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  • The Garcia-Blanco Lab
    will allow for improved prognostication but more importantly for the identification of biomarkers and targets for therapy that may prevent or delay metastatic progression Publications Bitting RL Boominathan R Rao C Kemeny G Foulk B Garcia Blanco MA Connelly M Armstrong AJ Development of a method to isolate circulating tumor cells using mesenchymal based capture Methods 2013 Jul 8 Armstrong AJ Shen T Halabi S Kemeny G Bitting RL Kartcheske

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/kemeny.htm (2014-06-13)
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  • The Garcia-Blanco Lab
    alternatively spliced to form two isoforms IIIb and IIIc which are characteristic of epithelial and mesenchymal cells respectively The splicing of this receptor is a very useful marker of epithelial mesenchymal transitions a phenotypic change that takes place during development

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/wang.html (2014-06-13)
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  • The Garcia-Blanco Lab
    Specialist Address Duke University Medical Center Box 3053 424 CARL Building Research Drive Durham NC 27710 Phone 919 613 8636 Fax 919 613 8646 Email annette kennett duke edu Joined

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/kennett.htm (2014-06-13)
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  • The Garcia-Blanco Lab
    characterizing tumor cells in the circulatory system to better understand EMT Publications A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2 FGFR1 autocrine growth loop Ware KE Hinz TK Kleczko E Singleton KR Marek LA Helfrich BA Cummings CT Graham DK Astling D Tan AC Heasley LE Oncogenesis 2013 Mar 25 2 e39 doi 10 1038 oncsis 2013 4 PMID 23552882 Upstream stimulatory factor 2 and hypoxia inducible factor 2α HIF2α cooperatively activate HIF2 target genes during hypoxia Pawlus MR Wang L Ware KE Hu CJ Mol Cell Biol 2012 Nov 32 22 4595 610 doi 10 1128 MCB 00724 12 Epub 2012 Sep 10 PMID 22966206 Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells Marshall ME Hinz TK Kono SA Singleton KR Bichon B Ware KE Marek L Frederick BA Raben D Heasley LE Clin Cancer Res 2011 Aug 1 17 15 5016 25 doi 10 1158 1078 0432 CCR 11 0050 Epub 2011 Jun 14 PMID 21673064 Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de repression of FGFR2 and FGFR3 expression Ware KE Marshall ME Heasley LR Marek L Hinz TK Hercule P Helfrich BA Doebele RC Heasley LE PLoS One 2010 Nov 29 5 11 e14117 doi 10 1371 journal pone 0014117 PMID 21152424 Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity Keating AK Kim GK Jones AE Donson AM Ware KE Mulcahy JM Salzberg DB Foreman NK Liang X Thorburn A Graham DK Mol Cancer Ther 2010 May 9 5 1298 307 doi 10 1158 1535 7163 MCT 09 0707 Epub 2010 Apr 27 PMID 20423999 The fibroblast growth factor receptor signaling pathway

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/ware.html (2014-06-13)
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  • The Garcia-Blanco Lab
    immune system and autoimmunity in the laboratory of Michael Holers at the University of Colorado publishing half a dozen articles about complement and Rheumatoid Arthritis In 2009 Brandt joined the Duke Molecular Genetics and Microbiology Phd program because of its strength in host pathogen interactions In 2010 he joined the Garcia Blanco laboratory where he studies exonucleases that act as pro flaviviral host factors for Dengue and Yellow Fever Virus RNA replication He anticipates a career in public health utilizing the problem solving and critical thinking skills gained through research Manuscripts 1 Initiation of the Alternative Pathway of Murine Complement by Immune Complexes is Dependent on N Glycans in IgG Antibodies Banda NK Takahashi M Wood A Levitt B Rudd P Royle L Abrahams J Stahl G Holers VM Arend WP Arthritis and Rheumatism Vol 58 No 10 October 2008 pp 3081 3089 2 Targeted Inhibition of the Complement Alternative Pathway with Complement Receptor 2 and Factor H Attenuates Collagen Antibody Induced Arthritis in Mice Banda NK Levitt B Glogowska MJ Thurman JM Takahashi K Stahl GL Tomlinson S Arend WP and Holers VM J Immunol Nov 2009 183 5928 5937 3 Complement activation pathways in murine immune complex induced

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/levitt.html (2014-06-13)
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  • The Garcia-Blanco Lab
    Wang A Z Biochemical failure in prostate cancer Chapter in Comprehensive Textbook of Prostate Cancer Springer Science and Business Media 2011 Werner M E Karve S Sukumar R Cummings N D Copp J A Chen R C Zhang T Wang A Z Folate targeted nanoparticle delivery of chemo and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis Biomaterials 2011 32 33 8548 54 DeRienzo C M Frush K Barfield M E Gopwani P R Griffith B C Jiang X Mehta A I Papavassiliou P Rialon K L Stephany A M Zhang T Andolsek K M Handoffs in the era of duty hours reform a focused review and strategy to address changes in the Accreditation Council for Graduate Medical Education Common Program Requirements Academic Medicine 2012 87 4 403 10 Zhang T Hamilton E Schneider A Patel K Kamal A H Peppercorn J M Prevalence and impact of correlative science in breast cancer phase II trials Breast Cancer Research and Treatment 2013 139 3 845 50 Zhang T Das S K Fels D R Hansen K S Wong T Z Dewhirst M W Vlahovic G 62CuATSM and 62CuPTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions American Journal of Roentgenology 2013 Manuscript accepted for Spublication Boggan J C Zhang T DeRienzo C Frush K Andolsek K Shift changes for the hospital team standardizing and evaluating transitions of care in the era of duty hour reform Journal of Graduate Medical Education 2013 Manuscript accepted for publication Zhang T and Armstrong A J Clinical subtypes of castration resistant prostate cancer Clinical Advances in Hematology and Oncology 2013 Review manuscript Abstracts Zhang T Hamilton E P Schneider A Patel K Kamal A H Peppercorn J M Prevalence and impact of correlative science in breast cancer phase II trials ASCO

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/lab/zhang.html (2014-06-13)
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  • The Garcia-Blanco Lab
    by altering the selection of exons to be included in the messenger This process is known as alternative splicing and it is the major engine of proteome diversity in humans My laboratory studies the regulation of processing of messenger RNAs focusing on the alternative splicing of the fibroblast growth factor receptor 2 FGFR2 transcripts FGFR2 transcripts are alternatively spliced to yield regulated expression of two receptors with dramatically different ligand specificity Not only is this process critical for normal development of many epithelial tissues but also during progression of prostate tumors the alternative splicing of FGFR2 was noted to be deregulated The laboratory has pioneered the use of reporter constructs to image alternative splicing decisions in vivo both in normal tissues in transgenic mice and in syngeneic prostate tumors in rats In the latter system imaging of alternative splicing has led to the unexpected discovery of epithelial plasticity epithelial mesenchymal and mesenchymal epithelial transitions in tumors presumed to be anaplastic These transitions appear to be essential for tumor progression and the development of metastases the major cause of morbidty and mortality in cancer patients This has led to a reevaluation of the importance of a plasticity phenotype in tumor fitness

    Original URL path: http://mgm.duke.edu/faculty/garcia/lab/about.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    684 9152 Fax 919 684 2790 Email rebecca beerman duke edu Research I received my Ph D in Cellular and Molecular Biology at the University of Pennsylvania in 2010 working with Tom Jongens to characterize the regulation and activity of the Drosophila homologue of the fragile X mental retardation gene dfmr1 I joined the Tobin lab as a post doctoral associate in 2011 where I am using the zebrafish to

    Original URL path: http://mgm.duke.edu/faculty/tobin/lab/beerman.html (2014-06-13)
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