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  • Nature online: December 14, 2011 | Newswire
    miR 126 an miRNA silenced in a variety of common human cancers non cell autonomously regulates endothelial cell recruitment to metastatic breast cancer cells in vitro and in vivo Through loss of function and epistasis experiments we delineate an miRNA regulatory network s individual components as novel and cell extrinsic regulators of endothelial recruitment angiogenesis and metastatic colonization newswire rockefeller edu Nature Genetics December 11 2011 In cancer molecular signals

    Original URL path: http://newswire.rockefeller.edu/2011/12/14/nature-online-december-14-2011/ (2016-02-13)
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  • Nature Genetics: December 11, 2011 | Newswire
    John Tolmie Alain Verloes Jean Laurent Casanova Arnold Munnich and Valérie Cormier Daire Using exome sequencing of individuals with Myhre syndrome we identified SMAD4 as a candidate gene that contributes to this syndrome on the basis of its pivotal role in the bone morphogenetic pathway BMP and transforming growth factor TGF β signaling We identified three distinct heterozygous missense SMAD4 mutations affecting the codon for Ile500 in 11 individuals with

    Original URL path: http://newswire.rockefeller.edu/2011/12/11/nature-genetics-december-11-2011/ (2016-02-13)
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  • 2011 Nobel Prize Ceremony to be webcast live | Newswire
    XVI Gustaf of Sweden The ceremony will be Webcast live beginning at 10 20 a m Eastern Time A video of the Nobel Prize Award Ceremony will also be available a few days later The Nobel Prize Award Ceremony takes place at the Stockholm Concert Hall Sweden on December 10 every year the anniversary of Alfred Nobel s death At the ceremony the Nobel Prize in physics chemistry physiology or medicine literature and the Prize in economic sciences are awarded to the Nobel Laureates Earlier this week Rockefeller University s Michel C Nussenzweig Sherman Fairchild Professor and head of the Laboratory of Molecular Immunology gave the Nobel Lecture in physiology or medicine at the Karolinska Institute on Steinman s behalf A video of his lecture will be available at the Nobel Prize Web site soon UPDATE 12 13 2011 The Nobel Prize Web site now has a photo gallery and video from Saturday s award ceremony as well as video of Michel Nussenzweig s Nobel lecture on behalf of Steinman Tags Michel C Nussenzweig nobel prize Ralph M Steinman newswire rockefeller edu Contact Joseph Bonner 212 327 8998 Nature online December 4 2011 Nature Genetics December 11 2011 Comments are

    Original URL path: http://newswire.rockefeller.edu/2011/12/09/2011-nobel-prize-ceremony-to-be-webcast-live/ (2016-02-13)
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  • Nature online: December 4, 2011 | Newswire
    structure shows how one layer of the gating ring in response to the binding of Ca 2 opens like the petals of a flower The degree to which it opens explains how Ca 2 binding can open the transmembrane pore These findings present a molecular basis for Ca 2 activation of K channels and suggest new possibilities for targeting the gating ring to treat conditions such as asthma and hypertension

    Original URL path: http://newswire.rockefeller.edu/2011/12/04/nature-online-december-4-2011/ (2016-02-13)
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  • Resident protection | Newswire
    to see that this entirely different population of dendritic cells inside lymph nodes form what looks like a stationary network says first author Randall Lindquist a Rockefeller University graduate student in the Laboratory of Molecular Immunology headed by Professor Michel Nussenzweig The network dendritic cells are just sitting there waving their processes They re not migrating Lindquist added To visualize the dendritic cells found tucked deep inside the lymph nodes alongside the body s nascent B and T cells the Rockefeller part of the research team created laboratory mice genetically modified so that their immature dendritic cells release a yellow fluorescent protein The protein coupled with a microscopic imaging technique that excites the fluorescent molecules with infrared light creates perfect conditions for studying molecular activity in living systems This imaging study has never been done before says first author Randall Lindquist All of the other live microscopy experiments looking at dendritic cells in lymph nodes used cells that came from other sources and that were labeled with fluorescent dye Lindquist and his colleagues imaging technique preserves the immune system s natural conditions to the fullest extent possible and most closely represents how the immune system really works Dendritic cells when mature spur B and T cells to seek and destroy foreign invaders usually microbes Dendritic cells in the non migrating network are a combination of mature and immature However Rockefeller scientists believe that this colony of dendritic cells specializes in informing T and B cells what the body s own tissues look like so that they are safe in the case of a real immune system emergency This immature but informative activity of dendritic cells is part of what immunologists call the steady state of the immune system The much studied mobile population of dendritic cells seems to interact with

    Original URL path: http://newswire.rockefeller.edu/2011/12/01/resident-protection/ (2016-02-13)
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  • In the News | Newswire
    unstoppable trend that is the logical outcome of what economists call the environmental Kuznets curve after its inventor Simon Kuznets This suggests that as countries industrialize they pass through an early cheap and dirty phase when they waste resources and generate massive pollution but they pass a tipping point beyond which they begin to invest in using resources more efficiently newswire rockefeller edu Cell online November 30 2011 Resident protection

    Original URL path: http://newswire.rockefeller.edu/2011/11/30/in-the-news-18/ (2016-02-13)
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  • Cell online: November 30, 2011 | Newswire
    structures of σ domain 2 bound to single stranded DNA bearing 10 element sequences The structures along with biochemical data support a model where the recognition of the 10 element sequence drives initial promoter opening as the bases of the nontemplate strand are extruded from the DNA double helix and captured by σ newswire rockefeller edu Nature online November 27 2011 In the News Comments are closed Search for Categories

    Original URL path: http://newswire.rockefeller.edu/2011/11/30/cell-online-november-30-2011/ (2016-02-13)
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  • Nature online: November 27, 2011 | Newswire
    Fumiaki Ohtake Hirochika Kitagawa Robert G Roeder Myles Brown and Shigeaki Kato In a genome wide analysis H2B S112 GlcNAcylation sites were observed widely distributed over chromosomes including transcribed gene loci with some sites co localizing with H2B K120 monoubiquitination These findings suggest that H2B S112 GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination presumably for transcriptional activation newswire rockefeller edu Immunity 35 819 831 November 23 2011 Cell

    Original URL path: http://newswire.rockefeller.edu/2011/11/27/nature-online-november-27-2011/ (2016-02-13)
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