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  • J84,HumGen,Mensink
    303 389 1984 Abstract Studies on the segregation of the red blood cell determinant Xg in 12 families with X linked inheritance of agammaglobulinemia XLA in 3 4 generations suggested linkage of Xg with XLA One extensive pedigree of a Dutch family with XLA in eight generations was investigated for Xg and the quantitative polymorphism 12E7 LIPED analysis indicated linkage disproven up to 25cM distance within this pedigree Taken together

    Original URL path: http://linkage.rockefeller.edu/pub/j84hg_m.html (2012-11-26)
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  • J83,Ann Neurology,Bird
    neuropathy HMSN type I showed affected family members to have slow motor nerve conduction velocities hypoactive tendon reflexes and distal muscle weakness and atrophy Results excluded close linkage of the neuropathy in this family to the Duffy blood group locus on chromosome 1 Previous studies in other families have shown positive linkage of HMSN type I to the Duffy locus The present results provide support for the concept of genetic

    Original URL path: http://linkage.rockefeller.edu/pub/j83an_b.html (2012-11-26)
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  • J83,MCP,Dyck
    studied and reported almost 20 years ago and used to show heterogeneity among kinships with peroneal muscular atrophy and to characterize HMSN I were investigated for linkage to various blood erythrocyte and lymphocyte HLA antigens Strong evidence against linkage to the Duffy blood group locus was found for one kinship whereas suggestive evidence for linkage was found for the other These data imply that HMSN I is heterogeneous that is

    Original URL path: http://linkage.rockefeller.edu/pub/j83mcp_d.html (2012-11-26)
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  • J83,AHG,Ott
    the recombination fraction may or may not involve a mixture of two groups of elements For the mixture situation families with or without linkage between two gene loci Morton s homogeneity test is compared with another test Admixture test with

    Original URL path: http://linkage.rockefeller.edu/pub/j83ahg_o.html (2012-11-26)
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  • J83,AnticancerRes,Weber
    statistical analysis of pedigree data suggest that genetic mechanisms play an important role in most cancer types This is illustrated in colorectal breast lung ovarian and childhood cancer Pedigree data are consistent with the hypothesis that cancer is sometimes inherited in an autosomal dominant Mendelian fashion These rare hereditary cancers might not be different pathogenetically from those arising sporadically A two stage model for carcinogenesis provides a framework for the

    Original URL path: http://linkage.rockefeller.edu/pub/j83ar_w.html (2012-11-26)
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  • J82,AJHG,Bird
    nerve conduction velocities Two families comprising 3 and 4 generations and a total of 23 affected persons were informative for the Duffy locus known to be on the long arm of chromosome 1 The maximum total lod score was 2 297 at recombination fraction theta 1 The third family was informative for PGM1 on the short arm of chromosome 1 There was no evidence for linkage of CMT to PGM1

    Original URL path: http://linkage.rockefeller.edu/pub/j82ajhg_b.html (2012-11-26)
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  • J80,JClinInv,Rossen
    juvenile rheumatoid arthritis In these families histocompatibility testing suggested that susceptibility to arthritis was controlled by a dominant allele with variable penetrance and expressivity at the rheumatoid like arthritis first locus RLA 1 The combined lod scores for the four families 2 70 indicated that the odds in favor of genetic linkage between the major histocompatibility complex and the postulated disease susceptibility gene RLA 1 were 500 1 In one

    Original URL path: http://linkage.rockefeller.edu/pub/j80jci_r.html (2012-11-26)
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  • J79,ClinGen,Ott
    i by determining postreduction frequencies by means of ovarian teratomas and ii by analysis of genetic linkage between a gene locus and a structural chromosome polymorphism near the centromere The two methods are comapred under complete interference It is shown

    Original URL path: http://linkage.rockefeller.edu/pub/j79cg_o.html (2012-11-26)
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