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  • Density does it: Fibrinogen concentration controls clot formation | Newswire
    or other surface that dictates whether additional platelets are recruited In a first edition paper published online in Blood Barry Coller David Rockefeller Professor and physician in chief of The Rockefeller University Hospital and research associate Marketa Jirouskova examine whether platelets react differently when binding to high and low density immobilized fibrinogen Jirouskova and Coller who s head of the Allen and Frances Adler Laboratory of Blood and Vascular Biology found that when fibrinogen was adsorbed on a surface in low density the platelets adhered to it quickly and recruited other platelets to the site When it was adsorbed on a surface in high density the platelets were nowhere near as active passively sticking to the fibrinogen in a single layer without engaging additional platelets The researchers believe that the difference in the platelets reactions lies in the interaction between the receptor on their surfaces dubbed αIIbβ3 and fibrinogen This interaction between the same ligand and the same receptor depending on the concentration of the ligand on the surface can lead to two completely different signals Jirouskova says She believes that depending on its concentration fibrinogen may change its conformation and by doing so change the entire signaling pathway that ensues Because the dance between stationary fibrinogen and platelets occurs on non wound surfaces too it can pose a problem by causing clots to form on stents and other implants Free floating fibrinogen can t activate platelets thereby ensuring it only initiates clotting when immobilized Consequently Coller and Jirouskova s research may help bioengineers create materials that are better compatible with the human body I think people could look at whether it s possible to immobilize fibrinogen at the right conformation to make a passive surface Jirouskova says She notes that it might be possible to do it in such

    Original URL path: http://newswire.rockefeller.edu/2007/04/10/density-does-it-fibrinogen-concentration-controls-clot-formation/ (2016-02-13)
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  • clot | Newswire
    fibrinogen The process not only creates scabs over wounds it can also play a role in strokes and heart attacks In a new finding that has implications for such diseases researchers show that it s the density of fibrinogen on a wound or other surface that dictates whether additional platelets are recruited More Tags Barry Coller clot fibrinogen Search for Categories Science News Awards and Honors Campus News Grants Gifts

    Original URL path: http://newswire.rockefeller.edu/tag/clot/ (2016-02-13)
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  • fibrinogen | Newswire
    10 2007 Science News Density does it Fibrinogen concentration controls clot formation Blood clots are the product of an intricate molecular dance between cell fragments called platelets in the blood and the glycoprotein fibrinogen The process not only creates scabs over wounds it can also play a role in strokes and heart attacks In a new finding that has implications for such diseases researchers show that it s the density

    Original URL path: http://newswire.rockefeller.edu/tag/fibrinogen/ (2016-02-13)
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  • In the News – Washington Post | Newswire
    Alzheimer s heart attacks MS coral reefs A stop heart attack refrain echoes through Rockefeller University s molecular biomedicine music video featuring some flashy animation and seriously geeky dancing Tags Barry S Coller newswire rockefeller edu Research hints at why stress is more devastating for some Hironori Funabiki promoted to professor Comments are closed Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015

    Original URL path: http://newswire.rockefeller.edu/2014/09/15/in-the-news-washington-post/ (2016-02-13)
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  • Rockefeller University receives $36.1 million to help translate science into cures | Newswire
    said Barbara Alving director of the National Center for Research Resources at the NIH They were tasked with transforming the way their institutions coordinate research to make it more proactive and effective in producing real world results and in the process they have served as innovative models nationwide Together the institutes represent a 498 million renewed commitment on NIH s part to expedite translational research nationwide NIH will release a progress report on the program in August highlighting specific research that has emerged from the CTSA program The renewal awards validate the success of Rockefeller s CCTS and its sister programs in creating a framework for scientists to move beyond the traditional silos of science to collaborate on promising research and find the training and resources to move those projects ahead We are delighted that NIH has renewed the funding of our Clinical and Translational Science Award which has provided crucial resources to support research and education at Rockefeller says CCTS Director Barry S Coller who is David Rockefeller Professor of Medicine and head of the Allen and Frances Adler Laboratory of Blood and Vascular Biology This success reflects the hard work of an outstanding multidisciplinary group of professionals who provide an ideal environment in which to conduct research designed to improve human health These awards which have now been awarded to 60 academic centers nationwide help NIH funded scientists collaborate with other NIH institutes and centers nationwide on research that applies to a broad range of diseases Alving said CTSA funded institutions also work with industry manufacturers patient groups and nonprofit organizations to ensure that potentially life saving new drugs and devices reach the public faster The renewal underscores the success of the programs the CCTS at Rockefeller University has been able to institute over the past five years

    Original URL path: http://newswire.rockefeller.edu/2011/07/22/rockefeller-university-receives-36-1-million-to-help-translate-science-into-cures/ (2016-02-13)
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  • Center for Clinical and Translational Science | Newswire
    five years of the NIH s Clinical and Translational Science Awards program More Tags Barry S Coller Center for Clinical and Translational Science National Institutes of Health November 10 2009 Campus News Rockefeller joins first national research study recruitment registry Rockefeller University has joined more than 50 U S research institutions in making information about its clinical research trials available on ResearchMatch the country s first registry for recruiting research

    Original URL path: http://newswire.rockefeller.edu/tag/center-for-clinical-and-translational-science/ (2016-02-13)
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  • Rockefeller joins Pfizer’s Global Centers For Therapeutic Innovation | Newswire
    development programs and offers equitable intellectual property and ownership rights to support continued experimentation and exploration as well as broad rights to publication Investigators will have access to Pfizer s proprietary antibody libraries and advanced research tools along with technical support When programs are successful and advance according to the terms determined by a joint steering committee Pfizer will grant milestone payments and royalties In return Pfizer will have the opportunity to potentially broaden its pipeline with novel and highly differentiated candidate drugs We are very pleased to join Pfizer s Centers for Therapeutic Innovation program which will provide resources to Rockefeller investigators to facilitate translating their scientific discoveries into biologic agents that improve human health says Barry S Coller who is physician in chief of The Rockefeller University Hospital David Rockefeller Professor and head of the Allen and Frances Adler Laboratory of Blood and Vascular Biology Six other New York City research based medical centers will be part of the CTI network New York University Langone Medical Center Memorial Sloan Kettering Cancer Center Mount Sinai Hospital Columbia University Medical Center Weill Cornell Medical College and Albert Einstein College of Medicine at Yeshiva Hospital Eventually Pfizer plans to extend the

    Original URL path: http://newswire.rockefeller.edu/2011/01/26/rockefeller-joins-pfizer%e2%80%99s-global-centers-for-therapeutic-innovation/ (2016-02-13)
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  • Rockefeller joins first national research study recruitment registry | Newswire
    of medical research institutions affiliated with the Clinical and Translational Science Awards CTSAs The CTSA program which is led by the National Center for Research Resources NCRR a part of the National Institutes of Health is focused on expanding local and national efforts to enhance the translation of laboratory discoveries into treatments for patients The Rockefeller University Center for Clinical and Translational Science is proud to be a founding collaborating institution of ResearchMatch says Barry S Coller vice president for medical affairs and codirector of Rockefeller s CCTS ResearchMatch is an important initiative in speeding both the discovery of new knowledge and the translation of that knowledge into improved health It incorporates a number of confidentiality and privacy protections and has been approved by a human subjects ethics committee Although other Web sites list available clinical trials ResearchMatch places the burden of connecting the right volunteers with the right study on the researchers Clinicaltrials gov in contrast asks volunteers to identify the trials that could work for them Participant recruitment continues to be a significant barrier to the completion of research studies nationwide Recent NIH data indicates that just four percent of the U S population has participated in clinical

    Original URL path: http://newswire.rockefeller.edu/2009/11/10/rockefeller-joins-first-national-research-study-recruitment-registry/ (2016-02-13)
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