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  • Netrin | Newswire
    Tags Alexander Jaworski axon guidance Laboratory of Brain Development and Repair Marc Tessier Lavigne NELL2 Netrin neurosciences and behavior Slit April 26 2006 Science News Netrin molecules help neruons shed their symmetry For years scientists have known that netrin molecules help guide growing neurons and their axons the long tendrils that conduct electrical signals But new research shows that these proteins are also important for helping create the neuron s

    Original URL path: http://newswire.rockefeller.edu/tag/netrin/ (2016-02-13)
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  • Slit | Newswire
    extend their branches to connect one half of the brain with the other A new study sheds light on the molecular mechanisms that guide the winding paths of their axons More Tags Alexander Jaworski axon guidance Laboratory of Brain Development and Repair Marc Tessier Lavigne NELL2 Netrin neurosciences and behavior Slit Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012

    Original URL path: http://newswire.rockefeller.edu/tag/slit/ (2016-02-13)
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  • Mutations in key cancer protein suggest new route to treatments | Newswire
    companies have focused on STAT3 because it is overactive in virtually all of the major human cancers breast prostate lung colon and some blood malignancies But earlier efforts have not succeeded in finding drugs that block the protein at low enough doses Darnell says In order to do its normal job an individual STAT3 is activated by addition of an electrically charged chemical group and then must pair with another STAT3 forming what s known as a dimer that adopts a particular configuration The shape is like an open pair of pliers grabbing a wire where the wire represents DNA says Darnell The points that touch the DNA sparking the process of converting its code into protein are known as the DNA binding domains At the tip of the pliers is the SH2 domain which keeps the two charged STAT3s together It s the SH2 domain that most scientists have focused on says Darnell because they believed that by blocking this domain the two halves of the dimer would fall apart and STAT3 couldn t do its job But despite many attempts scientists have yet to find a way to fully block the SH2 interactions he notes So Darnell and the other researchers including first author Claudia Mertens a senior research associate in the lab decided to approach the problem in a different way What if instead of trying to disable the domain that bound the two STAT3s together as a dimer they focused on another region of the STAT3 structure entirely The linker domain which connects the SH2 and DNA binding domains particularly interested them because of earlier work in the lab Interfering with this domain of STAT3 they reasoned could theoretically change either of the other two domains since it comes in contact with both Darnell and his

    Original URL path: http://newswire.rockefeller.edu/2015/11/18/mutations-in-key-cancer-protein-suggest-new-route-to-treatments/ (2016-02-13)
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  • chemical and structural biology | Newswire
    molecular machine that copies DNA Until now the exact configuration of the replisome a block of proteins that unzips the DNA helix and creates two duplicate helices was unknown After taking the first complete pictures of it researchers were surprised to find the complex possesses a counterintuitive architecture raising new questions about its functions More Tags Brain Chait chemical and structural biology DNA replication epigenetics Huilin Li Laboratory of DNA Replication Michael O Donnell replisome October 23 2015 Science News Researchers explore how a cell s protein making factories are assembled The intricate dynamics of ribosome assembly an elaborate and carefully coordinated process that happens continuously inside cells are not yet fully understood Using a new technique they devised researchers have mapped out the proteins involved in the early stages of the construction of a ribosome More Tags chemical and structural biology Laboratory of Protein and Nucleic Acid Chemistry Malik Chaker Margot ribosome sebastian klinge small ribosomal subunit October 5 2015 Science News Newly described ion channel structure reveals how excited neurons settle down The channel Slo2 2 helps restore neurons internal electrical state and so prevents them from firing at too high a frequency for too long which has

    Original URL path: http://newswire.rockefeller.edu/tag/chemical-and-structural-biology/ (2016-02-13)
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  • Claudia Mertens | Newswire
    transcription factor and so contribute to the proliferation of cancerous cells by altering a particular part of the protein This accomplishment suggests a basis for new targeted approaches to fighting cancer More Tags cancer chemical and structural biology Claudia Mertens James E Darnell Laboratory of Molecular Cell Biology sebastian klinge STAT Stat3 Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/claudia-mertens/ (2016-02-13)
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  • James E. Darnell | Newswire
    transcription factor and so contribute to the proliferation of cancerous cells by altering a particular part of the protein This accomplishment suggests a basis for new targeted approaches to fighting cancer More Tags cancer chemical and structural biology Claudia Mertens James E Darnell Laboratory of Molecular Cell Biology sebastian klinge STAT Stat3 Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/james-e-darnell/ (2016-02-13)
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  • Laboratory of Molecular Cell Biology | Newswire
    to James E Darnell Jr and Robert G Roeder Praised as towering figures in cell research the scientists are being recognized for helping to define how cells grow replicate and become specialized and in turn giving medical professionals and researchers the tools to improve health and combat diseases James E Darnell Jr head of the Laboratory of Molecular Cell Biology and Robert G Roeder head of the Laboratory of Biochemistry

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-molecular-cell-biology/ (2016-02-13)
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  • sebastian klinge | Newswire
    intricate dynamics of ribosome assembly an elaborate and carefully coordinated process that happens continuously inside cells are not yet fully understood Using a new technique they devised researchers have mapped out the proteins involved in the early stages of the construction of a ribosome More Tags chemical and structural biology Laboratory of Protein and Nucleic Acid Chemistry Malik Chaker Margot ribosome sebastian klinge small ribosomal subunit February 20 2014 Awards and Honors Sebastian Klinge awarded Sloan Research Fellowship Klinge who joined the faculty in September is among 126 early career scholars from a range of scientific disciplines to be recognized for their promise as the next generation of scientific leaders He will receive 50 000 over two years to further his research on the structure and function of ribosomes the cell s protein factories His lab is working to solve the structure of the macromolecules that catalyze key steps of ribosome creation in cells More Tags sebastian klinge sloan fellowship August 14 2013 Campus News Structural biologist interested in ribosome assembly to join Rockefeller faculty Sebastian Klinge has dedicated his career to understanding the ribosome with a particular emphasis on its atomic structure and the process by which it forms

    Original URL path: http://newswire.rockefeller.edu/tag/sebastian-klinge/ (2016-02-13)
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