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  • Arnold J. Levine | Newswire
    s most important defenses against many forms of cancer More Tags Albany Medical Center Prize Arnold J Levine July 27 2000 Campus News Three Leading New York Institutions Announce 160 Million Joint Investment in Biological Research Three of New York s leading research institutions announced the creation of a 160 million collaborative program in basic biological research sparked by a private donor who will contribute half the total investment The collaboration among Cornell University its Weill Medical College Memorial Sloan Kettering Cancer Center and The Rockefeller University will include the joint recruitment of a dozen new faculty members reflecting the level of investment demanded by the technological demands of science today More Tags Arnold J Levine March 16 2000 Campus News Bard College And Rockefeller University Establish New Collaborative Programs In Science Education Bard College and The Rockefeller University have established a new ongoing collaborative program in science education Rockefeller President Arnold Levine and Bard President Leon Botstein announced today More Tags Arnold J Levine Bard College Bard Rockefeller Program April 30 1999 Awards and Honors Rockefeller University Scientists Receive Prestigious Awards for Cancer Research Arnold J Levine Ph D newly appointed president of The Rockefeller University and Robert G Roeder Ph D professor and head of the Laboratory of Biochemistry and Molecular Biology have been recognized by the General Motors Cancer Research Foundation for their major contributions to cancer research More Tags Alfred P Sloan Prize Arnold J Levine Charles S Mott Prize General Motors Cancer Research Foundation Robert G Roeder December 2 1998 Campus News Arnold J Levine Becomes Eighth President of The Rockefeller University Arnold J Levine one of the world s leading cancer researchers officially became the eighth president of The Rockefeller University at the university s board meeting on Wed Dec 2 Levine who was

    Original URL path: http://newswire.rockefeller.edu/tag/arnold-j-levine/ (2016-02-13)
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  • General Motors Cancer Research Foundation | Newswire
    and Robert G Roeder Ph D professor and head of the Laboratory of Biochemistry and Molecular Biology have been recognized by the General Motors Cancer Research Foundation for their major contributions to cancer research More Tags Alfred P Sloan Prize Arnold J Levine Charles S Mott Prize General Motors Cancer Research Foundation Robert G Roeder Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive

    Original URL path: http://newswire.rockefeller.edu/tag/general-motors-cancer-research-foundation/ (2016-02-13)
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  • Study offers insight on how a new class of antidepressants works | Newswire
    sensitivity to the chemical message serotonin to depression This discovery helped to explain how selective serotonin reuptake inhibitor SSRI antidepressants work and has made it possible to improve upon them Now the research team led by first author Ko Woon Lee a research associate in the lab wanted to see if p11 had a similar effect on a different signaling system within the brain Because it is among the receptors targeted by the new class of antidepressants they focused on mGluR5 which responds to a number of chemical signals In the brain p11 and mGluR5 are both found in cells that produce glutamate as well as those that manufacture a competing signal GABA Glutamate signals prompt activity in neurons while GABA has the opposite effect tamping it down Imbalances between the two have been implicated in psychiatric disorders including depression After establishing that p11 interacts with mGluR5 and controls signaling by the receptor the researchers deleted p11 or mGluR5 in both GABA and glutamate producing cells They assessed the effects using behavioral tests including putting food in the middle of an open space and timing the animals response The results showed opposite roles for the molecules in the excitatory versus inhibitory neurons The loss of mGluR5 or p11 appeared to dampen the GABA neurons signaling as shown by the mice s increased willingness to pick up food pellets from an open field a proxy measure for resilience from depression and anxiety Meanwhile deletion of p11 or mGluR5 in glutamate neurons produced mice hesitant to retrieve the food a sign of a depression like state GABA and glutamate producing neurons can work in tandem with a particular class of GABA neurons tamping down excitatory glutamate signaling This is the secret to the new mGluR5 blocking drugs the researchers found In experiments

    Original URL path: http://newswire.rockefeller.edu/2015/09/30/study-offers-insight-on-how-a-new-class-of-antidepressants-works/ (2016-02-13)
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  • p11 | Newswire
    chemical messenger glutamate however it has been unclear how they work The recent discovery of a molecular amplification system helps explain how the drugs alter signaling in particular neurons to achieve an antidepressant effect More Tags depression Laboratory of Molecular and Cellular Neuroscience neurosciences and behavior p11 Paul Greengard Yong Kim Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012

    Original URL path: http://newswire.rockefeller.edu/tag/p11/ (2016-02-13)
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  • Yong Kim | Newswire
    identified within neurons a series of molecular interactions known as a pathway that can dampen the production of the Alzheimer s protein amyloid β These results suggest a new route in the search for therapies for this degenerative disease More Tags Alzheimer s disease amyloid β golgi Laboratory of Molecular and Cellular Neuroscience neurosciences and behavior Paul Greengard The Fisher Center for Alzheimer s Research WAVE1 Yong Kim February 4

    Original URL path: http://newswire.rockefeller.edu/tag/yong-kim/ (2016-02-13)
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  • New findings help explain how molecules are speedily transported into and out of the cell’s nucleus | Newswire
    professor at Rockefeller University and head of the Laboratory of Cellular and Structural Biology and David Cowburn a professor of biochemistry and of physiology biophysics at Albert Einstein College of Medicine sought to explain the speed with which transport factors ferry large molecules across the NPC a process that lasts only a few milliseconds It s understood how these transport factors selectively choose and bind to their cargo Rout says However it s been unclear how such a specific process can also shepherd molecules through the nuclear pore complex so quickly At the center of the NPC the transport factors and their cargo must pass through a selectivity filter made of proteins called FG Nups These proteins form a dense mesh that normally prevents large molecules from getting through Using a technique known as nuclear magnetic resonance spectroscopy the researchers collected atomic scale information about the behavior of the FG Nups focusing on Nsp1 the most studied representative of the FG Nups Normally proteins fold into large structures Relative to small molecules such as water these large protein structures move very slowly This means their interactions are correspondingly slow The researchers measured the physical state of FG repeats with and without transport factors bound to them They found that rather than folding like proteins generally do the FG Nups are loose and string like remaining highly dynamic and lacking a predictable structure Usually binding between traditionally folded proteins is a time consuming cumbersome process but because the FG Nups are unfolded they are moving very quickly very much like small molecules This means their interaction is very quick explains Rout The disordered structure of the FG regions is critical to the speed of transport allowing for quick loading and unloading of cargo carrying transport factors At the same time because

    Original URL path: http://newswire.rockefeller.edu/2015/09/17/new-findings-help-explain-how-molecules-are-speedily-transported-into-and-out-of-the-cells-nucleus/ (2016-02-13)
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  • cellular transport | Newswire
    Cellular and Structural Biology Michael Rout molecular and cell biology nuclear pore complex Nup June 5 2015 Science News Research reveals key interaction that opens the channel into the cell s nucleus Scientists have uncovered crucial steps in the dynamic dance that dilates and constricts the nuclear pore complex Their ongoing work has shown this elaborate portal to and from the cell s nucleus is much more than the inert

    Original URL path: http://newswire.rockefeller.edu/tag/cellular-transport/ (2016-02-13)
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  • Laboratory of Cellular and Structural Biology | Newswire
    More Tags cellular transport Laboratory of Cellular and Structural Biology Michael Rout molecular and cell biology nuclear pore complex Nup November 2 2014 Science News New technique efficiently turns antibodies into highly tuned nanobodies Antibodies tiny cousins have many potential uses but scientists haven t been able to take advantage of them However a new technique may make nanobodies dramatically more accessible for all kinds of research More Tags antibodies

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-cellular-and-structural-biology/ (2016-02-13)
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