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  • In 1993 Dr Tanzi discovered the gene responsible for the neurological disorder known as Wilson s disease and over the past 25 years he has collaborated on studies identifying several other disease genes including those causing neurofibromatosis amyotrophic lateral sclerosis and autism Dr Tanzi currently spearheads the Alzheimer s Genome Project which identified several other AD gene including CD33 which plays a role in modulating neuroinflammation in AD This achievement was named one of the Top Ten Medical Breakthroughs of 2008 by Time Magazine In 1994 Dr Tanzi discovered that the metals zinc and copper are necessary for the formation of neurotoxic assemblies of the Aβ peptide the main component of β amyloid deposits in brains of AD patients Based on this discovery Dr Tanzi developed the Metal hypothesis of Alzheimer s disease which has led to clinical trials for treating and preventing AD by targeting Aβ metal interactions Prana Biotechnology LTD co founder Dr Tanzi is also developing a potent class of gamma secretase modulators for preventing and treating AD as well as therapies aimed at targeting the genes CD33 and TREM2 to curb neuroinflammation in AD In 2014 Dr Tanzi Dr Se Hoon Choi and Dr Doo Yeon Kim reported the first i n vitro model recapitualting AD neuropathology and showing that beta amyloid can induce neurofibrillary tangles using human stem cell derived neural cultures grown in three dimensional culture systems Dr Tanzi is one of the ten most cited researchers in AD having co authored over 475 research articles He is also listed by Thomson Reuter as one of the top 1 of researchers in the field of neuroscience He is also a co author the popular book Decoding Darkness The Search for the Genetic Causes of Alzheimer s Disease the New York Times best seller Super

    Original URL path: https://picower.mit.edu/cms/events/aging-brain-initiative-seminar-series-with-dr-rudolph-tanzi/ (2016-04-25)
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  • 00 pm 43 Vassar ST Room 46 3002 Cambridge MA 02139 Event Type Colloquia Availability Public Event Time Thursday 4 00 pm 5 00 pm Location Room 46 3002 43 Vassar ST Room 46 3002 Cambridge MA 02139 Abstract Coming Soon Speaker A fundamental capacity of the mammalian cerebral cortex is to process information in a form conducive to encoding storage and retrieval of memories A general organizational principle of cortical memory circuits states that these steps all require a precisely orchestrated spatio temporal interaction among a large number of relatively uniform excitatory and a numerically fewer but richly diverse population of inhibitory and neuromodulatory circuit elements However a mechanistic understanding of how these circuit motifs interact during elementary steps of memory processing is lacking The goal of Attila Losonczy s laboratory is to study the functional anatomical organization of memory circuits in the rodent hippocampus and to provide a biophysically based characterization of elementary memory processing and storage mechanisms present in individual neurons Losonczy uses high resolution optical and electrophysiological methods together with optogenetic manipulations of specified circuit motifs in vitro to study how dynamic interactions among excitatory inhibitory and neuromodulatory inputs in various subcellular domains of neurons underlie information processing and storage in the hippocampal circuit To link these elementary computations to memory functions Losonczy applies high resolution functional imaging in awake mice in vivo He plan to investigate numerous fundamental questions including i the role of specific spatio temporal patterns of inhibitory and neuromodulatory inputs in determining neuronal input output transformations ii the effect of local inhibition and global neuromodulation on the dynamics of subcellular integration and compartmentalization of inputs and iii regulation of various forms of synaptic and intrinsic plasticity by inhibitory and neuromodulatory inputs in the hippocampus Additional Details Additional Details Organizer The Picower Institute

    Original URL path: https://picower.mit.edu/cms/events/mit-colloquium-on-brain-cognition-with-dr-attila-losonczy/ (2016-04-25)
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  • Hyman Seminar Title Coming Soon 4 00 pm 5 00 pm 43 Vassar ST Room 46 3310 Cambridge MA 02139 Event Type Aging Brain Seminar Series Availability Public Event Time Wednesday 4 00 pm 5 00 pm Location Room 46 3310 43 Vassar ST Room 46 3310 Cambridge MA 02139 Abstract Coming soon Speaker Bradley Hyman MD PhD Dr Hyman directs the Alzheimer s disease research unit at the MassGeneral Institute for Neurodegenerative Disease with the goal of understanding the neuropathophysiologic and genetic factors that underlie dementia His laboratory studies the anatomical and molecular basis of dementia in Alzheimer s disease and dementia with Lewy bodies Dr Hyman received his M D and Ph D from the University of Iowa and he has received the Metropolitan Life Award the Potamkin Prize a National Institute on Aging MERIT award and an Alzheimer Association Pioneer Award He has been the Director of the Massachusetts Alzheimer s Disease Research Center since 2006 Additional Details Additional Details This seminar was originally planned for January 20 2016 but due to unforeseen conflicts it has been re scheduled for December 7 2016 Organizer The Picower Institute for Learning and Memory Contact Najat Kessler Tel 617 452

    Original URL path: https://picower.mit.edu/cms/events/aging-brain-initiative-seminar-series-with-dr-bradley-hyman/ (2016-04-25)
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  • Brain Cognition with Dr Ann Marie Craig 4 00 pm 5 00 pm 43 Vassar ST Room 46 3002 Cambridge MA 02139 Event Type Colloquia Availability Public Event Time Thursday 4 00 pm 5 00 pm Location Room 46 3002 43 Vassar ST Room 46 3002 Cambridge MA 02139 Abstract Coming soon Speaker Short bio Coming soon Organizer The Picower Institute for Learning and Memory Contact Najat Kessler Tel 617

    Original URL path: https://picower.mit.edu/cms/events/mit-colloquium-on-brain-cognition-with-dr-ann-marie-craig/ (2016-04-25)
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  • By Joshua Sarinana In Featured News Lab News Miller Lab News News Press Releases Posted March 17 2016 A new glimpse into working memory When you hold in mind a sentence you have just read or a phone number you re about to dial you re engaging a critical brain system known as working memory For the past several decades Read More 2 By Joshua Sarinana In Featured News Lab News News Press Releases Tonegawa Lab News Posted March 16 2016 Lost memories can be found In the early stages of Alzheimer s disease patients are often unable to remember recent experiences However a new study from MIT suggests that those memories are still stored in the brain Read More Load More News Topics Media Mentions Press Releases Neuroscience News Picower e Newsletter Publications Featured News Lab News Bear Lab News Brown Lab News Chung Lab News Flavell Lab News Heiman Lab News Littleton Lab News Miller Lab News Nedivi Lab News Sur Lab News Tonegawa Lab News Tsai Lab News Tye Lab News Wilson Lab News Xu Lab News Publications Bear Lab Publications Brown Lab Publications Chung Lab Publications Flavell Lab Publications Heiman Lab Publications Littleton Lab Publications Miller

    Original URL path: https://picower.mit.edu/cms/2016/03/ (2016-04-25)
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  • project to understand the specific needs of testicular and endometrial cancer survivors what sort of information they were looking for what information they weren t getting and what they needed as support to be able to transition into follow up care and return to their regular lives Shen explains Shen s team developed personalized documents called Survivorship Care Plans that patients fill out with their oncologists or nurses so they have an accessible organized record of all the information they might need While Shen appreciates the broad scope of laboratory research she enjoyed working in a clinical setting where she could directly improve the lives of her patients and have contact with them every day I think it adds a personal touch to what you re doing and it s a lot more encouraging and motivating when you re able to help the people that you re working with she explains Discovering a new passion While at MIT Shen has also developed a deep commitment to theater arts Shen was first exposed to MIT s theater program when as a high school senior visiting for Campus Preview Weekend she saw a musical performed by the theater group Next Act I thought it was a great program and that the show was beautiful she recalls I fell in love and have been involved ever since Shen joined Next Act as a freshman but it was a directing class during her sophomore year that really changed her perspective on theater The class a three hour workshop was her first theater class at MIT and it forced her to challenge herself in new ways That s a period of time where I really grew as an artist as a person she explains I became more open more confident about sharing my own ideas because I realized in theater there s not really a bad idea Everything can be spun to be seen as really interesting or really creative or really different The class motivated Shen to join Dramashop another theater group on campus and to pursue theater as her concentration for MIT s Humanities Arts and Social Sciences HASS requirement Her concentration expanded into a minor which eventually became a full blown theater arts major For Shen the decision was an obvious one I realized that I just wanted to take theater classes forever she says Theater has been one of the most influential and important experiences that I ve had at MIT Experiencing the world beyond MIT Shen has also had the opportunity to experience different cultures during her time at MIT through the MIT Science and Technology Initiatives MISTI program As a junior she spent three weeks over winter break living with a host family in Germany and teaching biology physics and chemistry to German high school students The following summer Shen who is fluent in French worked at a cancer center in France where she shadowed oncologists and conducted research Just being immersed in this totally different environment where people

    Original URL path: https://picower.mit.edu/cms/20160219/tsai-lab-member-abra-shen-takes-medicine-and-theater/ (2016-04-25)
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  • but she couldn t resist adding theater arts to her major in brain and cognitive sciences when the opportunity presented itself Read More 0 By Joshua Sarinana In Featured News Lab News News Press Releases Tye Lab News Posted February 11 2016 Pinpointing loneliness in the brain Humans like all social animals have a fundamental need for contact with others This deeply ingrained instinct helps us to survive it s much easier to find food shelter and other necessities Read More 0 By Joshua Sarinana In Featured News Lab News Media Mentions Miller Lab News News Posted February 4 2016 Bose s new beat Earl Miller Picower Institute Professor of Neuroscience and a recipient of a 2014 Bose grant studies brain waves More specifically he studies how the harmonization of the brain s Read More 1 By Joshua Sarinana In Featured News Lab News Nedivi Lab News News Press Releases Posted February 4 2016 A day in the life of a synapse reveals new facets of the adult brain A new study from the Picower Institute for Learning and Memory in the Feb 4 online edition ofNeuron sheds light on the innate plasticity of the adult brain at its most fundamental level the Read More Load More News Topics Media Mentions Press Releases Neuroscience News Picower e Newsletter Publications Featured News Lab News Bear Lab News Brown Lab News Chung Lab News Flavell Lab News Heiman Lab News Littleton Lab News Miller Lab News Nedivi Lab News Sur Lab News Tonegawa Lab News Tsai Lab News Tye Lab News Wilson Lab News Xu Lab News Publications Bear Lab Publications Brown Lab Publications Chung Lab Publications Flavell Lab Publications Heiman Lab Publications Littleton Lab Publications Miller Lab Publications Nedivi Lab Publications Sur Lab Publications Tonegawa Lab Publications Tsai Lab Publications Tye

    Original URL path: https://picower.mit.edu/cms/2016/02/ (2016-04-25)
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  • and a recipient of a 2014 Bose grant studies brain waves More specifically he studies how the harmonization of the brain s rhythms or brain waves contributes to consciousness He believes based on his research that we re using a lot more than the mythical 10 percent of our brains at any given moment Unlocking more like Scarlett Johansson s character in the film Lucy wouldn t give us additional abilities So what s the potential high reward pay off of his project The brain seems to hum to itself using rhythms and harmony for communication Dr Miller explains This humming helps different brain networks talk to one another We hope to use TES transcranial electrical stimulation to boost the humming in a way that will improve brain communication He conjectures that may also offer new treatments for diseases such as ADHD schizophrenia and autism Maresca is interested in all this on a personal level because he has a younger brother with severe autism Original Article Tags Brain Brain and Cognitive Sciences Earl Miller Neuroscience Picower Institute for Learning and Memory Recommended Posts How the brain processes emotions A new glimpse into working memory Lost memories can be found News Topics Media Mentions Press Releases Neuroscience News Picower e Newsletter Publications Featured News Lab News Bear Lab News Brown Lab News Chung Lab News Flavell Lab News Heiman Lab News Littleton Lab News Miller Lab News Nedivi Lab News Sur Lab News Tonegawa Lab News Tsai Lab News Tye Lab News Wilson Lab News Xu Lab News Publications Bear Lab Publications Brown Lab Publications Chung Lab Publications Flavell Lab Publications Heiman Lab Publications Littleton Lab Publications Miller Lab Publications Nedivi Lab Publications Sur Lab Publications Tonegawa Lab Publications Tsai Lab Publications Tye Lab Publications Wilson Lab Publications Xu Lab Publications

    Original URL path: https://picower.mit.edu/cms/20160204/14876/ (2016-04-25)
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