archive-edu.com » EDU » R » ROCKEFELLER.EDU

Total: 1631

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • 2014 | Newswire | Page 2
    that uses radio waves or magnetic fields to turn neurons on or off remotely This tool may allow them to study the role of neural circuits in behavior More Tags BRAIN Initiative neuroscience radiogenetics Sarah Stanley October 5 2014 Science News Programmable antibiotic harnesses an enzyme to attack drug resistant microbes By co opting a system bacteria normally use to defend themselves researchers targeted and killed off colonies of the antibiotic resistant Staph cells on mouse skin The treatment left behind the drug susceptible microbes More Tags antibiotic resistance Cas9 CRISPR David Bikard Luciano Marraffini Vincent Fischetti October 2 2014 Awards and Honors Rockefeller postdoc Stephen Brohawn named Blavatnik Award regional finalist Brohawn a member of Roderick MacKinnon s Laboratory of Molecular Neurobiology and Biophysics studies how proteins called mechanosensitive ion channels sense mechanical forces He is one of nine finalists from the New York region More Tags Blavatnik Award September 29 2014 Awards and Honors Stanford s Lucy Shapiro to receive 2014 Pearl Meister Greengard Prize The Rockefeller University has announced that Lucy Shapiro professor of developmental biology at Stanford University School of Medicine will receive the 2014 Pearl Meister Greengard Prize The annual award which celebrates the achievements of outstanding women in science will be presented to Shapiro on the Rockefeller campus November 11 More Tags Pearl Meister Greengard Prize September 24 2014 Science News New technique reveals a role for histones in cell division Researchers have found that key aspects of cell division such as the formation of the support structure for the envelope that surrounds the nucleus depend on the presence of DNA organizing proteins known as histones More Tags cell division Christian Zierhut Hironori Funabiki histones mitotic spindle nuclear envelope nuclear pore complex nucleosomes September 23 2014 Science News Imaging studies open a window on how effective antibodies are formed By imaging the immune response researchers have observed how two types of immune cells interact with one another during a critical period following infection in order to prepare the best antibodies and establish long lasting protection More Tags antibodies B cells fluorescent microscopy germinal center immunology Laboratory of Molecular Immunology Michel C Nussenzweig t cells September 17 2014 Campus News Hironori Funabiki promoted to professor Funabiki s research has pointed to a role for DNA packaging proteins known as histones in the formation of structures involved in cell division with implications for understanding and treating disease More Tags chromosomes Hironori Funabiki histones mitosis September 15 2014 In the News In the News Washington Post New cool videos from NIH look at Alzheimer s heart attacks MS coral reefs A stop heart attack refrain echoes through Rockefeller University s molecular biomedicine music video featuring some flashy animation and seriously geeky dancing Tags Barry S Coller September 2 2014 Science News Research hints at why stress is more devastating for some Some bounce back from stress while others struggle with it even developing anxiety and depression as a result In experiments with mice researchers have revealed the

    Original URL path: http://newswire.rockefeller.edu/2014/page/2/ (2016-02-13)
    Open archived version from archive


  • In the News – WSJ – Greengard | Newswire
    brain are all speaking to each other We re trying to figure out how they re speaking to each other Dr Greengard continued I m sure our brains are working unconsciously When you have a creative thought it s parts of the brain talking to each other without your awareness Tags Paul Greengard Pearl Meister Greengard Prize newswire rockefeller edu New research suggests an existing drug riluzole may prevent foggy

    Original URL path: http://newswire.rockefeller.edu/2014/12/22/in-the-news-wsj-greengard/ (2016-02-13)
    Open archived version from archive

  • In the News – Time – Vosshall | Newswire
    Vosshall of Rockefeller University in New York who led the study published in the journal Nature We provide the ideal lifestyle for mosquitoes We always have water around for them to breed in we are hairless and we live in large groups newswire rockefeller edu Research suggests how mosquitoes evolved an attraction to human scent 150 million from the Stavros Niarchos Foundation and David Rockefeller launches major campus extension Comments

    Original URL path: http://newswire.rockefeller.edu/2014/11/13/9002/ (2016-02-13)
    Open archived version from archive

  • New technique efficiently turns antibodies into highly tuned ‘nanobodies’ | Newswire
    much easier to grow in bacterial factories They can also access hard to reach places that may be off limits to larger molecules Nanobodies have tremendous potential as versatile and accessible alternatives to conventional antibodies but unfortunately current techniques present a bottleneck to meeting the demand for them says study author Michael Rout head of the Laboratory of Cellular and Structural Biology We hope that our system will make high affinity nanobodies more available and open up many new possible uses for them In their first studies the team generated high affinity antibodies those that are capable of most precisely binding to their targets directed against two fluorescent proteins that biologists often use as markers to visualize activity within cells GFP and mCherry Their new system like existing ones for generating antibodies begins with an animal in this case llamas housed in a facility in Massachusetts Llamas were chosen because the antibody variants they produce are easily modified to generate nanobodies which are only one tenth the weight of a regular antibody The llamas were immunized with GFP and mCherry prompting their immune systems to generate antibodies against these foreign proteins known as antigens The key was to figure out a relatively fast way of determining the genetic sequences of the antibodies that bind to the targets with the greatest affinity Up until now obtaining these high affinity sequences has been something of a holy grail says Brian Chait Camille and Henry Dreyfus Professor and head of the Laboratory of Mass Spectrometry and Gaseous Ion Chemistry Once those sequences are obtained it s easy to engineer bacteria to mass produce the antibodies The researchers led by graduate student Peter Fridy and postdoc Yinyin Li started by making antibody sequence databases from RNA isolated out of antibody producing cells in the llamas bone marrow Next they picked out the tightest binding GFP and mCherry antibodies from blood samples from the same llamas and chemically cut these into smaller pieces keeping only the antigen binding section to create nanobodies They then determined partial sequences of the amino acids that made up the protein of the nanobodies with a technique known as mass spectrometry Using a computer algorithm called llama magic developed by David Fenyö and Sarah Keegan of New York University School of Medicine they matched up the composition of the highest affinity nanobodies with the original RNA sequences With the sequences they could engineer bacteria to mass produce the nanobodies before putting them to use in experiments Antibodies are often used to isolate a particular structure within a cell so scientists can remove and examine it and the team did just that with their new nanobodies They purified various cellular structures tagged with GFP or mCherry and also visualized these structures in situ All in all their procedure generated 25 types of nanobodies capable of precisely targeting GFP and six for mCherry a far more diverse set of high affinity nanobodies than is typically possible with conventional techniques This abundance opens

    Original URL path: http://newswire.rockefeller.edu/2014/11/02/new-technique-efficiently-turns-antibodies-into-highly-tuned-nanobodies/ (2016-02-13)
    Open archived version from archive

  • Brian Chait | Newswire
    scientists haven t been able to take advantage of them However a new technique may make nanobodies dramatically more accessible for all kinds of research More Tags antibodies Brian Chait Laboratory of Cellular and Structural Biology Laboratory of Mass Spectrometry and Gaseous Ion Chemistry Michael Rout nanobodies Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact

    Original URL path: http://newswire.rockefeller.edu/tag/brian-chait/ (2016-02-13)
    Open archived version from archive

  • Laboratory of Mass Spectrometry and Gaseous Ion Chemistry | Newswire
    Ion Chemistry Michael Rout nanobodies December 10 2009 Science News Bacterial protein mimics its host to disable a key enzyme Bacteria use all sorts of cunning to trick hosts into doing their bidding One con in their bag of tricks the molecular mimic In this ruse bacteria or their agents look for all purposes like some native molecule in a cell but then do not behave accordingly Working with H pylori the bacterium responsible for gastric ulcers and cancer researchers have revealed one way bacteria pull this off deciphering the structure of a piece of CagA a bacterial protein that impersonates a human protein in order to disable a key enzyme More Tags Brian T Chait C Erec Stebbins Laboratory of Mass Spectrometry and Gaseous Ion Chemistry Laboratory of Structural Microbiology December 8 2009 Science News New molecule identified in DNA damage response Evolution places the highest premium on reproduction natural selection s only standard for biological success In the case of replicating cells life spares no expense to ensure that the offspring is a faithful copy of the parent Researchers have identified a new player in this elaborate system of quality control a gene whose mutation can cause a

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-mass-spectrometry-and-gaseous-ion-chemistry/ (2016-02-13)
    Open archived version from archive

  • nanobodies | Newswire
    haven t been able to take advantage of them However a new technique may make nanobodies dramatically more accessible for all kinds of research More Tags antibodies Brian Chait Laboratory of Cellular and Structural Biology Laboratory of Mass Spectrometry and Gaseous Ion Chemistry Michael Rout nanobodies Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow

    Original URL path: http://newswire.rockefeller.edu/tag/nanobodies/ (2016-02-13)
    Open archived version from archive

  • In the News – HuffPostSci – Friedman | Newswire
    t pillory people for being very tall or short Jeffrey Friedman said so it makes no sense to blame obese people for being that way or for obese people to feel ashamed Tags Jeffrey M Friedman Obesity newswire rockefeller edu In the News ABC McEwen New technique efficiently turns antibodies into highly tuned nanobodies Comments are closed Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics

    Original URL path: http://newswire.rockefeller.edu/2014/10/27/in-the-news-huffpostsci-friedman/ (2016-02-13)
    Open archived version from archive