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  • Will Guerrant | Oyelere Group
    Vishal Patil Imani Jones Celinah Mwakwari Derek Benicewicz Research Publications Funding Links Home Will Guerrant Personal Info Contact Email gth799k mail gatech edu Education Graduate Georgia Tech 10 Ph D Biochemistry Undergraduate University of Georgia 05 B S Biochemistry and Molecular Biology Status 5th year Ph D student Field Biochemistry Bio Will has been with us since 2006 He has enjoyed publishing papers in respected scientific journals on his findings

    Original URL path: http://ww2.chemistry.gatech.edu/oyelere/WillGuerrant (2015-06-03)
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  • Josh Canzoneri | Oyelere Group
    Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors J Med Chem 2012 55 4 1465 1477 Canzoneri J C Chen P C Oyelere A K Design and Synthesis of Novel Histone Deacetylase Inhibitor Derived from Nuclear Localization Signal Peptide Bioorg Med Chem Lett 2009 19 6588 6590 Canzoneri J C Oyelere A K Interaction of Anthracyclines with Iron Responsive Element mRNAs Nucleic Acids Res 2008 36 6825 6834 Patil V Canzoneri J C Samatov T R Lührmann R Oyelere A K Molecular Architecture of Zinc Chelating Small Molecules That Inhibit Spliceosome Assembly at Early Stage RNA In Review Canzoneri J C Pierce S E Williams L D Brodbelt J S Oyelere A K Preferential Binding of Anthracyclines to DNA Base Mismatches ChemBioChem In Review Guerrant W Patil V Canzoneri J C Yao L Hood R Oyelere A K Novel Dual Targeted Inhibitors of Histone Deacetylase and Topoisomerase I In Progress Canzoneri J C Washington A Z Benicewicz D B Oyelere A K Exploring the Ribosome with Novel Macrolide Peptide Conjugates In Progress Presentations Canzoneri J C Washington A Z Benicewicz D B Oyelere A K Exploring the Ribosome with Peptolides presented at the NASA Astrobiology Science Conference AbSciCon April 18

    Original URL path: http://ww2.chemistry.gatech.edu/oyelere/JoshCanzoneri (2015-06-03)
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  • Vishal Patil | Oyelere Group
    K Synthesis and structure activity relationship of histone deacetylase HDAC inhibitors with triazole linked cap group Bioorganic and medicinal chemistry 2008 16 9 4839 4853 Patil V Guerrant W Chen P C Gryder B Benicewicz D Khan S Tekwani B Oyelere A K Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole linked cap group Bioorganic and medicinal chemistry 2010 18 1 415 425 Mwakwari S C Guerrant W Patil V Khan S Tekwani B Gurard Levin Z Mrksich M Oyelere A K Non peptide Macrocyclic Histone Deacetylase Inhibitors Derived from Tricyclic Ketolide Skeleton J Med Chem 2010 Accepted Mwakwari S C Patil V Guerrant W Oyelere A K Macrocyclic Histone Deacetylase Inhibitors review article Current topics in medicinal chemistry 2010 submitted authors contributed equally Meetings Symposia Chen P C Patil V Guerrant W Green P Oyelere A K Synthesis and structure activity relationship of histone deacetylase HDAC inhibitors with triazole linked cap group 235 th ACS National Meeting New Orleans LA April 6 10 2008 Patil V Guerrant W Green P Verma M Canzoneri J Oyelere A K Dual Acting Histone Deacetylas Topoisomerase II Inhibitors 236 th ACS National Meeting Philadelphia PA August 17 21 2008 Hood R

    Original URL path: http://ww2.chemistry.gatech.edu/oyelere/VishalPatil (2015-06-03)
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  • Imani Jones | Oyelere Group
    Jones Celinah Mwakwari Derek Benicewicz Research Publications Funding Links Home Imani Jones Personal Info Contact Email ijones6 gatech edu Education Graduate Georgia Institute of Technology 13 Ph D Organic Chemistry Undergraduate Xavier University of Louisiana 01 B S Chemistry Status 4 th year Ph D student Field Bio organic Chemistry Nanochemistry Projects Functional ligands for gold nanoparticle therapeutics Targeting and Therapeutic Delivery Bio Imani has been with the Oyelere group

    Original URL path: http://ww2.chemistry.gatech.edu/oyelere/ImaniJones (2015-06-03)
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  • Celinah Mwakwari | Oyelere Group
    Ph D Organic Chemistry Undergraduate University of Nairobi Kenya 99 B S Chemistry Status Post doctoral Associate Field Organic Synthesis Projects Targeted HDACInhibition Bio Celinah has been working with the Oyelere group since 2007 and recently earned new position at Glaxo Smith Kline We will miss her Publications Sandra C Mwakwari William Guerrant Vishal Patil Shabana I Khan Babu L Tekwani Gurard Levin Zachary Mrksich Milan and Adegboyega K Oyelere Non Peptide Macrocyclic Histone Deacetylase Inhibitors Derived from Tricyclic Ketolide Skeleton J Med Chem 2010 Manuscript Accepted Sandra C Mwakwari Vishal Patil William Guerrant and Adegboyega K Oyelere Macrocyclic Histone Deacetylase Inhibitors Curr Topics Med Chem 2010 E Pub Ahead of Print William Guerrant Sandra C Mwakwari Po C Chen Shabana I Khan Babu L Tekwani and Adegboyega K Oyelere A Structure Activity Relationship Study of the Antimalarial and Antileishmanial Activities of Non peptide Macrocyclic Histone Deacetylase Inhibitors ChemMedChem 2010 Article Online in Advance of Print Adegboyega K Oyelere Po C Chen William Guerrant Sandra C Mwakwari Rebecca Hood Yunzhe Zhang and Yuhong Fan Nonpeptide Macrocyclic Histone Deacetylase HDAC Inhibitors J Med Chem 2009 52 2 456 468 Erik C Dreaden Sandra C Mwakwari Adegboyega K Oyelere and Mostafa A

    Original URL path: http://ww2.chemistry.gatech.edu/oyelere/CelinahMwakwari (2015-06-03)
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  • Derek Benicewicz | Oyelere Group
    Celinah Mwakwari Derek Benicewicz Research Publications Funding Links Home Derek Benicewicz Bio Derek has recently passed away and is incredibly missed by all who knew him Pictures Josh Derek and Michelle at our last group lunch outing pondering what to order Derek about had it with this asian guy the owner of the place probably Most annoying bad jokes ever but we laughed anyway Josh Derek Michelle and Dr Oyelere

    Original URL path: http://ww2.chemistry.gatech.edu/oyelere/DerekBenicewicz (2015-06-03)
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  • Research Overview | Oyelere Group
    over two dozen macrocyclic HDACi derived from AZ CL and TE 802 which elicit selective and potent anti proliferative activity against various human cancer cell lines These compounds have improved enzyme inhibition potency and isoform selectivity Computational analyses enabled us to have an understanding of the roles of the interaction between the HDAC enzymes outer rim and the inhibitors macrocyclic templates that are responsible for enhanced affinity and isoform selectivity We found that the macrocyclic templates of these HDACi adopt multiple yet productive docked postures In the pursuit of this project we have also introduced into the literature new HDACi SAR Another shortcoming of current HDACi is the broadness of their biological responses which could compromise their efficacy and therefore constitute a major obstacle to their long term clinical use An understanding of the structural attributes that confer a specific biological response to HDACi is vital Toward this end we are investigating the effects of our HDACi on the viability of many transformed human cell lines and two representative examples of rapidly proliferative pathogenic eukaryotes Plasmodium falciparum and Leismania donovani the causative parasites of human malaria and leishmaniasis respectively These studies have furnished important information regarding specific structural attributes that confer enhance a specific biological response to these HDACi To investigate the tissue distribution profiles of our macrocyclic HDACi we have developed a facile screening method that uses C 14 tag to follow the fate of the macrocyclic HDACi in healthy mice Balb c mice Using this facile screening method we have identified two lead compounds as promising candidates that are selectively accumulated in the lungs As part of our future plans we will expand our investigation to include other macrolide skeletons and systematically probe the effects of macrolide type ZBG and the linker group on compounds anti HDAC activity We will also extend this concept to design HDACi derived from other small molecule endowed with organ selective distribution Additionally we will advance the two lead compounds that we have identified into in vivo efficacy studies using a mouse orthotopic lung cancer model This research is currently funded by an RO1 grant with Prof Oyelere as the sole PI 2 Bio inspired approaches to targeted delivery of gold nanoparticles In line with our interest in targeted delivery of small molecules another direction of our program is targeted delivery of supramolecular architectures specifically plasmonic AuNPs Our efforts in this area in collaboration with the El sayed group focused on the use of small molecules to achieve selective delivery of AuNPs We published our first observation on the use of the nucleus localizing peptide from simian virus SV40 NLS Peptide in Bioconjugate Chemistry in July 2007 This article is among one of the most accessed articles published in Bioconjugate Chem in the 3rd quarter of 2007 Source http pubs acs org journals bcches promo most most accessed index html and one of the Editor selected paper in imaging representing high quality peer reviewed research published in the journal In a follow up

    Original URL path: http://ww2.chemistry.gatech.edu/oyelere/Research (2015-06-03)
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  • Publications | Oyelere Group
    El Sayed M A Antiandrogen Gold Nanoparticles Dual Target and Overcome Treatment Resistance in Hormone Insensitive Prostate Cancer Cells Bioconjugate Chemistry 2012 these authors contributed equally to this work DOI 10 1021 bc300158k Patil V Canzoneri J C Samatov T R Lührmann R Oyelere A K Molecular architecture of zinc chelating small molecules that inhibit spliceosome assembly at an early stage RNA 2012 18 1605 1611 DOI 10 1261 rna 034819 112 Dreaden E C Mwakwari S C Austin L A Kieffer M J Oyelere A K El Sayed M A Small Molecule Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells Small 2012 8 2819 2822 DOI 10 1002 smll 201200333 Guerrant W Patil V Canzoneri J C Oyelere A K Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors J Med Chem 2012 55 1465 1477 DOI 10 1021 jm200799p 2011 Gryder B Guerrant W Chen C H Oyelere A K Oxathiazole 2 one derivative of bortezomib Synthesis stability and proteasome inhibition activity Med Chem Comm 2011 2 1083 1086 DOI 10 1039 C1MD00208B 2010 Huang X Kan B Qian W Chen P C Oyelere A K El Sayed I H El Sayed M A Comparative study of photothermolysis of cancer cells with nuclear targeted or cytoplasm targeted gold nanospheres continuous wave or pulsed lasers J Biomed Optics 2010 15 058002 DIO 10 1117 1 3486538 Mwakwari S C Guerrant W Patil V Khan S I Tekwani B L Gurard Levin Z A Mrksich M Oyelere A K Nonpeptide Macrocyclic Histone Deacetylase HDAC Inhibitors Derived from Tricyclic Ketolide J Med Chem 2010 53 6100 6111 DIO 10 1021 jm100507q Mwakwari S C Patil V Guerrant W Oyelere A K Macrocyclic Histone Deacetylase HDAC Inhibitors Curr Top Med Chem 2010 10 1423 1440 DOI 10 2174 156802610792232079 Oyelere A K Macrocycles in Medicinal Chemistry and Drug Discovery Editorial Curr Top Med Chem 2010 10 1359 1360 Guerrant W Mwakwari S C Chen P C Khan S I Tekwani B L Oyelere A K A Structure Activity Relationship Study of the Antimalarial and Antileishmanial Activities of Non peptide Macrocyclic Histone Deacetylase Inhibitors ChemMedChem 2010 5 1232 1235 DOI 10 1002 cmdc 201000087 Patil V Guerrant W Chen P C Gryder B Benicewicz D B Khan S I Tekwani B L Oyelere A K Antimalarial and Antileishmanial Activities of Histone Deacetylase HDAC Inhibitors with Triazole Linked Cap Group Bioorg Med Chem 2010 18 415 425 DOI 10 1016 j bmc 2009 10 042 2009 Dreaden E C Mwakwari S C Sodji Q H Oyelere A K El Sayed M A Tamoxifen Poly ethylene glycol Thiol Gold Nanoparticle Conjugates Enhanced Potency and Selective Delivery for Breast Cancer Treatment Bioconjugate Chem 2009 20 2247 2253 DOI 10 1021 bc9002212 Canzoneri J C Chen P C Oyelere A K Design and Synthesis of Novel Histone Deacetylase Inhibitor Derived from Nuclear Localization Signal Peptide Bioorg Med Chem Lett 2009 19 6588 6590 Oyelere A K Chen P C

    Original URL path: http://ww2.chemistry.gatech.edu/oyelere/Publications (2015-06-03)
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