 Panda D Das A Dinh PX Subramaniam S Nayak D Barrows NJ Pearson JL Thompson J Kelly DL Ladunga I Pattnaik AK RNAi screening reveals requirement for host cell secretory pathway in infection by diverse families of negative strand RNA viruses Proc Natl Acad Sci U S

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/barrows.html (2014-06-13)
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  • The Garcia-Blanco Lab
    a wide array of human diseases My research interests lie at the interface of alternative splicing and human disease with particular focus on targeting alternative splicing for therapeutic intervention My current research project is centered on regulation of alternative splicing of the interleukin 7 receptor IL7R This receptor plays a central role in the homeostatic regulation of T cells and its dysfunction underlies the etiology of numerous immune disorders I

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/munoz.html (2014-06-13)
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