archive-edu.com » EDU » R » ROCKEFELLER.EDU

Total: 626

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • J89,Lancet,Palotie
    Peltonen Lancet 1 8644 924 927 1989 Apr 29 Abstract The genetic background of two families in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait was investigated Use of restriction fragment length polymorphisms within and around

    Original URL path: http://linkage.rockefeller.edu/pub/j89lan_p.html (2012-11-26)
    Open archived version from archive


  • J89,GenEpid,Sandkuyl
    disorders Apparently other genetic or environmental factors determine the clinical presentation of this disease gene We evaluated a three allele model where the clinical expression of the disease allele is determined by the other allele at the same locus In the presence of a proposed modifying allele the disease allele is expressed as major depression in the presence of the normal neutral allele as bipolar disorder I or II We

    Original URL path: http://linkage.rockefeller.edu/pub/j89ge_so.html (2012-11-26)
    Open archived version from archive

  • J89,HumGenet,Sandkuyl
    described that allows evaluating for genetic counseling the information potentially available from the linked marker before the marker data are actually obtained that is prior to drawing blood for marker typing For a consultand in a family pedigree the method determines the risk distribution small families or an approximation to it larger families and calculates the probability that the risk will deviate beyond certain limits from its a priori value

    Original URL path: http://linkage.rockefeller.edu/pub/j89hg_so.html (2012-11-26)
    Open archived version from archive

  • J89,HumGen,Sankila
    at theta 0 and proximal to DXYS4 and DXYS12 This agrees with the data obtained from other linkage studies and from physical mapping All the TCD males and carrier females studied have the same DXYS1 allele in coupling with TCD In Northeastern Finland 66 69 chromosomes carrying TCD had the same haplotype at loci DXS72 DXYS1 DXYS4 and DXYS12 The same haplotype is seen in only 15 99 chromosomes not

    Original URL path: http://linkage.rockefeller.edu/pub/j89hg_s.html (2012-11-26)
    Open archived version from archive

  • J89,AJHG,Zoghbi
    of spinocerebellar ataxia SCA1 was studied to determine whether the SCA1 gene maps centromeric or telomeric to the HLA loci The DNA markers flanking the HLA A B region were used for polymorphism studies and multilocus linkage analysis These two markers are the cDNA for the beta subunit of HLA DP which is centromeric to HLA A B and the cDNA for coagulation factor XIIIa F13A which is telomeric to HLA A B Haplotypes were constructed using multiple polymorphisms for these two DNA markers and pairwise linkage analysis revealed a maximum lod score of 2 18 for SCA1 versus HLA DP at a recombination fraction of 05 and a maximum lod score of 0 for SCA1 versus F13A at a recombination fraction of 50 A possible crossover between HLA A B and HLA DP was identified but lack of samples from key individuals hampered the analysis To clarify the phase and improve the analysis the two chromosomes 6 for the crossover individual were separated in somatic cell hybrids The results strongly favored the probability that the crossover occurred between HLA A B DR and HLA DP with SCA1 segregating with HLA DP consistent with a location centromeric to HLA A

    Original URL path: http://linkage.rockefeller.edu/pub/j89ajhg_z.html (2012-11-26)
    Open archived version from archive

  • J88,Genomics,Kwan
    43 1988 Jul Abstract The Wiskott Aldrich syndrome WAS is an X linked recessive genetic disease in which the molecular defect is unknown In 15 families with WAS seven restriction fragment length polymorphic loci from the X chromosome were used to map the disease locus Of the eight intervals studied the likelihood of the WAS gene lying between DXS7 Xp11 3 and DXS14 Xp11 was at least 128 times higher

    Original URL path: http://linkage.rockefeller.edu/pub/j88geno_k.html (2012-11-26)
    Open archived version from archive

  • J87,AnnHumanGen,Lathrop
    Exact tests for gene order are derived and compared for three loci using linkage data from phase known completely informative marker loci i e parents are heterozygotes with at most one allele identical at each locus or from triple back cross matings A simulation method based on resampling genotypes of children is introduced to obtain approximations to the distribution of the test statistics for general mating types in families consisting

    Original URL path: http://linkage.rockefeller.edu/pub/j87ahg_l.html (2012-11-26)
    Open archived version from archive

  • J87,GenEpid,Ott
    case of three point linkage analysis a simple goodness of fit test is proposed to test the order of gene loci To use it for testing one locus order against another one may apply the principle that evidence for one order comes from lack of fit of the observations to the other order With n 30 offspring from a phase known triple backcross mating at a recombination fraction of 20

    Original URL path: http://linkage.rockefeller.edu/pub/j87ge_o.html (2012-11-26)
    Open archived version from archive