archive-edu.com » EDU » M » MIT.EDU

Total: 339

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".

  • library preparation ChIP Seq is the latest next generation sequencing method to analyze protein interactions with genomic DNA This technique enables genome wide profiling analysis of binding sites for any protein of interest and is important to understand transcriptional regulation mediated by transcription factors chromatin remodelers and histone variants In this workshop we will briefly review the bench protocol for ChIP Seq library preparation ChIP Seq data analysis In the workshop we will start with the raw FASTQ format files obtained from Illumina sequencers and go through mapping of the raw reads removal of duplicate reads generation of signal intensity files peak calling enrichment analysis and data visualization with Picower bioinformatics server We will use some publicly available ChIP Seq data for the demo Please note that the workshop will last for 1 hour and all the participants are recommended to bring their own laptops for hands on practice Speaker Fan Gao Ph D The Picower Institute for Learning and Memory at MIT Fan is a staff bioinformatician with PILM Before moving to MIT Fan was working as a research associate at University of Southern California with a joint appointment at Zilkha Neurogenetic Institute and Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research Additional Details Additional Details Organizer The Picower Institute for Learning and Memory Calendar GoogleCal 43 Vassar ST Room 46 3310 Cambridge MA 02139 27 Apr 4 00 pm 5 00 pm Aging Brain Initiative Seminar Series with Dr Morgan Sheng New mechanistic insights into Alzheimer s and other neurodegenerative diseases 4 00 pm 5 00 pm 43 Vassar ST Room 46 3310 Cambridge MA 02139 Event Type Aging Brain Seminar Series Availability Public Event Time Wednesday 4 00 pm 5 00 pm Location Room 46 3189 43 Vassar ST Room 46 3310 Cambridge MA 02139 Abstract Alzheimer s disease AD afflicts five million people in the US and millions more globally but its pathogenesis remains poorly understood at the molecular and cellular level Our approach is to start from human genetics Genetic variants in TREM2 Triggering Receptor Expressed on Myeloid cells 2 greatly increase the risk of Alzheimer s disease AD 3 fold increase in risk which is on par with the largest genetic risk factor for AD apolipoprotein E4 APOE4 TREM2 is specifically expressed in myeloid cells and only by microglia in the brain implicating innate immunity mechanisms in the pathogenesis of AD I will present evidence that links TREM2 biochemically and functionally with two other major AD risk genes APOE and APOJ which encode apolipoproteins By revealing the cell biological function of TREM2 in microglia our findings can explain why mutations in TREM2 increase beta amyloid accumulation and elevate the risk of AD Human genetics point towards a crucial role of autophagy in the etiology of another class of neurodegenerative diseases ALS FTD amyotrophic lateral sclerosis frontotemporal dementia Haploinsufficiency of Progranulin a secreted protein is a common genetic cause of FTD Our studies have revealed that Progranulin is unexpectedly involved in

    Original URL path: http://picower.mit.edu/ (2016-04-25)
    Open archived version from archive



  • Lunches News Media Mentions Press Releases Neuroscience News Picower e Newsletter Publications Lab News Media Images Videos Podcasts Documents Contact Join Our Mailing List Home Join Our Mailing List Name Email Events Announcements List Monthly Digest Subscribe News Topics Media Mentions Press Releases Neuroscience News Picower e Newsletter Publications Featured News Lab News Bear Lab News Brown Lab News Chung Lab News Flavell Lab News Heiman Lab News Littleton Lab News Miller Lab News Nedivi Lab News Sur Lab News Tonegawa Lab News Tsai Lab News Tye Lab News Wilson Lab News Xu Lab News Publications Bear Lab Publications Brown Lab Publications Chung Lab Publications Flavell Lab Publications Heiman Lab Publications Littleton Lab Publications Miller Lab Publications Nedivi Lab Publications Sur Lab Publications Tonegawa Lab Publications Tsai Lab Publications Tye Lab Publications Wilson Lab Publications Xu Lab Publications Events Colloquia Picower Lectures Special Seminars Symposia Picower Retreats Plastic Lunches Press Inquiries Najat Kessler Communications Administrator Email najatk mit edu Phone 617 452 2485 The Picower Institute Director s Message Leadership History and Mission Graduate Students Careers News Center News Join Our Mailing List Media Mentions Press Releases Media Scientific Community Neuroscience News Publications RIKEN MIT Core Facilities and Resources Get

    Original URL path: https://picower.mit.edu/newsletter/ (2016-04-25)
    Open archived version from archive


  • Symposia Picower Retreats Plastic Lunches News Media Mentions Press Releases Neuroscience News Picower e Newsletter Publications Lab News Media Images Videos Podcasts Documents Contact Get Social Home Get Social The Picower Institute Director s Message Leadership History and Mission Graduate Students Careers News Center News Join Our Mailing List Media Mentions Press Releases Media Scientific Community Neuroscience News Publications RIKEN MIT Core Facilities and Resources Get In Touch The Picower

    Original URL path: https://picower.mit.edu/get-social/ (2016-04-25)
    Open archived version from archive


  • Xu Faculty Leadership Mark Bear Kwanghun Chung Myriam Heiman Troy Littleton Earl Miller Elly Nedivi Mriganka Sur Susumu Tonegawa Li Huei Tsai Kay Tye Matthew Wilson Weifeng Xu Scientific Advisory Board Michael Greenberg Richard Huganir Robert Knight Liqun Lou Linda Buck Thomas Sudhof Gina Turrigiano Administration Lab Directories Bear Lab Members Chung Lab Members Heiman Lab Members Littleton Lab Members Miller Lab Members Nedivi Lab Members Sur Lab Members Tonegawa

    Original URL path: https://picower.mit.edu/people/ (2016-04-25)
    Open archived version from archive


  • your primary contact for all MIT positions Home About Careers Massachusetts Institute of Technology is an Affirmative Action Equal Opportunity employer Qualified women and minority candidates especially are encouraged to apply Four of the Picower Institute s laboratories are sponsored by the Howard Hughes Medical Institute HHMI and some employee positions are supported directly by HHMI For information about these positions contact the HHMI office at MIT directly HHMI is an affirmative action employer Open Positions Load More Director s Message Leadership History and Mission RIKEN MIT Core Facilities and Resources Bioinformatics Resource Office iPS Core Facility Stanley Center for Psychiatric Research Viral Vector Core Facility Graduate Students Careers Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org Phone 617 714 8400 Viral Vector Core Facility Rachael Neve Ph D Director Viral Vector Core Facility Email rneve mit edu Phone 617 253 5972 Office 46 6319 Development Office Asha Bhakar Ph D Scientific

    Original URL path: https://picower.mit.edu/about/careers/ (2016-04-25)
    Open archived version from archive


  • Videos Podcasts Documents Contact Research Home Research How to Help How to Help Lean More Funding Priorities Funding Priorities Lean More Donor Profiles Donor Profiles Lean More Sponsored Research Sponsored Research Lean More Corporations Foundations Corporations Foundations Lean More Research Impact Research Impact Lean More The Promise of Neuroscience Support the Promise Our Funding Priorities Make a Gift Donor Impact Research Impact and Advancement in Neuroscience Stay Connected Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org Phone 617 714 8400 Viral Vector Core Facility Rachael Neve Ph D Director Viral Vector Core Facility Email rneve mit edu Phone 617 253 5972 Office 46 6319 Development Office Asha Bhakar Ph D Scientific Development Officer Email abhakar mit edu Phone 617 258 0759 Give Now Make a Gift Online Make a Gift by Mail The Picower Institute Director s Message Leadership History and Mission Graduate Students Careers News Center News Join Our Mailing List

    Original URL path: https://picower.mit.edu/research/ (2016-04-25)
    Open archived version from archive


  • Documents Contact Feedback Home Feedback Short Summary 0 Feedback Type Have a Question Make a Suggestion Submit a Praise Report a Bug Other or Combination 1 Your Feedback Please be as specific as you can 2 Page URL Link to the page s you are referring to One link per line 3 Environment Details Operating System Browser type version 4 Your Name 5 Email Address 6 Submit Feedback 7 Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org Phone 617 714 8400 Viral Vector Core Facility Rachael Neve Ph D Director Viral Vector Core Facility Email rneve mit edu Phone 617 253 5972 Office 46 6319 Development Office Asha Bhakar Ph D Scientific Development Officer Email abhakar mit edu Phone 617 258 0759 Give Now Make a Gift Online Make a Gift by Mail The Picower Institute Director s Message Leadership History and Mission Graduate Students Careers News Center News Join Our Mailing

    Original URL path: https://picower.mit.edu/feedback/ (2016-04-25)
    Open archived version from archive


  • stemming from disease and damage A marvel of biological engineering the brain s complexity is at once daunting and tantalizing Learn more Leadership The Picower Institute s internal leadership is comprised of a scientific component and an administrative headquarters component with Li Huei Tsai as the Director of both components Learn more History Mission The Picower Institute for Learning and Memory is an independent research entity within MIT s School of Science with faculty members holding academic appointments in the Department of Brain and Cognition Sciences Learn more RIKEN MIT The RIKEN MIT CNCG is lead by Nobel laureate Professor Susumu Tonegawa Created on April 2008 by a joint MIT and RIKEN effort Learn more Core Facilities Resources These core facilities integrate the various research goals of members of the Picower and McGovern Institutes the Department of Brain and Cognitive Sciences and the Broad Institute Learn more Graduate Students Graduate students interested in Picower Institute opportunities should go through Admissions at the Department of Brain and Cognitive Sciences or the Department of Biology at MIT Learn more Careers This section lists faculty research administrative and support positions available at the Picower Institute for Learning and Memory Learn more Contact Directions For a list of contacts and directions to the Picower Institute Learn more Director s Message Leadership History and Mission RIKEN MIT Core Facilities and Resources Bioinformatics Resource Office iPS Core Facility Stanley Center for Psychiatric Research Viral Vector Core Facility Graduate Students Careers Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org

    Original URL path: https://picower.mit.edu/about/ (2016-04-25)
    Open archived version from archive