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  • Joan Steitz | Newswire
    recognizes a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases Steitz will receive the award from National Geographic Explorer in Residence Sylvia Earle at a ceremony in Rockefeller s Caspary Auditorium on November 29 More Tags Joan Steitz Paul Greengard Pearl Meister Greengard Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/joan-steitz/ (2016-02-13)
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  • 2011 Pearl Meister Greengard Prize to be awarded to McGill University memory researcher | Newswire
    in this context says Milner I am very privileged for having been able to pursue my sense of curiosity within the culture of excellence at the Montreal Neurological Institute as well as to train and encourage talented young students driving forces throughout my career to which I attribute much of my success Milner s seminal research has provided many landmark discoveries in the study of human memory and the brain s temporal lobes which play a key role in emotional responses hearing memory and speech She was chosen as the 2011 recipient of the Pearl Meister Greengard Prize by the selection committee of ten jurors of which five are Nobel Laureates The members of the selection committee are Marc Tessier Lavigne president of Rockefeller University Torsten N Wiesel chair and Nobel Laureate Richard Axel Nobel Laureate Cori Bargmann Gunter Blobel Nobel Laureate Titia de Lange Joseph L Goldstein Nobel Laureate Philippa Marrack 2005 recipient of the Pearl Meister Greengard Prize Paul Nurse Nobel Laureate and David D Sabatini Milner began her career studying experimental psychology at the University of Cambridge where she received a bachelor s degree in 1939 She then began studies for a master s degree at Cambridge but soon joined a team interested in distinguishing fighter pilots from bomber pilots in aptitude tests at the beginning of the Second World War She moved to Canada in 1944 to take an academic position at the Institute of Psychology at the University of Montreal She changed her focus to memory in the 1950s during the course of her doctoral research at McGill where she administered perceptual tests to epileptic patients before and after surgery on their temporal lobes She later became known for her work with an epileptic patient known as H M who had become unable to form

    Original URL path: http://newswire.rockefeller.edu/2011/05/25/2011-pearl-meister-greengard-prize-to-be-awarded-to-mcgill-university-memory-researcher/ (2016-02-13)
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  • Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants | Newswire
    tasks that are sensitive to antidepressant treatment The behavioral responses to antidepressants were inhibited by anti inflammatory and analgesic treatments They then confirmed these effects in a human population finding that depressed individuals who reported anti inflammatory drug use were much less likely to have their symptoms relieved by an antidepressant than depressed patients who reported no anti inflammatory drug use The effect was dramatic in the absence of any anti inflammatory or analgesic use 54 percent of patients responded to the antidepressant whereas success rates dropped to approximately 40 percent for those who reported using anti inflammatory agents The mechanism underlying these effects is not yet clear Nevertheless our results may have profound implications for patients given the very high treatment resistance rates for depressed individuals taking SSRIs says Jennifer Warner Schmidt a research associate in Paul Greengard s Laboratory of Molecular and Cellular Neuroscience at Rockefeller Many elderly individuals suffering from depression also have arthritic or related diseases and as a consequence are taking both antidepressant and anti inflammatory medications Our results suggest that physicians should carefully balance the advantages and disadvantages of continuing anti inflammatory therapy in patients being treated with antidepressant medications says Greengard who is Vincent Astor Professor and director of the Fisher Center for Alzheimer s Disease Research at Rockefeller The study may be especially significant in the case of Alzheimer s disease Such patients commonly suffer from depression and unless this can be treated successfully the course of the illness is likely to be more severe Depression in the elderly is also a risk factor for developing Alzheimer s disease and researchers have suggested that treating depression in the elderly might reduce the risk of developing the disease This research was supported in part by grants from the National Institute of Mental Health

    Original URL path: http://newswire.rockefeller.edu/2011/04/25/anti-inflammatory-drugs-reduce-effectiveness-of-ssri-antidepressants/ (2016-02-13)
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  • Molecule that spurs cell’s recycling center may help Alzheimer’s patients | Newswire
    the removal of amyloid β for example by increasing autophagy Most prior strategies to develop Alzheimer s disease drugs were designed to inhibit the formation of the toxic amyloid β Greengard who directs the Fisher Center for Research on Alzheimer s Disease at Rockefeller and his colleagues propose a radically different approach boosting a cellular mechanism to enhance their clearance This approach says Marc Flajolet a research assistant professor in Greengard s lab may also be beneficial for targeting a hallmark of advanced Alzheimer s disease twisted fibers of tau protein that build up inside nerve cells and cause tangles The researchers led by Yuan Tian a postdoctoral fellow in Greengard s lab tested various compounds for their ability to reduce the buildup of amyloid β by exposing cultured cells to compounds known to activate autophagy They then compared the effect of these compounds by removing growth factors from the culture medium a well established stimulant of autophagy known as starvation The researchers found that SMER28 was the most effective compound and focused their studies on it to characterize the cellular components involved in this phenomenon They compared the effect of SMER28 on amyloid β formation using normal cells or cells where the expression of genes known to be involved in autophagy was reduced or abolished They found that three important autophagic players were involved and one of them was essential for SMER28 s effect Identifying a cure for Alzheimer s disease remains a major challenge Four drugs are currently approved by the Food and Drug Administration to treat Alzheimer patients Unfortunately none of these drugs halt progression of the disease and their impact on cognitive defects are minimal On top of that current strategies are associated with severe side effects This limitation was highlighted recently by failures in various

    Original URL path: http://newswire.rockefeller.edu/2011/03/08/molecule-that-spurs-cell%e2%80%99s-recycling-center-may-help-alzheimer%e2%80%99s-patients/ (2016-02-13)
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  • Vincent Astor | Newswire
    life for people with diseases caused by built up proteins in the brain More Tags Alzheimer s disease amyloid β Laboratory of Molecular and Cellular Neuroscience Paul Greengard Vincent Astor February 4 2009 Science News Ritalin may cause changes in the brain s reward areas A common treatment for attention deficit hyperactivity disorder prescribed millions of times a year may change the brain in the same ways that cocaine does

    Original URL path: http://newswire.rockefeller.edu/tag/vincent-astor/ (2016-02-13)
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  • 2010 Pearl Meister Greengard Prize goes to two pioneers of cancer genetics | Newswire
    cancer research and treatment The success of the targeted cancer drug Gleevec based on her discovery of the chromosome translocation in CML is a notable outcome of Rowley s seminal findings Rowley enrolled in the University of Chicago s four year college as a junior in high school She earned her B S in 1946 and her M D in 1948 from the University of Chicago In 1962 after a year as a research trainee in England Rowley returned to the University of Chicago as a research associate in the department of medicine She became an associate professor in 1969 and a full professor in 1977 In 1984 Rowley was named the Blum Riese Distinguished Service Professor She has been the recipient of numerous awards including the Albert Lasker Clinical Research Award the National Medal of Science the Gruber Prize in Genetics the Presidential Medal of Freedom the Jessie Stevenson Kovalenko Award from the National Academy of Sciences and the Award for Lifetime Achievement in Cancer Research from the American Association for Cancer Research King American Cancer Society Professor of Medicine and Genome Sciences at the University of Washington studies the genetics of complex common human conditions Her primary areas of interest are breast and ovarian cancer and genetic influences on major mental illness especially schizophrenia Her approach is to apply human genetics and genomics to the identification and characterization of critical genes in informative families and populations King was the first scientist to show that breast cancer is inherited in some families as the result of mutations in the gene that she named BRCA1 This discovery and her subsequent research on the genetics of schizophrenia and of hearing loss have transformed the understanding of complex disease inheritance King is also recognized as a pioneer in the development of DNA

    Original URL path: http://newswire.rockefeller.edu/2010/11/16/2010-pearl-meister-greengard-prize-goes-to-two-pioneers-of-cancer-genetics/ (2016-02-13)
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  • Janet Davison Rowley | Newswire
    Meister Greengard Prize awarded by The Rockefeller University Established by Nobel Prize winner Paul Greengard and his wife sculptor Ursula von Rydingsvard the prize honors women who have made extraordinary contributions to biomedical science a group that historically has not received appropriate recognition and acclaim More Tags Janet Davison Rowley Mary Claire King Paul Greengard Pearl Meister Greengard Prize Search for Categories Science News Awards and Honors Campus News Grants

    Original URL path: http://newswire.rockefeller.edu/tag/janet-davison-rowley/ (2016-02-13)
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