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  • Michel C. Nussenzweig elected to National Academy of Sciences | Newswire
    molecular biology with gene targeting and transgenic technologies to get an atomic level look at the workings of the immune system His research on adaptive immunity the part of the system that adapts to new pathogens and primes the body against future encounters with them focuses on B lymphocytes and antibodies his work on innate immunity which defends the body against all pathogens generically focuses on dendritic cells the sentinels of the immune system discovered at Rockefeller in 1973 Nussenzweig has provided important insights into how autoimmune diseases develop and has developed methods that target specific antigens to dendritic cells which may lead to both vaccines against pathogens and treatments for autoimmunity Nussenzweig obtained his Ph D working with Ralph M Steinman at Rockefeller University and an M D from New York University School of Medicine He completed clinical training at Massachusetts General Hospital and postdoctoral training in the lab of Philip Leder in the genetics department of Harvard Medical School He returned to Rockefeller as assistant professor in 1990 and became associate professor in 1994 and professor and senior physician of The Rockefeller University Hospital in 1996 He has been an HHMI investigator since 1999 Nussenzweig is the recipient of numerous other awards including a Lee C Howley Sr Prize for Arthritis Research an American Association of Immunologists Huang Foundation Meritorious Career Award and a Solomon A Berson Alumni Achievement Award for Basic Science from New York University He is a member of the Institute of Medicine the American Academy of Arts and Sciences and the American Society of Clinical Investigators The Rockefeller faculty now includes 37 members or foreign associates of the National Academy of Sciences an organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare Election to membership

    Original URL path: http://newswire.rockefeller.edu/2011/05/03/michel-c-nussenzweig-elected-to-national-academy-of-sciences/ (2016-02-13)
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  • New class of ‘dancing’ dendritic cells derived from blood monocytes | Newswire
    that reside in the lymph nodes known as classical dendritic cells After several years of searching he found antibodies that would attach to a protein called DC SIGN particular to the surface of monocyte derived dendritic cells a handle he could biochemically grab hold of to separate out the cells Using this tool Cheong was able to show that monocytes facing an infection of gram negative bacteria such as Escherichia coli or their cell wall component called lipopolysaccharid in the blood migrate to lymph nodes where they quickly develop into fully fledged monocyte derived dendritic cells capable of stimulating T cells and fighting the infection When he segregated the cells and looked at them in the microscope he saw that they had developed the unusual shape and manner of dendritic cells with extended arms actively probing the environment for infectious particles taking them up and presenting them to T cells It looks like these regular T cells are dancing with the stars he says The monocyte derived dendritic cells he had discovered outnumbered the classical dendritic cells in the infected mice and appeared to be as efficacious as their relatives in presenting invading particles to T cells although more experiments will be required to determine their exact function in the immune response The work contributes to an increasingly detailed picture of how dendritic cells are derived including work published last year in Science by Steinman s colleague and former protégé Michel C Nussenzweig Nussenzweig and colleagues clarified the lineages of different types of dendritic cells and in particular the point at which classical dendritic cells separate from the closely related monocytes even though they share a common ancestor in the bone marrow The research also shows that monocyte derived dendritic cells are in fact authentic dendritic cells with the same

    Original URL path: http://newswire.rockefeller.edu/2010/11/09/new-class-of-%e2%80%98dancing%e2%80%99-dendritic-cells-derived-from-blood-monocytes/ (2016-02-13)
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  • Cheolho Cheong | Newswire
    done on classical dendritic cells which are found in the lymph tissues of mice But these are hard to come by in the case of humans The new technique may allow the generation of authentic dendritic cells from human blood samples however which could make it much easier to advance dendritic cell based vaccines and cancer treatments that are under development now More Tags Cheolho Cheong dendritic cells Laboratory of

    Original URL path: http://newswire.rockefeller.edu/tag/cheolho-cheong/ (2016-02-13)
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  • New HIV vaccine trial first to target dendritic cells | Newswire
    the source The researchers are able to target dendritic cells because of a distinctive marker on the cell surface a receptor called DEC 205 which was discovered about 12 years ago by Schlesinger s colleague and Steinman s former student Michel C Nussenzweig head of the Laboratory of Molecular Immunology The team has engineered a powerful antibody called a monoclonal antibody to seek out DEC 205 and deliver a synthesized piece of an HIV protein They have also incorporated a special molecule called an adjuvant that will spur dendritic cells to grow into their fully matured disease fighting state In theory these dendritic cells then will tell the immune system to seek and destroy anything containing that synthesized HIV protein in other words HIV wherever it is found in the body This trial is the culmination of at least 15 years of laboratory research Schlesinger says We re very excited to try it out Vaccines must go through three stages of clinical trials before they can be licensed for use by the U S Food and Drug Administration The first following extensive testing in laboratory and animal studies tests for safety and tolerability in humans the second gauges whether the vaccine is creating the immune response that is desired only the third phase which involves thousands of patients costs tens of millions of dollars and can take a decade or longer establishes whether the candidate is truly effective The trial at Rockefeller is in the first safety stage but researchers intend to probe many questions about whether or not it is effective as well We wouldn t want to put this into people without learning as much as we can about what kind of immune response it is generating Schlesinger says To date only three vaccine candidates have made it

    Original URL path: http://newswire.rockefeller.edu/2010/07/02/new-hiv-vaccine-trial-first-to-target-dendritic-cells/ (2016-02-13)
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  • Zanvil A. Cohn | Newswire
    Now that s about to change Researchers at Rockefeller University where dendritic cells were discovered in 1973 are building on decades worth of research to launch a novel vaccine trial in hopes of mustering an immune response strong enough to defeat the deadly virus It s the first clinical trial of a dendritic cell based vaccine against infection and researchers hope it will mark a turning point in the battle

    Original URL path: http://newswire.rockefeller.edu/tag/zanvil-a-cohn/ (2016-02-13)
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  • Research defines dendritic cell lineage | Newswire
    significant for vaccine development Prior research had shown that two kinds of dendritic cells classical spleen dendritic cells cDCs and plasmacytoid dendritic cells pDCs as well as monocytes have a common ancestor cell in bone marrow Kang Liu a postdoctoral associate in Nussenzweig s lab led the genealogical research into where the lines diverged a question that has sparked controversy ever since dendritic cells were discovered She focused the investigation on cDCs which are expected to be more useful for vaccine development than the monocytes commonly used now Liu had a hunch about how an adolescent classical spleen dendritic cell might look She deduced that it would express one cell receptor common to all known dendritic cells Flt3 but would lack a certain protein that enables the grown up cell to capture bacteria or viruses and present them to other immune cells for destruction She developed markers for these theoretical dendritic adolescents and found them in bone marrow blood and lymph organs such as the spleen and lymph node which filter bodily fluids She named these cells preclassical spleen dendritic cells pre cDCs and found that wherever they were from they grew into adult dendritic cells in mice within days Using a two photon microscope and other biochemical tests Liu and her collaborators Gabriel Victora and Tanja Schwickert were able to trace the life cycle of cDCs from their original ancestor to their transformation into fully committed pre cDCs in the bone marrow their migration in the blood and growth into full fledged cDCs dancing around the lymph system The pre cDCs they injected grew up to behave just like the native cDCs in mice Liu also unveiled the related but distinct lineages of plasmacytoid dendritic cells and monocytes We identified the migrating dendritic cell precursor and really took it

    Original URL path: http://newswire.rockefeller.edu/2009/03/19/research-defines-dendritic-cell-lineage/ (2016-02-13)
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  • A natural approach for HIV vaccine | Newswire
    making them especially wily adversaries of the immune system In particular the surface protein of HIV gp140 is the site of a host of mutations that obstruct the few elements that all of the virus strains share Prior research has shown that only four super antibodies block the activity of that protein in a broad range of HIV strains neutralizing the virus But all attempts to coax the human body into producing those four have failed so far So Johannes Scheid a doctoral student in Nussenzweig s lab turned his attention to the antibodies produced by six people infected with HIV whose immune systems put up an exceptionally strong fight The patients represent the roughly 10 to 20 percent of HIV patients whose antibodies are able to kill not only their own virus but a wide range of HIV strains Somehow their immune systems B cells produce high levels of antivirus antibodies but until now researchers have known little about the antibodies or how effective they are With help from Rockefeller s Center for Clinical and Translational Science and Rockefeller scientists David D Ho and Jeffrey V Ravetch Scheid and colleagues isolated 433 B cells from these individuals blood that specifically target the envelope protein HIV s protean armor They then extracted the DNA encoding the B cells antibodies and cloned large amounts of them mapped which part of the envelope protein each targeted and gauged how effective each was in neutralizing the virus In the process the team identified a new part of the core of the envelope protein that had never been recognized as a potential target for antibodies Scheid s work shows that it s common for these antibodies to have neutralizing activity says Nussenzweig But each antibody alone has limited ability to fight the virus Individually

    Original URL path: http://newswire.rockefeller.edu/2009/03/17/a-natural-approach-for-hiv-vaccine/ (2016-02-13)
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  • In the News – BBC – Nussenzweig | Newswire
    to treatment out there already on two counts First because it comes from a human so it is natural in that respect And secondly it opens up the possibility of giving the patient s own weakened immune system a jolt Tags AIDS HIV Michel Nussenzweig newswire rockefeller edu In first human study new antibody therapy shows promise in suppressing HIV infection Research on the genetic roots of a blood disorder

    Original URL path: http://newswire.rockefeller.edu/2015/04/09/in-the-news-new-york-daily-news-nussenzweig/ (2016-02-13)
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