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  • Agata Smogorzewska | Newswire
    anemia These discoveries offer new insight on a repair process critical to maintaining certain tissues and preventing cancer More Tags Agata Smogorzewska cell division DNA repair Fanconi anemia interstrand crosslinks Laboratory of Genome Maintenance RAD51 UBE2T August 8 2012 Science News Collaboration finds kidney disease tied to DNA damage A research collaboration involving Rockefeller University and more than two dozen other institutions found that patients who had a specific kind of kidney disease called karyomegalic interstitial nephritis were likely to also have a mutation on FAN1 a gene that is involved in fixing DNA damage More Tags Agata Smogorzewska crosslink DNA damage kidney disease July 20 2010 Science News Researchers identify DNA damage repair gene in Fanconi anemia pathway The threats to our genes come fast and furious To fend them off evolution has come up with complex safety measures to preserve the stability of our DNA New research identifies a protein that is involved in guarding against a particularly dangerous peril called the inter strand crosslink when two strands of DNA become stuck together and can t be unzipped for their proper replication or transcription A mutation in the gene that produces this protein may lead to the deadly cancer causing disorder known as Fanconi anemia and may be involved in breast cancer as well the experiments show More Tags Agata Smogorzewska FAN1 Laboratory of Genome Maintenance November 12 2009 Science News Two proteins act as molecular tailors in DNA repair On average our cells encounter a very lethal form of DNA damage 10 times a day Lucky for us we have the capacity to repair each and every one of them New research now reveals exactly how two well known proteins are involved in the process a finding that not only helps shed light on cancer but also

    Original URL path: http://newswire.rockefeller.edu/tag/agata-smogorzewska/ (2016-02-13)
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  • interstrand crosslinks | Newswire
    crosslinks Laboratory of Genome Maintenance promotion August 7 2015 Science News Mutations linked to genetic disorders shed light on a crucial DNA repair pathway Researchers have identified two new genes in which mutations can interfere with a cell s ability to remove misplaced links between DNA strands and as a result cause a rare genetic disorder known as Fanconi anemia These discoveries offer new insight on a repair process critical

    Original URL path: http://newswire.rockefeller.edu/tag/interstrand-crosslinks/ (2016-02-13)
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  • Laboratory of Genome Maintenance | Newswire
    remove misplaced links between DNA strands and as a result cause a rare genetic disorder known as Fanconi anemia These discoveries offer new insight on a repair process critical to maintaining certain tissues and preventing cancer More Tags Agata Smogorzewska cell division DNA repair Fanconi anemia interstrand crosslinks Laboratory of Genome Maintenance RAD51 UBE2T July 20 2010 Science News Researchers identify DNA damage repair gene in Fanconi anemia pathway The threats to our genes come fast and furious To fend them off evolution has come up with complex safety measures to preserve the stability of our DNA New research identifies a protein that is involved in guarding against a particularly dangerous peril called the inter strand crosslink when two strands of DNA become stuck together and can t be unzipped for their proper replication or transcription A mutation in the gene that produces this protein may lead to the deadly cancer causing disorder known as Fanconi anemia and may be involved in breast cancer as well the experiments show More Tags Agata Smogorzewska FAN1 Laboratory of Genome Maintenance November 12 2009 Science News Two proteins act as molecular tailors in DNA repair On average our cells encounter a very lethal

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-genome-maintenance/ (2016-02-13)
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  • promotion | Newswire
    January 16 2015 Campus News Cancer biologist and physician Sohail Tavazoie is promoted to associate professor Tavazoie who joined Rockefeller in 2009 works to understand how cancer cells become able to escape a tumor and invade other organs a process known as metastasis He searches for genes and molecular pathways cancer cells exploit in order to metastasize and with that knowledge hopes to develop future treatments to prevent or interfere

    Original URL path: http://newswire.rockefeller.edu/tag/promotion/ (2016-02-13)
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  • New faculty member probes actions of molecular machines in gene expression | Newswire
    spectroscopy in which molecules of interest are tagged with light emitting fluorophores and their movement tracked and force spectroscopy which probes the mechanical characteristics of molecular motors by applying force or torque to these nanometer scale engines Unlike most traditional methods that report the average property of many molecules single molecule approaches monitor the action of biological complexes one at a time thus revealing their individual characteristics and behavior Moreover these approaches can provide real time dynamic information about biological reactions information that was otherwise difficult to obtain While at Harvard Liu s projects included examining the movement of HIV reverse transcriptase the target of many anti AIDS therapies as it makes a DNA copy of viral RNA During his postdoc Liu studied how certain viruses such as those that cause herpes use a common type of ring shaped molecular motor to pack their genetic material in a protective protein shell during viral assembly He found that this motor coordinates the activities of its subunits in a highly controlled yet adaptable manner This discovery represented a new paradigm for understanding the operation of ring motors At Rockefeller his research will investigate the fundamental gene expression process during which a series of molecular machines act in concert to transcribe DNA code into RNA and then translate RNA into protein He is interested in interactions among the molecular machines responsible for the synthesis translation and degradation of messenger RNA in bacterial cells Liu also plans to study how the DNA transcribing enzyme known as RNA polymerase reads through nucleosomes the DNA organizing units found in eukaryotic cells and how this process is regulated by additional factors and epigenetic modifications In addition to single molecule biophysical tools Liu will also leverage the power of modern biochemical and genomic approaches to elucidate the molecular

    Original URL path: http://newswire.rockefeller.edu/2015/06/24/new-faculty-member-probes-actions-of-molecular-machines-in-gene-expression/ (2016-02-13)
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  • Laboratory of Nanoscale Biophysics and Biochemistry | Newswire
    investigates how these individual machines within the cell interact and in many cases cooperate to accomplish critical tasks such as DNA transcription and gene regulation Liu will establish the Laboratory of Nanoscale Biophysics and Biochemistry as of January 1 More Tags gene expression Laboratory of Nanoscale Biophysics and Biochemistry molecular machines Shixin Liu single molecule techniques Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-nanoscale-biophysics-and-biochemistry/ (2016-02-13)
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  • molecular machines | Newswire
    these individual machines within the cell interact and in many cases cooperate to accomplish critical tasks such as DNA transcription and gene regulation Liu will establish the Laboratory of Nanoscale Biophysics and Biochemistry as of January 1 More Tags gene expression Laboratory of Nanoscale Biophysics and Biochemistry molecular machines Shixin Liu single molecule techniques Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015

    Original URL path: http://newswire.rockefeller.edu/tag/molecular-machines/ (2016-02-13)
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  • single-molecule techniques | Newswire
    how these individual machines within the cell interact and in many cases cooperate to accomplish critical tasks such as DNA transcription and gene regulation Liu will establish the Laboratory of Nanoscale Biophysics and Biochemistry as of January 1 More Tags gene expression Laboratory of Nanoscale Biophysics and Biochemistry molecular machines Shixin Liu single molecule techniques Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive

    Original URL path: http://newswire.rockefeller.edu/tag/single-molecule-techniques/ (2016-02-13)
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