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  • Research | Hud Lab
    are also applying our knowledge of nucleic acids to problems that are of current importance in medicine and biotechnology Specific projects include investigations of 1 the origin and evolution of RNA 2 cation solvent and small molecule interactions with nucleic acids 3 nucleic acid condensation and packaging and 4 folding and evolution of the ribosome Our research involves the application of a wide variety of physical and chemical techniques Visit

    Original URL path: http://ww2.chemistry.gatech.edu/hud/node/2 (2015-06-03)
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  • Publications | Hud Lab
    of base pairing oligonucleotides in a prebiotic world Proc Natl Acad Sci USA 107 5288 5293 doi 10 1073 pnas 0914172107 58 Mamajanov I Engelhart A E Bean H D and Hud N V 2010 DNA and RNA in anhydrous media duplex triplex and G Quadruplex secondary structures in a deep eutectic solvent Angew Chem Int Ed 49 6310 6314 doi 10 1002 ange 201001561 57 Bean H D Lynn D G and Hud N V 2010 Self Assembly and the Origin of the First RNA Like Polymers Chemical Evolution II From the Origins of Life to Modern Society ACS Symposium Series 1025 109 132 doi 10 1021 bk 2009 1025 ch006 56 Joung I S Çetinkol Ö P Hud N V and Cheatham III T E 2009 Molecular dynamics simulations and coupled nucleotide substitution experiments indicate the nature of A center dot A base pairing and a putative structure of the coralyne induced homo adenine duplex Nucleic Acids Res 37 7715 7727 doi 10 1093 nar gkp730 55 Sheng Y Bean H D Mamajanova I Hud N V and Leszczynski J 2009 A comprehensive investigation of the energetics of pyrimidine nucleoside formation in a model prebiotic reaction J Am Chem Soc 131 16088 16095 doi 10 1021 ja900807m 54 Hud N V 2009 Nucleotide Adsorption on Mineral Surfaces A mixed blessing for the RNA World Astrobiology 9 253 255 doi 10 1089 ast 2008 0928 53 Tsai A G Engelhart A E Hatmal M M Houston S I Hud N V Haworth I S and Lieber M R 2009 Conformational variants of duplex DNA correlated with cytosine rich chromosomal fragile sites J Biol Chem 284 7157 7164 doi 10 1074 jbc M806866200 52 Horowitz E D Lilavivat S Holladay B W Germann M W and Hud N V 2009 Solution structure and thermodynamics of 2 5 RNA intercalation J Am Chem Soc 131 5716 6036 doi 10 1021 ja810068e 51 Sarkar T Petrov A S Vitko J R Santai C T Harvey S C Mukerji I and Hud N V 2009 Integration host factor IHF dictates the structure of polyamine DNA condensates Implications for the role of IHF in the compaction of bacterial chromatin Biochemistry 48 667 675 doi 10 1021 bi8019965 50 Engelhart A E Morton T H and Hud N V 2009 Evidence of strong hydrogen bonding by 8 amino guanine Chem Comm 647 649 doi 10 1039 B818409G 49 Çetinkol Ö P and Hud N V 2009 Molecular recognition of poly A by small ligands An alternative method of analysis reveals nanomolar cooperative and shape selective binding Nucleic Acids Res 37 611 621 doi 10 1093 nar gkn977 48 Nucleic Acid Metal Ion Interactions Nicholas V Hud Ed Royal Society of Chemistry 2009 448 pp ISBN 978 0854041954 47 Çetinkol Ö P Engelhart A E Nanjunda R K Wilson W D and Hud N V 2008 Submicromolar selective G quadruplex ligands from one pot Thermodynamic and structural studies of human telomeric DNA binding by azacyanines ChemBioChem 9 1889 1892 doi 10 1002 cbic 200800234 46 Persil Ö and Hud N V 2007 Harnessing DNA intercalation Trends Biotech 25 433 436 doi 10 1016 j tibtech 2007 08 003 45 Bean H D Sheng Y Collins J P Anet F A L Leszczynski J and Hud N V 2007 Formation of a β pyrimidine nucleoside by a free pyrimidine base and ribose in a plausible prebiotic reaction J Am Chem Soc 129 9556 9557 doi 10 1021 ja072781a 44 Podbevsek P Hud N V and Plavec J 2007 NMR evaluation of ammonium ion movement within a unimolecular G quadruplex in solution Nucleic Acids Res 35 2554 2563 doi 10 1093 nar gkm138 43 Hud N V Jain S S Li X and Lynn D G 2007 Addressing the problems of base pairing and strand cyclization in template directed synthesis Chem Biodiv 4 768 783 doi 10 1002 cbdv 200790063 42 Hud N V and Morton T H 2007 DFT energy surfaces for aminopurine homodimers and their conjugate acid ions J Phys Chem A 111 3369 3377 doi 10 1021 jp065786n 41 Sarkar T Vitoc I Mukerji I and Hud N V 2007 Bacterial protein HU dictates the morphology of DNA condensates produced by crowding agents and polyamines Nucleic Acids Res 35 951 961 doi 10 1093 nar gkl1093 40 Plavec J and Hud N V The Role of Ions in Governing the structure and properties of quadruplexes In Quadruplex Nucleic Acids Royal Society of Chemistry London 2006 S Balsubramanian and S Neidle Eds 100 130 pp Link 39 Horowitz E D and Hud N V 2006 Ethidium and proflavine binding to a 2 5 linked RNA duplex J Am Chem Soc 128 15380 15381 doi 10 1021 ja065339l 38 Vilfan I D Conwell C C Sarkar T and Hud N V 2006 A time study of DNA condensate morphology Implications regarding the nucleation crowth and equilibrium populations of toroids and rods Biochemistry 45 8174 8183 doi 10 1021 bi060396c 37 Bean H B Anet F A L Gould I R and Hud N V 2006 Glyoxylate as a linkage for an ancestor of RNA Origins Life Evol B 36 39 63 doi 10 1007 s11084 005 2082 4 2001 2005 36 Hud N V and Vilfan I D 2005 Toroidal DNA condensates Unraveling the rine structure and the role of nucleation in determining size in vitro Ann Rev Biophys Biomol Struc 34 295 318 doi 10 1146 annurev biophys 34 040204 144500 35 Sarkar T Conwell C C Harvey L C and Hud N V 2005 Condensation of oligonucleotides assembled into nicked and gapped duplexes Potential structures for oligonucleotide delivery Nucleic Acids Res 33 143 151 doi 10 1093 nar gki156 34 Hud N V and Lynn D G 2004 Model systems From life s origins to a synthetic biology Editorial overview Curr Opin Chem Biol 8 627 628 doi 10 1016 j cbpa 2004 10 008 33 Persil Ö Santai C Jain S S and Hud

    Original URL path: http://ww2.chemistry.gatech.edu/hud/node/4 (2015-06-03)
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  • Current Hud Lab Members | Hud Lab
    2008 2009 Spelman College Pat Bishop 2003 2004 Indiana University Lili Harvey 2001 2002 Agnes Scott College Janez Plavec 2000 02 04 Natl Inst Chem Slovenia Frank A L Anet Continuous UCLA Graduates and Post Docs Ragan Buckley Ph D 2012 Gardner Groff Greenwald Villanueva Patent Law Ford Lannan M S 2012 United States Military Academy Lecturer Aaron Engelhart Ph D 2011 Harvard University Post doc Dr Samanta Pino Post Doc 10 11 Università Sapienza Italy Daniel Bånkestad M S 2011 Exchange Chalmers U Sweden Dr Sara Walker Post Doc 10 11 Arizona State U Asst Prof Dr Dipti Shingnapurkar Post Doc 09 10 Eric Horowitz Ph D 2009 UNC Post doc Heather Bean Ph D 2008 Texas A M Post doc Özgül Persil Çentikol Ph D 2008 Dogus Üniversitesi Asst Prof Swapan Jain Ph D 2006 Bard Asst Prof Tumpa Sarkar Ph D 2006 South Carolina Cathy Santai Ph D 2006 Wilson College Asst Prof Jim Collins M S 2005 Igor Vilfan Ph D 2005 Pacific Biosciences Christine Conwell Ph D 2004 Managing Director CCE Dr Matjaž Polak Post Doc 03 05 Natl Inst Chem Slovenia Brian Mutschler M S 2001 Kelly Law Registry Undergraduates Allison Lord B S

    Original URL path: http://ww2.chemistry.gatech.edu/hud/node/11 (2015-06-03)
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  • Media | Hud Lab
    2008 Evolution Revolution Talk 2008 Molecular Midwives 2004 Press Releases Chemical Substitution On Early Earth Iron May Have Performed Magnesium s RNA Folding Job Center for Chemical Evolution Awarded 20M Grant August 2010 Origin of Life Adding UV Light Helps Form Missing G of RNA Building Blocks June 2010 Unselfish Molecules May Have Helped Give Birth to the Genetic Material of Life March 2010 The Origins Project Awarded 1 5M

    Original URL path: http://ww2.chemistry.gatech.edu/hud/node/9 (2015-06-03)
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  • Center for Chemical Evolution | Hud Lab
    Media CCE The Center for Chemical Evolution is a Phase II chemistry center that is jointly funded by NSF and NASA Visit the Center for Chemical Evolution site by clicking

    Original URL path: http://ww2.chemistry.gatech.edu/hud/node/8 (2015-06-03)
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  • Archived News | Hud Lab
    to Ford Lannan for completing his master s degree He will be lecturing at the United States Military Academy 2012 Congratulations to Michael Chen for graduating with a bachelor s degree He will be doing a PhD at the Univ of Cambridge with Shankar Balasubramanian 2012 Aaron Engelhart is now Dr Aaron Engelhart He was also awarded a NASA postdoctoral fellowship to work with Jack Szostak at Harvard Medical School

    Original URL path: http://ww2.chemistry.gatech.edu/hud/node/28 (2015-06-03)
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  • Dr. Wendy Kelly | Wendy Kelly Research Group
    University of Wisconsin Madison 1996 B S Pharmacy Oregon State University Honors Awards and Recognitions 2009 DARPA Young Faculty Award 2008 ACS PROGRESS Dreyfus Lectureship Award 2007 Needle Assistant Professor Chair Georgia Institute of Technology 2006 Camille and Henry Dreyfus New Faculty Award 2006 Present Georgia Institute of Technology Institute for Bioengineering and Bioscience Parker H Petit Scholar 2004 2006 National Institutes of Health Postdoctoral Fellowship 2002 2004 Sonneborn Fellowship

    Original URL path: http://ww2.chemistry.gatech.edu/kelly/dr_kelly (2015-06-03)
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  • Group Members | Wendy Kelly Research Group
    University of Chemical Technology Karen Goeders B S 2006 Chemistry Louisiana State University Katy Roege B S Biology B A Chemistry 2006 University of North Carolina Wilmington Lisa Pan B S 2006 University of Florida Mallori Burse Undergraduate Georgia Tech Candice Sherwood Undergraduate Georgia Tech Kelly group Spring 2009 Kelly group Spring 2008 Former Group Members Tala Suidan B S in Chemistry 2010 Kelly Jones Undergraduate Researcher during 2009 Currently

    Original URL path: http://ww2.chemistry.gatech.edu/kelly/groupmembers (2015-06-03)
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