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  • Laboratory of Developmental Genetics | Newswire
    Chalasani who were named finalists in the third annual competition in September were honored last night with six other winners at the New York Academy of Sciences Science and the City Gala More Tags Blavatnik Awards Cori Bargmann Laboratory of Developmental Genetics Laboratory of Neural Circuits and Behavior Shai Shaham Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-developmental-genetics/ (2016-02-13)
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  • Research defines neurons that control sociability in worms | Newswire
    central integrating hub of a network of sensory neurons that feeds the worm readings of its environment such as whether food is available how much oxygen is in the air and other factors known to influence gregarious behavior Only when the right conditions are met will the animals congregate Evan Macosko an M D Ph D student in the Bargmann lab found that the crucial trigger for aggregation is a switch in the response to other worms pheromones RMG and a pheromone detecting neuron named ASK are the essential players in the hub and spoke circuit that drives social behavior Pheromones are known to bring creatures together in many species from insects such as ants and moths to mammals including prairie voles and possibly even people In social strains of C elegans a transparent one millimeter long roundworm the same is true Bargmann determined that ASK known to be involved in the attraction of the relatively rare males to the more common hermaphrodites senses pheromones ASK is relatively inactive in solitary hermaphrodites which ignore or avoid pheromones However in social worms RMG amplifies the signal from pheromone sensitive ASK neurons driving the worms toward each other and increasing sociability The hub and spoke circuit Bargmann says is a relatively rare but recurring theme in the map of C elegans s nervous system known as its wiring diagram The neurons connected in such circuits primarily communicate electrically across gap junctions rather than through the more common connections of chemical synapses Bargmann believes that hub and spoke circuits could be the integrative sites that coordinate different characteristic behaviors in worms and other species RMG is the hub of the worm s social brain and also a hub of genetic differences in social behavior The activity of one receptor gene in the worm

    Original URL path: http://newswire.rockefeller.edu/2009/04/10/research-defines-neurons-that-control-sociability-in-worms/ (2016-02-13)
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  • worms | Newswire
    sophisticated socialites of all Relatively little is known about the neuronal underpinnings of our gregarious instincts however New research tackles the problem in the worm identifying a neural circuit perhaps the world s simplest social brain that drives pheromone attraction and social behavior More Tags Cori Bargmann worms Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About

    Original URL path: http://newswire.rockefeller.edu/tag/worms/ (2016-02-13)
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  • Cori Bargmann wins 2009 Lounsbery Award | Newswire
    elegans s neural circuits develop identifies the genes and neural pathways for its actions and investigates how sensory inputs regulate those circuits Bargmann is also a Howard Hughes Medical Institute investigator and a member of the National Academy of Sciences and the American Academy of Arts and Sciences In addition to the Lounsbery Award she has received a Dargut and Milena Kemali International Prize for Research in the Field of Basic and Clinical Neurosciences a Charles Judson Herrick Award for comparative neurology a Takasago Award for olfaction research and a W Alden Spencer Award for neuroscience research among numerous other honors Established in 1979 by Vera Lounsbery in memory of her husband and supported by the Richard Lounsbery Foundation the Lounsbery Award exists to encourage reciprocal scientific exchanges between the United States and France It is presented in alternate years to young French and American scientists in recognition of extraordinary scientific achievement in biology or medicine Bargmann s award includes 50 000 and additional funds to visit a laboratory or research institute in France Past recipients of the Lounsbery Award include Rockefeller University s Günter Blobel Jean Laurent Casanova and Elaine Fuchs Cori s work on neural circuits and behavior

    Original URL path: http://newswire.rockefeller.edu/2009/01/30/cori-bargmann-wins-2009-lounsbery-award/ (2016-02-13)
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  • Lounsbery Award | Newswire
    s neural circuits develop identifies the genes and neural pathways for its actions and investigates how sensory inputs regulate those circuits is the recipient of this year s Richard Lounsbery Award from the National Academy of Sciences More Tags Cori Bargmann Lounsbery Award Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The

    Original URL path: http://newswire.rockefeller.edu/tag/lounsbery-award/ (2016-02-13)
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  • By recognizing odors, a single neuron controls reactions | Newswire
    pursued the question in a simpler creature and context In Caenorhabditis elegans a one millimeter long worm known as the bloodhound of the invertebrates for its olfactory acumen what biochemical process causes a change in odor preference The worm has a relatively compact nervous system of 302 neurons Bargmann s lab focused on the only one that is sensitive to the odor butanone a mild slightly oily smell that attracts normal worms when they first encounter it The experiments showed that if worms are fed in the presence of butanone they fall in love with it twisting their way more quickly toward the odor But if those same worms are starved in the presence of the smell for two hours they have the opposite reaction They get really mad says Bargmann who is also a Howard Hughes Medical Institute investigator Not only will they not go to the odor they will run away from it Bargmann found a worm with a specific mutation to the gcy 28 gene that altered the neuron under study known as AWC on causing naive worms to flee from butanone By systematically examining worms with different mutations affecting the AWC on neuron as well as other neurons that might impact the worm s reaction to butanone the researchers were able to confirm that a specific chemical signaling pathway is used by the AWC on neuron to direct the worms movement either toward or away from the odor These as well as other tests including the use of a laser to destroy specific neurons demonstrated that a single sensory neuron responding to stimuli from both inside and outside the worm could change the worm s preferences and behaviors The finding defies the pure labeled line theory of sensation which holds that sensory neurons are specialized to

    Original URL path: http://newswire.rockefeller.edu/2008/10/20/by-recognizing-odors-a-single-neuron-controls-reactions/ (2016-02-13)
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  • olfactory | Newswire
    December 5 2007 Science News Small experience during critical period alters brain Genes may provide the land but experience defines the landscape Now researchers at Rockefeller University show that a fly s external environment can alter the genetically determined circuit that detects carbon dioxide a gas that alerts flies to sources of food and other flies that are experiencing stress While the structure and function of the neurons that pick up the sensory signals and send them to the brain remain unaltered those that communicate between the two show significant changes in function and confer neural plasticity onto the fly brain More Tags glomerulus Leslie B Vosshall olfactory November 8 2007 Science News Biologists use microfluidics chips to watch worm behavior For the first time researchers have visualized neural impulses in C elegans olfactory neurons at the moment they occur Using specialized chips that can monitor the roundworms behavior they ve found that the worm neural system has similarities to our own More Tags Cori Bargmann olfactory October 17 2007 Science News Accessory protein determines whether pheromones are detected Pheromones are big fatty molecules that living organisms emit in order to send messages to individuals of the same species New research at Rockefeller University has identified an unanticipated protein that snatches these pheromones and hands them off to their specific pheromone receptor It is the first time this CD36 related protein called SNMP and its mechanism of action have been implicated in pheromone detection the mechanism also appears to underlie the diverse biological functions regulated by CD36 proteins ranging from how we taste fats to how our immune system detects and responds to foreign invaders More Tags Leslie B Vosshall olfactory pheromones September 16 2007 Science News Gene determines whether male body odor smells pleasant Up to one third of the adult human population does not perceive an odor in androstenone a component of male body odor that has been shown to induce physiological responses in both men and women To those who do androstenone either takes on a pleasant sweet odor or a repulsive urine like one New research from Rockefeller University and Duke University traces this variability to point mutations in a single odorant receptor gene a finding that raises questions of how people detect other people s body odor More Tags androstenone Leslie B Vosshall olfactory August 16 2007 Science News Mice use specialized neurons to detect carbon dioxide in the air New research shows that a special set of olfactory neurons helps mice detect carbon dioxide a finding that may have implications for how predicted increases in atmospheric levels of the gas may affect animal behavior More Tags olfactory Peter Mombaerts May 15 2007 Science News Left right wiring determined by neural communication in the embryonic worm Although most animals appear symmetrical at first glance they hide a glut of internal asymmetries The roundworm C elegans has nerves on its left and right sides that perform different functions and which nerve runs down which side seems

    Original URL path: http://newswire.rockefeller.edu/tag/olfactory/ (2016-02-13)
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  • $4.5 million grant funds interdisciplinary fellowships at Rockefeller | Newswire
    the Presidential Fellows Program is an initiative to recruit young scientists in broad areas of biology biomedicine and the physical and quantitative sciences The Levy Fellowships in Neuroscience will be established within the Shelby White and Leon Levy Center for Mind Brain and Behavior originally founded in 1998 through a grant from Leon Levy and his wife Shelby White to conduct research on the neural basis of complex mental processes Shelby White founding trustee of the Leon Levy Foundation said Leon had an intense interest in the function of the human brain and its effects on behavior He was particularly interested in psychology We have long supported the pioneering scientific discovery at Rockefeller University particularly through the Leon Levy and Shelby White Center for Mind Brain and Behavior We are pleased to continue that tradition with these important neuroscience fellowships The White Levy Center is directed by President Emeritus Torsten N Wiesel who shared the 1981 Nobel Prize in Physiology or Medicine for studies of how visual information collected by the retina is transmitted to and processed in the visual cortex of the brain Two Rockefeller professors will serve as mentors for the fellowship program Cori Bargmann Torsten N Wiesel Professor and head of the Laboratory of Neural Circuits and Behavior and A James Hudspeth F M Kirby Professor and head of the Laboratory of Sensory Neuroscience Both professors are also investigators at the Howard Hughes Medical Institute To move neuroscience forward in significant ways we need the contributions of scientists who can develop and apply theoretical approaches to study the brain as a complex system says Bargmann who is also associate director of the White Levy Center Independent thinkers who can apply the higher order tools of physics and mathematics to biological problems will play a critical role in

    Original URL path: http://newswire.rockefeller.edu/2008/03/25/4-5-million-grant-funds-interdisciplinary-fellowships-at-rockefeller/ (2016-02-13)
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