archive-edu.com » EDU » R » ROCKEFELLER.EDU

Total: 1631

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Immunity 35: 819–831 (November 23, 2011) | Newswire
    Velinzon In Hyuk Jung Ji Young Yoo Goo Taeg Oh and Ralph M Steinman Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages We looked for these cells in the steady state adult mouse aorta and surprisingly we found a dominance of dendritic cells DCs in the intima newswire rockefeller edu Statin intolerant patients need a different type of clinical trial Rockefeller researchers say

    Original URL path: http://newswire.rockefeller.edu/2011/11/23/immunity-35-819%e2%80%93831-november-23-2011/ (2016-02-13)
    Open archived version from archive

  • Statin-intolerant patients need a different type of clinical trial, Rockefeller researchers say | Newswire
    the discrepancy of reported adverse effects For example high levels of an enzyme called creatine phosphokinase typically indicate statin associated myopathy but this condition is not necessarily accompanied by elevated levels of this enzyme Finally cognitive impairment the most common neurologic problem associated with statin use is generally not measured in the clinic or it s disregarded as a consequence of aging Maningat and Breslow argue that introduction of new drugs for people who can t tolerate statins lags because most non statin therapies are tested in clinical trials as additive therapies on top of statins For example in a recent trial on the benefits of combining niacin with statins called the AIM HIGH trial 94 percent of those enrolled were taking a statin drug at the time they were enrolled In this study niacin combined with a statin was found to have no cardiovascular benefits and a trend towards increased risk of ischemic strokes In the AIM HIGH trial niacin was not found to be useful when combined with a statin and indeed it might be harmful says Breslow Fortunately we do know that niacin alone can be beneficial However if a new drug was tested with a statin and the same result was found it would be impossible to determine if it had standalone benefits and its value would be lost for statin intolerant patients Since statins have been shown to reduce the risk of cardiovascular disease and have become standard of care placebos are considered by some experts to be unacceptable when studying the effectiveness of new cholesterol modifying drugs and therefore most studies employ the study drug as an add on to statin therapy That severely complicates the conduct of meaningful trials for statin intolerant patients But Maningat and Breslow say that pragmatic trials which occur

    Original URL path: http://newswire.rockefeller.edu/2011/11/17/statin-intolerant-patients-need-a-different-type-of-clinical-trial-rockefeller-researchers-say/ (2016-02-13)
    Open archived version from archive

  • In the News | Newswire
    he has an idealistic view of science as a liberalising and progressive force for humanity He sees science as a truly international activity that breaks down barriers between the peoples of the world Science he says is a profoundly aesthetic experience which gives pleasure not unlike the reading of a great poem newswire rockefeller edu Nature online November 13 2011 Statin intolerant patients need a different type of clinical trial

    Original URL path: http://newswire.rockefeller.edu/2011/11/14/in-the-news-16/ (2016-02-13)
    Open archived version from archive

  • Nature online: November 13, 2011 | Newswire
    docks in the analogous groove that binds DNA substrates in PLs Conserved Trp 536 juts into the CRY catalytic centre to mimic PL recognition of DNA photolesions The FAD anionic semiquinone found in the crystals assumes a conformation to facilitate restructuring of the tail helix These results help reconcile the diverse functions of the CRY PL family by demonstrating how conserved protein architecture and photochemistry can be elaborated into a

    Original URL path: http://newswire.rockefeller.edu/2011/11/13/nature-online-november-13-2011/ (2016-02-13)
    Open archived version from archive

  • In the News | Newswire
    the biggest discoveries in the science of memory And she s still working today at McGill University in Montreal Canada She s also the winner of the prestigious Pearl Meister Greengard Prize for her achievements which includes 100 000 in award money newswire rockefeller edu In the News Nature online November 13 2011 Comments are closed Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/2011/11/08/in-the-news-19/ (2016-02-13)
    Open archived version from archive

  • In the News | Newswire
    New York she would be picking up a major award the Pearl Meister Greengard Prize which honors female researchers who have made extraordinary contributions to the biomedical sciences She is the eighth recipient of the prize since its creation by Paul Greengard a neuroscientist at Rockefeller University who used his own funds including his award for winning the Nobel Prize in Physiology or Medicine along with contributions from his university

    Original URL path: http://newswire.rockefeller.edu/2011/11/06/in-the-news-20/ (2016-02-13)
    Open archived version from archive

  • University joins 10 leading medical and research institutions to form New York Genome Center | Newswire
    2012 its 120 000 square foot facility will be located in Manhattan Joining Rockefeller are Cold Spring Harbor Laboratory Columbia University Cornell University Weill Cornell Medical College Memorial Sloan Kettering Cancer Center Mount Sinai Medical Center NewYork Presbyterian Hospital New York University NYU School of Medicine North Shore LIJ Health System The Jackson Laboratory and Stony Brook University The Hospital for Special Surgery is an associate founding member The NYGC receives support from New York City as well as private companies and foundations In the decade since the human genome was sequenced the application of high throughput sequencing and other genomic tools has led to great advances in identifying the genetic drivers of several cancers and other diseases and is dramatically accelerating the development of new drugs for these conditions says Marc Tessier Lavigne president of The Rockefeller University The New York Genome Center and the collaborations it affords will enable us to apply these powerful tools even more broadly to extend this success to many other diseases Through this collaboration scientists and physicians from member institutions will share diverse clinical and genomic data on a scale not yet realized in order to discover the molecular underpinnings of disease identify

    Original URL path: http://newswire.rockefeller.edu/2011/11/03/university-joins-10-leading-medical-and-research-institutions-to-form-new-york-genome-center/ (2016-02-13)
    Open archived version from archive

  • 2010 | Newswire
    Cheolho Cheong dendritic cells Laboratory of Cellular Physiology and Immunology Michel C Nussenzweig Ralph M Steinman October 19 2010 Science News Reaper protein strikes at mitochondria to kill cells Many billions of cells in the human body kill themselves every day as the old and decrepit make way for the new and healthy This process of programmed cell death called apoptosis is crucial in early development and in the routine maintenance of life New research conducted in the cells of fruit fly eyes delves into the molecular complexity of the process and returns fresh insights about the proteins that initiate cell death The results suggest a technique that could allow for highly efficient targeted killing of problematic cells such as those that drive the uncontrolled growth of tumors More Tags Cristinel Sandu Hermann Steller Strang Laboratory of Apoptosis and Cancer Biology October 18 2010 Science News New faculty member wants to know how flies make decisions Gaby Maimon who will join the university on January 1 has developed a unique system for studying the neural basis for decision making in fruit flies By using fluorescence microscopy and glass capillaries pulled to ultrafine tips Maimon records the electrical activity of specific neurons in the fly brain as it flies allowing him to understand what s going on as the fly is exposed to and reacts to various stimuli More Tags Drosophila melanogaster Gaby Maimon October 14 2010 Science News Gene identified that prevents stem cells from turning cancerous Stem cells have tremendous regenerative power but their potency can also be lethal Now researchers have identified a gene that prevents stem cells from turning into tumors in mice by regulating the process of programmed cell death or apoptosis The work is the first to show that interfering with the programmed death of stem cells can have fatal consequences More Tags ARTS Hermann Steller Maria Garcia Fernandez stem cells Strang Laboratory of Apoptosis and Cancer Biology October 13 2010 Awards and Honors Robert G Roeder to receive Salk Institute Medal for Research Excellence Robert G Roeder head of the Laboratory of Biochemistry and Molecular Biology will receive the Salk Institute s Medal for Research Excellence for his contributions to the understanding of RNA synthesis in animal cells More Tags Laboratory of Biochemistry and Molecular Biology RNA synthesis Robert G Roeder Salk Institute s Medal for Research Excellence October 11 2010 Awards and Honors Two Rockefeller scientists elected to Institute of Medicine Rockefeller University scientists Robert B Darnell head of the Laboratory of Molecular Neuro oncology and Titia de Lange head of the Laboratory of Cell Biology and Genetics have been elected to the Institute of Medicine the health and medicine branch of the National Academy of Sciences More Tags Laboratory of Cell Biology and Genetics Laboratory of Molecular Neuro oncology Robert B Darnell Titia de Lange October 7 2010 Campus News Paul Nurse named top of the list of 100 most important people in British science Rockefeller University President Paul Nurse has been

    Original URL path: http://newswire.rockefeller.edu/2010/ (2016-02-13)
    Open archived version from archive