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  • Sound investment: A new mathematical method provides a better way to analyze noise | Newswire
    could make into a histogram a visual two dimensional map of how a sound s individual frequencies move in time When they tested their technique against other sound analysis programs they found that it gave them a much greater ability to tease out the sound they were interested in from the noise that surrounded it One fundamental observation enabled this vast improvement They were able to visualize the areas in which there was no sound at all The two researchers used white noise hissing similar to what you might hear on an un tuned FM radio because it s the most complex sound available with exactly the same amount of energy at all frequency levels When they plugged their algorithm into a computer it reassigned each tone and plotted the data points on a graph in which the x axis was time and the y axis was frequency The resulting histograms showed thin froth like images each bubble encircling a blue spot Each blue spot indicated a zero or a moment during which there was no sound at a particular frequency There is a theorem Magnasco says that tells us that we can know what the sound was by knowing when there was no sound In other words their pictures were being determined not by where there was volume but where there was silence If you want to show that your analysis is a valid signal estimation method you have to understand what a sound looks like when it s embedded in noise Magnasco says So he added a constant tone beneath the white noise That tone appeared in their histograms as a thin yellow band bubble edges converging in a horizontal line that cut straight through the center of the froth This he says proves that their algorithm is

    Original URL path: http://newswire.rockefeller.edu/2006/06/07/sound-investment-a-new-mathematical-method-provides-a-better-way-to-analyze-noise/ (2016-02-13)
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  • algorithm | Newswire
    fast and researchers say that s because the brain can perform a series of intricate calculations that translate minimal input into maximal understanding In a potential breakthrough in sound analysis Rockefeller researchers have now created an algorithm that mimics human auditory processing and is proving far more accurate than any other sound analysis program available More Tags algorithm hearing Marcelo O Magnasco sound Search for Categories Science News Awards and

    Original URL path: http://newswire.rockefeller.edu/tag/algorithm/ (2016-02-13)
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  • Marcelo O. Magnasco | Newswire
    from going haywire More Tags Marcelo O Magnasco Neural networks June 7 2006 Science News Sound investment A new mathematical method provides a better way to analyze noise Even though the brain has only a small fraction of its sensory receptors dedicated to sound the human auditory system is lightning fast and researchers say that s because the brain can perform a series of intricate calculations that translate minimal input

    Original URL path: http://newswire.rockefeller.edu/tag/marcelo-o-magnasco/ (2016-02-13)
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  • Researchers Identify Molecule That Senses Osmotic Pressure in Vertebrates | Newswire
    Rockefeller headed by A James Hudspeth M D Ph D also an investigator at the Howard Hughes Medical Institute Heller is now an assistant professor at Harvard Medical School Liedtke discovered VR OAC while looking in a region of the brain called the hypothalamus for genes operative in the regulation of body temperature The hypothalamus monitors and regulates a score of vital parameters in the body including osmotic pressure energy balance and temperature Of those systemic osmotic pressure is the most aggressively defended setpoint value in vertebrate animals including humans An increase in osmotic pressure leads to the sense of thirst and drinking behavior and osmoreceptors in the hypothalamus send signals to nerve cells that manufacture antidiuretic hormone ADH the primary regulator of body water Micrograph depicting the lamina terminalis adjacent to the anterior hypothalamus of a mouse For orientation III frontal portion of the 3rd ventricle part of the cavity system of the brain which is filled with cerebrospinal fluid VOLT denotes organum vasculosum lamina terminalis This part of the lamina terminalis lacks a functional blood brain barrier The nerve cells labeled in blue express VR OAC and can sense the osmotic pressure in the serum a physiological setpoint hold tightly at 295 mmol kg These neurons are regarded as primary sensory cells for the milieu interne and have been shown to have functional relevant connections to the neurons producing antidiuretic hormone the principal hormonal regulator of bodily water courtesy of Wolfgang Liedtke Liedtke found VR OAC expressed in neurons in brain structures called the circumventricular organs Most of the brain is protected by the blood brain barrier a gateway that allows only certain substances to pass into the brain The circumventricular organs are located inside the brain but outside the blood brain barrier Circumventricular organs are recognized as important sites for communication of the central nervous system with the remainder of the organism through the blood serum Liedtke collaborated with Heller and colleagues in the Laboratory of Sensory Neuroscience who had cloned VR OAC from a chicken inner ear gene library Liedtke thought that VR OAC could be an ion channel that responds to osmotic pressure They showed that VR OAC was also present in hair cells of the inner ear which Hudspeth s lab has studied and functionally characterized These cells are the principal mechanotransductory cells essential for the perception of sound and the sensing of acceleration in the inner ear s sense of equilibrium VR OAC may be key in helping to regulate the salt and water household of these cells As an alternative model and a more general concept VR OAC could be part of sensory cells mechanosensitive molecular apparatus an exciting possibility says Liedtke We are very eager to examine this in follow up studies Working with hamster cells driven to express VR OAC the researchers showed that VR OAC is exquisitely sensitive to subtle changes in osmotic pressure VR OAC does not respond to changes in temperature but it is fine tuned by

    Original URL path: http://newswire.rockefeller.edu/2000/10/27/researchers-identify-molecule-that-senses-osmotic-pressure-in-vertebrates-2/ (2016-02-13)
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  • osmotic pressure | Newswire
    and Rockefeller University have identified a molecule in vertebrates that senses osmotic pressure the measure of saltiness essential for living cells and may provide an inroad into understanding inner ear function and the sense of touch More Tags inner ear Jeffrey M Friedman osmotic pressure Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv

    Original URL path: http://newswire.rockefeller.edu/tag/osmotic-pressure/ (2016-02-13)
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  • Immunologist Michel Nussenzweig elected to Institute of Medicine | Newswire
    the immune system His research on adaptive immunity the part of the system that adapts to new pathogens and primes the body against future encounters with them focuses on B lymphocytes and antibodies his work on innate immunity which defends the body against all pathogens generically focuses on dendritic cells the sentinels of the immune system discovered at Rockefeller in 1973 Nussenzweig has provided important insights into how autoimmune diseases develop and has developed methods that target specific antigens to dendritic cells which may lead to both vaccines against pathogens and treatments for autoimmunity Nussenzweig obtained his Ph D working with Ralph M Steinman at Rockefeller University and an M D from New York University School of Medicine He completed clinical training at Massachusetts General Hospital and postdoctoral training in the lab of Philip Leder in the genetics department of Harvard Medical School He returned to Rockefeller as assistant professor in 1990 and became associate professor in 1994 and professor and senior physician of The Rockefeller University Hospital in 1996 He has been an HHMI investigator since 1999 Nussenzweig is the recipient of numerous other awards including a Lee C Howley Sr Prize for Arthritis Research an American Association of Immunologists Huang Foundation Meritorious Career Award and a Solomon A Berson Alumni Achievement Award for Basic Science from New York University He is a member of the American Academy of Arts and Sciences and the American Society of Clinical Investigators Established in 1970 by the National Academy of Sciences the Institute of Medicine has become recognized as a national resource for independent scientifically informed analysis and recommendations on health issues Institute studies and initiatives during the past year include among many others a review of the long term effects of traumatic brain injury among military personnel an assessment of the

    Original URL path: http://newswire.rockefeller.edu/2009/10/12/immunologist-michel-nussenzweig-elected-to-institute-of-medicine/ (2016-02-13)
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  • Jeffrey Ravetch elected to Institute of Medicine | Newswire
    of Yale and Rockefeller Universities as well as Cornell University Medical College Ravetch joined the faculty of Rockefeller University in 1996 and is currently Theresa and Eugene M Lang Professor He is the 14th current Rockefeller faculty member to be elected to the Institute of Medicine Jeff s research has contributed greatly to our understanding of immunotherapy His work is of great relevance to the fight against cancer and other devastating diseases and this recognition of Jeff s contribution membership to the Institute of Medicine is very well deserved says university president Paul Nurse Established in 1970 as a unit of the National Academy of Sciences the Institute of Medicine was founded for the protection and advancement of the biomedical sciences and health professions the promotion of research and development pertinent to health and the improvement of health care The institute is also concerned with other areas of study as they are related to health including the behavioral and social sciences humanities administration law the physical sciences and engineering In pursuit of its mission the institute conducts studies of specific problems Institute members contribute their knowledge and professional judgment to the development of findings and the formulation of recommendations relating

    Original URL path: http://newswire.rockefeller.edu/2007/10/08/jeffrey-ravetch-elected-to-institute-of-medicine/ (2016-02-13)
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  • Jeffrey Friedman elected to Institute of Medicine | Newswire
    serve as an independent scientific advisor to the federal government on health matters Election to the IOM recognizes those who have made major contributions to the advancement of the medical sciences health care and public health and it is considered one of the highest honors in these fields Friedman joins 13 other Rockefeller scientists who are IOM members Prior to Friedman s groundbreaking research little was known about the components of the biologic system that controls weight with many scientists questioning the very existence of such a homeostatic system With leptin and Friedman s subsequent studies the logic of an entirely new physiologic system has been established with direct implications for the pathophysiology of human obesity Friedman is Marilyn M Simpson Professor and head of the Laboratory of Molecular Genetics at Rockefeller and an investigator at the Howard Hughes Medical Institute He also directs the Starr Center for Human Genetics at Rockefeller A member of the National Academy of Sciences Friedman received the Passano Foundation Award and the Gairdner Foundation International Award earlier this year Among his recent honors are the 2002 Banting Lecture Award and the 2001 Bristol Myers Squibb Award for Distinguished Achievement in Metabolic Research Tags Institute

    Original URL path: http://newswire.rockefeller.edu/2005/10/24/jeffrey-friedman-elected-to-institute-of-medicine/ (2016-02-13)
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