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  • Nathaniel Heintz | Newswire
    and coordinated attack possible More Tags F Nina Papavasiliou Laboratory of Lymphocyte Biology Nathaniel Heintz Peter Model April 16 2009 Science News New nucleotide could revolutionize epigenetics Genes alone cannot explain the vast differences in the complexity of life Scientists have found that what makes a worm and a human so much different isn t the amount of DNA they carry which is about the same but rather the dynamic regulation of those genes by nongenetic factors epigenetics New research at The Rockefeller University has now uncovered a novel system of epigenetic regulation one that adds a new nucleotide to the mammalian DNA code More Tags Nathaniel Heintz nucleotide February 19 2009 Science News Gene linked to anxious behavior in mice Mice and men are different in many ways of course especially when it comes to the psychological But new research linking a gene in mice to anxious behavior raises the prospect that we get some anxiety disorders from a piece of DNA we share with the little mammals The gene Lynx2 alters neurotransmission in parts of the mouse brain associated with anxiety The same parts are associated with anxiety in humans More Tags Lynx2 Nathaniel Heintz Stress November 13 2008 Science News Breakthrough in cell type analysis offers new way to study development and disease It s sometimes said that disease does not discriminate but that s not true Many diseases are very particular about the types of cells they attack laying waste to one population while sparing its nearly identical neighbors for no apparent reason New research from The Rockefeller University for the first time enables scientists to carefully study the biomolecular differences among types of cells in order to learn what makes some susceptible to attack and others resistant More Tags Nathaniel Heintz Paul Greengard TRAP method

    Original URL path: http://newswire.rockefeller.edu/tag/nathaniel-heintz/ (2016-02-13)
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  • neurosciences and behavior | Newswire
    new tool to study Huntington s disease The most common lab animals rats and mice can t tell scientists much about speech disorders However a new study shows how songbirds specifically zebra finches may be able to aid research on neurodegenerative disorders that affect speech and vocalization More Tags Fernando Nottebohm Huntington s disease Laboratory of Animal Behavior neurodegeneration neurosciences and behavior Wan chun Liu October 1 2015 Grants and Gifts Funding from Kavli Foundation to establish new institute at Rockefeller devoted to neuroscience The Kavli Foundation and The Rockefeller University today announced the formation of the Kavli Neural Systems Institute Kavli NSI at Rockefeller funded by a 20 million endowment supported equally by Kavli and Rockefeller The Institute will become part of a network of seven Kavli Institutes carrying out fundamental research in neuroscience and a broader network of 20 Kavli Institutes dedicated to astrophysics nanoscience neuroscience and theoretical physics More Tags Cori Bargmann Jeffrey Friedman Jeffrey M Friedman Kavli Foundation Kavli NSI Leslie B Vosshall Leslie Vosshall neurosciences and behavior September 30 2015 Science News Study offers insight on how a new class of antidepressants works The experimental drugs target brain cells ability to respond to the chemical messenger glutamate however it has been unclear how they work The recent discovery of a molecular amplification system helps explain how the drugs alter signaling in particular neurons to achieve an antidepressant effect More Tags depression Laboratory of Molecular and Cellular Neuroscience neurosciences and behavior p11 Paul Greengard Yong Kim August 24 2015 Science News Promising class of new cancer drugs causes memory loss in mice New research shows that a family of experimental cancer drugs can induce neurological changes in mice The findings underscore the need for more research to determine whether these compounds can enter the brain where

    Original URL path: http://newswire.rockefeller.edu/tag/neurosciences-and-behavior/ (2016-02-13)
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  • nicotine | Newswire
    that fuels craving but it wasn t clear how this happened In new experiments researchers have learned that one of these neurotransmitters acetylcholine regulates the other glutamate to reinforce nicotine dependence More Tags addiction habenula Ines Ibanez Tallon Laboratory of Molecular Biology molecular and cell biology Nathaniel Heintz neurosciences and behavior nicotine Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/nicotine/ (2016-02-13)
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  • A newly discovered signaling molecule helps neurons find their way in the developing brain | Newswire
    the right and left sides of the CNS A number of inborn diseases have been linked to early developmental failures in which commissural axons lose their way and make inappropriate connections In the past two decades work led by Tessier Lavigne and others has identified a number of cell secreted molecules including two groups of proteins called Netrins and Slits that direct the routes of these axons These factors can directionally attract or repel axons by binding to receptors on their tips But scientists still have an incomplete understanding of how neurons receive and integrate inputs from several guidance cues at once or how their responsiveness to certain factors changes over time For example commissural neurons are able to get to the midline because they are attracted there by certain factors including Netrins Tessier Lavigne says But once they ve crossed the midline they need to move on and to do so the neurons somehow switch off their sensitivity to the attractants At the same time the neurons become sensitive to repelling factors in the midline such as Slits This prevents them from backtracking and helps them move forward Focusing on the Robo3 receptor From previous work the researchers knew that a receptor protein called Robo3 is a key controller of the switch in which commissural neurons are initially attracted to the midline and then begin to avoid it They also knew that it did so by boosting the action of attractants Netrins and blocking the action of repellents Slits In the current study which began while Tessier Lavigne and Jaworski were at Genentech and was continued at Rockefeller the researchers made the unexpected discovery that Robo3 has a third action that dovetails with the first two By biochemically isolating proteins that bind to Robo3 from a vast pool of

    Original URL path: http://newswire.rockefeller.edu/2015/11/19/a-newly-discovered-signaling-molecule-helps-neurons-find-their-way-in-the-developing-brain/ (2016-02-13)
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  • Alexander Jaworski | Newswire
    extend their branches to connect one half of the brain with the other A new study sheds light on the molecular mechanisms that guide the winding paths of their axons More Tags Alexander Jaworski axon guidance Laboratory of Brain Development and Repair Marc Tessier Lavigne NELL2 Netrin neurosciences and behavior Slit Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012

    Original URL path: http://newswire.rockefeller.edu/tag/alexander-jaworski/ (2016-02-13)
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  • axon guidance | Newswire
    extend their branches to connect one half of the brain with the other A new study sheds light on the molecular mechanisms that guide the winding paths of their axons More Tags Alexander Jaworski axon guidance Laboratory of Brain Development and Repair Marc Tessier Lavigne NELL2 Netrin neurosciences and behavior Slit Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012

    Original URL path: http://newswire.rockefeller.edu/tag/axon-guidance/ (2016-02-13)
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  • Laboratory of Brain Development and Repair | Newswire
    of Brain Development and Repair Marc Tessier Lavigne NELL2 Netrin neurosciences and behavior Slit January 21 2015 Science News Study detailing axonal death pathway may provide drug targets for neurodegenerative diseases Experiments show that a protein already implicated in degeneration called Sarm1 functions to trigger the MAP kinase pathway Inactivation of this pathway at any of three levels could block the death of damaged axons More Tags Alzheimer s disease Laboratory of Brain Development and Repair Marc Tessier Lavigne Parkinson s November 7 2014 Science News 3D deep imaging advance likely to drive new biological insights In a significant technical advance a team of neuroscientists at The Rockefeller University has devised a fast inexpensive imaging method for probing the molecular intricacies of large biological samples in three dimensions an achievement that could have far reaching implications in a wide array of basic biological investigations More Tags iDISCO imaging Laboratory of Brain Development and Repair Marc Tessier Lavigne neurobiology neuroscience March 16 2011 Campus News Marc Tessier Lavigne becomes Rockefeller s tenth president Marc Tessier Lavigne a leading neuroscientist and the former chief scientific officer of Genentech takes over as president of The Rockefeller University today replacing Paul Nurse who has

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-brain-development-and-repair/ (2016-02-13)
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  • NELL2 | Newswire
    extend their branches to connect one half of the brain with the other A new study sheds light on the molecular mechanisms that guide the winding paths of their axons More Tags Alexander Jaworski axon guidance Laboratory of Brain Development and Repair Marc Tessier Lavigne NELL2 Netrin neurosciences and behavior Slit Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012

    Original URL path: http://newswire.rockefeller.edu/tag/nell2/ (2016-02-13)
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