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  • chemotherapy | Newswire
    treatments some of which manipulate DNA repair in malignant cells More Tags chemotherapy DNA repair Francisca Lottersberger Laboratory of Cell Biology and Genetics microtubules Taxol telomeres Titia de Lange February 15 2007 Science News A chemotherapy drug packs a one two punch How cancer cells are killed could turn out to be an important element in activating a patient s immune system A new study shows that one chemotherapy drug may kill tumor cells in such a way that the immune system can recognize the cancerous cells and help fight the disease more effectively More Tags chemotherapy Kavita Dhodapkar myeloma January 8 2002 Science News Malignant Cells Survive and Replicate Because Cancer causing Molecule Jams Normal p53 Cell suicide Trigger A cancer causing molecule called WISP 1 may explain why some people with cancer do not benefit from chemotherapy while others with the same form of cancer respond to the treatment according to researchers at The Rockefeller University The findings reported in the Jan 1 issue of Genes and Development suggest that drugs designed to block WISP 1 may increase the effectiveness of chemotherapy in colon cancer and perhaps other cancers More Tags Arnold J Levine chemotherapy James E Darnell

    Original URL path: http://newswire.rockefeller.edu/tag/chemotherapy/ (2016-02-13)
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  • DNA repair | Newswire
    genetic disorders shed light on a crucial DNA repair pathway Researchers have identified two new genes in which mutations can interfere with a cell s ability to remove misplaced links between DNA strands and as a result cause a rare genetic disorder known as Fanconi anemia These discoveries offer new insight on a repair process critical to maintaining certain tissues and preventing cancer More Tags Agata Smogorzewska cell division DNA repair Fanconi anemia interstrand crosslinks Laboratory of Genome Maintenance RAD51 UBE2T May 27 2009 Campus News New Rockefeller faculty member studies mechanisms of DNA repair Agata Smogorzewska a physician scientist whose research focuses on DNA repair and on the molecular basis of Fanconi anemia a genomic instability syndrome that leads to leukemia and other forms of cancer will join The Rockefeller University as head of the Laboratory of Genome Maintenance More Tags Agata Smogorzewska DNA repair October 24 2008 Science News Scientists discover how a well known protein repairs broken DNA ends In the first ever study to film live footage of protected and unprotected telomeres scientists have discovered how a protein called 53BP1 helps fuse dangly DNA ends in need of repair The findings could change how scientists think about double stranded DNA breaks the most lethal type of DNA damage and also leads to new insights about how the human immune system adapts to new threats More Tags DNA repair telomeres August 11 2008 Science News Researchers solve structure of an enzyme vital for DNA repair As freshly made DNA coils into a chromosome cells recognize DNA damage in need of repair Now a new study shows how an enzyme known as Rtt109 which creates slack in the coils in order to allow the cell access to fix the errors is regulated More Tags Andre Hoelz DNA repair

    Original URL path: http://newswire.rockefeller.edu/tag/dna-repair/ (2016-02-13)
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  • Francisca Lottersberger | Newswire
    strands the damaged ends move about during repair Scientists believe a better understanding of this mysterious mechanism could improve the use of cancer treatments some of which manipulate DNA repair in malignant cells More Tags chemotherapy DNA repair Francisca Lottersberger Laboratory of Cell Biology and Genetics microtubules Taxol telomeres Titia de Lange Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/francisca-lottersberger/ (2016-02-13)
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  • microtubules | Newswire
    cancer treatments some of which manipulate DNA repair in malignant cells More Tags chemotherapy DNA repair Francisca Lottersberger Laboratory of Cell Biology and Genetics microtubules Taxol telomeres Titia de Lange April 11 2003 Science News First images of protein export in cells illuminate structural highways called microtubules as sole conduits of protein cargo For the first time scientists have viewed and recorded on camera the final pathway followed by a protein as it exits the body cell that created it Once released from a cell a protein is free to perform its duties as a neurotransmitter hormone cell surface receptor or one of the many other work horses that function outside of body cells every second of the day More Tags exocytosis microtubules Sanford M Simon March 10 2003 Science News Rockefeller researchers identify new mechanism that ensures accurate partitioning of genetic material in dividing cells Every minute the human body replaces 300 million of its dying cells with new ones through the vital biological process known as cell division When dividing and multiplying a parent cell must segregate with exquisite precision each of its 46 chromosomes so that two daughter cells inherit all of its genetic information More Tags

    Original URL path: http://newswire.rockefeller.edu/tag/microtubules/ (2016-02-13)
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  • Taxol | Newswire
    the damaged ends move about during repair Scientists believe a better understanding of this mysterious mechanism could improve the use of cancer treatments some of which manipulate DNA repair in malignant cells More Tags chemotherapy DNA repair Francisca Lottersberger Laboratory of Cell Biology and Genetics microtubules Taxol telomeres Titia de Lange Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012

    Original URL path: http://newswire.rockefeller.edu/tag/taxol/ (2016-02-13)
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  • Study reveals the architecture of the molecular machine that copies DNA | Newswire
    in simpler single celled bacteria but the more complex version has over 30 different gears or proteins and required about 15 years for O Donnell s lab to obtain Through these previous studies his lab has learned how to assemble the more complex replisome from its components But until now no pictures existed to show just how everything fit together in the eukaryotic replisome To create them the team began building the complete structure piece by piece and examining its shape in the electron microscope a powerful device used to study protein structures and a specialty of co author Huilin Li a molecular biologist at Brookhaven National Laboratory and Stony Brook University The pictures Li and members of his lab captured were the first ever made of a complete replisome from any type of cell The DNA helix has two DNA strands and each is duplicated by a separate DNA polymerase an enzyme that creates DNA molecules by pairing single nucleotides the basic units of DNA with their matching partners Another enzyme in the replisome is the helicase that like a zipper is responsible for separating DNA into two single strands in preparation for replication For years the two polymerases were thought to follow along behind the helicase or below it as it unzips the strands But the new pictures of the replisome showed that one polymerase sits above the helicase A link to epigenetics To identify which polymerase was at the top of the helicase the team enlisted the help of co authors postdoc Yi Shi and Brian Chait the Camille and Henry Dreyfus Professor at Rockefeller and head of the Laboratory of Mass Spectrometry and Gaseous Ion Chemistry They identified the top polymerase as Pol ε Why the eukaryotic replisome developed such a structure is not known O

    Original URL path: http://newswire.rockefeller.edu/2015/11/02/study-reveals-the-architecture-of-the-molecular-machine-that-copies-dna/ (2016-02-13)
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  • Brain Chait | Newswire
    DNA helix and creates two duplicate helices was unknown After taking the first complete pictures of it researchers were surprised to find the complex possesses a counterintuitive architecture raising new questions about its functions More Tags Brain Chait chemical and structural biology DNA replication epigenetics Huilin Li Laboratory of DNA Replication Michael O Donnell replisome Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive

    Original URL path: http://newswire.rockefeller.edu/tag/brain-chait/ (2016-02-13)
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  • DNA replication | Newswire
    tasks such as transcribing instructions for proteins More Tags DNA replication Laboratory of DNA Replication Michael O Donnell October 17 2008 Science News Molecule stops DNA replication in its tracks When a dividing cell duplicates its genetic material a molecular machine called a sliding clamp travels along the DNA double helix tethering the proteins that perform the replication Rockefeller University scientists have discovered a small molecule that stops the sliding clamp in its tracks a finding that will enable researchers to better study the proteins that duplicate DNA and may ultimately provide a platform for developing improved antibiotics More Tags DNA replication June 28 2007 Science News Critical protein prevents damaged DNA from persisting through generations When B lymphocytes lack the ATM protein chromosomal breaks created during their maturation go unrepaired and checkpoints that normally prevent the damaged cell from replicating are lost More Tags ATM DNA replication Michel C Nussenzweig April 20 2007 Science News New study reveals inner workings of a molecular clamp critical to DNA replication The process by which DNA is copied an essential biological function which occurs millions of times a day in an average mammal is driven by three core protein complexes New research from Rockefeller University now shows that one of these complexes a clamp loader requires several previously unidentified steps to get the process started More Tags DNA replication Mike O Donnell molecular clamp February 5 2007 Science News With no plan for DNA replication cells depend on random selection New research in yeast from Rockefeller University shows that instead of going about DNA replication in an organized way the cell takes a random approach using a range of efficient and inefficient origins The results leave scientists wondering how the cell ensures that the process is completed on time More Tags DNA

    Original URL path: http://newswire.rockefeller.edu/tag/dna-replication/ (2016-02-13)
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