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  • Marc Tessier-Lavigne | Newswire
    unmet medical needs as well as in helping to create an environment that fosters the growth of the industry in the New York metropolitan area More Tags Marc Tessier Lavigne November 7 2014 Science News 3D deep imaging advance likely to drive new biological insights In a significant technical advance a team of neuroscientists at The Rockefeller University has devised a fast inexpensive imaging method for probing the molecular intricacies of large biological samples in three dimensions an achievement that could have far reaching implications in a wide array of basic biological investigations More Tags iDISCO imaging Laboratory of Brain Development and Repair Marc Tessier Lavigne neurobiology neuroscience July 28 2014 In the News In the News WSJ 7 28 14 Wanted Biotech Startups in New York City A lot of the legal and commercial groundwork has been established between Accelerator and its partner institutions which should help speed the business development process said Marc Tessier Lavigne president of Rockefeller University Tags Marc Tessier Lavigne June 30 2013 Campus News Rockefeller president joins U S university leaders in Israel to explore collaborative opportunities Rockefeller s president Marc Tessier Lavigne will join several U S university leaders in Israel this week to explore opportunities for collaborations with Israeli institutions in areas such as brain science environmental sustainability biotechnology diversity and women s leadership The visit has been arranged by Project Interchange a non profit educational institute of the American Jewish Committee which is an advocacy group based in New York More Tags Israel Marc Tessier Lavigne April 24 2013 Awards and Honors Marc Tessier Lavigne and Jeffrey Friedman elected to American Academy of Arts and Sciences Tessier Lavigne Rockefeller president and head of the Laboratory of Brain Development and Jeffrey M Friedman head of the Laboratory of Molecular Genetics were elected to the honorary society and independent policy research center along with 198 other leaders in science art academia and the civic corporate and philanthropic arenas The current membership includes some 250 Nobel laureates and more than 60 Pulitzer Prize winners and 23 other Rockefeller University faculty members are fellows More Tags American Academy of Arts and Sciences Jeffrey M Friedman Marc Tessier Lavigne September 21 2012 Awards and Honors Jeffrey M Friedman awarded 11th IPSEN Endocrine Regulation Prize Friedman is being recognized for his groundbreaking discovery of leptin a hormone that regulates food intake and energy expenditure His observations provided scientists with a new target for treating obesity and other metabolic diseases More Tags Bruce S McEwen Donald W Pfaff IPSEN Jeffrey M Friedman Marc Tessier Lavigne March 19 2012 Awards and Honors Marc Tessier Lavigne to receive Friesen International Prize President Marc Tessier Lavigne will receive the Henry G Friesen International Prize in Health Research established by the Friends of Canadian Institutes of Health Research in collaboration with the Canadian Academy of Health Sciences to recognize exceptional innovation by a visionary health leader of international stature More Tags Marc Tessier Lavigne October 17 2011 Awards and Honors Marc Tessier

    Original URL path: http://newswire.rockefeller.edu/tag/marc-tessier-lavigne/ (2016-02-13)
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  • A newly discovered form of immunity helps explain how bacteria fight off viruses | Newswire
    during the late phase of infection they cut up viral RNA The CRISPR clustered regularly interspersed short palindromic repeats system is a type of adaptive bacterial immune response that relies on sections of DNA containing sequences matching those in viral genetic code CRISPR associated genes use these sequences as guides to target invaders for destruction Typically CRISPR defense systems attack and destroy the viral DNA within minutes after it has been injected into the bacterial cell so the invading virus doesn t get a chance to replicate However the specific type of CRISPR investigated in the study called type III CRISPR Cas system waits for the virus to replicate and mounts its attack during a later phase of the infection after the viral DNA has been copied and is being transcribed into RNA It appears that type III CRISPR Cas actually needs the virus to produce RNA before it can target and destroy the viral DNA says Wenyan Jiang a graduate student who is the paper s first author As a result the system has to deal with hundreds of viral DNA strands instead of one and can take up to nine hours instead of minutes to clear the infection An extra safeguard There is an inherent peril in waiting until this point and because of the large number of viral genomes present the typical DNA cutting enzymes employed by CRISPR Cas systems can t stop the infection alone So type III CRISPR Cas also uses the enzymes Csm3 and Csm6 to target the viral RNA the researchers found To observe this RNA focused defense in action Marraffini Jiang and Poulami Samai a research associate in the lab generated a mutated form of Staphylococcus epidermidis bacteria that lacked the Csm3 and Csm6 enzymes When they infected both the mutant and

    Original URL path: http://newswire.rockefeller.edu/2016/02/04/a-newly-discovered-form-of-immunity-helps-explain-how-bacteria-fight-off-viruses/ (2016-02-13)
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  • bacterial immune system | Newswire
    type of immune system found in many species of bacteria Some data showed that this mechanism would target the virus s DNA while other experiments suggested it could only disable a virus once it had started replicating itself New results suggest both mechanisms play a role More Tags bacteria bacterial immune system CRISPR Laboratory of Bacteriology Luciano Marraffini type III CRISPR Cas August 31 2014 Science News Discovery reveals how

    Original URL path: http://newswire.rockefeller.edu/tag/bacterial-immune-system/ (2016-02-13)
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  • CRISPR | Newswire
    target the virus s DNA while other experiments suggested it could only disable a virus once it had started replicating itself New results suggest both mechanisms play a role More Tags bacteria bacterial immune system CRISPR Laboratory of Bacteriology Luciano Marraffini type III CRISPR Cas March 26 2015 Science News Researchers master gene editing technique in mosquito that transmits deadly diseases Rockefeller University researchers have successfully harnessed a technique CRISPR Cas9 editing to use in an important and understudied species the mosquito Aedes aegypti which infects hundreds of millions of people annually with the deadly diseases chikungunya yellow fever and dengue fever More Tags aedes aegypti chikungunya CRISPR CRISPR Cas9 dengue fever gene editing Laboratory of Neurogenetics and Behavior Leslie B Vosshall Leslie Vosshall mosquitos yellow fever February 20 2015 Science News Virus cutting enzyme helps bacteria remember a threat The enzyme Cas9 is well known for its ability to make precise cuts in a genome New research reveals a new role for Cas9 in its native bacteria helping the microbial immune system acquire a memory of an invading virus More Tags adaptive immune system Cas9 CRISPR Laboratory of Bacteriology Luciano Marraffini microbiology Poulami Samai Robert Heler October 5 2014 Science News Programmable antibiotic harnesses an enzyme to attack drug resistant microbes By co opting a system bacteria normally use to defend themselves researchers targeted and killed off colonies of the antibiotic resistant Staph cells on mouse skin The treatment left behind the drug susceptible microbes More Tags antibiotic resistance Cas9 CRISPR David Bikard Luciano Marraffini Vincent Fischetti August 31 2014 Science News Discovery reveals how bacteria distinguish harmful versus helpful viruses Viruses can kill bacteria or viruses can help the microbes by lending them potentially useful genes New research shows Staph bacteria have an immune system capable of distinguishing

    Original URL path: http://newswire.rockefeller.edu/tag/crispr/ (2016-02-13)
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  • CRISPR-Cas | Newswire
    an immune defense mechanism in bacteria that allows these microorganisms to respond to viral infections with remarkable precision Their findings could have implications for the development of new therapies against infectious diseases More Tags bacterial immune system CRISPR CRISPR Cas Laboratory of Bacteriology Luciano Marraffini Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv

    Original URL path: http://newswire.rockefeller.edu/tag/crispr-cas/ (2016-02-13)
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  • Laboratory of Bacteriology | Newswire
    antibiotic resistance Marraffini studies CRISPR Cas systems which enable some bacteria to acquire immunity against viruses and is investigating ways to use them to fight off microbial pathogens More Tags antibiotic resistance CRISPR Hans Sigrist Prize Laboratory of Bacteriology Luciano Marraffini August 13 2015 Awards and Honors Luciano Marraffini and Robert Roeder recognized by ASBMB awards Marraffini who studies the adaptive immune systems known as CRISPR Cas systems found in some bacteria and used in genome editing has won the Earl and Thressa Stadtman Scholar Award Meanwhile Robert Roeder who investigates the mechanisms that regulate transcription the process by which genes are copied into RNA is the recipient of the Herbert Tabor Research Award More Tags ASBMB awards and honors Laboratory of Bacteriology Laboratory of Biochemistry and Molecular Biology Luciano Marraffini Robert Roeder May 22 2015 Awards and Honors Luciano Marraffini selected as a Blavatnik National Award finalist Marraffini who studies the CRISPR Cas systems that enable some bacteria to acquire immunity against viruses is among 32 highly qualified young faculty researchers selected to compete for this national award More Tags Blavatnik Awards Blavatnik National Award Laboratory of Bacteriology Luciano Marraffini May 7 2015 Science News Rockefeller scientists resolve long standing debate over how many bacteria fight off invaders For years researchers have puzzled over conflicting results about the workings of type III CRISPR Cas systems a type of immune system found in many species of bacteria Some data showed that this mechanism would target the virus s DNA while other experiments suggested it could only disable a virus once it had started replicating itself New results suggest both mechanisms play a role More Tags bacteria bacterial immune system CRISPR Laboratory of Bacteriology Luciano Marraffini type III CRISPR Cas February 20 2015 Science News Virus cutting enzyme helps bacteria remember

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-bacteriology/ (2016-02-13)
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  • Luciano Marraffini | Newswire
    bacteria to acquire immunity against viruses is among 32 highly qualified young faculty researchers selected to compete for this national award More Tags Blavatnik Awards Blavatnik National Award Laboratory of Bacteriology Luciano Marraffini May 7 2015 Science News Rockefeller scientists resolve long standing debate over how many bacteria fight off invaders For years researchers have puzzled over conflicting results about the workings of type III CRISPR Cas systems a type of immune system found in many species of bacteria Some data showed that this mechanism would target the virus s DNA while other experiments suggested it could only disable a virus once it had started replicating itself New results suggest both mechanisms play a role More Tags bacteria bacterial immune system CRISPR Laboratory of Bacteriology Luciano Marraffini type III CRISPR Cas February 20 2015 Science News Virus cutting enzyme helps bacteria remember a threat The enzyme Cas9 is well known for its ability to make precise cuts in a genome New research reveals a new role for Cas9 in its native bacteria helping the microbial immune system acquire a memory of an invading virus More Tags adaptive immune system Cas9 CRISPR Laboratory of Bacteriology Luciano Marraffini microbiology Poulami Samai Robert Heler October 5 2014 Science News Programmable antibiotic harnesses an enzyme to attack drug resistant microbes By co opting a system bacteria normally use to defend themselves researchers targeted and killed off colonies of the antibiotic resistant Staph cells on mouse skin The treatment left behind the drug susceptible microbes More Tags antibiotic resistance Cas9 CRISPR David Bikard Luciano Marraffini Vincent Fischetti August 31 2014 Science News Discovery reveals how bacteria distinguish harmful versus helpful viruses Viruses can kill bacteria or viruses can help the microbes by lending them potentially useful genes New research shows Staph bacteria have an immune

    Original URL path: http://newswire.rockefeller.edu/tag/luciano-marraffini/ (2016-02-13)
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  • Study reveals how herpes virus tricks the immune system | Newswire
    and first author of the paper Michael Oldham One piece of the machinery involved in getting bits of virus to the cell s surface is a protein called TAP It s a transporter that acts as a bridge to move the virus pieces across the membrane of the endoplasmic reticulum a structure within the cell that packages the virus bits From here they move to the cell s surface alerting immune cells to the virus s presence We knew that TAP was involved in our inability to have an effective immune response to this virus but no one really knew what TAP looks like or how it works says Chen Our findings show exactly how this viral protein jams TAP which has two effects One it precludes the regular protein from binding Two it makes the transporter stuck in this conformation Microscopy breakthrough It has been notoriously difficult to investigate the structure of proteins embedded in cellular membranes such as TAP because the samples are not stable and disintegrate easily In this study the researchers used a technique known as cryo electron microscopy in which the purified protein is frozen in a thin layer of ice This stabilizes the sample allowing scientists to retrieve data and computationally determine the structure The usefulness of cryo EM was previously restricted by its inability to yield detailed molecular structures but recent breakthroughs in detector technology now allow the capture of structural information at the scale of tenths of nanometers Through a collaboration with Thomas Walz head of the Laboratory of Molecular Electron Microscopy at Rockefeller and using sophisticated cryo EM tools Chen s team was able to investigate TAP s structure in great detail Virus as teacher Therapeutics to prevent cold sores is not something that will emerge in the near future due

    Original URL path: http://newswire.rockefeller.edu/2016/02/03/study-reveals-how-herpes-virus-tricks-the-immune-system/ (2016-02-13)
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