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  • Rockefeller ranks first among global universities in several measures of scientific impact | Newswire
    receive this many top slots U Multirank grades institutions on 31 indicators across four categories and is the largest global university ranking incorporating the most comprehensive information system according to its creators Ranked alongside much larger institutions including MIT and Harvard Rockefeller received the top spot for the citation rate of publications by university researchers the proportion of those publications that are highly cited and the number of publications cited in patents When the university s size was taken into account Rockefeller also received high honors for number of research publications and patents awarded No matter how you slice the data Rockefeller s impact in the sciences is second to none says Marc Tessier Lavigne the university s president The U Multirank survey shows that our scientific output leads the world in several categories related to the impact of its publications and patents and competes favorably with institutions many times our size The results confirm that our recipe for transformational science is uniquely effective and that our faculty s energy creativity and brilliance have made them undisputed international leaders in their fields Another European based international ranking system the CWTS Leiden Ranking which focuses solely on scientific impact has also recognized Rockefeller for having the highest percentage of frequently cited scientific publications among 750 top universities worldwide U Multirank originated with a call for a new way to compare universities internationally across a range of different activities First launched in 2014 with information from 850 institutions U Multirank s newest edition compares more than 1 200 institutions from 83 countries across five broad areas teaching and learning research knowledge transfer international orientation and regional engagement The rankings can be accessed online using an interactive tool that can drill down into the underlying data rather than relying on composite scores that

    Original URL path: http://newswire.rockefeller.edu/2015/03/31/rockefeller-ranks-first-among-global-universities-in-several-measures-of-scientific-impact/ (2016-02-13)
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  • To survive, a parasite mixes and matches its disguises, study suggests | Newswire
    family of variant surface glycoproteins VSGs At any time a single VSG covers the parasite and during an infection the parasites in the bloodstream periodically switch to a new VSG Together with Nina Papavasiliou and André and Bella Meyer Professor Emeritus George Cross Monica Mugnier a graduate student in Papavasiliou s lab set out to take a close look at these switches by tracking the VSG genes expressed over time during an infection Little is known about the dynamics of VSG switching by the sleeping sickness parasite What is known is that the coat is highly antigenic and stimulates a very strong immune response that wipes out most of the parasite population The prevailing paradigm regarding the ability of the parasite to evade the immune response comes from studies completed decades ago These suggested that a parasite changes its coat and stimulates an immune response on a weekly basis Monica s work totally upends this picture and therefore the assumptions about how this parasite interacts with the immune response says study author Associate Professor Nina Papavasiliou head of the Laboratory of Lymphocyte Biology A novel technique Mugnier developed to track the rise and fall of individual VSGs over time made this new insight possible Previously it was assumed that as the immune system begins to recognize a parasites VSG and clear it only one or a few VSGs would emerge to make up the next wave of parasites However our results contradict this paradigm Mugnier says We find as many as 80 distinct trypanosome coats at any given time This has substantial implications for the interaction of this parasite with its host Cross says For example it is now clear that the diversity of the VSGs required to maintain an extended infection exceeds the number of functional genes responsible for

    Original URL path: http://newswire.rockefeller.edu/2015/03/26/to-survive-a-parasite-mixes-and-matches-its-disguises-study-suggests/ (2016-02-13)
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  • antigenic variation | Newswire
    revealed that the blood parasites assume a surprising diversity of protein coat disguises In fact the number of disguises necessary to maintain a long term infection appears to exceed the functional genes that encode them More Tags antigenic variation F Nina Papavasiliou George Cross Laboratory of Lymphocyte Biology Monical Mugnier parasitic infection sleeping sickness Trypanosoma brucei VSG Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics

    Original URL path: http://newswire.rockefeller.edu/tag/antigenic-variation/ (2016-02-13)
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  • VSG | Newswire
    revealed that the blood parasites assume a surprising diversity of protein coat disguises In fact the number of disguises necessary to maintain a long term infection appears to exceed the functional genes that encode them More Tags antigenic variation F Nina Papavasiliou George Cross Laboratory of Lymphocyte Biology Monical Mugnier parasitic infection sleeping sickness Trypanosoma brucei VSG Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics

    Original URL path: http://newswire.rockefeller.edu/tag/vsg/ (2016-02-13)
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  • Changes in a blood-based molecular pathway identified in Alzheimer’s disease | Newswire
    disease would be a significant advance says first author Daria Zamolodchikov a postdoctoral associate in the Strickland lab The new study grew from the lab s ongoing work that looks at how the vascular system is involved in Alzheimer s disease It has been shown that amyloid β can activate a protein in plasma called factor XII the first step in a pathway known as the contact system When activated this system leads to the release of a small peptide called bradykinin a molecule known to promote potentially damaging inflammation Although some studies have found these molecules in the cerebral spinal fluid and brain tissue of Alzheimer s patients no one had studied them in Alzheimer s patient plasma Using plasma from people with and without diagnosed Alzheimer s disease the researchers measured the activation levels of the contact system They found increased activation of this system in the plasma of Alzheimer s patients potentially implicating it in the inflammatory pathology of the disease Moreover in a subset of patients whose amyloid β levels in the cerebral spinal fluid were known the researchers demonstrated a positive correlation between activation of the contact system and changes in cerebral spinal fluid amyloid β levels which as mentioned above are correlated with the development of Alzheimer s The researchers found similar activation of the contact system in mouse models of Alzheimer s which are genetically modified to overproduce amyloid β They then conducted a follow up experiment with healthy mice We went one step further and took completely normal wild type mice and injected them with amyloid β We found that on its own injection with amyloid β can activate this system It s a proof of principle in a complex environment says Zamolodchikov These findings will need to be supported by studies

    Original URL path: http://newswire.rockefeller.edu/2015/03/20/changes-in-a-blood-based-molecular-pathway-identified-in-alzheimers-disease/ (2016-02-13)
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  • diagnostic | Newswire
    hallmarks of Alzheimer s That bridge a molecular cascade known as the contact system suggests the possibility of a simple blood test that could diagnose the disease early and non invasively More Tags Alzheimer s disease amyloid β diagnostic inflammation neurobiology patricia and john rosenwald laboratory of neurobiology and genetics Sidney Strickland Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/diagnostic/ (2016-02-13)
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  • patricia and john rosenwald laboratory of neurobiology and genetics | Newswire
    and chronic inflammation two hallmarks of Alzheimer s That bridge a molecular cascade known as the contact system suggests the possibility of a simple blood test that could diagnose the disease early and non invasively More Tags Alzheimer s disease amyloid β diagnostic inflammation neurobiology patricia and john rosenwald laboratory of neurobiology and genetics Sidney Strickland Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/patricia-and-john-rosenwald-laboratory-of-neurobiology-and-genetics/ (2016-02-13)
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  • New antibody therapy dramatically improves psoriasis symptoms in clinical trial | Newswire
    something very different from our current model of treating psoriasis with immunosuppressive drugs throughout an adult lifetime says study author James Krueger director of the Milstein Medical Research Program D Martin Carter Professor in Clinical Investigation and head of the Laboratory of Investigative Dermatology It raises the possibility of working toward long term remission in other words a cure The Journal of Allergy and Clinical Immunology published the results on Thursday March 12 Psoriasis is a debilitating disease in which the body s immune system mistakenly turns on the skin producing red itchy scaly patches In 2004 Krueger and colleagues suggested a dominant role for interleukin 23 in the disease and research since then has supported this hypothesis It appears that interleukin 23 a type of immune signaling molecule known as a cytokine kicks off a cascade of interactions that leads to inflammation in the skin and excessive growth of skin cells and dilation of blood vessels The discovery of interleukin 23 s role has led to tests of a number of new antibody based therapies that target it but the compound known as BI 655066 stands out BI 655066 is a human antibody that targets interleukin 23 and blocks it from binding to the receptors on cells that respond to it Only a single treatment produced what the team describes as rapid substantial and durable clinical improvement in patients with moderate to severe psoriasis On average patients who received the treatment had a more than 80 percent improvement in the severity and extent of their skin lesions that continued until tracking ended six weeks after treatment Meanwhile genetic sequencing from skin samples revealed that the antibody s action reduced the expression of many of the cytokines and other molecules that define psoriasis J Allergy Clin Immunol online March 12

    Original URL path: http://newswire.rockefeller.edu/2015/03/13/new-antibody-therapy-dramatically-improves-psoriasis-symptoms-in-clinical-trial/ (2016-02-13)
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