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  • Michael Rout | Newswire
    cellular transport Laboratory of Cellular and Structural Biology Michael Rout molecular and cell biology nuclear pore complex Nup November 2 2014 Science News New technique efficiently turns antibodies into highly tuned nanobodies Antibodies tiny cousins have many potential uses but scientists haven t been able to take advantage of them However a new technique may make nanobodies dramatically more accessible for all kinds of research More Tags antibodies Brian Chait

    Original URL path: http://newswire.rockefeller.edu/tag/michael-rout/ (2016-02-13)
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  • nuclear pore complex | Newswire
    passes in and out of the cell nucleus play a crucial role in the cell s metabolism and signaling Defects in structure and function of these gatekeepers known as nuclear pore complexes can have lethal consequences New research reveals secrets about what may be a key design feature of these structures a flexibility enabling the import and export of large molecules More Tags nuclear pore complex July 9 2009 Science News Research suggests core nuclear pore elements shared by all eukaryotes About 1 7 billion years ago the cell nucleus burst onto the scene sequestering the cell s genetic material inside a protective inner membrane and setting the stage for the evolution of increasingly sophisticated creatures from yeast say to plants and human beings Now research shows that one of the most basic design principles of this new eukaryotic life form the gatekeeper to the cell nucleus known as the nuclear pore complex is largely shared across even the most distantly related eukaryotes More Tags eukaryotes nuclear pore complex June 7 2009 Science News Research identifies 3D structure of key nuclear pore building block New research into the molecular machine that filters all information traveling in or out of the cell nucleus contributes to an unfolding picture of cellular evolution that shows a common architecture for the nuclear pore complex NPC and the vehicles that transport material between different parts of the cell Scientists have for the first time glimpsed in three dimensions the subcomplex of the NPC that is its key building block More Tags Günter Blobel Martin Kampmann nuclear pore complex February 10 2009 Science News Molecular machine turns packaged messenger RNA into a linear transcript The nuclear pore complex is the only way in or out of the cell nucleus This assembly also plays a key role in assuring the quality of the genetic information that passes through it New research shows how one of the pore s proteins magnetically couples with another molecule to form a machine that helps unpack messenger RNA More Tags Andre Hoelz nuclear pore complex January 6 2009 Science News Researchers develop a device that mimics one of nature s key transport machines A cell s nuclear pore complex controls transport of materials from one side to the other Now by trying to recreate the structure scientists have gained a broader understanding of how it works More Tags Brian T Chait nuclear pore complex December 24 2008 Science News Structural study backs new model for the nuclear pore complex Inside the cell nucleus DNA is transcribed into RNA that then leaves the nucleus and binds to the cell s ribosomes where it is translated into proteins But in order to get to the ribosome the RNA must pass through a relatively large complicated and little understood structure called the nuclear pore complex Researchers at The Rockefeller University have a new model for the gatekeeper to the nucleus and have discovered the crystal structure of a protein pair that backs it up More

    Original URL path: http://newswire.rockefeller.edu/tag/nuclear-pore-complex/ (2016-02-13)
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  • Nup | Newswire
    and out of the nucleus is capable of an impressive feat allowing large molecules to pass through both selectively and quickly Researchers have now identified the molecular mechanism that makes this possible More Tags cellular transport Laboratory of Cellular and Structural Biology Michael Rout molecular and cell biology nuclear pore complex Nup Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/nup/ (2016-02-13)
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  • A newly discovered molecular feedback process may protect the brain against Alzheimer’s | Newswire
    he adds it may be possible to develop drugs to reduce amyloid β that potentially could be used to either treat or prevent Alzheimer s disease WAVE1 is known to help to build filaments of a protein called actin that serve as basic components of cellular structures In the current study the team including first author Ilaria Ceglia who conducted this work while a research associate in the lab examined the levels of WAVE1 in mouse and cellular models of Alzheimer s disease and found that they were unusually low Research done by a collaborator at Columbia University found this was also true for the brains of human patients with the disease To take a closer look at the relationship between amyloid β and WAVE1 the researchers tested the brains and memories of mice genetically altered to produce high levels of amyloid β and varying levels of WAVE1 They found a dose dependent response Mice brains with low WAVE1 levels produced less amyloid β and these animals performed better on memory tests Next the researchers wanted to know how WAVE1 affects the production of amyloid β The precursor to this Alzheimer s protein is not harmful by itself and does not normally yield brain damaging products However sometimes the precursor is processed in such a way that it produces disease promoting amyloid β The team found high levels of both the amyloid precursor protein and WAVE1 in a compartment within the cell known as the Golgi which acts as a sort of shipping department Here proteins are packaged before they are sent out to various destinations within the cell In the case of the amyloid precursor protein the first destination is the cell s outer membrane From there it travels into the compartments within the cell where it is processed

    Original URL path: http://newswire.rockefeller.edu/2015/08/17/a-newly-discovered-molecular-feedback-process-may-protect-the-brain-against-alzheimers/ (2016-02-13)
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  • amyloid-β | Newswire
    with the compound RU 505 showed less inflammation and better blood flow than those of untreated mice The treated mice also performed better on memory tests More Tags Alzheimer s disease amyloid β blood clots fibrinogen Hyung Jin Ahn RU 505 Sidney Strickland March 8 2011 Science News Molecule that spurs cell s recycling center may help Alzheimer s patients A molecule that activates the cell s natural recycling program may flush away the protein fragments that accumulate and form senile plaques in Alzheimer s disease New research suggests that stimulating this activity either through drugs or natural processes may improve the quality of life for people with diseases caused by built up proteins in the brain More Tags Alzheimer s disease amyloid β Laboratory of Molecular and Cellular Neuroscience Paul Greengard Vincent Astor December 20 2010 Science News Therapy for fearsome brain disease could target blood Alzheimer s disease isn t just about twisted brain cells but also the blood vessels that feed those neurons Previous research at Rockefeller University showed that the most common element of telltale plaque deposits in Alzheimer s brains leads to the formation of tougher blood clots which could choke off oxygen flow to neurons The new research shows how these clots are formed suggesting a target for a drug that might prevent them More Tags Alzheimer s disease amyloid β Laboratory of Neurobiology and Genetics Sidney Strickland September 1 2010 Science News Scientists identify protein that spurs formation of Alzheimer s plaques Rockefeller researchers report that the cancer drug Gleevec reduces Alzheimer s plaques in a mouse model of the disease by binding to a molecule called gamma secretase activating protein or GSAP By knocking out the gene that produces GSAP the researchers reduced the primary component of senile plaques They say that

    Original URL path: http://newswire.rockefeller.edu/tag/amyloid-%ce%b2/ (2016-02-13)
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  • golgi | Newswire
    that can dampen the production of the Alzheimer s protein amyloid β These results suggest a new route in the search for therapies for this degenerative disease More Tags Alzheimer s disease amyloid β golgi Laboratory of Molecular and Cellular Neuroscience neurosciences and behavior Paul Greengard The Fisher Center for Alzheimer s Research WAVE1 Yong Kim Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/golgi/ (2016-02-13)
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  • The Fisher Center for Alzheimer’s Research | Newswire
    Fisher Center for Alzheimer s Research August 17 2015 Science News A newly discovered molecular feedback process may protect the brain against Alzheimer s Researchers have identified within neurons a series of molecular interactions known as a pathway that can dampen the production of the Alzheimer s protein amyloid β These results suggest a new route in the search for therapies for this degenerative disease More Tags Alzheimer s disease

    Original URL path: http://newswire.rockefeller.edu/tag/the-fisher-center-for-alzheimers-research/ (2016-02-13)
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  • WAVE1 | Newswire
    disease amyloid β golgi Laboratory of Molecular and Cellular Neuroscience neurosciences and behavior Paul Greengard The Fisher Center for Alzheimer s Research WAVE1 Yong Kim September 1 2006 Science News Phosphorylation of WAVE1 protein remodels neuronal connections In a paper that marks the 50th anniversary of Paul Greengard s first Nature publication Greengard Yong Kim and their colleagues show how an interaction of several proteins alters neurons scaffolding to regulate

    Original URL path: http://newswire.rockefeller.edu/tag/wave1/ (2016-02-13)
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