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  • Fahrni Research Group - People
    Her current research primarily involves studying the redistribution of transition metals during cell division and embryogenesis In her free time Daisy enjoys yoga running and spending time with her 14 year old miniature pinscher Jill Adam McCallum Graduate Student adam mccallum gatech edu Phone 404 385 1176 Adam McCallum came to Georgia Tech from Northern Kentucky University where he graduated in 2012 with a B S in Chemistry with an emphasis in Biochemistry His current research is focused on the design synthesis optimization and photophysical characterization of Zn II responsive fluorescent probes for live cell elucidation of Zn II trafficking When he s not in the lab he avidly enjoys playing tennis hiking camping and reading Haylie L Hancock Graduate Student hhancock7 gatech edu Phone 404 385 1176 Haylie Hancock graduated in 2013 from Bridgewater State University with her BS in chemistry and a concentration in biochemistry Over the past year she has taught Biochemistry II laboratory to seniors in the chemistry program Her research is focused on the elucidation of thermodynamic aspects of Cu I trafficking and storage in mammalian cells Margaret E Read Undergraduate Student mread93 gatech edu Phone 404 385 1176 Maggie is a 4th year undergraduate

    Original URL path: http://ww2.chemistry.gatech.edu/fahrni/people.html (2015-06-03)
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  • Fahrni Research Group - Projects
    protein binding affinities requires competing reference ligands with similar binding strengths In this project we designed synthesized and characterized a series of roubust Cu I affinity standards that form discrete Cu I complexes with 1 1 stoichiometry and are capable of buffering Cu I concentrations between 10 10 and 10 17 M Dynamic Imaging of Zinc During Cell Proliferation and Development Ratiometric Zn II Selective Fluorescent Probes for Two Photon Microscopy Two photon excitation fluorescence microscopy TPEM has rapidly evolved into a widely used imaging modality in biological and biomedical research Compared to conventional fluorescence microscopy TPEM offers intrinsic 3D resolution combined with reduced phototoxicity increased specimen penetration and negligible background fluorescence In this project we focus on the development of emission ratiometric Zn II selective fluorescent probes that are optimized for the use in two photon excitation microscopy The probes are built upon a donor acceptor motif that elicits a strong spectral shift upon binding of Zn II while maintaining a balanced two photon cross section Our current efforts are geared towards expanding the affinity range of the probes and further optimizing their photophysical properties Inheritance of Zinc During Mitosis Despite the importance of trace metals to cell proliferation mechanisms governing their regulation re distribution and ultimate partitioning into the daughter cells upon completion of cell division remain largely unexplored In this project we employ a combination of synchrotron x ray fluorescence imaging and two photon excitation microscopy to unravel the redistribution of transition metals in NIH 3T3 cells as they pass through the indidual mitotic stages Our studies revealed an intriguing redistribution dynamics of zinc and copper as well as an unexpected sharp increase of cellular zinc levels in mitotic compared to interphase cells 3D Imaging of Trace Elements by X ray Fluorescence Tomography By acquiring a series

    Original URL path: http://ww2.chemistry.gatech.edu/fahrni/research.html (2015-06-03)
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  • Fahrni Research Group - Publications
    thermodynamics in polyfluorinated 1 3 5 triarylpyrazolines based on multiple linear free energy relationships Org Biomol Chem 2009 7 1536 1546 pubmed link McRae R Bagchi P Sumalekshmy S Fahrni C J In situ imaging of metals in cells and tissues Chem Rev 2009 109 4780 4827 pubmed link Fahrni C J Fluorescent probes and labels for cellular imaging Chimia 2009 63 714 720 link Solntsev K M McGrier P L Fahrni C J Tolbert L M Bunz U H F Anomalous photophysics of bis hydroxystyryl benzenes A twist on the para meta dichotomy Org Lett 2008 10 2429 2432 pubmed link McRae R L Phillips R L Kim I B Bunz U H F Fahrni C J Molecular recognition based on low affinity polyvalent interactions Selective binding of a carboxylated polymer to fibronectin fibrils of live fibroblast cells J Am Chem Soc 2008 130 7851 7853 pubmed link Cody J Mandal S Yang L C Fahrni C J Differential tuning of the electron transfer parameters in 1 3 5 triarylpyrazolines A rational design approach for optimizing the contrast ratio of fluorescent probes J Am Chem Soc 2008 130 13023 13032 pubmed link Wu Y G Lawson P V Henary M M Schmidt K Bredas J L Fahrni C J Excited state intramolecular proton transfer in 2 2 arylsulfonamidophenyl benzimidazole derivatives Insights into the origin of donor substituent induced emission energy shifts J Phys Chem A 2007 111 4584 4595 pubmed link Sumalekshmy S Henary M M Siegel N Lawson P V Wu Y Schmidt K Bredas J L Perry J W Fahrni C J Design of emission ratiometric metal ion sensors with enhanced two photon cross section and brightness J Am Chem Soc 2007 129 11888 11889 pubmed link Henary M M Wu Y G Cody J Sumalekshmy S Li J Mandal S Fahrni C J Excited state intramolecular proton transfer in 2 2 arylsulfonamidophenyl benzimidazole derivatives The effect of donor and acceptor substituents J Org Chem 2007 72 4784 4797 pubmed link Fahrni C J Biological applications of X ray fluorescence microscopy exploring the subcellular topography and speciation of transition metals Curr Opin Chem Biol 2007 11 121 127 pubmed link McRae R Lai B Vogt S Fahrni C J Correlative microXRF and optical immunofluorescence microscopy of adherent cells labeled with ultrasmall gold particles J Struct Biol 2006 155 22 29 pubmed link Yang L McRae R Henary M M Patel R Lai B Vogt S Fahrni C J Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x ray fluorescence microscopy Proc Natl Acad Sci USA 2005 102 11179 11184 pubmed link Zhou Z Fahrni C J A fluorogenic probe for the copper I catalyzed azide alkyne ligation reaction Modulation of the fluorescence emission via 3 n pi 1 pi pi inversion J Am Chem Soc 2004 126 8862 8863 pubmed link Samia A C S Cody J Fahrni C J Burda C The effect of ligand constraints on the metal to

    Original URL path: http://ww2.chemistry.gatech.edu/fahrni/publications.html (2015-06-03)
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  • Fahrni Research Group - Gallery
    Christoph J Fahrni Ph D Professor School of Chemistry and Biochemistry Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA USA fahrni chemistry gatech edu 2014 Fahrni

    Original URL path: http://ww2.chemistry.gatech.edu/fahrni/gallery.html (2015-06-03)
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  • Fahrni Research Group - Resources
    Standards and pH Buffers Monovalent copper ligands MCL Series Goods buffer Christoph J Fahrni Ph D Professor School of Chemistry and Biochemistry Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA USA fahrni chemistry gatech edu 2014

    Original URL path: http://ww2.chemistry.gatech.edu/fahrni/resources.html (2015-06-03)
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  • Fahrni Research Group - Contact
    30332 USA Office 404 385 1164 Lab 404 385 1176 Fax 404 894 2295 Directions Shipping Address Georgia Institute of Technology IBB Building 315 Ferst Atlanta GA 30332 USA Christoph J Fahrni Ph D Professor School of Chemistry and Biochemistry

    Original URL path: http://ww2.chemistry.gatech.edu/fahrni/contact.html (2015-06-03)
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  • Professor Fernandez | Fernandez Group
    from the University of Buenos Aires Argentina During his tenure as an assistant professor he received 6 awards including the NSF CAREER award During his tenure as an associate professor he received 5 awards including the Ron A Hites award from the Journal of the American Society for Mass Spectrometry In 2008 he was invited to join the editorial advisory board of The Analyst a publication of the Royal Society of Chemistry In 2011 he was invited as a member of the National Academies committee on technology assessment for demilitarization applications He is currently a standing member of the EBIT NIH study section and of the scientific advisory committee of Oxford University s Worldwide Antimalarial Resistance Network During his tenure at Georgia Tech he has been invited to give 47 talks at conferences and 46 talks at universities companies or interest groups He is the co chair of the Atlanta Athens Mass Spectrometry Discussion Group He reviews approximately 20 manuscripts per year for journals such as Analytical Chemistry The Analyst Trends in Analytical Chemistry Journal of the American Society of Mass Spectrometry Mass Spectrometry Reviews Journal of the American Chemical Society Angewandte Chemie PNAS etc Office Ford Environmental Science and Technology Building ES T L1 244 DIRECTIONS Office Phone 404 385 4432 Fax 404 385 6447 E mail facundo fernandez chemistry gatech edu Package Delivery address 311 Ferst Drive NW ES T loading dock Atlanta GA 30332 Administrative Assistant Sue Winters Phone 404 385 6682 Fax 404 894 2295 sue winters chemistry gatech edu Professional Experience Jan 2009 Georgia Institute of Technology School of Chemistry and Biochemistry Associate Professor 2004 2009 Georgia Institute of Technology School of Chemistry and Biochemistry Assistant Professor 2002 2003 Postdoctoral researcher University of Arizona Advisor Prof Vicki H Wysocki 2000 2001 Postdoctoral researcher Stanford University

    Original URL path: http://ww2.chemistry.gatech.edu/fernandez/professor-fernandez (2015-06-03)
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  • Research | Fernandez Group
    questions of great societal and scientific significance To this purpose we have integrated with cross cutting teams devoted to problems that range from explaining the origins of life on Earth and diagnosing cancer at an early stage to tracking the sources and prevalence of counterfeit pharmaceuticals worldwide The common theme along these questions is the need for highly accurate tools for quantifying identifying and imaging trace chemicals in complex mixtures

    Original URL path: http://ww2.chemistry.gatech.edu/fernandez/research (2015-06-03)
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