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  • Duke University Center for Microbial Pathogenesis
    annually in the United States alone Presumably macrophage activation occurs in most individuals who develop only an inapparent or acute respiratory infection which resolves without complication However 5 10 of infections progress in the lung or disseminate to visceral organs and these patients can be difficult to treat with current antifungal drugs Even patients who appear to recover may suffer a recurrence months to years later particularly when immunocompromised by chemotherapy or AIDS Initial host pathogen interactions and the recognition of Histoplasma cells by host macrophages in the lungs are poorly understood Histoplasma produces a cell wall component α 1 3 glucan which masks the cell surface β 1 3 glucan from recognition by dectin 1 and subsequent production of IL 23 and may facilitate Histoplasma pathogenesis by preventing the induction of the IL 23 Th17 response pathway An alternative hypothesis is that α 1 3 glucan may be masking cell wall chitin from recognition by the host immune response and altering cytokine production and immune cell recruitment to the site of infection My current work involves examine the role of exposed chitin on the surface of Histoplasma in α 1 3 glucan synthase mutants in stimulating the host immune

    Original URL path: http://mgm.duke.edu/microbial/training/mmptp/okagaki.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    he applied molecular and cellular biology approaches to study neural development and disorder in cultured neurons and discovered an important role of AKT local degradation of in the establishment and maintenance of neuronal polarity As a postdoctoral fellow in Dr Yishi Jin s lab at the University of California San Diego he furthered his study of neural development and disorder in vivo using the genetic model organism C elegans Here

    Original URL path: http://mgm.duke.edu/faculty/yan/bio.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Chia Hui Chen PhD Student Dong Yan Assistant Professor Lingfeng Meng Postdoctoral Fellow The Yan lab is interested in recruiting students and postdoctoral fellows with backgrounds and interests in neurobiology cell and molecular biology and genetics Applicants should send their

    Original URL path: http://mgm.duke.edu/faculty/yan/lab.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    terminals new findings from C elegans Current Opinion in Neurobiology 22 3 431 7 PMID 22036768 Lizhen Chen Zhiping Wang Anindya Ghosh Roy Thomas Hubert Dong Yan Sean O Rourke Bruce Bowerman Zilu Wu Yishi Jin Andrew D Chisholm 2011 Axon regeneration pathways identified by systematic genetic screening in C elegans Neuron 271 6 1043 57 PMID 21943602 Gloriana Trujillo Katsunori Nakata Dong Yan Ichi N Maruyama and Yishi Jin 2010 A Ubiquitin E2 Variant Protein Acts in Axon Termination and Synaptogenesis in Caenorhabditis elegans Genetics 186 135 145 PMCID PMC2940282 Dong Yan Zilu Wu Andrew D Chisholm and Yishi Jin 2009 The DLK 1 kinase pathway promotes CEBP 1 mRNA stability and local translation in C elegans synapse maintenance and axon regeneration Cell 138 1005 1018 PMCID PMC2772821 Hailan Yao Kechun Zhou Dong Yan Mingtao Li and Yizheng Wang 2009 The Kv2 1 channels mediate neuronal apoptosis induced by excitotoxicity Journal of Neurochemistry 108 909 919 Dong Yan Li Guo Yizheng Wang 2006 Requirement of dendritic Akt degradation by ubiquitin proteasome system for neuronal polarity The Journal of Cell Biology 174 3 415 24 PMCID PMC2064237 Co first Author Qiaoyun Yang Dong Yan Yizheng Wang 2006 Intracellular K selectively

    Original URL path: http://mgm.duke.edu/faculty/yan/pubs.htm (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Lab Members Michael Kuo Undergraduate Student 270 Jones Building Box 3580 DUMC Durham N C 27710 Phone 919 668 2449 Fax 919 668 0795 Email mk101 duke edu Bio not

    Original URL path: http://mgm.duke.edu/faculty/aballay/lab/kuo.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    4657 Fax 919 684 8735 Email sc292 duke edu I received my BS in Microbiology from UC Davis in 2011 After joining Dr Pickup s lab in 2012 I have been focusing on investigating the viral host interactions of vaccinia MVA and cowpox Currently we are looking at improving the immunogenicity of MVA as a vaccine vector I am also interested in the role of virus contained in ATIs and

    Original URL path: http://mgm.duke.edu/faculty/pickup/lab/crawford.html (2014-06-13)
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  • Duke University Department of Molecular Genetics & Microbiology
    Fax 919 684 8735 Email ashley gartin duke edu I am a class of 2016 undergraduate majoring in biology with a probable chemistry minor I am particularly interested in virology and immunology Since September 2012 I have been working in the Pickup lab where I am engaged in a project to improve on current live viral vaccine vectors One objective is to determine if alterations to a vaccinia virus vector

    Original URL path: http://mgm.duke.edu/faculty/pickup/lab/gartin.html (2014-06-13)
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  • Duke University Center for Microbial Pathogenesis
    Rico Chester Emmons at the NIH Pablo Negroni in Argentina and G C Ainsworth in England comprised the first generation of medical mycologists Dr Conant co authored several editions of the Manual of Clinical Mycology which was the seminal text for this new discipline He taught the Duke Summer Mycology Course from 1948 until he retired in 1973 directed numerous dissertations and supervised many others who came from all parts of the world to learn about medical fungi To some degree he influenced every medical mycologist who was trained prior to 1970 The second generation of eminent medical mycologists who studied with Dr Conant included Drs Libero Ajello Margarita Silva Hutner Howard Larsh Morris Gordon and of course Lorraine Friedman After leaving Duke Dr Friedman supervised or co mentored the doctoral dissertations of a number of prominent medical mycologists including George S Kobayashi Donald Greer Judith E Domer Angela Restrepo and Jim E Cutler Her orbit at Tulane provided an inspiring and heady atmosphere for medical mycology and Mitchell was fortunate to have been there For his postdoctoral fellowship Mitchell joined the laboratory of Paul G Quie M D in pediatrics at the University of Minnesota Medical School and investigated the chemotaxis and phagocytosis of C albicans by human neutrophils In September 1974 Mitchell was recruited to the Department of Microbiology and Immunology at Duke University Medical Center completing a circle in the lineage of medical mycologists with ties to Duke Charged with the daunting privilege of replacing Dr Conant Mitchell was appointed director of the Clinical Mycology Laboratory assumed responsibility for teaching medical mycology in the medical and graduate schools and established a basic research program supported by extramural funds Mitchell joined the ASM in 1969 and has been a continuous member for 40 years His service for the

    Original URL path: http://mgm.duke.edu/microbial/mycology/mitchell/bio.htm (2014-06-13)
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