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  • Rockefeller University Honors Brooke Astor, Presents Honorary Degrees to Sydney Brenner and Viktor Hamburger and Awards 25 Doctorates at Graduation Ceremonies | Newswire
    and programs including the New York Zoological Society the New York Botanical Garden the Pierpont Morgan Library the South Street Seaport and the New York Public Library for which she serves as honorary chairman The Metropolitan Museum of Art also has benefited from her generosity Astor joined the Rockefeller University board of trustees in 1972 and she was elected the institution s first life trustee in 1983 In 1974 Astor established two Vincent Astor Professorships at the university which are held by Paul Greengard head of the Laboratory of Molecular and Cellular Neuroscience and James E Darnell Jr head of the Laboratory of Molecular Cell Biology In 1980 she established the Vincent and Brooke Astor Professorship held by Wiesel Brenner Brenner worked at the M R C Laboratory of Molecular Biology in Cambridge U K which he directed from 1979 to 1986 He is an honorary professor of genetic medicine at the University of Cambridge and a fellow of King s College Cambridge His research revealed the general nature of the genetic code and the identity of messenger RNA the molecules that transfer genetic information from the DNA sequences of genes for the synthesis of proteins Later he initiated an entire new area of developmental genetics centered on the nematode C elegans He received his master of science degree in 1947 and medical degress M B B Ch in 1951 both from the University of Witwatersrand in Johannesburg South Africa and a doctorate of philosophy in 1954 from Oxford University His honors include the Albert Lasker Medical Research Award the Royal Medal and Copley medal of the Royal Society the Kyoto Prize and the King Faisal International Prize for Science Hamburger Hamburger is the E Mallinckrodt Distinguished Professor Emeritus at Washington University in St Louis Mo A key contributor in the field of experimental embryology he pioneered studies on the growth and development of the nervous system A native of Germany he received his doctorate degree in 1925 from the University of Freiburg From 1941 to 1968 he served as chairman and professor of zoology at Washington University joining the emeriti faculty in 1968 Among his awards are the Horwitz Prize the U S National Medal of Science and the Karl Lashley Award He is a member of the National Academy of Sciences U S A the Society of Developmental Biology and the International Society of Developmental Biology Students The 1996 graduating students and their thesis topics follow Students marked with also will receive a medical degree from Cornell University Miriam Berman B A Platelet Endothelial Cell Adhesion Molecule 1 PECAM 1 Adhesive Properties and Roles in Leukocyte Migration and Integrin Activation Claudio Bertuccioli B A M S In vivo Structure Function Analysis of the Paired Segmentation Gene A Paradigm for Pax Gene Function Sandy Chang B S MacMARCKS and the Protein Kinase C Signal Transduction Pathway Role in Neural Secretion and Development Sek Jin Chew M B B S M S An Ethological Framework for Understanding Long term Memory

    Original URL path: http://newswire.rockefeller.edu/1996/06/13/rockefeller-university-honors-brooke-astor-presents-honorary-degrees-to-sydney-brenner-and-viktor-hamburger-and-awards-25-doctorates-at-graduation-ceremonies/ (2016-02-13)
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  • Brooke Astor | Newswire
    civic leader and philanthropist Brooke Astor and award honorary doctorate degrees to scientists Sydney Brenner D Phil a pioneer of modern molecular genetics and Viktor Hamburger Ph D a founder of developmental neurobiology at the institution s 38th commencement exercises Thursday June 13 1996 More Tags Brooke Astor D Phil graduation Sydney Brenner Viktor Hamburger Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive

    Original URL path: http://newswire.rockefeller.edu/tag/brooke-astor/ (2016-02-13)
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  • Plant-Based Therapies Examined for Colon Cancer Prevention | Newswire
    is the pigment that gives the yellow color to the seasoning curry mustard and turmeric the powdered form of the root of Curcuma longa Linn Curcumin is an approved additive for foods in the United States Quercetin can be naturally found in most fruits and vegetables such as cranberries and onions as well as tea Rutin when digested in the colon breaks down into quercetin Many colorectal cancers begin as noncancerous growths called polyps in the mucosal lining of the colon and rectum the last part of the digestive tract An inherited defective gene can cause some forms of the disease but not all The polyps develop because the normal routine of cell division and apoptosis goes awry When apoptosis is disabled tissues that rely on it no longer have a way to regulate their cell populations and cancer may ensue In the study Shiff and fellow researchers will examine the influence of administering different amounts of either curcumin rutin or quercetin on the amount of colorectal cells replaced and the speed of this process during the normal functions of the intestine The study includes looking for and measuring the size and kind of any intestinal polyps that develop in the participants Ideally we would like to find the lowest optimal dose of each of the three plant compounds that would safely inhibit the development of colorectal cancer explains Shiff The study lasts for up to 10 weeks During the first two weeks participants eat a controlled diet so that initial information can be collected In the following weeks the investigators randomly assign the participants to continue on the initial diet alone or a diet supplemented with one of the plant phenolic compounds or sulindac the NSAID During this second phase participants stay for an additional four or eight weeks

    Original URL path: http://newswire.rockefeller.edu/1997/09/23/plant-based-therapies-examined-for-colon-cancer-prevention/ (2016-02-13)
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  • curcumin | Newswire
    ability to prevent colorectal cancer which afflicts some 150 000 Americans each year The compounds have the potential to be safer than cancer thwarting nonsteroidal antiinflammatory drugs NSAIDs widely used aspirin like drugs known to prevent colorectal cancer as well as reduce related deaths by half More Tags colon cancer curcumin phenolics Steven J Shiff Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive

    Original URL path: http://newswire.rockefeller.edu/tag/curcumin/ (2016-02-13)
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  • Model suggests how life’s code emerged from primordial soup | Newswire
    say that each triplet sequence on messenger RNA known as a codon represents an outlet that can only accept a tRNA with a complementary anticodon Translation works because each codon anticodon match corresponds with an amino acid As each tRNA is plugged in a chain of amino acids is formed in the same order as the codons until translation is complete However primitive tRNAs were not as finicky as tRNAs are today and could load any amino acid known to exist during the time of prebiotic Earth Without the ability of tRNAs to discriminate between various amino acids such a random system might not be able to self assemble into a highly organized code capable of supporting life To find out if it could Libchaber and Lehmann together with Michel Cibils at the Swiss Federal Institute of Technology EPFL in Lausanne Switzerland worked with a simple theoretical system They took two of the simplest amino acids thought to exist billions of years ago two primitive tRNAs and an RNA template with two complementary codons and then developed an algorithm to incrementally change the concentration of each molecule Their goal was to see which conditions if any could coax the system to specifically translate codons in a nonrandom fashion They found that the properties of the molecules set the concentrations at which the molecules needed to exist for a coded regime to emerge At these concentrations the scientists found that a vetting process began to unfold whereby tRNA and amino acid began to seek each other out All in all an elementary translation process depended on two timescales the time during which a tRNA remains bound to its codon hybridization and the time it takes for the amino acid on that tRNA to form a new chemical bond with the amino

    Original URL path: http://newswire.rockefeller.edu/2009/08/07/model-suggests-how-lifes-code-emerged-from-primordial-soup/ (2016-02-13)
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  • Amino acids | Newswire
    This colorful metaphor by astronomer Fred Hoyle points out the difficulties encountered by scientists when they try to understand how life could have emerged billions of years ago Researchers at Rockefeller University now show how crude pieces of a genetic system could self assemble and generate the rules of life s most fundamental code More Tags Amino acids Building blocks Life RNA Search for Categories Science News Awards and Honors

    Original URL path: http://newswire.rockefeller.edu/tag/amino-acids/ (2016-02-13)
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  • Life | Newswire
    colorful metaphor by astronomer Fred Hoyle points out the difficulties encountered by scientists when they try to understand how life could have emerged billions of years ago Researchers at Rockefeller University now show how crude pieces of a genetic system could self assemble and generate the rules of life s most fundamental code More Tags Amino acids Building blocks Life RNA Search for Categories Science News Awards and Honors Campus

    Original URL path: http://newswire.rockefeller.edu/tag/life/ (2016-02-13)
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  • Tenure awarded to RNA researcher Thomas Tuschl | Newswire
    focuses on RNA interference RNAi the process by which small RNA molecules interfere with gene expression For many years RNAs were simply seen as vehicles that transport genetic information from the nucleus to the site of protein synthesis but it has become obvious that particular small RNA molecules can regulate this process in a gene specific manner Working with Drosophila melanogaster Tuschl and his colleagues showed that long double stranded RNAs generate short double stranded RNAs of 19 to 23 base pair length called small interfering RNAs siRNAs and that these short molecules mediate RNAi gene silencing Tuschl then became the first to show that this gene silencing machinery exists in mammalian cells a discovery that helped create an entire industry of producing small RNAs and exploring their therapeutic applications Once Tuschl and his colleagues saw that this small RNA machinery could selectively turn off genes in mammals including humans they further dissected its mechanism of action by identifying which proteins these small RNAs recognize Building off their work and others they then identified the now well known molecules called microRNAs the natural small RNA occupants of the RNA silencing machinery and ultimately went on to create a microRNA atlas that defines microRNA gene expression in both healthy and diseased tissues It was a very intense time in the field says Tuschl It was very competitive trying to get the first key findings defining the biochemistry of RNA interference and understand how small RNAs could connect with diseases and be put to use clinically Researchers including Tuschl have since discovered some 500 microRNAs in human cells that have shown to play key roles in a host of diseases ranging from Alzheimer s disease to cancer We now believe that the RNA interference caused by microRNAs is actually one of the

    Original URL path: http://newswire.rockefeller.edu/2009/07/24/tenure-awarded-to-rna-researcher-thomas-tuschl/ (2016-02-13)
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