archive-edu.com » EDU » R » ROCKEFELLER.EDU

Total: 1631

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Malik Chaker-Margot | Newswire
    happens continuously inside cells are not yet fully understood Using a new technique they devised researchers have mapped out the proteins involved in the early stages of the construction of a ribosome More Tags chemical and structural biology Laboratory of Protein and Nucleic Acid Chemistry Malik Chaker Margot ribosome sebastian klinge small ribosomal subunit Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015

    Original URL path: http://newswire.rockefeller.edu/tag/malik-chaker-margot/ (2016-02-13)
    Open archived version from archive


  • ribosome | Newswire
    Chaker Margot ribosome sebastian klinge small ribosomal subunit August 14 2013 Campus News Structural biologist interested in ribosome assembly to join Rockefeller faculty Sebastian Klinge has dedicated his career to understanding the ribosome with a particular emphasis on its atomic structure and the process by which it forms in the cell Klinge is the first faculty member to be recruited to the university under its 2012 strategic plan he was

    Original URL path: http://newswire.rockefeller.edu/tag/ribosome/ (2016-02-13)
    Open archived version from archive

  • Researchers identify potential new leukemia drug target | Newswire
    Genes and Development the researchers describe how they identified the molecular mechanism behind this gene activation The researchers led by Robert G Roeder Arnold and Mabel Beckman Professor and head of Rockefeller s Laboratory of Biochemistry and Molecular Biology began by searching for proteins that interact with the mutant protein known as AE produced by a DNA rearrangement Their screen identified JMJD1C an enzyme that removes chemical tags known as methyl groups from histones which are proteins contained in chromosomes These tags serve as repressive marks indicating that genes in the associated region should be turned off To investigate the relationship between JMJD1C and AE the team first explored the broader effects of removing JMJD1C We found that numerous genes were down regulated upon loss of JMJD1C and the set overlaps significantly with the genes that are normally activated by AE explains first author Mo Chen a postdoc in Roeder s lab The loss of gene expression turns out to have dramatic consequences for the disease The team found that acute myeloid leukemia cells are addicted to the presence of JMJD1C and without it they cannot survive In fact these cells were very sensitive to depletion of JMJD1C says Chen We see an increase in apoptosis a sort of cellular suicide The team confirmed that JMJD1C interacts with AE and demonstrated that the enzyme is required for AE to exert its cancer promoting effects But they also found that JMJD1C plays an even a broader role in acute myeloid leukemia beyond its interaction with AE We were very surprised to find that JMJD1C is required for the proliferation of other acute myeloid leukemia cell lines which do not have AE so we looked for other proteins that might be responsible for JMJD1C addiction says Chen The team found at least

    Original URL path: http://newswire.rockefeller.edu/2015/10/21/researchers-identify-potential-new-leukemia-drug-target/ (2016-02-13)
    Open archived version from archive

  • acute myeloid leukemia | Newswire
    mutant protein is known to cause dramatic changes in gene expression Now researchers have identified a second protein with similar function that plays an even broader role in the disease More Tags acute myeloid leukemia cancer Laboratory of Biochemistry and Molecular Biology Mo Chen Robert Roeder Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow

    Original URL path: http://newswire.rockefeller.edu/tag/acute-myeloid-leukemia/ (2016-02-13)
    Open archived version from archive

  • Mo Chen | Newswire
    protein is known to cause dramatic changes in gene expression Now researchers have identified a second protein with similar function that plays an even broader role in the disease More Tags acute myeloid leukemia cancer Laboratory of Biochemistry and Molecular Biology Mo Chen Robert Roeder Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv

    Original URL path: http://newswire.rockefeller.edu/tag/mo-chen/ (2016-02-13)
    Open archived version from archive

  • Jean-Laurent Casanova elected to the National Academy of Medicine | Newswire
    Casanova In what is considered to be one of the highest honors in medicine new members are elected annually in recognition of their outstanding professional achievements and commitment to service Jean Laurent s work has established that unusual vulnerability among young people to specific infectious diseases such as the flu and mycobacterial infections can arise from single gene errors He has helped drive a paradigm shift within the fields of genetics and infectious disease that has enabled dramatic improvements in patients health says Marc Tessier Lavigne the university president It is gratifying to see the great significance of his research recognized by his peers in the academy Through his research Casanova has identified inborn errors of immunity conferring increased susceptibility to specific pathogens including mycobacterial diseases such as tuberculosis invasive pneumococcal disease herpes simplex encephalitis and chronic mucocutaneous candidiasis His work has driven the revelation that many immunological processes thought to play a broad defensive role are essential against only one or a few specific infections The discovery of single gene based vulnerabilities in otherwise healthy children has profound clinical implications offering families the possibility of molecular diagnosis and genetic counseling as well as treatments aimed at restoring the deficient immune response Casanova received his M D from the University of Paris Descartes and his Ph D in immunology from the Pierre and Marie Curie University in Paris As a professor of pediatrics at the Necker Hospital in Paris he and Laurent Abel cofounded and codirected the Laboratory of Human Genetics of Infectious Diseases In 2008 Casanova joined Rockefeller He is the recipient of numerous awards Most recently he was elected as a foreign associate of the National Academy of Sciences Established in 1970 and formerly known as the Institute of Medicine the Academy of Medicine is a national resource

    Original URL path: http://newswire.rockefeller.edu/2015/10/19/jean-laurent-casanova-elected-to-the-national-academy-of-medicine/ (2016-02-13)
    Open archived version from archive

  • Institute of Medicine | Newswire
    development Tessier Lavigne has pioneered the identification of the molecules that direct the formation of connections among nerve cells to establish neuronal circuits in the mammalian brain and spinal cord Tessier Lavigne is among 65 new members and five foreign associates elected to the Institute this year More Tags Institute of Medicine Marc Tessier Lavigne October 12 2009 Awards and Honors Immunologist Michel Nussenzweig elected to Institute of Medicine The head of Rockefeller University s Laboratory of Molecular Immunology Nussenzweig s considerable contributions to the field of immunology include insights into how autoimmune diseases progress and the development of methods that may lead to dendritic cell vaccines Nussenzweig is one of 14 current Rockefeller researchers who are members of the Institute of Medicine More Tags Institute of Medicine Michel C Nussenzweig October 8 2007 Awards and Honors Jeffrey Ravetch elected to Institute of Medicine Jeffrey V Ravetch head of Rockefeller University s Leonard Wagner Laboratory of Molecular Genetics and Immunology is one of 65 new members and four foreign associates whose election to the Institute of Medicine was announced today More Tags Institute of Medicine Jeffrey Ravetch October 24 2005 Awards and Honors Jeffrey Friedman elected to Institute of Medicine

    Original URL path: http://newswire.rockefeller.edu/tag/institute-of-medicine/ (2016-02-13)
    Open archived version from archive

  • National Academy of Medicine | Newswire
    unusual vulnerability to specific infectious diseases among young people receives one of the highest honors within the field of medicine Seventeen Rockefeller scientists are currently members of the academy of medicine More Tags Institute of Medicine Jean Laurent Casanova National Academy of Medicine St Giles Laboratory of Human Genetics of Infectious Diseases Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013

    Original URL path: http://newswire.rockefeller.edu/tag/national-academy-of-medicine/ (2016-02-13)
    Open archived version from archive