archive-edu.com » EDU » M » MIT.EDU

Total: 339

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".

  • synaptic plasticity is the NMDA receptor NMDAR dependent LTP and LTD referred as LTP an LTD thereafter which is mainly studied at hippocampal Schaffer collateral CA3 CA1 synapses The hippocampus also plays a fundamental role in some forms of learning and memory and has been implicated in a number of neurological and psychiatric disorders including epilepsy Alzheimer s disease and schizophrenia Thus understanding the mechanism underlying LTP and LTD may afford great insight in how synapses can be modified by experience We will use lentivirus mediated gene silencing and molecular replacement approaches to test how postsynaptic proteins regulate synaptic AMPAR function and how signaling specificity is achieved during the process of LTP and LTD Role of Calcium homeostasis in synaptic plasticity and learning Calcium Ca2 influx via membrane receptors and ion channels is essential in these processes translating extracellular events into intracellular signaling cascades through Ca2 calmodulin sensitive processes Calmodulin binds to Ca2 and is ubiquitously expressed in neurons There are small neuronal proteins known to interact with calmodulin and regulate the affinity of calmodulin for Ca2 binding Changes in these calmodulin binding proteins will presumably influence the downstream signaling pathways that are important for synaptic plasticity and learning and memory One example is neurogranin whose levels change in response to behavioral environmental and hormonal stimulation in rodent models and under pathological conditions in humans The neurogranin gene has been associated with neurological and neuropsychiatric disorders including schizophrenia and mental retardation We have evidence suggesting that the activity dependent translation of neurogranin serves as a key positive modulator of neural plasticity and learning via shifting the threshold of neural plasticity We are currently using virus mediated gene transfer to manipulate the levels and the activity dependent translation of neurogranin and test the functional impact on synaptic plasticity and learning Our study will help understand the function and regulation of neurogranin important for calcium homeostasis in health and diseases and may provide therapeutic substrate for pharmacological interventions for schizophrenia patients Short Bio Weifeng Xu majored in biophysics at Peking University She received her PhD in neuroscience from Brown University She completed her postdoctoral training in the Nancy Pritzker laboratory of Robert C Malenka at the department of psychiatry and behavioral sciences at Stanford University Medical Center In January 2009 she joined the Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory at MIT Awards The Pathway to Independence Award from the National Institute of Mental Health Publications 0 By Joshua Sarinana In Publications Xu Lab Publications Posted November 6 2015 Emergence of dominant initiation sites for interictal spikes in rat neocortex Vitantonio D Xu W Geng X Wolff BS Takagaki K Motamedi GK Wu JY J Neurophysiol 2015 Oct 7 jn 00471 2014 doi 10 1152 jn 00471 2014 Read More 0 By Joshua Sarinana In Xu Lab Publications Posted February 1 2014 Differential Requirement for NMDAR activity in SAP97β mediated regulation of the number and strength of glutamatergic AMPAR containing synapses Liu M Lewis LD

    Original URL path: https://picower.mit.edu/people/faculty-leadership/weifeng-xu/ (2016-04-25)
    Open archived version from archive



  • Longwood Ave Boston MA 02115 Email meg hms harvard edu Phone 617 432 2510 Mike Greenberg grew up in Brooklyn New York attended Wesleyan University in Connecticut and received his PhD from Rockefeller University in 1982 Following postdoctoral training with Dr Edward Ziff at New York University Medical School Dr Greenberg moved to Harvard Medical School in 1986 He is currently the Nathan Marsh Pusey Professor of Neurobiology and Chair of the Department of Neurobiology at Harvard Medical School Mike Greenberg s research interests span a broad range of topics related to the development of the nervous system His characterization of signaling networks that control brain development has provided new insight into how disruption of normal nervous system development leads to neurological disorders including mental retardation and autism Dr Greenberg has received a number of awards for his research In 2003 he was elected to the American Academy of Arts and Sciences He is the 2006 recipient of the A Clifford Barger Award for Excellence in Mentoring Harvard Medical School and the 3rd Annual Edward M Scolnick Prize in Neuroscience In 2008 he was elected to the National Academy of Science and received the J Allyn Taylor International Prize in Medicine Michael Greenberg Richard Huganir Robert Knight Liqun Lou Linda Buck Thomas Sudhof Gina Turrigiano Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org Phone 617 714 8400 Viral Vector Core Facility Rachael Neve Ph D Director Viral Vector Core Facility Email rneve mit edu Phone 617 253 5972 Office 46 6319 Development

    Original URL path: https://picower.mit.edu/people/scientific-advisory-board/michael-greenberg/ (2016-04-25)
    Open archived version from archive


  • of Neuroscience Johns Hopkins University School of Medicine 1009A Hunterian Bldg 725 N Wolfe Street Baltimore MD 21205 Email rhuganir jhmi edu Phone 410 955 4050 Richard Huganir is Professor and Director of the Solomon H Snyder Department of Neuroscience Co Director of the Johns Hopkins Brain Science Institute and an Investigator with the Howard Hughes Medical Institute Dr Huganir received his Ph D degree from Cornell University in 1982 and was a postdoctoral fellow with the Nobel Laureate Paul Greengard at Yale University School of Medicine from 1982 1984 Dr Huganir then moved to Rockefeller University where he was an Assistant Professor of from 1984 1988 Dr Huganir moved to the Johns Hopkins University School of Medicine in 1988 as an Associate Investigator in the Howard Hughes Medical Institute and an Associate Professor in the Department of Neuroscience Dr Huganir has received the Young Investigator Award and the Julius Axelrod Award from the Society for Neuroscience and is a Fellow of the American Association for the Advancement of Science and is a member of the American Academy of Arts and Sciences and the National Academy of Sciences Michael Greenberg Richard Huganir Robert Knight Liqun Lou Linda Buck Thomas Sudhof Gina Turrigiano Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org Phone 617 714 8400 Viral Vector Core Facility Rachael Neve Ph D Director Viral Vector Core Facility Email rneve mit edu Phone 617 253 5972 Office 46 6319 Development Office Asha Bhakar Ph D Scientific Development Officer Email abhakar mit edu Phone

    Original URL path: https://picower.mit.edu/people/scientific-advisory-board/richard-huganir/ (2016-04-25)
    Open archived version from archive


  • Berkeley 132 Barker Hall Berkeley CA 94720 3190 Email rtknight berkeley edu Phone 510 643 9744 Dr Knight received a BS degree in Physics from the Illinois Institute of Technology an MD from Northwestern University Medical School obtained Neurology training at UC San Diego and did post doctoral training at the Salk Institute for Biological Studies He was a faculty member in the Department of Neurology at the UC Davis School of Medicine from 1980 1998 In 1998 Dr Knight moved to UC Berkeley and served as Director of the Helen Wills Neuroscience Institute from 2001 until 2011 His laboratory utilizes electrophysiology and neuropsychological techniques in neurological and neurosurgical patients to delineate the role of prefrontal cortex in human cognition Electrocorticographic recordings from neurosurgical patients with implanted subdural electrodes is used to study cortical mechanisms supporting goal directed behavior and for the development of neural prosthesis for motor and language restoration Dr Knight has received the Jacob Javits Award from the National Institute of Neurological Disorders and Stroke for distinguished contributions to understanding neurological disorders the IBM Cognitive Computing Award the Humboldt Prize in Neurobiology and the Neurobionics Prize for contributions to Brain Machine Interface research Michael Greenberg Richard Huganir Robert Knight Liqun Lou Linda Buck Thomas Sudhof Gina Turrigiano Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org Phone 617 714 8400 Viral Vector Core Facility Rachael Neve Ph D Director Viral Vector Core Facility Email rneve mit edu Phone 617 253 5972 Office 46 6319 Development Office Asha Bhakar Ph D

    Original URL path: https://picower.mit.edu/people/scientific-advisory-board/robert-knight/ (2016-04-25)
    Open archived version from archive


  • and Technology of China After obtaining his PhD in Brandeis University and postdoctoral training at the University of California San Francisco Dr Luo started his own lab in the Department of Biology Stanford University in late 1996 Together with his postdoctoral fellows and graduate students Dr Luo studies the logic of brain wiring using genetic tools They have developed mosaic marking systems in flies and mice and used them to study how signals are transduced from cell surface receptors to the cytoskeleton how neuronal processes are pruned and how neural circuits are organized and built Dr Luo is currently a Professor of Biology and an investigator of the Howard Hughes Medical Institute He teaches to Stanford undergraduate and graduate students Molecular and Cellular Neurobiology and Exploring Neural Circuits Dr Luo has served on the editorial boards of several scientific journals including Neuron eLife and Annual Review of Neuroscience He has also served on the Pew Scholar National Committee and Scientific Advisory Committee of Damon Runyon Cancer Research Foundation He is recipient of the McKnight Technological Innovation in Neuroscience Award the Society for Neuroscience Young Investigator Award the Jacob Javits Award from National Institute of Neurological Disorders and Stroke HW Mossman Award from American Association of Anatomists and the Lawrence Katz Prize Dr Luo is a Member of the National Academy of Sciences and a Fellow of the American Academy of Arts and Sciences Michael Greenberg Richard Huganir Robert Knight Liqun Lou Linda Buck Thomas Sudhof Gina Turrigiano Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email

    Original URL path: https://picower.mit.edu/people/scientific-advisory-board/liqun-lou/ (2016-04-25)
    Open archived version from archive


  • D Linda Buck Scientific Advisory Board Member The Picower Institute for Learning and Memory Investigator HHMI Affiliate Professor Department of Physiology and Biophysics University of Washington Fred Hutchinson Cancer Research Center 1100 Fairview Ave N B3 201 Seattle WA 98109 1024 Email lbuck fredhutch org Phone 206 667 1024 Nobelprize Linda shares the Nobel Prize in Medicine or Physiology 2004 with Richard Axel for their work in olfactory receptors Michael Greenberg Richard Huganir Robert Knight Liqun Lou Linda Buck Thomas Sudhof Gina Turrigiano Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org Phone 617 714 8400 Viral Vector Core Facility Rachael Neve Ph D Director Viral Vector Core Facility Email rneve mit edu Phone 617 253 5972 Office 46 6319 Development Office Asha Bhakar Ph D Scientific Development Officer Email abhakar mit edu Phone 617 258 0759 Give Now Make a Gift Online Make a Gift by Mail The Picower Institute Director s

    Original URL path: https://picower.mit.edu/people/scientific-advisory-board/linda-buck/ (2016-04-25)
    Open archived version from archive


  • as Alzheimer s and autism Südhof s interests have include understanding possible molecular mechanisms contributing to these and related disorders The projects in the Südhof laboratory are guided by two overall directions that are closely related to each other and linked to different psychiatric diseases First the Südhof laboratory is interested in understanding how synapses are formed Synapses exhibit a high degree of specificity in terms of which neurons they connect and an astounding diversity in terms of physiological properties Here Südhof s laboratory is focusing on synaptic cell adhesion molecules in particular neurexins and neuroligins that are essential components of synapses The laboratory would like to understand how these molecules and their many intra and extracellular binding partners shape the properties of synapses such that their function is among the key determinants for the formation and specification of synapses Moreover neurexins and neuroligins mutations have been observed in autism spectrum disorders and in schizophrenia suggesting that their role in shaping synaptic communication is impaired in these diseases To study how neurexins and neuroligins shape synapse properties and how their dysfunction contributes to disease the Südhof laboratory uses an interdisciplinary approach ranging from mouse genetics to behavior and electrophysiology Second the Südhof laboratory would like to understand how information transfer is triggered at a synapse rapidly and precisely Work in the laboratory over the last two decades demonstrated that the neurotransmitter signal is released when calcium in the presynaptic neuron binds to a protein called synaptotagmin which serves as the switch for release Release then occurs by fusion of neurotransmitter containing vesicles at the active zone of the presynaptic neuron The Südhof laboratory now focuses on understanding how this fusion process works how calcium regulates fusion beyond binding to synaptotagmin and how fusion becomes impaired in neurodegenerative diseases that appear

    Original URL path: https://picower.mit.edu/people/scientific-advisory-board/thomas-sudhof/ (2016-04-25)
    Open archived version from archive


  • MA 02453 Email turrigia brandeis edu Phone 781 736 2684 Gina Turrigiano received her BA in biology from Reed College in 1984 and her PhD in neuroscience from University of California San Diego in 1990 She then trained as a postdoc with Eve Marder at Brandeis University before joining the faculty in 1994 She is now the Levitan professor in the Dept of Biology the Volen Center for Complex Systems and the Center for Behavioral Genomics at Brandeis Her scientific interests include mechanisms of synaptic and intrinsic plasticity and the experience dependent development of cortical microcircuitry Her discovery of homeostatic synaptic plasticity synaptic scaling in 1998 produced a paradigm shift in the field of synaptic plasticity and launched a new field of enquiry that continues to grow rapidly and likely has numerous implications for understanding brain health and neurological disorders She has received many awards for her research including a MacArthur foundation genius award McKnight Foundation Technological Innovation and Neurobiology of Disease awards an NIH director s pioneer award the Nakasone Award a Javitz Neuroscience Investigator award and was recently elected to the America Academy of Arts and Sciences and the National Academy of Science Michael Greenberg Richard Huganir Robert Knight Liqun Lou Linda Buck Thomas Sudhof Gina Turrigiano Bioinformatics Resource Office Fan Gao Ph D Supervisor of Bioinformatics Resource Office Email fangao mit edu Phone 617 324 2471 Office 46 2303L iPS Core Facility Tak Ko Reseach Scientist iPS Core Facility Supervisor Email kotak mit edu Phone 617 324 4457 Office 46 4277 Stanley Center Stanley Center for Psychiatric Research Email stanleyadmin broadinstitute org Phone 617 714 8400 Viral Vector Core Facility Rachael Neve Ph D Director Viral Vector Core Facility Email rneve mit edu Phone 617 253 5972 Office 46 6319 Development Office Asha Bhakar Ph D Scientific

    Original URL path: https://picower.mit.edu/people/scientific-advisory-board/gina-turrigiano/ (2016-04-25)
    Open archived version from archive



  •