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  • to stay awake the researchers say The paper s other first author is Jakob Voigts an MIT graduate student in brain and cognitive sciences Senior authors are Emery Brown the Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience at MIT and an anesthesiologist at Massachusetts General Hospital and Michael Halassa an assistant professor at New York University Other authors are MIT research affiliate Francisco Flores and Matthew Wilson the Sherman Fairchild Professor in Neurobiology and a member of MIT s Picower Institute for Learning and Memory Local control Until now most sleep research has focused on global control of sleep which occurs when the entire brain is awash in slow waves oscillations of brain activity created when sets of neurons are silenced for brief periods However recent studies have shown that sleep deprived animals can exhibit slow waves in parts of their brain while they are still awake suggesting that the brain can also control alertness at a local level The MIT team began its investigation of local control of alertness or drowsiness with the TRN because its physical location makes it perfectly positioned to play a role in sleep Lewis says The TRN surrounds the thalamus like a shell and can act as a gatekeeper for sensory information entering the thalamus which then sends information to the cortex for further processing Using optogenetics a technique that allows scientists to stimulate or silence neurons with light the researchers found that if they weakly stimulated the TRN in awake mice slow waves appeared in a small part of the cortex With more stimulation the entire cortex showed slow waves We also found that when you induce these slow waves across the cortex animals start to behaviorally act like they re drowsy They ll stop moving around their muscle tone will go down Lewis says The researchers believe the TRN fine tunes the brain s control over local brain regions enhancing or reducing slow waves in certain regions so those areas can communicate with each other or inducing some areas to become less alert when the brain is very drowsy This may explain what happens in humans when they are sleep deprived and momentarily zone out without really falling asleep I m inclined to think that happens because the brain begins to transition into sleep and some local brain regions become drowsy even if you force yourself to stay awake Lewis says The strength of this paper is that it s the first to use optogenetics to try to dissect the role of part of the thalamo cortical circuitry in generating slow waves in the cortex says Mark Opp a professor of anesthesiology and pain medicine at the University of Washington who was not part of the research team Natural sleep and general anesthesia Understanding how the brain controls arousal could help researchers design new sleep and anesthetic drugs that create a state more similar to natural sleep Stimulating the TRN can induce deep non REM like sleep states and

    Original URL path: https://picower.mit.edu/cms/20151013/how-the-brain-controls-sleep/ (2016-04-25)
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  • pm 2 00 pm 43 Vassar ST Room 46 6309 Cambridge MA 02139 Event Type Special Seminars Availability Picower Community Only Time Monday 1 00 pm 2 00 pm Location Room 46 6309 43 Vassar ST Room 46 6309 Cambridge MA 02139 Abstract This workshop is suitable for postdocs and graduate students who would like to learn the basics of ChIP chromatin immunoprecipitation sequencing data analysis Prior knowledge of chromatin biology is needed to participate in this workshop The workshop will consist of a short lecture followed by demonstrations ChIP Seq library preparation ChIP Seq is the latest next generation sequencing method to analyze protein interactions with genomic DNA This technique enables genome wide profiling analysis of binding sites for any protein of interest and is important to understand transcriptional regulation mediated by transcription factors chromatin remodelers and histone variants In this workshop we will briefly review the bench protocol for ChIP Seq library preparation ChIP Seq data analysis In the workshop we will start with the raw FASTQ format files obtained from Illumina sequencers and go through mapping of the raw reads removal of duplicate reads generation of signal intensity files peak calling enrichment analysis and data visualization with Picower bioinformatics server We will use some publicly available ChIP Seq data for the demo Please note that the workshop will last for 1 hour and all the participants are recommended to bring their own laptops for hands on practice Speaker Fan Gao Ph D The Picower Institute for Learning and Memory at MIT Fan is a staff bioinformatician with PILM Before moving to MIT Fan was working as a research associate at University of Southern California with a joint appointment at Zilkha Neurogenetic Institute and Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research Additional Details

    Original URL path: https://picower.mit.edu/cms/events/picower-bioinformatics-monthly-workshop-chip-seq-data-analysis/ (2016-04-25)
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  • Alzheimer s disease AD afflicts five million people in the US and millions more globally but its pathogenesis remains poorly understood at the molecular and cellular level Our approach is to start from human genetics Genetic variants in TREM2 Triggering Receptor Expressed on Myeloid cells 2 greatly increase the risk of Alzheimer s disease AD 3 fold increase in risk which is on par with the largest genetic risk factor for AD apolipoprotein E4 APOE4 TREM2 is specifically expressed in myeloid cells and only by microglia in the brain implicating innate immunity mechanisms in the pathogenesis of AD I will present evidence that links TREM2 biochemically and functionally with two other major AD risk genes APOE and APOJ which encode apolipoproteins By revealing the cell biological function of TREM2 in microglia our findings can explain why mutations in TREM2 increase beta amyloid accumulation and elevate the risk of AD Human genetics point towards a crucial role of autophagy in the etiology of another class of neurodegenerative diseases ALS FTD amyotrophic lateral sclerosis frontotemporal dementia Haploinsufficiency of Progranulin a secreted protein is a common genetic cause of FTD Our studies have revealed that Progranulin is unexpectedly involved in regulation of autophagy Speaker Morgan Sheng Ph D I started at Genentech in September 2008 Prior to that I spent 14 years in academia focused on molecular and cellular neuroscience first at Massachusetts General Hospital Harvard Medical School and then at Massachusetts Institute of Technology MIT where I was the Menicon Professor of Neuroscience and an Investigator of the Howard Hughes Medical Institute Before I got into research I completed a residency in general medicine in London U K So I have seen human disease from two sides as a scientist investigating basic mechanisms and as a medical doctor treating patients I came

    Original URL path: https://picower.mit.edu/cms/events/aging-brain-initiative-seminar-series-with-dr-morgan-sheng/ (2016-04-25)
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  • Cambridge MA 02139 28 Apr 12 00 pm 1 00 pm Plastic Lunch Boyden Brown Labs 12 00 pm 1 00 pm 43 Vassar ST Room 46 3310 Cambridge MA 02139 Event Type Plastic Lunches Availability Not a Public Event Time Thursday 12 00 pm 1 00 pm Location Room 46 3310 43 Vassar ST Room 46 3310 Cambridge MA 02139 Calendar GoogleCal The Picower Institute Director s Message Leadership

    Original URL path: https://picower.mit.edu/cms/events/plastic-lunch-boyden-brown-labs/ (2016-04-25)
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  • weakening the connections between neurons known as synapses is vital to the brain s development and everyday function One way that neurons weaken their synapses is by Read More 1 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point process GLMs Song W Cajigas I Brown EN Giszter SF Front Syst Neurosci 2015 Apr 28 9 62 doi 10 3389 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Dextroamphetamine but Not Atomoxetine Induces Reanimation from General Anesthesia Implications for the Roles of Dopamine and Norepinephrine in Active Emergence Kenny JD Taylor NE Brown EN Solt K PLoS One 2015 Jul 6 10 7 e0131914 doi 10 1371 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 An optimization formulation for characterization of pulsatile cortisol secretion Faghih RT Dahleh MA Brown EN Front Neurosci 2015 Aug 11 9 228 doi 10 3389 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep Van Dort CJ Zachs DP Kenny JD Zheng S Goldblum RR Gelwan NA Ramos DM Nolan MA Wang K Weng FJ Lin Y Wilson MA Brown EN Proc Natl Acad Sci U S A 2015 Jan 13 112 2 584 9 doi 10 1073 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Modulation depth estimation and variable selection in state space models for neural interfaces Malik WQ Hochberg LR Donoghue JP Brown EN IEEE Trans Biomed Eng 2015 Feb 62 2 570 81 doi 10 1109 Read More 1 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Probabilistic Common Spatial Patterns for Multichannel EEG Analysis Wu W Chen Z Gao X Li Y Brown EN Gao S IEEE Trans Pattern Anal Mach Intell 2015 Mar 37 3 639 53 doi 10 1109 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 The American Geriatrics Society National Institute on Aging Bedside to Bench Conference Research Agenda on Delirium in Older Adults AGS NIA Delirium Conference Writing Group Planning Committee and Faculty J Am Geriatr Soc 2015 May 63 5 843 52 doi 10 1111 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 The BRAIN Initiative developing technology to catalyse neuroscience discovery Jorgenson LA Newsome WT Anderson DJ Bargmann CI Brown EN Deisseroth K Donoghue JP Hudson KL Ling GS MacLeish PR Marder E Normann RA Sanes JR Schnitzer MJ Sejnowski TJ Tank DW Read More 1 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Measuring the signal to noise ratio of a neuron Czanner G Sarma SV Ba D Eden UT Wu W Eskandar E Lim HH Temereanca S Suzuki WA Brown EN Proc

    Original URL path: https://picower.mit.edu/cms/author/josh-sarinana/ (2016-04-25)
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  • in Older Adults AGS NIA Delirium Conference Writing Group Planning Committee and Faculty J Am Geriatr Soc 2015 May 63 5 843 52 doi 10 1111 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 The BRAIN Initiative developing technology to catalyse neuroscience discovery Jorgenson LA Newsome WT Anderson DJ Bargmann CI Brown EN Deisseroth K Donoghue JP Hudson KL Ling GS MacLeish PR Marder E Normann RA Sanes JR Schnitzer MJ Sejnowski TJ Tank DW Read More 1 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Measuring the signal to noise ratio of a neuron Czanner G Sarma SV Ba D Eden UT Wu W Eskandar E Lim HH Temereanca S Suzuki WA Brown EN Proc Natl Acad Sci U S A 2015 Jun 9 112 23 7141 6 doi 10 1073 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Nitrous oxide induced slow and delta oscillations Pavone KJ Akeju O Sampson AL Ling K Purdon PL Brown EN Clin Neurophysiol 2015 Jun 10 pii S1388 2457 15 00629 X doi 10 1016 Read More 1 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Age dependent electroencephalogram EEG patterns during sevoflurane general anesthesia in infants Cornelissen L Kim SE Purdon PL Brown EN Berde CB Elife 2015 Jun 23 4 e06513 doi 10 7554 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Reference free removal of EEG fMRI ballistocardiogram artifacts with harmonic regression Krishnaswamy P Bonmassar G Poulsen C Pierce ET Purdon PL Brown EN Neuroimage 2015 Jul 5 pii S1053 8119 15 00593 5 doi 10 1016 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Reply to Grace Role of cholinergic neurons in rapid eye movement REM sleep control Van Dort CJ Brown EN Proc Natl Acad Sci U S A 2015 Jul 21 112 29 E3756 doi 10 1073 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Robust control of burst suppression for medical coma Westover MB Kim SE Ching S Purdon PL Brown EN J Neural Eng 2015 Aug 12 4 046004 doi 10 1088 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Quantifying Pituitary Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing Faghih RT Dahleh MA Adler GK Klerman EB Brown EN IEEE Trans Biomed Eng 2015 Oct 62 10 2379 88 doi 10 1109 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 The human burst suppression electroencephalogram of deep hypothermia Brandon Westover M Ching S Kumaraswamy VM Akeju O Pierce E Cash SS Kilbride R Brown EN Purdon PL Clin Neurophysiol 2015 Oct 126 10 1901 14 doi 10 1016 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted

    Original URL path: https://picower.mit.edu/cms/category/news/publications/brown-lab-publications/ (2016-04-25)
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  • Suzuki WA Brown EN Proc Natl Acad Sci U S A 2015 Jun 9 112 23 7141 6 doi 10 1073 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Nitrous oxide induced slow and delta oscillations Pavone KJ Akeju O Sampson AL Ling K Purdon PL Brown EN Clin Neurophysiol 2015 Jun 10 pii S1388 2457 15 00629 X doi 10 1016 Read More 1 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Age dependent electroencephalogram EEG patterns during sevoflurane general anesthesia in infants Cornelissen L Kim SE Purdon PL Brown EN Berde CB Elife 2015 Jun 23 4 e06513 doi 10 7554 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Reference free removal of EEG fMRI ballistocardiogram artifacts with harmonic regression Krishnaswamy P Bonmassar G Poulsen C Pierce ET Purdon PL Brown EN Neuroimage 2015 Jul 5 pii S1053 8119 15 00593 5 doi 10 1016 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Reply to Grace Role of cholinergic neurons in rapid eye movement REM sleep control Van Dort CJ Brown EN Proc Natl Acad Sci U S A 2015 Jul 21 112 29 E3756 doi 10 1073 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Robust control of burst suppression for medical coma Westover MB Kim SE Ching S Purdon PL Brown EN J Neural Eng 2015 Aug 12 4 046004 doi 10 1088 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Quantifying Pituitary Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing Faghih RT Dahleh MA Adler GK Klerman EB Brown EN IEEE Trans Biomed Eng 2015 Oct 62 10 2379 88 doi 10 1109 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 The human burst suppression electroencephalogram of deep hypothermia Brandon Westover M Ching S Kumaraswamy VM Akeju O Pierce E Cash SS Kilbride R Brown EN Purdon PL Clin Neurophysiol 2015 Oct 126 10 1901 14 doi 10 1016 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Clinical Electroencephalography for Anesthesiologists Part I Background and Basic Signatures Purdon PL Sampson A Pavone KJ Brown EN Anesthesiology 2015 Oct 123 4 937 60 doi 10 1097 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Thalamic reticular nucleus induces fast and local modulation of arousal state Lewis LD Voigts J Flores FJ Schmitt LI Wilson MA Halassa MM Brown EN Elife 2015 Oct 13 4 pii e08760 doi 10 7554 eLife 08760 Read More 0 By Joshua Sarinana In Brown Lab Publications Publications Posted December 29 2015 Detangling extrinsic and intrinsic hysteresis for detecting dynamic switch of electric dipoles using graphene field effect transistors on ferroelectric gates Ma C Gong Y

    Original URL path: https://picower.mit.edu/cms/2015/12/ (2016-04-25)
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  • to elastic loads and BMI robot controls during rat locomotion examined with point process GLMs Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point process GLMs By Joshua Sarinana Posted December 29 2015 In Brown Lab Publications Publications 1 Song W Cajigas I Brown EN Giszter SF Front Syst Neurosci 2015 Apr 28 9 62 doi 10 3389 Recent Posts How the brain processes emotions A new glimpse into working memory Lost memories can be found News Topics Media Mentions Press Releases Neuroscience News Picower e Newsletter Publications Featured News Lab News Bear Lab News Brown Lab News Chung Lab News Flavell Lab News Heiman Lab News Littleton Lab News Miller Lab News Nedivi Lab News Sur Lab News Tonegawa Lab News Tsai Lab News Tye Lab News Wilson Lab News Xu Lab News Publications Bear Lab Publications Brown Lab Publications Chung Lab Publications Flavell Lab Publications Heiman Lab Publications Littleton Lab Publications Miller Lab Publications Nedivi Lab Publications Sur Lab Publications Tonegawa Lab Publications Tsai Lab Publications Tye Lab Publications Wilson Lab Publications Xu Lab Publications Events Colloquia Picower Lectures Special Seminars Symposia Picower Retreats Plastic Lunches Press Inquiries Najat Kessler Communications Administrator Email

    Original URL path: https://picower.mit.edu/cms/20151229/adaptation-to-elastic-loads-and-bmi-robot-controls-during-rat-locomotion-examined-with-point-process-glms/ (2016-04-25)
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