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  • J97,Genomics,Jensen
    to 1p35 p36 a region spanning approximately 40 Mb To anchor the integrated map a framework genetic map was constructed with 24 genetic markers and a marker order of 1000 1 odds yielding an average resolution of 2 8 cM An additional 106 genetic markers were localized relative to the framework genetic map To place markers more precisely within 1p35 p36 a chromosome 1 specific radiation reduced hybrid RH panel

    Original URL path: http://linkage.rockefeller.edu/pub/j97geno_j.html (2012-11-26)
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  • J97,PNAS,Karayiorgou
    Physicians and Surgeons Center for Neurobiology and Behavior New York NY 10032 Communicated by Donald W Pfaff Rockefeller University New York NY February 24 1997 received for review January 14 1997 Proc Natl Acad Sci USA Vol 94 pp 4572 4575 April 1997 Abstract In the present study we address the role of the gene for catechol O methyltransferase COMT a key modulator of dopaminergic and noradrenergic neurotransmission in the

    Original URL path: http://linkage.rockefeller.edu/pub/j97pnas_k.html (2012-11-26)
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  • J97,GenEpi,Leal
    Genetic Epidemiology 14 6 1097 1100 1997 Abstract Complex traits have been modeled under various modes of two locus inheritance One example of a two locus threshold model is the situation where an individual is susceptible to a disease trait if he or she carries three or more disease alleles Under this model if each locus is examined individually the inheritance appears recessive for some mating types and dominant for

    Original URL path: http://linkage.rockefeller.edu/pub/j97ge_leal.html (2012-11-26)
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  • J97,GenEpi,Lucek
    University New York 2 Laboratory of Statistical Genetics Rockefeller University New York Correspondence to Jurg Ott NYS Psychiatric Unit Columbia University 722 West 168th Street Box 58 New York NY 10032 Genetic Epidemiology 14 6 1101 1106 1997 Abstract Neural

    Original URL path: http://linkage.rockefeller.edu/pub/j97ge_lucek.html (2012-11-26)
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  • J98,AJHG,McGee
    with autosomal dominant retinitis pigmentosa RP display reduced penetrance with some asymptomatic gene carriers showing no retinal abnormalities by ophthalmic examination or by electroretinography Here we describe a study of three families with reduced penetrance RP In all three families the disease gene appears to be linked to chromosome 19q13 4 the region containing the RP11 locus as defined by previously reported linkage studies based on five other reduced penetrance

    Original URL path: http://linkage.rockefeller.edu/pub/j97ajhg_m.html (2012-11-26)
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  • J97,JMolMed,Ott
    of testing for interference in human genetic maps are reviewed Two aspects of interference are distinguished numerical interference referring to the numbers of crossovers occurring and positional interference referring to the positions of crossovers Tests for interference generally address only one or the other of these two aspects Published investigations of interference presume fully informative marker maps while in reality genetic markers are of limited heterozygosity which weakens some of

    Original URL path: http://linkage.rockefeller.edu/pub/j97jmm_o.html (2012-11-26)
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  • J97,Genetics,Ott
    1997 Abstract The relationship between marker heterozygosity and the power to detect linkage disequilibrium is examined through the analysis of an example and through a simulation study The analysis suggests that despite the penalties for multiple testing incurred with multiple

    Original URL path: http://linkage.rockefeller.edu/pub/j97genetics_or.html (2012-11-26)
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  • J98,AJHG,Tsou
    Eng 4 Peter Steck 5 Jurg Ott 2 Sean V Tavtigian 3 and Monica Peacocke 1 1 Department of Dermatology Columbia University College of Physicians and Surgeons and 2 Laboratory of Statistical Genetics Rockefeller University New York 3 Myriad Genetics Inc Salt Lake City 4 Dana Farber Cancer Institute Harvard Medical School Boston and 5 Department of Neuro Oncology and Pathology The Brain Tumor Center University of Texas M D Anderson Cancer Center Houston Abstract Cowden syndrome CS is an autosomal dominant disorder associated with the development of hamartomas and benign tumors in a variety of tissues including the skin thyroid breast endometrium and brain It has been suggested that women with CS are at increased risk for breast cancer A locus for CS was recently defined on chromosome 10 in 12 families resulting in the identification of the CS critical interval between the markers D10S215 and D10S541 More recently affected individuals in four families with CS have been shown to have germ line mutations in a gene known as PTEN or MMAC1 which is located in the CS critical interval on chromosome 10 In this study we report three novel MMAC1 mutations in CS and demonstrate that MMAC1 mutations

    Original URL path: http://linkage.rockefeller.edu/pub/j97ajhg_t.html (2012-11-26)
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