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  • molecular and cell biology | Newswire
    compensation December 1 2015 Science News Study reveals new mechanism in nicotine addiction Two chemical signals acetylcholine and glutamate were known to act as part of the negative reward system that fuels craving but it wasn t clear how this happened In new experiments researchers have learned that one of these neurotransmitters acetylcholine regulates the other glutamate to reinforce nicotine dependence More Tags addiction habenula Ines Ibanez Tallon Laboratory of Molecular Biology molecular and cell biology Nathaniel Heintz neurosciences and behavior nicotine October 2 2015 Science News Researchers probe the physical forces involved in creating the mitotic spindle Scientists have gained new insight into the formation of the spindle which is the molecular machine that divides up genetic material prior to cell division Their work focuses on the motor protein kinesin 5 which helps to organize the spindle s filaments More Tags cell division kinesin 5 Laboratory of Chemistry and Cell Biology mitotic spindle molecular and cell biology Scott Forth Tarun Kapoor September 17 2015 Science News New findings help explain how molecules are speedily transported into and out of the cell s nucleus The nuclear pore complex a gate into and out of the nucleus is capable of an

    Original URL path: http://newswire.rockefeller.edu/tag/molecular-and-cell-biology/ (2016-02-13)
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  • Philip Kidd | Newswire
    response to temperature which can shift the clock forward or backward but cannot change its 24 hour period New experiments help explain how this is possible More Tags Center for Studies in Physics and Biology circadian clock Eric Siggia genetics and genomics Laboratory of Genetics Michael W Young molecular and cell biology Philip Kidd temperature compensation Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/philip-kidd/ (2016-02-13)
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  • temperature compensation | Newswire
    response to temperature which can shift the clock forward or backward but cannot change its 24 hour period New experiments help explain how this is possible More Tags Center for Studies in Physics and Biology circadian clock Eric Siggia genetics and genomics Laboratory of Genetics Michael W Young molecular and cell biology Philip Kidd temperature compensation Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/temperature-compensation/ (2016-02-13)
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  • Study reveals new mechanism in nicotine addiction | Newswire
    spherical structures called vesicles which reside at the ends of neurons Upon receiving certain signals neurons release their vesicle contents into the synapse perpetuating the signal onto the next neuron Neurons can recycle neurotransmitters by reabsorbing them through reuptake a process that allows them to precisely control the amounts of neurotransmitters in the synapse Even a small upset in the balance of neurotransmitters can result in altered behavior In the case of acetylcholine it can influence our ability to cope with addiction To understand how these neurotransmitters work we created a mouse model whose habenular neurons don t make acetylcholine because the mice lack a key gene involved in acetylcholine processing says Ibanez Tallon In our experiments we observed that the elimination of acetylcholine affected glutamate in this brain region in two ways First the amount of glutamate released by neurons was reduced And second the reuptake of glutamate back into vesicles was impaired Both of these mechanisms affect the excitability of neurons meaning normal signaling is disrupted Based on these findings the researchers suggest that acetylcholine regulates how much glutamate is released into the synapse and at what frequency It also facilitates the packaging of glutamate into vesicles Studies using electron microscopy confirmed that the neurotransmitters are in the same place at the same time and are able to affect one another How does this affect behavior Behaviorally removing acetylcholine from the habenula caused the mice to become insensitive to the rewarding properties of nicotine and they did not develop a tolerance to continued nicotine exposure In addition these mice did not experience withdrawal symptoms such as body shakes and scratching These findings and others indicate that without acetylcholine nicotine addiction would not occur Although smoking rates have decreased in recent years there s a consistent portion of the

    Original URL path: http://newswire.rockefeller.edu/2015/12/01/study-reveals-new-mechanism-in-nicotine-addiction/ (2016-02-13)
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  • addiction | Newswire
    back From a biological standpoint the difference may be as slight as a single amino acid suggests new research from the Rockefeller University laboratories of Mary Jeanne Kreek and Paul Greengard By tracking individual amino acids in a single protein in mice and noticing how they change when the mice are given access to cocaine scientists are beginning to understand how an individual s underlying genetics can reinforce his addictive behavior More Tags addiction Mary Jeanne Kreek Paul Greengard January 3 2006 Science News New genetic sequencing technique reveals possible genetic protection from heroin addiction New research from the laboratory of Mary Jeanne Kreek at Rockefeller University uses a novel sequencing approach to show that even very tiny differences within genes may help protect someone from heroin addiction and perhaps addiction disorders in general More Tags addiction Mary Jeanne Kreek April 1 2005 Science News Rockefeller University researchers are changing the face of addiction treatment People addicted to heroin alcohol and other drugs of abuse often fail to stay clean because they won t go to or won t stay in treatment Reporting in the January issue of the Journal of Substance Abuse Treatment Scott Kellogg Ph D and Mary Jeanne Kreek M D at The Rockefeller University and colleagues at the New York City Health and Hospitals Corporation HHC and at Johns Hopkins University show that a treatment approach called contingency management improves patients motivation to stay in treatment and increases their therapeutic progress More Tags addiction contingency management Mary Jeanne Kreek April 25 2003 Science News New test for drug and alcohol addiction focuses solely on time of heaviest use A new survey can quickly test for addiction to cocaine heroin and alcohol simply by asking about the time in the person s life when he or she was drinking or using these substances the most according to a study by Rockefeller University researchers More Tags addiction Mary Jeanne Kreek testing April 15 2002 Science News Nature s Own Antidote to Cocaine Some people s brains may harbor their own built in defense system against the addictive powers of cocaine According to new research at The Rockefeller University a naturally occurring brain opiate called dynorphin may in certain individuals serve as an antidote to counter the pleasurable yet dangerous effects of cocaine More Tags addiction Dynorphin Mary Jeanne Kreek March 16 2001 Science News Researchers Identify an Enzyme That Regulates the Action of Chronic Cocaine Scientists have found that an enzyme called Cdk5 regulates the action of chronic cocaine in the brain In a paper published in the March Nature members of Paul Greengard s Laboratory of Molecular and Cellular Neuroscience and colleagues at other institutions identify Cdk5 s role in the long term changes associated with cocaine addiction By combining behavioral and biochemical studies they found that Cdk5 which stands for cyclin dependent kinase 5 is a key player in a series of biochemical events that occur in certain brain cells with exposure to chronic cocaine More

    Original URL path: http://newswire.rockefeller.edu/tag/addiction/ (2016-02-13)
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  • habenula | Newswire
    that fuels craving but it wasn t clear how this happened In new experiments researchers have learned that one of these neurotransmitters acetylcholine regulates the other glutamate to reinforce nicotine dependence More Tags addiction habenula Ines Ibanez Tallon Laboratory of Molecular Biology molecular and cell biology Nathaniel Heintz neurosciences and behavior nicotine Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/habenula/ (2016-02-13)
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  • Ines Ibanez-Tallon | Newswire
    system that fuels craving but it wasn t clear how this happened In new experiments researchers have learned that one of these neurotransmitters acetylcholine regulates the other glutamate to reinforce nicotine dependence More Tags addiction habenula Ines Ibanez Tallon Laboratory of Molecular Biology molecular and cell biology Nathaniel Heintz neurosciences and behavior nicotine Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014

    Original URL path: http://newswire.rockefeller.edu/tag/ines-ibanez-tallon/ (2016-02-13)
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  • Laboratory of Molecular Biology | Newswire
    reward system that fuels craving but it wasn t clear how this happened In new experiments researchers have learned that one of these neurotransmitters acetylcholine regulates the other glutamate to reinforce nicotine dependence More Tags addiction habenula Ines Ibanez Tallon Laboratory of Molecular Biology molecular and cell biology Nathaniel Heintz neurosciences and behavior nicotine Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-molecular-biology/ (2016-02-13)
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