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  • human embryonic stem cells | Newswire
    embryonic stem cells develop Tags Ali Brivanlou human embryonic stem cells June 30 2014 Science News Using geometry researchers coax human embryonic stem cells to organize themselves By confining colonies of human embryonic stem cells to tiny circular patterns on glass plates researchers have for the first time coaxed them into organizing themselves just as they would under natural conditions More Tags Ali H Brivanlou BMP signaling developmental biology gastrulation

    Original URL path: http://newswire.rockefeller.edu/tag/human-embryonic-stem-cells/ (2016-02-13)
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  • New research sheds light on the molecular origins of Parkinson’s disease | Newswire
    shifts are consequences others are causes We set out to find which cause cell death among neurons Using a new combination of techniques Greengard adds we identified two of these so called master regulatory molecules a discovery that offers an unexpected explanation as to why one population of neurons degenerates in Parkinson s while similar neighbors do not suffer from the same degree of degeneration Parkinson s disease often first shows up as a slight tremor of the hands and progresses to affect speech facial muscles and other movements This deterioration is caused by the progressive loss of neurons located in a midbrain region called the substantia nigra pars compacta SNpc These neurons produce dopamine a molecule that transmits signals between neurons and it is the loss of dopamine that causes the loss of motor control associated with Parkinson s Some deterioration also occurs in the dopamine producing neurons of a neighboring brain region the ventral tegmental area VTA but the VTA neurons are much less affected than those of the SNpc Typically when scientists want to look for molecular changes associated with a condition they use genetic sequencing to create a profile of variations in gene expression But with conventional profiling approaches it is difficult to pick out the changes that occur in a particular type of cell and distinguish those that are truly important It is also very hard to tell which changes arise from the master regulator genes which can act as control dials turning their target genes up or down To overcome these issues the team led by first author Lars Brichta a senior research associate in Greengard s lab adapted a technique previously developed in Greengard s and Nathaniel Heintz s labs which involves genetically engineering mice to capture the genetic messages being translated into proteins in a specific population of cells They then mapped the interactions of regulator genes with their target genes in the mouse brain and used this new tool to interpret the changes they documented between normal mice and those suffering from Parkinson s like degeneration This led them to two molecules the proteins SATB1 and ZDHHC2 which are more abundant in the dopaminergic neurons in the SNpc versus the VTA When the researchers reduced the abundance of these molecules in the brains of normal mice rapid degeneration like that seen in Parkinson s disease followed Conventional gene activity profiling approaches would not have been able to identify SATB1 and ZDHHC2 as key protective factors because the levels of these proteins do not change But even though they continue to be expressed within the neurons it appears that their regulatory activity drops off and they no longer stimulate their target genes Brichta says We later found similar changes in activity in the brains of Parkinson s patients particularly those in the early stages Their findings also challenge the prevailing thought as to the molecular origins of Parkinson s that VTA neurons had some sort of factor protecting them against the kind

    Original URL path: http://newswire.rockefeller.edu/2015/08/10/new-research-sheds-light-on-the-molecular-origins-of-parkinsons-disease/ (2016-02-13)
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  • Laboratory of Molecular and Cellular Neuroscience | Newswire
    by this degenerative disease When the activity of these molecules wanes disease sets in This discovery suggests new avenues for preventing or treating Parkinson s More Tags dopamine neurons Laboratory of Molecular and Cellular Neuroscience Lars Brichta neurodegeneration Parkinson s disease Paul Greengard SNpc VTA April 25 2011 Science News Anti inflammatory drugs reduce effectiveness of SSRI antidepressants Scientists have shown that anti inflammatory drugs which include ibuprofen aspirin and naproxen reduce the effectiveness of the most widely used class of antidepressant medications the selective serotonin reuptake inhibitors or SSRIs often prescribed for depression and obsessive compulsive and anxiety disorders More Tags Alzheimer s disease Laboratory of Molecular and Cellular Neuroscience Paul Greengard The Fisher Center for Alzheimer s Research Foundation March 8 2011 Science News Molecule that spurs cell s recycling center may help Alzheimer s patients A molecule that activates the cell s natural recycling program may flush away the protein fragments that accumulate and form senile plaques in Alzheimer s disease New research suggests that stimulating this activity either through drugs or natural processes may improve the quality of life for people with diseases caused by built up proteins in the brain More Tags Alzheimer s disease amyloid β Laboratory of Molecular and Cellular Neuroscience Paul Greengard Vincent Astor September 2 2010 Awards and Honors Paul Greengard receives Karolinska Institutet s Bicentennial Gold Medal The gold medal is the highest award conferred by the Karolinska Institutet one of the world s leading medical universities during its 200th anniversary celebrations The medal recognizes the work of an individual not permanently located at the Karolinska Institutet who has contributed to and has achieved acknowledged eminence in the university s activities More Tags Karolinska Institutet Karolinska Institutet s Bicentennial Gold Medal Laboratory of Molecular and Cellular Neuroscience Paul Greengard July 27 2010 Science News MicroRNAs play a role in cocaine addiction MicroRNAs short stretches of RNA that silence genes have already been linked to cancer heart disease and mental disorders such as schizophrenia New research by Rockefeller University scientists suggests microRNAs are also involved in regulating the motivation to consume cocaine a finding that could ultimately lead to new ways of combating addictive diseases in humans More Tags Anne Schaefer Argonaute 2 Laboratory of Molecular and Cellular Neuroscience MicroRNAs Paul Greengard June 10 2010 Science News Alzheimer s brain protein may provide target for treating mental retardation Reducing the level of β amyloid a protein found in the brains of patients with Alzheimer s disease and Down syndrome may improve the cognitive abilities of children with Down syndrome The new study by Rockefeller University scientists may provide a model for developing new anti amyloid drugs More Tags Alzheimer s disease Down syndrome Laboratory of Molecular and Cellular Neuroscience Paul Greengard β amyloid April 26 2010 Science News Scientists identify potential new target for schizophrenia drugs A protein that boosts the signaling power of a receptor involved in relaying messages between brain cells may provide a new target for the development

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-molecular-and-cellular-neuroscience/ (2016-02-13)
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  • Lars Brichta | Newswire
    effect in the set of neurons most affected by this degenerative disease When the activity of these molecules wanes disease sets in This discovery suggests new avenues for preventing or treating Parkinson s More Tags dopamine neurons Laboratory of Molecular and Cellular Neuroscience Lars Brichta neurodegeneration Parkinson s disease Paul Greengard SNpc VTA Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014

    Original URL path: http://newswire.rockefeller.edu/tag/lars-brichta/ (2016-02-13)
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  • Parkinson’s disease | Newswire
    effect in the set of neurons most affected by this degenerative disease When the activity of these molecules wanes disease sets in This discovery suggests new avenues for preventing or treating Parkinson s More Tags dopamine neurons Laboratory of Molecular and Cellular Neuroscience Lars Brichta neurodegeneration Parkinson s disease Paul Greengard SNpc VTA Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014

    Original URL path: http://newswire.rockefeller.edu/tag/parkinsons-disease/ (2016-02-13)
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  • SNpc | Newswire
    in the set of neurons most affected by this degenerative disease When the activity of these molecules wanes disease sets in This discovery suggests new avenues for preventing or treating Parkinson s More Tags dopamine neurons Laboratory of Molecular and Cellular Neuroscience Lars Brichta neurodegeneration Parkinson s disease Paul Greengard SNpc VTA Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/snpc/ (2016-02-13)
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  • In the News – The Lancet – Dubos | Newswire
    about the mutability and adaptability of pathogens in the face of shifting disease ecologies and changing social patterns Although Lederberg s main concern was new viral diseases such as AIDS in a 1988 address at the Rockefeller he included the evolution of antibiotic resistance within a new category he termed emergent diseases Tags antibiotic resistance gramicidin history Joshua Lederberg Rene Dubos newswire rockefeller edu Mutations in key cancer protein suggest

    Original URL path: http://newswire.rockefeller.edu/2015/11/18/in-the-news-the-lancet-dubos/ (2016-02-13)
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  • gramicidin | Newswire
    Dubos Fortunately Lederberg had been paying attention and in the late 1980s he used his position as head of the Rockefeller University to revive Dubos s warnings about the mutability and adaptability of More Tags antibiotic resistance gramicidin history Joshua Lederberg Rene Dubos Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The

    Original URL path: http://newswire.rockefeller.edu/tag/gramicidin/ (2016-02-13)
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