archive-edu.com » EDU » R » ROCKEFELLER.EDU

Total: 1631

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • consanguineous marriage | Newswire
    left the University of California San Diego to establish his lab at Rockefeller where he will continue hunting down the single gene mutations responsible for an array of neurodevelopmental disorders More Tags consanguineous marriage genome sequencing Joseph Gleeson Laboratory of Pediatric Brain Diseases single gene mutations Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow

    Original URL path: http://newswire.rockefeller.edu/tag/consanguineous-marriage/ (2016-02-13)
    Open archived version from archive


  • Laboratory of Pediatric Brain Diseases | Newswire
    has left the University of California San Diego to establish his lab at Rockefeller where he will continue hunting down the single gene mutations responsible for an array of neurodevelopmental disorders More Tags consanguineous marriage genome sequencing Joseph Gleeson Laboratory of Pediatric Brain Diseases single gene mutations Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact

    Original URL path: http://newswire.rockefeller.edu/tag/laboratory-of-pediatric-brain-diseases/ (2016-02-13)
    Open archived version from archive

  • single-gene mutations | Newswire
    left the University of California San Diego to establish his lab at Rockefeller where he will continue hunting down the single gene mutations responsible for an array of neurodevelopmental disorders More Tags consanguineous marriage genome sequencing Joseph Gleeson Laboratory of Pediatric Brain Diseases single gene mutations Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow

    Original URL path: http://newswire.rockefeller.edu/tag/single-gene-mutations/ (2016-02-13)
    Open archived version from archive

  • Structural biologist, focused on cell transport machinery, to join faculty | Newswire
    mapped in detail how the parts of a particular ABC transporter protein the maltose transporter work together to transport sugar into the bacterium E coli She made what is perhaps her most important contribution so far by revealing the complete cycle of the maltose transporter protein which scientists use as a model to study other members of the ABC family The maltose transporter works by bringing a sugar known as maltose into bacterial cells and converting it into ATP which in turn powers the transporter Using a technique known as X ray crystallography Chen and her colleagues explored the protein s structure down to the atomic level and devised a way to capture the transporter in mid action Jue s research has thrown light onto the operation of ubiquitous cellular machines that transport key molecules into and out of cells and her ongoing work will have many important implications for human health says Rockefeller president Marc Tessier Lavigne It is my pleasure to welcome her to the Rockefeller community where she will join a strong group of structural biologists working to solve some of the toughest problems in biology Moving forward Chen wants to apply the lessons from the maltose transporter to human disease and immune response The human body contains 48 different ABC transporters that participate in all kinds of important cellular processes About a dozen have been linked to various diseases including cystic fibrosis One such protein for instance plays a protective role in the blood brain barrier that protects the central nervous system This transporter p glycoprotein turns harmful in cancerous cells It has turned out that p glycoprotein actually pumps the drugs out of the cancer cell before they reach their targets inside the cell Chen says She is also tackling new questions related to transporter

    Original URL path: http://newswire.rockefeller.edu/2014/06/18/structural-biologist-focused-on-cell-transport-machinery-to-join-faculty/ (2016-02-13)
    Open archived version from archive

  • transporter proteins | Newswire
    tenured professor of biology at Purdue University in Indiana and Howard Hughes Medical Institute investigator studies transporter proteins that act as the cell s pumping machinery and their role in health and disease More Tags Jue Chen structural biology transporter proteins X ray crystallography Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like

    Original URL path: http://newswire.rockefeller.edu/tag/transporter-proteins/ (2016-02-13)
    Open archived version from archive

  • X-ray crystallography | Newswire
    tenured professor of biology at Purdue University in Indiana and Howard Hughes Medical Institute investigator studies transporter proteins that act as the cell s pumping machinery and their role in health and disease More Tags Jue Chen structural biology transporter proteins X ray crystallography Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like

    Original URL path: http://newswire.rockefeller.edu/tag/x-ray-crystallography/ (2016-02-13)
    Open archived version from archive

  • In the News – CUNY TV – Tessier-Lavigne | Newswire
    its faculty Rockefeller University scientists are working to unlock the mysteries of dreaded diseases such as cancer and Alzheimer s Rockefeller s President Dr Marc Tessier Lavigne tells Jim Zirin of some of Rockefeller s breakthrough discoveries and updates the prospects for further advances in the service of humanity Tags Alzheimer s disease cancer Marc Tessier Lavigne newswire rockefeller edu Researchers develop gene filtering tool to identify disease causing mutations

    Original URL path: http://newswire.rockefeller.edu/2016/01/11/in-the-news-cuny-tv-tessier-lavigne/ (2016-02-13)
    Open archived version from archive

  • Study detailing axonal death pathway may provide drug targets for neurodegenerative diseases | Newswire
    preserving the axons long structures A few components of this axonal death pathway have been identified over the years says Marc Tessier Lavigne Rockefeller president Carson Family Professor head of the Laboratory of Brain Development and Repair and senior author on the new study What we ve done is to flesh out the pathway by detailing a key early point along the way a classical signaling component called the MAP kinase pathway The MAP kinase pathway which is in many ways an environmental sensor pathway is involved in the damage response and if you block it you can slow or block axonal degeneration The research team s experiments showed that a protein already implicated in degeneration called Sarm1 functions to trigger the MAP kinase pathway which itself is a three level cascade of activation They found that inactivation of the MAP kinase pathway at any of those three levels could block the death of damaged axons With this knowledge in hand we were able to show that this sensor pathway is activated very rapidly after injury within minutes says Jing Yang a postdoctoral associate in the Tessier Lavigne laboratory and first author on the study In fact we were able to see that it is activated and then deactivated we were able to follow that biochemically and that there is then a lag before degeneration Additionally the scientists found that an important downstream step was a loss of ATP the central molecular player in the cellular energy cycle ATP depletion and a resulting cellular energy deficit preceded axonal breakdown and death Next steps in the laboratory will include investigations into how widespread this regulatory step is in neurodegenerative diseases as diverse as Alzheimer s disease Parkinson s disease glaucoma multiple sclerosis and amyotrophic lateral sclerosis better known as ALS or

    Original URL path: http://newswire.rockefeller.edu/2015/01/21/study-detailing-axonal-death-pathway-may-provide-drug-targets-for-neurodegenerative-diseases/ (2016-02-13)
    Open archived version from archive