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  • prmd16 | Newswire
    is returning to Rockefeller where he did his graduate work In his new lab Cohen will study the molecular origins of obesity related metabolic disease with the goal of developing treatments More Tags beige fat faculty search Laboratory of Molecular Metabolism Obesity Paul Cohen prmd16 Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv

    Original URL path: http://newswire.rockefeller.edu/tag/prmd16/ (2016-02-13)
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  • $150 million from the Stavros Niarchos Foundation and David Rockefeller launches major campus extension | Newswire
    then the discoveries of the University s many renowned scientists have dramatically advanced knowledge saved countless lives and improved health worldwide I am honored to join with the Stavros Niarchos Foundation in strengthening this great organization in the critically important work it does We are deeply grateful to the Stavros Niarchos Foundation and David Rockefeller for enabling this transformative project which will ensure the strength of the University s scientific and educational programs for decades to come said Russell L Carson chair of the University s Board of Trustees These two extraordinary pledges put us on the path to establishing a new campus that will enable our researchers to remain at the forefront in today s golden age of scientific discovery Dr Tessier Lavigne added Thanks to recent technological advances a revolution is under way in genetics brain science biological imaging cancer biology and immunotherapy to name just a few fields that are being transformed We now have the power to answer fundamental questions about the body in health and in disease that were beyond our reach just a few years ago The Stavros Niarchos Foundation David Rockefeller River Campus will bring leading scientists together and provide them with the resources to make breakthrough discoveries In addition to thanking these two philanthropic pioneers Dr Tessier Lavigne also acknowledged a number of New York City leaders including Manhattan Borough President Gale A Brewer former Mayor Michael Bloomberg and Mayor Bill de Blasio We are tremendously appreciative of these leaders for their essential support Dr Tessier Lavigne said We are also especially grateful to our council member Ben Kallos for his active partnership in shaping the new campus for the benefit of both The Rockefeller University and the New York City community more broadly About the Stavros Niarchos Foundation The Stavros Niarchos Foundation is one of the world s leading private international philanthropic organizations making grants in the areas of arts and culture education health and sports and social welfare The Foundation funds organizations and projects that are expected to achieve a broad lasting and positive impact for society at large and exhibit strong leadership and sound management The Foundation also seeks actively to support projects that facilitate the formation of public private partnerships as an effective means for serving public welfare From 1996 until today the Stavros Niarchos Foundation has made grant commitments of 1 49 billion 1 13 billion through 2 809 grants to nonprofit organizations in 111 nations around the world In 2012 and 2013 the Foundation announced two new initiatives of 100 000 000 130 million each to help the efforts to address the crisis in Greece While the initiative in 2012 which has been completed aimed to provide immediate relief against the adverse effects of the deepening crisis the one in 2013 aims to address the high percentage of youth unemployment seeking to create better employment prospects and new opportunities for the young The Foundation s largest single gift 796 million 566 million is the Stavros Niarchos

    Original URL path: http://newswire.rockefeller.edu/2014/11/24/150-million-from-the-stavros-niarchos-foundation-and-david-rockefeller-launch-major-campus-extension/ (2016-02-13)
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  • Hironori Funabiki promoted to professor | Newswire
    built on the chromosomes and then disassembled in a highly ordered manner during mitosis to support chromosome segregation This machinery includes the mitotic spindle the dynamic fibrous apparatus that drives cell division by separating the duplicate sets of chromosomes and the nuclear envelope which must form around the chromosomes separating them from the rest of the cell to support chromosome replication Scientists have suspected that histones proteins that provide structure for DNA play an important role in triggering the construction of these elements Funabiki s lab has developed a new technique to directly manipulate histones in frog egg extract making possible new experiments that may provide insight into histones role in mitosis A series of studies by Funabiki has also unveiled a signaling cascade involving the kinases Aurora B and Haspin that puts phosphorylation marks on histones and helps restrict assembly of the spindle and the nucleus at the right time and place Current projects in the Funabiki lab focus on modifications to histones and other processes that affect chromosomes during in cell division For instance he is examining how a key chemical mark on certain histones attracts proteins that generate tightly packed DNA packages known as heterochromatin which form at the spot where spindle fibers attach during cell division He is also interested in the attachment process itself and in particular how the cell responds when a fiber attaches at the wrong spot He also wants to better understand how over generations cells avoid losing repetitive DNA sequences found at these attachment points the loss of these sequences can cause errors when chromosomes are segregated a problem frequently observed in cancer cells Hiro s innovative work is helping us to understand one of the most fundamental processes of life cell division and how structural elements form in the cell

    Original URL path: http://newswire.rockefeller.edu/2014/09/17/hironori-funabiki-promoted-to-professor/ (2016-02-13)
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  • chromosomes | Newswire
    one another but they did not More Tags chromosomes Laboratory of Cell Biology andGenetics Rap1 Shaheen Kabir shelterin telomeres Titia de Lange September 17 2014 Campus News Hironori Funabiki promoted to professor Funabiki s research has pointed to a role for DNA packaging proteins known as histones in the formation of structures involved in cell division with implications for understanding and treating disease More Tags chromosomes Hironori Funabiki histones mitosis

    Original URL path: http://newswire.rockefeller.edu/tag/chromosomes/ (2016-02-13)
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  • Hironori Funabiki | Newswire
    understanding and treating disease More Tags chromosomes Hironori Funabiki histones mitosis August 15 2010 Science News Experiments decipher key piece of the histone code in cell division The division of one cell into two is one of the most basic processes of life One of the many tricks involved is the segregation of copied chromosomes to opposite ends of the cell before it divides New research details for the first time the role of an epigenetic modification to the proteins that package DNA in the fundamental biological phenomenon known as mitosis More Tags C David Allis epigenetics Hironori Funabiki Laboratory of Chromosome and Cell Biology December 8 2009 Science News New molecule identified in DNA damage response Evolution places the highest premium on reproduction natural selection s only standard for biological success In the case of replicating cells life spares no expense to ensure that the offspring is a faithful copy of the parent Researchers have identified a new player in this elaborate system of quality control a gene whose mutation can cause a rare but lethal disease More Tags Brian T Chait Hironori Funabiki Laboratory of Chromosome and Cell Biology Laboratory of Mass Spectrometry and Gaseous Ion Chemistry July 30 2007 Science News Chromosomes are responsible for a critical enzyme s activation during cell division The microtubule structures that chromosomes use to migrate to opposite ends of a cell must have impeccable timing They need to materialize when chromosomes are present then dissipate when they re no longer needed Now new research suggests that the enzyme Aurora B is the reason that the microtubules show up on time More Tags cell division Hironori Funabiki July 23 2004 Science News Preparing for a safe split As it prepares to divide a human cell makes exact copies of all of its

    Original URL path: http://newswire.rockefeller.edu/tag/hironori-funabiki/ (2016-02-13)
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  • histones | Newswire
    Science News New technique reveals a role for histones in cell division Researchers have found that key aspects of cell division such as the formation of the support structure for the envelope that surrounds the nucleus depend on the presence of DNA organizing proteins known as histones More Tags cell division Christian Zierhut Hironori Funabiki histones mitotic spindle nuclear envelope nuclear pore complex nucleosomes September 17 2014 Campus News Hironori Funabiki promoted to professor Funabiki s research has pointed to a role for DNA packaging proteins known as histones in the formation of structures involved in cell division with implications for understanding and treating disease More Tags chromosomes Hironori Funabiki histones mitosis January 28 2014 Awards and Honors David Allis pioneer in epigenetics to receive prestigious Japan Prize Allis s discovery that chemical tags bind to specific sections of histone proteins in order to activate or silence nearby genes has ignited the field of epigenetics a relatively new area of study which explores the inheritance of physical changes that cannot be traced back to mutations in the DNA sequence The Japan Prize worth approximately half a million dollars is among the most prestigious prizes in science More Tags awards C David Allis chromatin epigenetics histones japan prize March 29 2013 Science News Mechanism of mutant histone protein in childhood brain cancer revealed Scientists in David Allis s laboratory have shown how a mutated histone protein inhibits an enzyme which normally keeps cell growth in check and causes a rare form of pediatric brain cancer called DIPG Their findings reveal a mechanism for inhibiting enzymes and could lead to the development of pharmaceuticals that mimic the action of these mutant proteins More Tags C David Allis histones Starr Cancer Consortium February 1 2013 Awards and Honors David Allis awarded 1 million

    Original URL path: http://newswire.rockefeller.edu/tag/histones/ (2016-02-13)
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  • mitosis | Newswire
    research has pointed to a role for DNA packaging proteins known as histones in the formation of structures involved in cell division with implications for understanding and treating disease More Tags chromosomes Hironori Funabiki histones mitosis Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The Rockefeller University RU Footer The Rockefeller University

    Original URL path: http://newswire.rockefeller.edu/tag/mitosis/ (2016-02-13)
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  • New faculty member uses genetic sequencing to investigate childhood brain disease | Newswire
    in a day Dodging political conflict communicable disease and war is a risk of the work These patients and their families are desperate for some hope and some improvement in their lives Gleeson says Gleeson who trained as a pediatric neurologist wanted to do more for his patients with brain disorders and his research is focused on delineating these conditions and developing new treatments Sequencing technology with its ability to interpret the entire protein coding region of a genome at once as well as mouse cell and other models of potential culprit mutations are crucial tools for defining new causes of disease And with them he and colleagues have identified mutations that would otherwise be nearly impossible to pinpoint For example within samples from families with children suffering from autism and seizures Gleeson and colleagues identified a cause a mutation in a gene BCKDK involved in essential amino acid metabolism This discovery brought with it a promising treatment replacing the depleted amino acids with a nutritional supplement This newly defined disorder is part of a class of diseases we have discovered that have the potential for treatment at least to some degree by administering to patients something to replace a natural substance typically made by the body Gleeson says These discoveries suggest as yet undiscovered treatments exist for other disorders When searching for the gene responsible for a disease Gleeson uses genetic sequencing an approach he adopted as a postdoc at Harvard Medical School hunting down the gene behind an abnormal brain development disorder called double cortex syndrome At the time in the late 1990s the technology was just becoming available It took us four years to find that gene Now we can find a gene in a day and most days we find more than one Gleeson says With

    Original URL path: http://newswire.rockefeller.edu/2014/07/14/new-faculty-member-uses-genetic-sequencing-to-investigate-childhood-brain-disease/ (2016-02-13)
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