archive-edu.com » EDU » R » ROCKEFELLER.EDU

Total: 1631

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Newly Identified Protein Caps Chromosomes Ends | Newswire
    chromosomes As a consequence human chromosomes run out of their telomeric caps after a large number of cell divisions Because chromosomes need the caps for protection telomeric attrition is thought to limit the vitality of normal human cells In the study the scientists isolated the first protein component of human telomeres called telomeric repeat binding factor or TRF They cloned the gene that carries the instructions to make TRF and found the protein sits on both ends of every human chromosome by specifically binding to a section of repeating DNA sequences TRF recognizes this terminal repeating sequence which use six nucleotides The findings demonstrate that human telomeres form a complex of protein and DNA which we anticipated but for which we lacked direct proof before cloning TRF says senior author Titia de Lange Ph D associate professor and head of the cell biology and genetics laboratory at Rockefeller With the telomeric protein in hand we can now study how telomeres function in aging cells and in cancer In addition to understanding telomeres composition in normal cells de Lange s findings should shed light on the actions of telomerase an enzyme that halts the decline of telomeres in cancer cells Telomerase is at the center of intense investigation as a possible target for anti cancer drug therapy de Lange explains Investigators in her laboratory study whether TRF or other proteins regulate or interfere with telomerase de Lange s coauthors at Rockefeller are Laura Chong B A assistant for research Bas van Steensel Ph D postdoctoral fellow Dominique Broccoli Ph D postdoctoral fellow and John Hanish Ph D postdoctoral fellow and at Memorial Sloan Kettering Hediye Erdjument Bromage Ph D research associate and Paul Tempst Ph D associate member Tempst also is an associate professor at C ornell Graduate School of Medical

    Original URL path: http://newswire.rockefeller.edu/1995/12/07/newly-identified-protein-caps-chromosomes-ends/ (2016-02-13)
    Open archived version from archive


  • Titia de Lange | Newswire | Page 2
    welfare More Tags Charles D Gilbert Jeffrey Ravetch Michael O Donnell Titia de Lange U S National Academy of Sciences September 29 2005 Awards and Honors Titia de Lange receives NIH Pioneer Award The National Insitutes of Health has selected Titia de Lange who examines how cells respond to DNA damage to receive up to 500 000 in direct costs per year for five years The prestigious Pioneer Award now in its second year supports groundbreaking high risk research that if successful will have a significant impact More Tags National Institutes of Health Pioneer Award Titia de Lange March 28 2002 Science News How Aging Cells Retire As we grow older our hair turns gray our bones grow thin and among other changes our telomeres shrink But more than markers of the passage of time telomeres the tips of chromosomes may harbor answers to the fundamental mechanisms of aging and cancer More Tags cell division telomeres Titia de Lange December 7 1995 Science News Newly Identified Protein Caps Chromosomes Ends A newly isolated protein is a vital part of human telomeres the shields that guard the ends of chromosomes against damage and destruction Scientists at Rockefeller University and Memorial Sloan

    Original URL path: http://newswire.rockefeller.edu/tag/titia-de-lange/page/2/ (2016-02-13)
    Open archived version from archive

  • Titia de Lange to receive Canada Gairdner International Award | Newswire
    the ends of chromosomes that protect a cell s genetic material from molecular attack often well intentioned repair complexes that may mistake chromosome ends for DNA breaks that need to be fixed de Lange discovered that telomeres are bound by a complex of proteins she named shelterin and her work has established how distinct shelterin subunits repress different DNA damage response pathways that threaten the integrity of the genome Titia s research has shown us a great deal about how telomeres work to protect and preserve DNA unveiling processes that are crucial for understanding the aging process and the development of human disorders such as cancer says Marc Tessier Lavigne president of The Rockefeller University She is a phenomenal scientist and it is a pleasure to see her work recognized by the Gairdner Foundation Human telomeres as seen through a fluorescence microscope A native of the Netherlands de Lange is an American Cancer Society Research Professor and the director of the Anderson Center for Cancer Research Her many honors include the 2013 Breakthrough Prize in Life Sciences the 2012 Dr H P Heineken Prize for Biochemistry and Biophysics the 2011 Vilcek Prize in Biomedical Science the 2010 AACR Clowes Memorial Award the 2008 Massachusetts General Hospital Cancer Center Prize and the 2005 NIH Director s Pioneer Award She is an elected member of the Royal Dutch Academy of Sciences the European Molecular Biology Organization the American Academy of Arts and Sciences and a foreign associate of the National Academy of Sciences The Canada Gairdner International Awards were created in 1959 to recognize and reward the achievements of medical researchers whose work contributes significantly to improving the quality of human life The awards will be presented at a dinner in Toronto on October 30 as part of the Gairdner National Program

    Original URL path: http://newswire.rockefeller.edu/2014/03/26/titia-de-lange-to-receive-canada-gairdner-international-award/ (2016-02-13)
    Open archived version from archive

  • Gairdner Award | Newswire
    on circadian rhythms the biological clocks that regulate our bodies patterns of sleep and wakefulness metabolism and response to disease The Gairdner which is Canada s highest scientific award is considered among the top ten most prestigious international prizes in science The scientists will each receive 100 000 from the Gairdner Foundation More Tags Gairdner Award Jeffrey Ravetch Michael W Young April 18 2007 Awards and Honors David Allis to receive Gairdner Award Allis who studies DNA packaging proteins called histones is one of five scientists to be honored by the Gairdner Foundation for fundamental discoveries that will have impact on human genetic development cancer and other diseases More Tags C David Allis Gairdner Award April 13 2005 Awards and Honors Jeffrey Friedman discoverer of leptin receives Gairdner Passano awards Rockefeller University s Jeffrey M Friedman M D Ph D a molecular geneticist whose discovery of the hormone leptin and its role in regulating body weight has changed our understanding of the causes of human obesity has received two prestigious awards for this work the Gairdner Foundation International Award and the Passano Foundation Award More Tags Gairdner Award Jeffrey M Friedman Passano Award April 11 2003 Science News Gairdner Prize

    Original URL path: http://newswire.rockefeller.edu/tag/gairdner-award/ (2016-02-13)
    Open archived version from archive

  • Titia de Lange to receive Heineken Prize | Newswire
    of the Netherlands received her Ph D from the University of Amsterdam and came to Rockefeller in 1990 where she focused her research on how telomeres protect chromosome ends de Lange identified a protein complex at telomeres called shelterin and has shown how this complex hides the chromosome end from the cellular machinery that detects and repairs broken DNA ends Telomeres undergo erosion in the early stages of cancer development and de Lange s work has clarified how the loss of telomere function generates genome instability and can drive cancer progression Titia s research on telomeres has had a significant impact on our understanding of how a cell responds when its DNA is damaged says Marc Tessier Lavigne president of The Rockefeller University Her work has shed light on the causes of human cancer and is a prime example of the importance of basic research in the fight against cancer and I am greatly pleased to see her recognized with this important prize An American Cancer Society Research Professor and the director of the Anderson Center for Cancer Research de Lange s many honors include the 2011 Vilcek Prize in Biomedical Science the 2010 AACR Clowes Memorial Award the 2008 Massachusetts General Hospital Cancer Center Prize and the 2005 NIH Director s Pioneer Award She is an elected member of the Royal Dutch Academy of Sciences the European Molecular Biology Organization the American Academy of Arts and Sciences and a foreign associate of the National Academy of Sciences The Heineken Prizes are awarded biennially to five internationally renowned scientists and one highly talented Dutch visual artist for their contributions to science Dutch art and society The scientific prizes are given to individuals who show unique achievement in biochemistry and biophysics medicine environmental sciences history and cognitive science Previous recipients of

    Original URL path: http://newswire.rockefeller.edu/2012/03/15/titia-de-lange-to-receive-heineken-prize/ (2016-02-13)
    Open archived version from archive

  • Dr H.P. Heineken Prize for Biochemistry and Biophysics | Newswire
    De Lange is honored for her work on telomeres the protective DNA sequences located at the tips of chromosomes which play a crucial role in such processes as ageing and cancer More Tags Dr H P Heineken Prize for Biochemistry and Biophysics Titia de Lange Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv

    Original URL path: http://newswire.rockefeller.edu/tag/dr-h-p-heineken-prize-for-biochemistry-and-biophysics/ (2016-02-13)
    Open archived version from archive

  • Rockefeller postdoc named finalist for Blavatnik Awards for Young Scientists | Newswire
    15 000 respectively Sfeir obtained her Ph D in cell biology in 2006 from the University of Texas Southwestern Medical Center in Dallas where she received the Nominata award She then joined the laboratory of Titia de Lange to work on a fundamental question in cell biology how telomeres solve the end protection problem Telomeres are nucleoprotein structures that shield the natural ends of linear chromosomes from the DNA damage response Telomeric DNA is composed of long tracts of TTAGGG repeats that act as binding sites for a six member protein complex termed shelterin The main focus of Sfeir s postdoctoral research has been to discern the function of two shelterin proteins TRF1 and Rap1 She showed that TRF1 is required for the efficient replication of telomeric DNA whereas Rap1 function to block DNA repair at chromosome ends Her recent work supported by a Susan G Komen For the Cure Postdoctoral Fellowship was published in Cell in 2009 and in Science in 2010 This year s 12 finalists including seven faculty and five postdocs from the Tri state area are selected for exceptionally elegant innovative and significant interdisciplinary research projects in life sciences physical sciences and engineering The finalists will be honored and the winners announced at the New York Academy of Sciences seventh annual Science and the City Gala on November 15 Previous Blavatnik Awards went to Leslie B Vosshall HHMI investigator and head of Rockefeller s Laboratory of Neurogenetics and Behavior in 2007 Tom W Muir head of the Selma and Lawrence Ruben Laboratory of Synthetic Protein Chemistry in 2008 and Shai Shaham head of the Laboratory of Developmental Genetics and Sreekanth Chalasani a postdoctoral associate in the Laboratory of Neural Circuits and Behavior in 2009 Past finalists from Rockefeller have included Tarun Kapoor head of the Laboratory

    Original URL path: http://newswire.rockefeller.edu/2010/07/02/rockefeller-postdoc-named-finalist-for-blavatnik-awards-for-young-scientists/ (2016-02-13)
    Open archived version from archive

  • Agnel Sfeir | Newswire
    Cell Biology and Genetics has been named a finalist in the fourth annual Blavatnik Awards for Young Scientists competition which recognizes the contributions of young scientists and engineers in New York New Jersey and Connecticut More Tags Agnel Sfeir Blavatnik Awards Laboratory of Neurogenetics and Behavior Leslie B Vosshall Titia de Lange Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/agnel-sfeir/ (2016-02-13)
    Open archived version from archive