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  • Students apply advanced technology to tackle challenges
    and juniors will engage in university level research on OSC s advanced computer systems while interacting with scientists who lead tours of their labs and supervise the sponsored research being conducted by students Our program has become much more applications based over the year in order for students to understand their projects applicability to academic and industrial research said Alan Chalker Ph D SI director The Summer Institute provides a support system for the state s best and brightest students offering them an incredible opportunity to further develop their career skills during the program and beyond Working in four project teams the students solve practical yet complex science and engineering problems In the process they develop and apply fundamental computing skills in areas such as programming languages and techniques operating systems and visualization The four teams will focus on Obstacle Avoidance Roomba The team will standardize the precision and speed of a Roomba an autonomous vehicle used for vacuuming This project is sponsored by OSU and the National Science Foundation s Cyber Physical Systems CPS Program Image Processing This group will locate comets in sun observation images from the Solar and Heliospheric Observatory spacecraft SOHO is a cooperative mission between the European Space Agency and NASA Biomechanical Regulation of Cellular Signaling and Organization The team will determine how cells communicate with each other and with collagen fibers to grow new tissue in the leg Molecular Dynamics of the Bird Flu Virus This group will explore one of the scientific approaches that researchers use to study the avian influenza virus for early diagnosis treatment and prevention of the disease During a final ceremony the students will present their findings to an audience of scientists OSC staff key stakeholders and parents SI is an excellent place to learn how to be a computational scientist stated Tom Shkurti an Upper Arlington High School student who worked on the Roomba project last year I gained a renewed appreciation for what people in the artificial intelligence field have to deal with in terms of handling unexpected situations and understanding how you can make a machine mimic the natural thinking process of a human Through OSC s Ralph Regula School of Computational Science OSC provides a variety of education programs to encourage student interest in science technology engineering and math STEM careers This year more than 50 K 12 students will participate in these programs which include SI Young Women s Summer Institute for middle school girls and internships for nearby Metro High School students In addition to OSC SI 2011 is sponsored by MathWorks The program also received support from the NSF Cyber Physical Systems Program grant to OSU on Autonomous Driving in Mixed Traffic Urban Environments and the NSF Civil Mechanical and Manufacturing Innovation CMMI Program to the Department of Biomedical Engineering at OSU Since the program s inception in 1989 hundreds of Ohio students have participated in SI s unique learning opportunity For more information on this year s program including video and

    Original URL path: http://archive.osc.edu/press/releases/2011/si11.shtml (2013-06-13)
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  • IDC Announces First Recipients of HPC Innovation Excellence Award
    Innovation Excellence Award recognizes noteworthy achievements by users of High Performance Computing HPC technologies The program s main goals are to showcase return on investment ROI and scientific success stories involving HPC to help other users better understand the benefits of adopting HPC and justify HPC investments especially for small and medium size businesses SMBs to demonstrate the value of HPC to funding bodies and politicians and to expand public support for increased HPC investments IDC research has shown that HPC can greatly improve ROI and scientific advancement The award program aims to collect a large set of success stories across many industries and application areas said Earl Joseph program vice president High Performance Computing at IDC The initial winners achieved clear success in applying HPC to greatly improve business ROI scientific advancement and or engineering successes Many of the achievements also directly benefit society The award winners and project leaders announced at ISC11 are as follows contact IDC for additional details about the projects Beijing Genomics Institute China BGI has created genomics solutions that speed science and commercialization BGI estimates that the solutions have saved hundreds of thousands of dollars Lin Fang BMI U S Fuel saving aerodynamic truck design Estimated savings of 5 000 per truck per year Mike Henderson Department of Defense HPC Modernization Program DEW U S 13 8 million initial savings from virtual prototyping of countermeasures based on high power microwaves with much greater potential savings Cray Henry Department of Defense HPC Modernization Program COAMPS U S Significantly improved model for tropical cyclone forecasting Documented savings of 6 million in one event alone with far greater potential savings Lawrence Livermore National Laboratory U S Achieved 17 improvement in fuel economy of Class 8 tractor trailers Potential savings 24 2 billion annually Kambiz Salari National Energy Research Scientific Computing Center U S International study has enabled much more detailed and longer 100 years record of past weather to improved climate studies Gilbert P Compo and National Energy Research Scientific Computing Center Ohio Supercomputer Center Edison Welding Institute U S Weld Predictor simulation tool cuts costs by an average 50 by minimizing experimental trials Shanghai Supercomputer Center China New method to determine molecular configurations of large molecules on metal surfaces Tao Wang Shanghai Supercomputer Center China Substantial time and costs savings in engineering design Jiancheng Wu On behalf of Intel Corporation I would like to commend all the winners of the HPC Innovation Excellence Award for leading the HPC community in showcasing the real world benefits this community brings to society said Raj Hazra general manager High Performance Computing Intel The Council on Competitiveness would like to congratulate all the winners of the inaugural HPC Innovation Excellence Award and thank all of those who submitted entries The significance of HPC to the private sector will only be fully appreciated when examples such as these are recognized for their economic value said Dr Cynthia McIntyre senior vice president for the HPC Initiative at the Council on Competitiveness IDC

    Original URL path: http://archive.osc.edu/press/releases/2011/eweld.shtml (2013-06-13)
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  • Nimbis Services, Inc. Announces Manufacturing Vertical APPs Development and Hosting Service DARPA Award
    chain of manufacturers supplying the Tier 1 original equipment manufacturers OEMs The goal of expanded usage will be accomplished by encouraging developers and entrepreneurs to produce highly tailored digital manufacturing models based on simulation applications and domain specific portals says Robert Graybill Nimbis Services president and CEO In addition developing new resources on an on demand as needed basis similar to the iPhone APPs business model increases accessibility and use The Phase 2 technical objectives based on Nimbis Services extensive understanding of the target market drivers portal developer and user requirements are as follows Develop an end user friendly digital manufacturing e commerce storefront ecosystem that enables supply chain manufacturers to rapidly access and perform digital analysis computing using a SaaS model Develop an environment that enables commercial vendors universities and entrepreneurs to easily design their own digital manufacturing domain specific portal implementations as plug ins to the Nimbis hosting service Prototype demonstrate and beta test an integrated portal vertical APPS ecosystem The end commercial product will be a tightly integrated turn key commercial package incorporating a portal development environment a hosting service for the new domain specific portal application products and a web based ecommerce digital manufacturing portal storefront Our experience is that domain specific portal applications are more fully embraced by a larger contingent of companies said Ashok Krishnamurthy interim co executive director at the Ohio Supercomputer Center For example the Edison Welding Institute EWI Weld Predictor portal a web based interface generated by OSC has allowed over 100 companies to run thousands of jobs simulating virtual welds greatly reducing the time and material wasted with physical prototypes The DARPA SBIR seeks to enhance or to lower the technical computing access barriers for companies in the Department of Defense supply chain and manufacturing base by developing an online

    Original URL path: http://archive.osc.edu/press/releases/2011/nimbis2011.shtml (2013-06-13)
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  • PolymerOhio, in Collaboration with Ohio Supercomputer Center, Announces Launch of Polymer Portal
    the traditional iterative process of physical prototyping with a one shot build process that reduces labor and cost by utilizing software prototyping While this approach has previously been price prohibitive for SMEs the Polymer Portal now offers a pay per use model that provides a scalable and immediately accessible alternative opening the door for smaller companies to aggressively create new products and enter opportune markets The current modeling and simulation software offered is Moldex3D from CoreTech System Co Ltd the world s largest independent molding CAE solution provider Additional software products will be added in coming months providing models for extrusion manufacturing efficiency and supply chain management In initial rollout the program will focus on Ohio polymer companies to be followed by national expansion to all types of manufacturing In order to maintain and grow our valuable manufacturing sector it s critically important that we enable more companies to participate in advanced product development said Richard Markham vice president of programs for PolymerOhio This is a fast and affordable track for individual companies to spur growth We also anticipate economic impact on the Ohio polymer industry given that 90 of all Ohio polymer companies are SMEs Ohio s impressive network of small businesses and innovative entrepreneurs makes our state fertile ground to cultivate new opportunities through the Polymer Portal U S Sen Sherrod Brown said That s why the exciting work at PolymerOhio is crucial to attracting 21st century jobs to our state By providing tools that reduce the cost of developing new products Polymer Portal can help American workers out compete and out innovate the rest of the world The Polymer Portal will demonstrate to SMEs that a tremendous return on investment can be achieved by applying computational methods to quickly solve their problems without incurring the cost of

    Original URL path: http://archive.osc.edu/press/releases/2011/polymerportal.shtml (2013-06-13)
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  • Gordon tapped as president-elect of petascale consortium
    education research and outreach Steven I Gordon PhD Currently representing the most powerful computers in the world petascale computing refers to computation done mostly at national labs using a system capable of reaching performance in excess of one petaflop i e one quadrillion floating point operations per second Petascale computing is used to do advanced computation in fields such as weather and climate modeling nuclear reaction simulations cosmology and quantum chemistry Gordon is currently the interim co executive director at OSC and directs the Ralph Regula School of Computational Science RRSCS As director of RRSCS he manages multi institution programs in computational science at both two and four year colleges and universities across the state and has begun new certificate programs aimed at providing similar training for those currently in the workforce He has collaborated on a number of national community wide programs including the Partnership for Advanced Computational Infrastructure Education Program the EPIC project and Teragrid Gordon has served as The Ohio State University OSU representative to the Board of Directors of GLCPC since its inception Member institutions include universities and colleges national laboratories the Southeastern Universities Research Association educational foundations and K 12 school districts that are developing educational and workforce development programs to help realize the full potential of petascale computing To facilitate widespread effective use of petascale computing the GLCPC has coordinated multi institutional efforts to advance research practice and education in petascale class computer and computational science and engineering to real world problems Over the past several years Gordon has been responsible for a major portion of the SC education program organizing the workshops on computational science in engineering and computational thinking and providing leadership in the design of the entire program He is also the editor in chief of the new online journal the

    Original URL path: http://archive.osc.edu/press/releases/2011/gordon11.shtml (2013-06-13)
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  • UT physicist accelerates simulations of thin film growth
    cycle Daniel Janies PhD In a paper for the journal Systematic Biology sysbio oxfordjournals org Daniel Janies Ph D a computational biologist in the department of Biomedical Informatics at The Ohio State University OSU leveraged computer systems at the Ohio Supercomputer Center OSC to help support his contention that class level status of Xyloplax does not reflect their evolutionary history Although Xyloplax does not represent a new class it an even more interesting animal now because it represents a rare example of how natural selection can shape the whole the life cycle he explained By omitting the large adult stage Xylopax found how to make a living in the nooks and crannies of sunken timbers on the deep sea floor Janies collaborated on the paper with co authors Janet R Voight Ph D in the department of Zoology at the Field Museum of Natural History in Chicago and Marymegan Daly Ph D in the department of Evolution Ecology and Organismal Biology at Ohio State Janies and his colleagues are examining echinoderms starfish sea urchins and their close relatives as part of a study for the United States National Science Foundation s Assembling the Tree of Life project Several OSU scientists including Janies and Daly have won these grants typically valued at 3 million over five years to better understand the interrelationships of all forms of life http echinotol org As tree of life analyses are computationally difficult the current project is enabled by the computational muscle of OSC s flagship system the 9 500 node IBM 1350 Opteron Glenn Cluster Last year OSC deployed a 4 million expansion to the Glenn Cluster with a specific focus on supporting researchers like Drs Janies and Daly in Ohio s growing biosciences sector said Ashok Krishnamurthy interim co executive director of OSC The center provides a world class computing environment for amazing bioscience research projects at places like OSU s Department of Biomedical Informatics the Research Institute at Nationwide Children s Hospital and the Cleveland Clinic The researchers examined both genetic and anatomical data to support their hypothesis comparing Xyloplax with a total of 86 species representing major lineages of the five living classes of echinoderms sea cucumbers sea urchins starfish brittle stars and sea lilies For accurate comparisons they applied several analytical methods to search for the shared mutations and changes in anatomy among the lineages The results describe the relationships in a phylogenetic tree representing the best supported hypothesis on how Xyloplax evolved from other echinoderms Phylogenetics is the study of the evolutionary relationships and changes among various biological species as they evolve from a common ancestor Prior to this study molecular investigations of Xyloplax were limited because specimens in two early collections in the 1980s were fixed in a solution which degrades DNA Voight recently collected specimens of Xyloplax in the northeastern Pacific Ocean and carefully preserved them in ethanol From these specimens Daly was able to sequence several genes for Xyloplax The newer specimens of Xyloplax also included several

    Original URL path: http://archive.osc.edu/press/releases/2011/janies11.shtml (2013-06-13)
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  • Biophysicist targeting IL-6 to halt breast, prostate cancer
    and cancer explained Li In the case of breast cancers a medical review systematically tabulated IL 6 levels in various categories of cancer patients all showing that IL 6 levels elevated up to 40 fold especially in later stages metastatic cases and recurrent cases In 2002 Japanese researchers found that a natural non toxic molecule created by marine bacteria madindoline A MDL A could be used to mildly suppress the IL 6 signal Unfortunately the researchers also found the molecule wouldn t bind strongly enough to be effective as a cancer drug and would be too difficult and expensive to synthesize commercially And most surprisingly they found the bacteria soon mutated to produce a different totally ineffectual compound Around the same time Stanford scientists were able to construct a static image of the crystal structure of IL 6 and two additional proteins Li recognized the potential of these initial insights and partnered last year with an organic chemist and a cancer biologist at OSU s James Cancer Hospital to further investigate using an OSC supercomputer to construct malleable three dimensional color simulations of the protein complex The proximity of two outstanding research organizations the James Cancer Hospital and OSC provide a potent enticement for top medical investigators such as Dr Li to conduct their vital computational research programs at Ohio State University said Ashok Krishnamurthy interim co executive director of OSC We proposed using computational intelligence to re engineer a new set of compounds that not only preserve the original properties but also would be more potent and efficient Li said Our initial feasibility study pointed to compounds with a high potential to be developed into a non toxic orally available drug Li accessed 64 nodes of OSC s Glenn IBM 1350 Opteron cluster to simulate IL 6 and the two additional helper proteins needed to convey the signal the receptor IL 6R and the common signal transducing receptor GP130 Two full sets of the three proteins combine to form a six sided molecular machine or hexamer that transmits the signals that will in time cause cellular inflammation and potentially cancer Li employed the AMBER Assisted Model Building with Energy Refinement and AutoDock molecular modeling simulation software packages to help define the interactions between those proteins and the strength of their binding at five hot spots found in each half of the IL 6 IL 6R GP130 hexamer By plugging small molecules like MDL A into any of those hot spots Li could block the hexamer from forming So he examined the binding strength of MDL A at each of the hexamer hotspots identifying most promising location which turned out to be between IL 6 and the first segment or modular domain D1 of the GP130 To design a derivative of MDL A that would dock with D1 at that specific hot spot Li used the CombiGlide screening program to search through more than 6 000 drug fragments So far he has identified two potential solutions by combining the top

    Original URL path: http://archive.osc.edu/press/releases/2011/chenglongli.shtml (2013-06-13)
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  • OSU chemist develops solution to nerve agent exposure
    A docking simulation constructed by Ohio State Professor Christopher Hadad illustrates binding in the active site of tabun inhibited AChE Columbus OH April 5 2011 Scientists are working to develop a new drug that will regenerate a critical enzyme in the human body that ages after a person is exposed to deadly chemical warfare agents Christopher Hadad Ph D professor of chemistry at The Ohio State University OSU is leveraging Ohio Supercomputer Center OSC resources to help develop a more effective antidote to lethal chemicals called organophosphorus OP nerve agents This project is a combination of synthetic and computational organic chemistry conducted through OSC at Ohio State and biochemical studies conducted by colleagues at the U S Army Medical Research Institute of Chemical Defense at Aberdeen Proving Ground in Maryland said Hadad OP nerve agents inhibit the ability of an enzyme called acetylcholinesterase AChE to turn off the messages being delivered by acetylcholine ACh a neurotransmitter to activate various muscles glands and organs throughout the body After exposure to OP agents AChE undergoes a series of reactions culminating in an aging process that inactivates AChE from performing its critical biological function Without the application of an effective antidote neurosynaptic communication continues unabated resulting in uncontrolled secretions from the mouth eyes and nose as well as severe muscle spasms which if untreated result in death Conventional antidotes to OP nerve agents block the activity of the nerve agent by introducing oxime compounds which have been the focus of a number of studies These compounds attach to the phosphorus atom of the nerve agent after the OP is bound to AChE and then split it away from the AChE enzyme allowing the AChE to engage with receptors and finally relax the tissues However in some cases the combined nerve agent AChE molecule undergo a process called aging in which groups of single bonded carbon and hydrogen atoms called alkyl groups are removed from the molecule and a phosphonate residue is left behind in the AChE active site Relatively unstudied in nerve agents this process called dealkylation makes the nerve agent AChE molecule unreceptive to oximes an unfortunate situation considering that certain nerve agents e g soman can undergo aging within minutes of exposure to AChE Hadad s study is focused on the identification of compounds that would return an appropriate alkyl group to the aged nerve agent AChE molecule thus allowing treatment with oximes to provide for complete recovery The project is investigating common OP nerve agents Tabun VX VR Sarin Soman Cyclosarin and Paraoxon all of which take on a similar molecular structure upon aging Computational studies of the interaction of the alkylating compounds with AChE were used to provide insight for the design of selective reagents Hadad explained Ligand receptor docking followed by molecular dynamics simulations of the interactions of alkylating compounds with aged OP AChE was carried out in conjunction with experimental studies to investigate the binding of alkylating compounds to AChE These results were then used to suggest

    Original URL path: http://archive.osc.edu/press/releases/2011/hadad.shtml (2013-06-13)
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