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  • MRSA | Newswire
    viruses that attack them known as phage More Tags Anthrax bacteriophage C Erec Stebbins lysin MRSA Vincent A Fischetti April 4 2011 Science News Researchers put potent staph killer to the test hope for new drug treatment The ever escalating war between evolving bacteria and antibiotics could be taking a promising turn in favor of the humans Scientists have genetically engineered a powerful killer of one of the most dangerous bacteria methicillin resistant Staphylococcus aureus MRSA It s been tested on MRSA in the test tube on infections in mice and a clinical trial has begun to probe its ability to kill MRSA infected cells from psoriasis lesions in people Next up per the recommendation of the FDA is a test in minipigs It s the start of a new class of drugs says the lead researcher and early signs suggest it s stronger than anything of its kind currently on the market More Tags James Kreuger Laboratory of Bacterial Pathogenesis and Immunology Laboratory of Investigative Dermatology Mina Pastagia MRSA mupirocin Vincent Fischetti December 4 2008 Science News Scientists drill holes through deadly bacteria s Kevlar like hide At a time when bacteria continue to acquire superbug powers researchers at Rockefeller University are devising ways to strip them of their infectious properties Now they ve figured out how to drill holes through the tough hide of gram positive bacteria without obliterating them and in so doing have made it possible to study from the inside out most of the known bacteria on the planet More Tags MRSA Vincent A Fischetti July 2 2008 Science News New antibiotic beats superbugs at their own game The problem with antibiotics is that eventually bacteria outsmart them and become resistant But Rockefeller University scientists have tested a new drug called Ceftobiprole that may be

    Original URL path: http://newswire.rockefeller.edu/tag/mrsa/ (2016-02-13)
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  • Rockefeller University establishes $25 million fund for drug discovery | Newswire
    Marc Tessier Lavigne the university s president Julian Robertson s extraordinary gift will enable these projects to move forward and the fund s flexible multi tiered structure will ensure that the resources are used efficiently to support projects that have the greatest potential to benefit patients Projects will be selected for either proof of concept funding to jump start initiatives aimed at identifying and validating potential therapeutic targets or for larger early clinical development grants which will pay for drug design toxicology testing and in some cases phase I clinical trials Grant requests will be reviewed by an independent committee of experts drawn from the pharmaceutical biotech and life sciences investment industries A newly hired program director Bruce Conway will administer the grants and work with faculty to guide the design and execution of their projects Conway who has a Ph D in pharmacology and toxicology and twenty years of experience in drug discovery and early development project management has worked in both the pharmaceutical and biotech industries He will report to Rockefeller s vice president for university strategy and research operations and will work closely with its Technology Transfer Office The Robertson Therapeutic Development Fund will be an important complement to the Tri Institutional Therapeutics Discovery Institute TDI a newly formed venture with Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College designed to link academic researchers with partners in the pharmaceutical sector The Fund will support projects in the early and late stages of the drug development process that are not covered by TDI as well as biological products that are not part of TDI s current mission such as therapeutic antibodies In this way the Fund will help to bridge critical gaps in drug discovery ensuring that important findings made in the university s labs have

    Original URL path: http://newswire.rockefeller.edu/2014/01/22/rockefeller-university-establishes-25-million-fund-for-drug-discovery/ (2016-02-13)
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  • Rockefeller creates Cohn-Steinman Professorship to honor discoverers of dendritic cells | Newswire
    000 toward Rockefeller s goal of raising 3 million to create the new chair The 500 000 donation from the Steinman family came directly from his Nobel Prize winnings Zanvil Cohn left and Ralph Steinman in 1983 Marc Tessier Lavigne president of the university decided to establish the chair to create an enduring memorial to Steinman and his mentor and collaborator Cohn It was Steinman s wish during his lifetime to honor Cohn We believe there could be no more fitting tribute to the work of these two brilliant scientists than the establishment of a named chair in their honor The Cohn Steinman Professorship would honor Zan and Ralph in perpetuity and celebrate the extraordinary roles they played both on the Rockefeller campus and in the global scientific community says Tessier Lavigne To create the Cohn Steinman chair Rockefeller has received gifts totaling 1 5 million toward the 3 million goal Claudia Steinman and her children have donated the entire proceeds of Dr Steinman s Nobel Prize to charity 500 000 of which they are giving to the Cohn Steinman Professorship and 250 000 to The Steinman Family Foundation to support the careers of young scientists and science education Their generosity inspired a Rockefeller University alumnus and former faculty member to anonymously contribute 1 million to the chair in honor of Steinman and Cohn with whom he worked while at Rockefeller As a family we were very moved by the creation of this chair in Ralph and Zan s honor says Claudia Steinman The Rockefeller University was Ralph s scientific home for 40 years His commitment to mentoring and cooperation were hallmarks of his career as they were for his dear friend Zan Cohn Ralph often said none of us is as smart as all of us We know that

    Original URL path: http://newswire.rockefeller.edu/2012/04/20/rockefeller-creates-cohn-steinman-professorship-to-honor-discoverers-of-dendritic-cells/ (2016-02-13)
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  • $15 million gift from Helmsley Trust to fund research on digestive diseases | Newswire
    today but little is known about the fundamental causes and basic biology of these conditions says Marc Tessier Lavigne the university s president The grant from the Helmsley Trust will allow us to bring together faculty for intensive interdisciplinary collaboration that will pave the way for new treatments for a broad range of disorders Major progress in the medical management of digestive disorders depends on large scale efforts that integrate basic biological investigations and clinical studies says Barry S Coller the university s vice president for medical affairs and the physician in chief of The Rockefeller University Hospital who has been named founding director of the Center Rockefeller s new center will be an enormous help in this regard It will advance the work of scientists doing basic research related to the digestive system as well as those faculty members who want to accelerate the translation of their discoveries from the laboratory bench to the patient s bedside through disease focused studies in our hospital We believe that the Center will be a springboard for the development of new diagnostic tools therapeutics and preventive measures for digestive disease In addition to supporting laboratories working in the fields of immunology microbiology cancer biology and metabolic disease the new center will help fund the training of Ph D students postdoctoral researchers and physician scientists and provide seed funding for early phase projects involving promising new paths to discovery The center will also sponsor seminars symposia and retreats and provide support for the purchase of essential shared equipment We are thrilled about this grant says John Codey one of four trustees of the Helmsley Charitable Trust Some of the most interesting problems in science are found at the intersections of disciplines and the best way to solve them is through collaboration Rockefeller University

    Original URL path: http://newswire.rockefeller.edu/2012/02/27/15-million-gift-from-helmsley-trust-to-fund-research-on-digestive-diseases/ (2016-02-13)
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  • Papavasiliou and Stavropoulos receive “transformative” NIH grant | Newswire
    and Strategic Initiatives who guides the Common Fund s High Risk Research program The awards are intended to catalyze giant leaps forward for any area of biomedical research allowing investigators to go in entirely new directions Papavasiliou with Pete Stavropoulos a former Bristol Myers Squibb Postdoctoral Fellow in her laboratory propose to use the host pathogen interaction between the immune system and the organism that causes African sleeping sickness to produce novel vaccines African Trypanosomes are single celled parasitic protozoa which can be carried by insects plants birds and mammals trypanosomes are blood borne parasites with a super dense surface coat which they use as a decoy to trick the immune system into making specific and long lasting antibody responses Once antibodies are made toward the prevalent coat trypanosomes switch and the immune response starts all over again against a parasite that now looks different but isn t Papavasiliou and Stavropoulos propose to decorate trypanosome coats with disease associated targets and use these engineered trypanosomes to trick the immune system to making therapeutic antibodies against such targets which they reported in proof of principle experiments published last year This could open the door for novel vaccines to a number of communicable diseases ranging from HIV to flu as well as non communicable diseases for which antibodies to disease associated targets have been shown to ameliorate disease burden such as various cancers neurodegenerative diseases and drug addiction While using a pathogen like the African trypanosome to cure disease may seem counterintuitive or even dangerous we do this all the time with attenuated bacteria and viruses says Stavropoulos We can attenuate trypanosomes as well and their dense surface coat with tens of millions of copies of the same protein provides a unique and potent array for displaying vaccine epitopes to the immune

    Original URL path: http://newswire.rockefeller.edu/2011/09/20/papavasiliou-and-stavropoulos-receive-%e2%80%9ctransformative%e2%80%9d-nih-grant/ (2016-02-13)
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  • New Innovator Award goes to cancer researcher Sohail Tavazoie | Newswire
    of the body Chemotherapy treatments have proven effective at prolonging the lives of some patients with aggressive cancers but another large subset of patients proves resistant to the remedy The toll of chemotherapy both to the community and the individual patient is usually quite high and there exist no clinical parameters to distinguish between those who will benefit from it and those who will not resulting in a large faction of patients receiving treatment that is not only expensive and painful but also ineffective Employing molecular in vitro in vivo and human clinical analyses of colorectal cancer a particularly common and aggressive cancer Tavazoie aims to identify small pieces of RNA known as microRNAs that may signal a high potential for metastasis or that can effectively distinguish between cancers that will be responsive to chemotherapy and those that would be better candidates for alternative and experimental therapies Tavazoie received his Ph D from Harvard University and his M D from Harvard Medical School and the Harvard MIT Division of Health Sciences and Technology Following a residency and internship at Brigham and Women s Hospital and Harvard Medical School he joined Memorial Sloan Kettering Cancer Center as a clinical fellow in 2005 and became a research fellow in medical oncology in 2006 He joined Rockefeller as Leon Hess Assistant Professor earlier this year Tavazoie is a recipient of the American Society of Clinical Oncology Young Investigator Award and was named a Rita Allen Foundation Scholar and a Sidney Kimmel Foundation for Cancer Research Scholar Established in 2007 the Director s New Innovator Award program is designed to support unusually creative new investigators with highly innovative research ideas at an early stage of their career when they may lack the preliminary data required for NIH s more traditional funding vehicles To that

    Original URL path: http://newswire.rockefeller.edu/2009/09/24/new-innovator-award-goes-to-cancer-researcher-sohail-tavazoie/ (2016-02-13)
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  • Rockefeller virologists and MIT tissue engineers receive $5.8 million NIH grant to study hepatitis | Newswire
    in the way of developing treatments Both viruses for example employ robust replication systems that are difficult to permanently disrupt The hepatitis C virus furthermore has already exhibited resistance to antiviral drugs currently available to help fight it Coinfection with both viral strains is relatively common compounding their individual impacts And scientists do not currently have in vitro or in vivo models that accurately imitate human liver biology and pathogenesis which would help facilitate research In collaboration with Sangeeta N Bhatia professor in the Harvard MIT Division of Health Sciences and Technology researchers in Rockefeller s Laboratory of Virology and Infectious Disease headed by Charles M Rice Maurice R and Corinne P Greenberg Professor first aim to address this last issue by refining cell culture techniques recently developed by Bhatia and Salman Khetani a former postdoctoral associate in Bhatia s laboratory who is now director of research at Hepregen Recent investigations with such cultures by Alexander Ploss a research associate in the Rice lab have already revealed important insights about the disease progression of the two viruses The team is also developing three dimensional human liver organoids for use in mice reconstituted with a human immune system With these tools Rice Bhatia Ploss and their colleagues propose to characterize hepatitis B and C infections to clarify how they influence each other on both the cellular and systemic levels and ultimately to inform the development of novel preventive and therapeutic remedies The Transformative R01 TR01 program was launched this year under the NIH Roadmap for Medical Research an umbrella program established in 2004 to identify and address traditional roadblocks to innovative research TR01 grants support exceptionally innovative high risk original and or unconventional research projects that have the potential to create or overturn fundamental paradigms These projects tend to be inherently

    Original URL path: http://newswire.rockefeller.edu/2009/09/24/rockefeller-virologists-and-mit-tissue-engineers-receive-5-8-million-nih-grant-to-study-hepatitis/ (2016-02-13)
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  • National Institutes of Health | Newswire
    the notoriously complex mechanisms underlying hepatitis B and C virus infection More Tags hepatitis C National Institutes of Health October 3 2006 Grants and Gifts Rockefeller University receives 45 million NIH grant for clinical translational science With the award Rockefeller University has established the Center for Clinical and Translational Science which will bring together translational researchers at Rockefeller University and its affiliated and collaborating institutions In addition the award will support a new training program for physician scientists entering careers in translational research More Tags National Institutes of Health October 6 2005 Grants and Gifts Rockefeller researchers receive 10 million grant to study how molecules interact within cells The National Center for Research Resources at the National Institutes of Health announced this week that Rockefeller s Michael P Rout will be a recipient of a five year 10 million grant to study how molecules interact with one another within and between cells More Tags Michael P Rout National Center for Research Resources National Institutes of Health September 29 2005 Awards and Honors Titia de Lange receives NIH Pioneer Award The National Insitutes of Health has selected Titia de Lange who examines how cells respond to DNA damage to receive up to 500 000 in direct costs per year for five years The prestigious Pioneer Award now in its second year supports groundbreaking high risk research that if successful will have a significant impact More Tags National Institutes of Health Pioneer Award Titia de Lange June 29 2005 Grants and Gifts Rockefeller University vaccine researchers selected for grant from Foundation for NIH A team of researchers led by Rockefeller University immunologist Ralph M Steinman M D has been selected for a grant offer from the Foundation for the NIH FNIH of 14 million to support the design of novel vaccines that

    Original URL path: http://newswire.rockefeller.edu/tag/national-institutes-of-health/ (2016-02-13)
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