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  • community engagement | Newswire
    River Esplanade between 63rd and 68th Streets as part of the campus extension project The esplanade will also be improved with a new bike lane landscaping and a noise barrier along the FDR Drive More Tags community engagement Marie Josée and Henry R Kravis Research Building Stavros Niarchos Foundation David Rockefeller River Campus Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014

    Original URL path: http://newswire.rockefeller.edu/tag/community-engagement/ (2016-02-13)
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  • Marie-Josée and Henry R. Kravis Research Building | Newswire
    supports the East River Esplanade between 63rd and 68th Streets as part of the campus extension project The esplanade will also be improved with a new bike lane landscaping and a noise barrier along the FDR Drive More Tags community engagement Marie Josée and Henry R Kravis Research Building Stavros Niarchos Foundation David Rockefeller River Campus Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/marie-josee-and-henry-r-kravis-research-building/ (2016-02-13)
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  • Stavros Niarchos Foundation–David Rockefeller River Campus | Newswire
    supports the East River Esplanade between 63rd and 68th Streets as part of the campus extension project The esplanade will also be improved with a new bike lane landscaping and a noise barrier along the FDR Drive More Tags community engagement Marie Josée and Henry R Kravis Research Building Stavros Niarchos Foundation David Rockefeller River Campus Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/stavros-niarchos-foundation-david-rockefeller-river-campus/ (2016-02-13)
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  • Researchers discover new aspect of gene regulation and a possible target for cancer drugs | Newswire
    therapeutics act in the cell and could facilitate future drug development The human body is made up of more than 200 different cell types and the specific complement of genes that are active defines one cell type from another A skin cell uses different genes than a neuron just as a healthy cell activates different genes than a leukemia cell Because gene regulation is so important the cell uses a highly intricate multi step process to convert the genes encoded in our DNA into proteins In one of the earliest steps a molecular machine called RNA polymerase II races along the gene transcribing the DNA letters into a message RNA that can later be translated into proteins More than a decade ago researchers discovered that RNA polymerase II can pause at the beginning of genes Most cells use around half their 20 000 genes at any given time explains co first author Ming Yu a postdoc in the lab RNA Polymerase II is paused at about 75 percent of those genes making it a very important form of gene regulation for the cell In the recent study the team sought to identify new regulators that release the paused polymerase They identified a complex of six proteins known as PAF1C that is essential for the polymerase to launch across the gene In the past researchers thought that PAF1C functioned much later in transcription says Roeder but we have found a novel role for the complex at the very beginning in the release of the poised transcription machinery In experiments in which they reduced PAF1C levels in cells the team found that RNA polymerase II failed to release and remained paused at the start of the gene The extended pause has a significant effect on gene expression We found that reducing PAF1C

    Original URL path: http://newswire.rockefeller.edu/2015/12/10/researchers-discover-new-aspect-of-gene-regulation-and-a-possible-target-for-future-cancer-drugs/ (2016-02-13)
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  • gene regulation | Newswire
    Molecular Biology Ming Yu PAF1C RNA polymerase pausing Robert G Roeder Robert Roeder November 10 2014 Awards and Honors C David Allis wins the 2015 Breakthrough Prize in Life Sciences Allis is recognized for his foundational research on the unexpected regulation of gene activation by modifications to proteins that package DNA work with implications for many diseases including cancer The Breakthrough Prize is worth 3 million making it the richest prize in the life sciences roughly double the Nobel Prize More Tags Breakthrough Prize C David Allis chromatin epigenetics gene regulation histones Laboratory of Chromatin Biology and Epigenetics October 31 2005 Science News High blood pressure linked to gene regulation Genes as much as treadmills and salads dictate blood pressure But new research from Rockefeller University suggests that even the tiniest changes to our DNA can create a predisposition to hypertension More Tags gene regulation Jurg Ott February 24 2000 Science News Rockefeller University researchers identify protein that regulates RNA in nerve tissue Protein may play a key role in nervous system function Rockefeller University researchers have identified a protein that is responsible for regulating RNA splicing in nerve cells a process essential for the development and operation of complex

    Original URL path: http://newswire.rockefeller.edu/tag/gene-regulation/ (2016-02-13)
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  • genomics and genetics | Newswire
    in which the DNA transcribing enzyme hesitates before going to work Experiments have identified the complex of proteins that helps restart this enzyme when it stalls and so helped to explain how some promising cancer drugs work More Tags gene regulation genomics and genetics Laboratory of Biochemistry and Molecular Biology Ming Yu PAF1C RNA polymerase pausing Robert G Roeder Robert Roeder Search for Categories Science News Awards and Honors Campus

    Original URL path: http://newswire.rockefeller.edu/tag/genomics-and-genetics/ (2016-02-13)
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  • Laboratory of Biochemistry and Molecular Biology | Newswire
    broader role in the disease More Tags acute myeloid leukemia cancer Laboratory of Biochemistry and Molecular Biology Mo Chen Robert Roeder August 13 2015 Awards and Honors Luciano Marraffini and Robert Roeder recognized by ASBMB awards Marraffini who studies the adaptive immune systems known as CRISPR Cas systems found in some bacteria and used in genome editing has won the Earl and Thressa Stadtman Scholar Award Meanwhile Robert Roeder who investigates the mechanisms that regulate transcription the process by which genes are copied into RNA is the recipient of the Herbert Tabor Research Award More Tags ASBMB awards and honors Laboratory of Bacteriology Laboratory of Biochemistry and Molecular Biology Luciano Marraffini Robert Roeder March 28 2012 Awards and Honors Albany Medical Center Prize awarded to James E Darnell Jr and Robert G Roeder Praised as towering figures in cell research the scientists are being recognized for helping to define how cells grow replicate and become specialized and in turn giving medical professionals and researchers the tools to improve health and combat diseases James E Darnell Jr head of the Laboratory of Molecular Cell Biology and Robert G Roeder head of the Laboratory of Biochemistry and Molecular Biology will share the 500 000 prize from the 12th annual award given at a May 11 ceremony in Albany NY More Tags Albany Medical Center Prize James E Darnell Jr Laboratory of Biochemistry and Molecular Biology Laboratory of Molecular Cell Biology Robert G Roeder October 13 2010 Awards and Honors Robert G Roeder to receive Salk Institute Medal for Research Excellence Robert G Roeder head of the Laboratory of Biochemistry and Molecular Biology will receive the Salk Institute s Medal for Research Excellence for his contributions to the understanding of RNA synthesis in animal cells More Tags Laboratory of Biochemistry and Molecular Biology

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-biochemistry-and-molecular-biology/ (2016-02-13)
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  • Ming Yu | Newswire
    in which the DNA transcribing enzyme hesitates before going to work Experiments have identified the complex of proteins that helps restart this enzyme when it stalls and so helped to explain how some promising cancer drugs work More Tags gene regulation genomics and genetics Laboratory of Biochemistry and Molecular Biology Ming Yu PAF1C RNA polymerase pausing Robert G Roeder Robert Roeder Search for Categories Science News Awards and Honors Campus

    Original URL path: http://newswire.rockefeller.edu/tag/ming-yu/ (2016-02-13)
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