archive-edu.com » EDU » R » ROCKEFELLER.EDU

Total: 1631

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Newly identified cells make fat | Newswire
    produce new fat cells But identifying these fat precursor cells has been difficult With the assistance of researchers in Rockefeller s Flow Cytometry Resource Center first author Matt Rodeheffer a postdoctoral associate in Friedman s Laboratory of Molecular Genetics used a cell sorting technique called fluorescence activated cell sorting or FACS to search for cell populations that could produce fat in cell cultures and identified two such populations To determine if these cells could develop into fat cells in living animals Rodeheffer injected these cell populations into the fat depots of a genetically engineered mouse called fatless developed at the National Institutes of Health that lacks white fat and mimics a condition in humans called lipodystrophy which also results in diabetes Rodeheffer found that only one of the isolated cell populations the one that expresses the CD24 cell surface marker protein produced fat tissue in the fatless mouse This population normally represents only 08 percent of the nonadipocyte population in adipose tissue An imaging assay recently developed by coauthor Kivanç Birsoy a graduate student in Friedman s laboratory enabled Rodeheffer to observe the CD24 expressing cells form fat in a living animal Birsoy s technique reported in August in Proceedings of the National Academy of Sciences uses another animal strain called the leptin luciferase mouse in which the visibly detectable marker luciferase is expressed under the control of the promoter of the gene that produces the hormone leptin In this mouse strain the luciferase marker gene switches on only in mature fat cells and provides a noninvasive way of watching immature fat cell precursors develop into mature fat cells in a living animal over time I injected the CD24 cells which represent a very small population of cells in normal adipose tissue into a site where the fat would normally

    Original URL path: http://newswire.rockefeller.edu/2008/10/03/newly-identified-cells-make-fat/ (2016-02-13)
    Open archived version from archive

  • adipocyte | Newswire
    Rockefeller University scientists have discovered an important fat precursor cell that may in time explain how changes in the numbers of fat cells might increase and lead to obesity The scientists finding could also have implications for understanding how fat cells affect conditions such as diabetes and cardiovascular disease More Tags adipocyte Jeffrey M Friedman Obesity Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/adipocyte/ (2016-02-13)
    Open archived version from archive

  • Obesity researcher awarded Danone nutrition prize | Newswire
    Institute International Prize for Nutrition in 1997 and has since recognized six leading scientists around the world for their accomplishments in nutrition research There are 17 Danone Institutes worldwide comprising more than 250 international diet and nutrition experts Danone Institutes are funded by local Danone Companies including The Dannon Company which produces one of the top selling brands of yogurt in the United States Friedman Marilyn M Simpson Professor at Rockefeller University and an investigator at the Howard Hughes Medical Institute is honored for his research on the role of genetics and leptin a hormone he discovered in body weight regulation By discovering the endocrine function of leptin in regulating adipose fat tissue and demonstrating that appetite and body weight depend on a complex physiological system Friedman opened the door for scientists to study the relationship between biology and obesity Friedman remains at the forefront of research studying the role of leptin and other new compounds in regulating appetite and weight gain Friedman graduated from Rensselaer Polytechnic Institute and received his medical degree from Albany Medical College of Union University in Albany New York He completed two residencies at Albany Medical Center Hospital and postgraduate fellowships at both Rockefeller University

    Original URL path: http://newswire.rockefeller.edu/2007/07/11/obesity-researcher-awarded-danone-nutrition-prize/ (2016-02-13)
    Open archived version from archive

  • Danone | Newswire
    sixth Danone Institute International Prize for Nutrition an award that honors innovative nutritional research was given to Rockefeller University s Jeffrey Friedman today at the European Nutrition Conference in Paris More Tags Danone Jeffrey M Friedman Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The Rockefeller University RU Footer The Rockefeller University

    Original URL path: http://newswire.rockefeller.edu/tag/danone/ (2016-02-13)
    Open archived version from archive

  • Jeffrey Friedman to receive Kovalenko Medal | Newswire
    be honored for the discovery of leptin and its role in the regulation of appetite energy expenditure and the molecular mechanisms underlying obesity By awarding the Kovalenko Medal to Jeff the National Academy of Sciences recognizes a very important advance in our understanding of how body weight is regulated This work is not only a beautiful piece of research but also holds real promise for improving treatments for obesity says Paul Nurse president of The Rockefeller University Prior to Friedman s research little was known about the components of the biologic system that controls weight with many scientists questioning the very existence of such a homeostatic system With the discovery of leptin and Friedman s subsequent studies the logic of an entirely new physiologic system has been established with direct implications for the pathophysiology of human obesity The award which will be presented at a ceremony on April 29 during the Academy s annual meeting in Washington D C was established by a gift of Michael S Kovalenko in memory of his wife Jessie Stevenson Kovalenko and has been presented since 1952 In addition to Friedman five other Rockefeller scientists have received the Kovalenko medal Peyton Rous 1955 Eugene L

    Original URL path: http://newswire.rockefeller.edu/2007/01/17/jeffrey-friedman-to-receive-kovalenko-medal/ (2016-02-13)
    Open archived version from archive

  • Kovalenko Medal | Newswire
    that Rockefeller University scientist Jeffrey M Friedman will receive the National Academy of Sciences Jessie Stevenson Kovalenko Medal a medal and prize of 25 000 awarded every three years for important contributions to the medical sciences More Tags Jeffrey M Friedman Kovalenko Medal Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The

    Original URL path: http://newswire.rockefeller.edu/tag/kovalenko-medal/ (2016-02-13)
    Open archived version from archive

  • Genetic data from an island population proves to be useful tool in understanding disease | Newswire
    parents and one child the group used DNA chips to determine the genetic makeup or genotype of each participant When they compared selected results to those from the HapMap project they found that more than 98 percent of the data points matched providing evidence that the HapMap data can likely be used for whole genome studies in groups beyond the four initial study populations And likely due to the islanders isolation the analysis yielded two other important results reduced genetic diversity and longer than normal segments of linked DNA variations something called linkage disequilibrium In other words Kosrae s citizens offer a tool that may be even more powerful than the HapMap With less diversity and longer segments of linkage disequilibrium you can extract more information than from other populations says Friedman head of the Laboratory of Molecular Genetics and director of the university s Starr Center for Human Genetics The first clue that the residents of Kosrae might provide a key perspective on the impact of genetics on disease came in a study published by Breslow and his colleagues in 2004 which announced the discovery of a mutant gene that affects a person s cholesterol absorption But looking at more complex diseases which involve multiple genes or genes that respond to environmental influence requires an immense set of data So using the same chips that they used to genotype the parent child trios Friedman Breslow and Stoffel have now genotyped nearly every resident of the island more than 3 000 in all In the second paper published in the Proceedings of the National Academy of Sciences the three researchers analyzed the island s extended family tree in combination with genotype data from 2 188 of their participants They were looking for the potential genetic locations of a group of

    Original URL path: http://newswire.rockefeller.edu/2006/04/19/genetic-data-from-an-island-population-proves-to-be-useful-tool-in-understanding-disease/ (2016-02-13)
    Open archived version from archive

  • Jeffrey Friedman, discoverer of leptin, receives Gairdner, Passano awards | Newswire
    that these individuals lose weight with leptin treatment Friedman is now performing clinical studies at The Rockefeller University Hospital to determine the effects of leptin on the response to significant weight loss in obese patients on a very low calorie diet In 2002 Friedman and colleagues at Rockefeller and the University of Wisconsin at Madison uncovered another component of the biological system that controls body weight they showed that an enzyme called SCD 1 works through leptin to signal the body to either store fat or burn it The scientists believe that leptin acts in part by suppressing SCD 1 s activity which in turn activates a metabolic pathway that promotes the burning of fat Last year Friedman and colleagues at Rockefeller and Yale showed that leptin affects both the architecture and function of neural circuits in the brain by changing the wiring of the brain a phenomenon known as plasticity Leptin alters the wiring by controlling synapses the inputs and outputs to neurons that in this case regulate feeding behavior Syndrome X studies on the island of Kosrae Friedman also is the director of the Starr Center for Human Genetics one of the largest U S centers for the study of diseases linked to heredity Friedman with Jan Breslow M D Frederick Henry Leonhardt Professor and head of the Laboratory of Biochemical Genetics and Metabolism and Markus Stoffel M D Ph D R ob ert and Harriet Heilbrunn Professor and head of the Laboratory of Metabolic Diseases leads a team of Rockefeller researchers that is studying the genetic causes of a cluster of health pr ob lems called Syndrome X obesity diabetes high blood pressure and high blood cholesterol in a remote population of over 3 000 people on the Micronesian island Kosrae The Rockefeller scientists have turned to the people of Kosrae for two reasons One most Kosraeans can trace their heritage to a relatively small founder population of about 50 people who came from Polynesia about 1 000 years ago Later in the mid to late 19th century Caucasian whalers visited and in many cases settled on the island and so today many Kosraeans can trace their ancestry to both groups The second reason the Kosraeans are ideal for studies of Syndrome X involves the more recent westernization of their lifestyles For most of their thousand year history Kosraeans were active They ate native foods and were reported to be relatively lean But in the years following World War II most began leading a sedentary lifestyle while eating foods with high salt and fat contents Subsequently a disproportionate percentage of people on the island have developed one or more conditions associated with Syndrome X By analyzing the genetic inheritance patterns of the entire Kosraean population Friedman Breslow and Stoffel hope to solve the ongoing mystery of why some people develop these diseases while others with the same lifestyle do not War on obesity not the obese Friedman recently has become concerned about the stigmatization of the obese

    Original URL path: http://newswire.rockefeller.edu/2005/04/13/jeffrey-friedman-discoverer-of-leptin-receives-gairdner-passano-awards/ (2016-02-13)
    Open archived version from archive